Luca Unione

Ikerbasque Research Associate, CIC bioGUNE

Ikerbasque Research Associate at CIC bioGUNE.

Research line:

Molecular recognition in Host/Pathogen interactions.

EU ITN Marie Curie Pre-doctoral Fellow, Torres Quevedo contract, International Human Frontier Science Fellowship (HFSP), Juan de la Cierva incorporación Fellow. ERC StG.

Previous research experience at Biology Research Center CIB-CSIC (Spain), Pharmaceutical Company ATLAS Molecular Pharma (Spain), Utrecht University (The Netherlands) and Center for Cooperative Research CIC bioGUNE, (Spain).

PhD in in Biomedicine and Pharmacy.

Publicaciones

2024

Article / Structures of the Inhibitory Receptor Siglec-8 in Complex with a High-Affinity Sialoside Analogue and a Therapeutic Antibody

JACS Au

Maria Pia Lenza, Unai Atxabal, Corwin Nycholat, Iker Oyenarte, Antonio Franconetti, Jon Imanol Quintana, Sandra Delgado, Reyes Núñez-Franco, Carmen Teresa Garnica Marroquín, Helena Coelho, Luca Unione, Gonzalo Jiménez-Oses, Filipa Marcelo, Mario Schubert, James C Paulson 2, Jesús Jiménez-Barbero, June Ereño-Orbea

Article / Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b

Nature Communications

Maria Pia Lenza, Leire Egia-Mendikute, Asier Antoñana-Vildosola, Cátia O. Soares, Helena Coelho, Francisco Corzana, Alexandre Bosch, Prodhi Manisha, Jon Imanol Quintana, Iker Oyenarte, Luca Unione, María Jesús Moure, Mikel Azkargorta, Unai Atxabal, Klaudia Sobczak, Felix Elortza, James D. Sutherland, Rosa Barrio, Filipa Marcelo, Jesús Jiménez-Barbero, Asis Palazon & June Ereño-Orbea

Article / A Multidisciplinary Structural Approach to the Identification of the Haemophilus influenzae Type b Capsular Polysaccharide Protective Epitope

ACS Central Science

Nonne, F.; Iacono, L.D.; Bertuzzi, S.; Unione, L.; Proietti, D.; Norais, N.; Margarit, I.; Adamo, R.; Jiménez-Barbero, J.; Carboni, F.; Romano, M.R.

Article / Probing altered receptor specificities of antigenically drifting human H3N2 viruses by chemoenzymatic synthesis, NMR, and modeling

Nature Communications

Unione, L.; Ammerlaan, A.N.A.; Bosman, G.P.; Uslu, E.; Liang, R.; Broszeit, F.; van der Woude, R.; Liu, Y.; Ma, S.; Liu, L.; Gómez-Redondo, M.; Bermejo, I.A.; Valverde, P.; Diercks, T.; Ardá, A.; de Vries, R.P.; Boons, G.J.

Article / The impact of glycosylation on the structure, function, and interactions of CD14

Glycobiology

Quintana, J.I.; Delgado, S.; Rábano, M.; Azkargorta, M.; Florencio-Zabaleta, M.; Unione, L.; dM Vivanco, M.; Elortza, F.; Jiménez-Barbero, J.; Ardá, A.

Article / Antigenic determinants driving serogroup-specific antibody response to Neisseria meningitidis C, W, and Y capsular polysaccharides: Insights for rational vaccine design

Carbohydrate Polymers

Pietri, G.P.; Bertuzzi, S.; Karnicar, K.; Unione, L.; Lisnic, B.; Malic, S.; Miklic, K.; Novak, M.; Calloni, I.; Santini, L.; Usenik, A.; Romano, M.R.; Adamo, R.; Jonjic, S.; Turk, D.; Jiménez-Barbero, J.; Lenac Rovis, T.

Article / IMMUNOTHERAPY: The power lies in the glycans

eLife

Unione, L.; Jiménez-Barbero, J.

Review / NMR investigations of glycan conformation, dynamics, and interactions

Progress in Nuclear Magnetic Resonance Spectroscopy

Angulo, J.; Ardá, A.; Bertuzzi, S.; Canales, A.; Ereño-Orbea, J.; Gimeno, A.; Gomez-Redondo, M.; Muñoz-García, J.C.; Oquist, P.; Monaco, S.; Poveda, A.; Unione, L.; Jiménez-Barbero, J.

2023

Article / Total Synthesis and Structural Studies of Zwitterionic Bacteroides fragilis Polysaccharide A1 Fragments

J Am Chem Soc

Wang Z, Poveda A, Zhang Q, Unione L, Overkleeft HS, van der Marel GA, Jimenez-Barbero J, Codée JDC

Article / Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b

Nature Communications

Lenza, M.P.; Egia-Mendikute, L.; Antoñana-Vildosola, A.; Soares, C.O.; Coelho, H.; Corzana, F.; Bosch, A.; Manisha, P.; Quintana, J.I.; Oyenarte, I.; Unione, L.; Moure, M.J.; Azkargorta, M.; Atxabal, U.; Sobczak, K.; Elortza, F.; Sutherland, J.D.; Barrio, R.; Marcelo, F.; Jiménez-Barbero, J.; Palazon, A.; Ereño-Orbea, J.

Article / SARS-CoV-2 Spike N-Terminal Domain Engages 9-O-Acetylated α2-8-Linked Sialic Acids

ACS Chemical Biology

Tomris, I.; Unione, L.; Nguyen, L.; Zaree, P.; Bouwman, K.M.; Liu, L.; Li, Z.; Fok, J.A.; Ríos Carrasco, M.; van der Woude, R.; Kimpel, A.L.M.; Linthorst, M.W.; Kilavuzoglu, S.E.; Verpalen, E.C.J.M.; Caniels, T.G.; Sanders, R.W.; Heesters, B.A.; Pieters, R.J.; Jiménez-Barbero, J.; Klassen, J.S.; Boons, G.J.; de Vries, R.P.

Article / Biomimetic Tweezers for N-Glycans: Selective Recognition of the Core GlcNAc2 Disaccharide of the Sialylglycopeptide SGP

Chemistry - A European Journal

Milanesi, F.; Unione, L.; Ardá, A.; Nativi, C.; Jiménez-Barbero, J.; Roelens, S.; Francesconi, O.

Article / Structures of the Inhibitory Receptor Siglec-8 in Complex with a High-Affinity Sialoside Analogue and a Therapeutic Antibody

JACS Au

Lenza, M.P.; Atxabal, U.; Nycholat, C.; Oyenarte, I.; Franconetti, A.; Quintana, J.I.; Delgado, S.; Núñez-Franco, R.; Garnica Marroquín, C.T.; Coelho, H.; Unione, L.; Jiménez-Oses, G.; Marcelo, F.; Schubert, M.; Paulson, J.C.; Jiménez-Barbero, J.; Ereño-Orbea, J.

Article / Total Synthesis and Structural Studies of Zwitterionic Bacteroides fragilis Polysaccharide A1 Fragments

Journal of the American Chemical Society

Wang, Z.; Poveda, A.; Zhang, Q.; Unione, L.; Overkleeft, H.S.; van der Marel, G.A.; Jesús, J.B.; Codée, J.D.C.

Review / Exploring multivalent carbohydrate-protein interactions by NMR

Chemical Society Reviews

Quintana, J.I.; Atxabal, U.; Unione, L.; Ardá, A.; Jiménez-Barbero, J.

2022

Article / The SARS-CoV-2 Spike Glycoprotein Directly Binds Exogeneous Sialic Acids: A NMR View

Angewandte Chemie - International Edition

Unione, L.; Moure, M.J.; Lenza, M.P.; Oyenarte, I.; Ereño-Orbea, J.; Ardá, A.; Jiménez-Barbero, J.