Paolo Bonifazi

Ikerbasque Research Associate, Biobizkaia Health Research Institute

Computational Neuroimaging Lab at Biobizkaia Health Research Institute.

Research line:

Structure-function of brain circuitries: from micro-circuits to brain networks; multi-scale neuronal networks’ structure/dynamics; Optical/electrical multi-unit measurements of neuronal networks; Complex networks .

Marie Curie Actions: Intra-European Fellowship (FP7, 2008-2010); Italian National Scientific Qualification for Associate Professor of Physiology and Applied Physics.

Previous research experience at: Max-Planck Institute for Biochemistry (Martinsried, Germany, 2000), SISSA/ISAS (Trieste, Italy, 2001-2005), University of Cambridge (Cambridge, UK, 2006), INMED-INSERM U901 (Marseille, France, 2007-2010), Tel Aviv University (Tel Aviv, Israel, 2011-2015).

Doctor in Neuroscience (2005) from International School for Advanced Studies (SISSA/ISAS), Trieste, Italy.

2024

Article / Open datasets and code for multi-scale relations on structure, function and neuro-genetics in the human brain

Scientific Data

Jimenez-Marin, A.; Diez, I.; Erramuzpe, A.; Stramaglia, S.; Bonifazi, P.; Cortes, J.M.

2023

Article / Blockage of STAT3 during epileptogenesis prevents GABAergic loss and imprinting of the epileptic state

Brain

Martín-Suárez, S.; Cortes, J.M.; Bonifazi, P.

2022

Article / Brain Mapping of Behavioral Domains Using Multi-Scale Networks and Canonical Correlation Analysis

frontiers in neuroscience

Fernandez-Iriondo I, Jimenez-Marin A, Sierra B, Aginako N, Bonifazi P, Cortes JM.

Article / Acute inhibition of the STA3 signaling pathway during epileptogenesis prevent GABAergic cells’ loss and imprinting of epileptic state: an in-vitro proof

biorxiv

Martin-Suarez S., Cortes JM, Bonifazi P.

Article / Brain Mapping of Behavioral Domains Using Multi-Scale Networks and Canonical Correlation Analysis

Frontiers in Neuroscience

Fernandez-Iriondo, I.; Jimenez-Marin, A.; Sierra, B.; Aginako, N.; Bonifazi, P.; Cortes, J.M.

Review / Neuromorphic-based neuroprostheses for restoring neural functions

Brain Sciences

M Chiappalone, S Buccelli, M Carè, M Di Florio, R Beaubois, F Barban, A Averna, M Brofiga, F Bonacini, D J. Guggenmos, Y Bornat, P Massobrio, P Bonifazi and T Levi

Review / Neuromorphic-Based Neuroprostheses for Brain Rewiring: State-of-the-Art and Perspectives in Neuroengineering

Brain Sciences

Chiappalone, M.; Cota, V.R.; Carè, M.; Di Florio, M.; Beaubois, R.; Buccelli, S.; Barban, F.; Brofiga, M.; Averna, A.; Bonacini, F.; Guggenmos, D.J.; Bornat, Y.; Massobrio, P.; Bonifazi, P.; Levi, T.

2021

Article / Small variation in dynamic functional connectivity in cerebellar networks

neurocomputing

Fernandez-Iriondo I, Jimenez-Marin A, Diez I, Bonifazi P, Swinnen SP, Muñoz MA, Cortes JM

Article / Small variation in dynamic functional connectivity in cerebellar networks

Neurocomputing

Fernandez-Iriondo, I.; Jimenez-Marin, A.; Diez, I.; Bonifazi, P.; Swinnen, S.P.; Muñoz, M.A.; Cortes, J.M.

2020

Article / Microglial phagocytosis dysfunction is related to local neuronal activity in a genetic model of epilepsy.

Epilepsia

Sierra-Torre V, Plaza-Zabala A, Bonifaci P, Abiega O, Diaz-Aparicio I, Tejelberg S, Lehesjoki AE, Valero J, Sierra A.

Article / Microglial phagocytosis dysfunction in the dentate gyrus is related to local neuronal activity in a genetic model of epilepsy

Epilepsia

Sierra-Torre, V.; Plaza-Zabala, A.; Bonifazi, P.; Abiega, O.; Díaz-Aparicio, I.; Tegelberg, S.; Lehesjoki, A.E.; Valero, J.; Sierra, A.

Article / Toward neuroprosthetic real-time communication from in silico to biological neuronal network via patterned optogenetic stimulation

Scientific Reports

Mosbacher, Y.; Khoyratee, F.; Goldin, M.; Kanner, S.; Malakai, Y.; Silva, M.; Grassia, F.; Simon, Y.B.; Cortes, J.; Barzilai, A.; Levi, T.; Bonifazi, P.

Article / Structure-function connectomics reveals aberrant developmental trajectory occurring at preadolescence in the autistic brain

Cerebral Cortex

He, C.; Chen, H.; Uddin, L.Q.; Erramuzpe, A.; Bonifazi, P.; Guo, X.; Xiao, J.; Chen, H.; Huang, X.; Li, L.; Sheng, W.; Liao, W.; Cortes, J.M.; Duan, X.

2019

Chapter / In vitro neuronal networks: from culturing methods to neuro-technological applications

Paolo Bonifazi and Paolo Massobrio

Article / Abrupt growth for neurons and major brain structures during birth in a rat model of autism

Science Advances

R. Cloarec, B. Riffault, A. Dufour, H. Rabiei, L-A. Gouty-Colomer, C. Dumon, D. Guimond, A. Pons-Benaceur, P. Bonifazi, S. Eftekhari, N. Lozovaya, D. C. Ferrari, Y. Ben-Ari.

Article / Early alterations in a mouse model of Rett syndrome: the GABA developmental shift is abolished at birth

Scientific Reports

Lozovaya, N.; Nardou, R.; Tyzio, R.; Chiesa, M.; Pons-Bennaceur, A.; Eftekhari, S.; Bui, T.T.; Billon-Grand, M.; Rasero, J.; Bonifazi, P.; Guimond, D.; Gaiarsa, J.L.; Ferrari, D.C.; Ben-Ari, Y.

Article / A Neuromorphic Prosthesis to Restore Communication in Neuronal Networks

iScience

Buccelli, S.; Bornat, Y.; Colombi, I.; Ambroise, M.; Martines, L.; Pasquale, V.; Bisio, M.; Tessadori, J.; Nowak, P.; Grassia, F.; Averna, A.; Tedesco, M.; Bonifazi, P.; Difato, F.; Massobrio, P.; Levi, T.; Chiappalone, M.

Article / The GABA Developmental Shift Is Abolished by Maternal Immune Activation Already at Birth

Cerebral Cortex

Fernandez, A.; Dumon, C.; Guimond, D.; Tyzio, R.; Bonifazi, P.; Lozovaya, N.; Burnashev, N.; Ferrari, D.C.; Ben-Ari, Y.

Article / Pyramidal neuron growth and increased hippocampal volume during labor and birth in autism

Science Advances

Cloarec, R.; Riffault, B.; Dufour, A.; Rabiei, H.; Gouty-Colomer, L.A.; Dumon, C.; Guimond, D.; Bonifazi, P.; Eftekhari, S.; Lozovaya, N.; Ferrari, D.C.; Ben-Ari, Y.

2018

Chapter / Nonlinear Dynamics in Computational Neuroscience

F. Corinto and A. Torcini

Luccioli S., Ben-Jacob E., Barzilai A., Bonifazi P., and Torcini A.

Article / The emergence of dynamical instantaneous memory in the spontaneous activity of spatially confined neuronal assemblies in-vitro

bioRxiv

Piasetzky Y., Bisio M., Kanner S., Olivenbaum M., Ben-Jacob E., Chiappalone M., Barzilai A. and Bonifazi P

Article / Structure–function multi-scale connectomics reveals a major role of the fronto-striato-thalamic circuit in brain aging

Human Brain Mapping

Bonifazi, P.; Erramuzpe, A.; Diez, I.; Gabilondo, I.; Boisgontier, M.P.; Pauwels, L.; Stramaglia, S.; Swinnen, S.P.; Cortes, J.M.

Article / Interaction information along lifespan of the resting brain dynamics reveals a major redundant role of the default mode network

Entropy

Camino-Pontes, B.; Diez, I.; Jimenez-Marin, A.; Rasero, J.; Erramuzpe, A.; Bonifazi, P.; Stramaglia, S.; Swinnen, S.; Cortes, J.M.

Article / Modeling driver cells in developing neuronal networks

PLoS Computational Biology

Luccioli, S.; Angulo-Garcia, D.; Cossart, R.; Malvache, A.; Módol, L.; Sousa, V.H.; Bonifazi, P.; Torcini, A.

Article / Astrocytes restore connectivity and synchronization in dysfunctional cerebellar networks

Proceedings of the National Academy of Sciences of the United States of America

Kanner, S.; Goldin, M.; Galron, R.; Jacob, E.B.; Bonifazi, P.; Barzilai, A.

2017

Article / Enhanced pre-frontal functional-structural networks to support postural control deficits after traumatic brain injury in a pediatric population.

network neuroscience

Diez I., Drijkoningen D., Stramaglia S., Bonifazi P., Marinazzo D., Gooijers J., Swinnen S. P., Cortes J. M.

Article / Group-level progressive alterations in brain connectivity patterns revealed by diffusion-tensor brain networks across severity stages in Alzheimer's disease

Frontiers in Aging Neuroscience

Rasero, J.; Alonso-Montes, C.; Diez, I.; Olabarrieta-Landa, L.; Remaki, L.; Escudero, I.; Mateos, B.; Bonifazi, P.; Fernandez, M.; Arango-Lasprilla, ; Stramaglia, S.; Cortes, J.M.

Article / Enhanced prefrontal functional–structural networks to support postural control deficits after traumatic brain injury in a pediatric population

Network Neuroscience

Diez, I.; Drijkoningen, D.; Stramaglia, S.; Bonifazi, P.; Marinazzo, D.; Gooijers, J.; Swinnen, S.P.; Cortes, J.M.

2015

Article / A novel brain partition highlights the modular skeleton shared by structure and function

Scientific Reports

Diez, I.; Bonifazi, P.; Escudero, I.; Mateos, B.; Muñoz, M.A.; Stramaglia, S.; Cortes, J.M.

2011

Book / Neuroinformatica

P. Massobrio, V. Pasquale, M. Garofalo, P. Bonifazi, M. Chiappalone, S. Martinoia

2019

Oral presentation | Topological properties of neuronal circuits emerging from spontaneous dynamics: from hub neurons to cerebellar networks failures

18th Meeting of the Spanish Society of Neuroscience - Oral presentation

Paolo Bonifazi

Oral presentation | Patho-topologies in neuronal microcircuits: astrocytes impact and restore connectivity, a proof of principle from Ataxia-Telangiectasia

International congress on dravet syndrome and refractory epilepsy - Oral presentation

Paolo Bonifazi

Poster presentation | Brain Hierarchical Atlas: Multi-Scale versus Optimal Strategies in the Pathological Brain

2019 Organization for Human Brain Mapping (OHBM) Annual Meeting; Rome, 9-13 June 2019 - Poster presentation

Cortes JM, Bonifazi P, Escudero I, Mateos B, Muñoz MA, Stramaglia S, Camino-Pontes B, Jimenez-Marin A, Rasero J, Erramuzpe A, Swinnen S, Gabilondo I, Boisgontier MP, Pauwels L, Olabarrieta-Landa L, Fernandez Martinez M, Arango Lasprilla JC, Drijkoninge

Poster presentation | Structure-function multi-scale connectomics is an accurate predictor of brain aging

2019 Organization for Human Brain Mapping (OHBM) Annual Meeting; Rome, 9-13 June 2019 - Poster presentation

Bonifazi P, Erramuzpe A, Diez I, Gabilondo I, Boisgontier M, Pauwels L, Stramaglia S, Swinnen S, Camino-Pontes B, Jimenez-Marin A, Cortes J.

Poster presentation | Structure-function multi-scale connectomics is an accurate predictor of brain aging

28th Annual Computational Neuroscience Meeting - Poster presentation

Bonifazi P, Erramuzpe A, Diez I, Gabilondo I, Boisgontier M, Pauwels L, Stramaglia S, Swinnen S, Camino-Pontes B, Jimenez-Marin A, Cortes J

2017

Invited talk | Astrocytes Replacement Recovers Neuronal Synchronizations in ATM-Deficient Cerebellar Circuits in-Vitro.

2nd International Symposium on Neuromorphic, non-linear, Neurofluidic Engineering - Invited talk

Paolo Bonifazi

Invited talk | Sparse synchronizations and neuronal network failures: astrocytes replacement recovers global synchronizations in Atm-deficient cerebellar circuits in-vitro.

Workshop on recent methods and analyses for neuronal population recordings, 26th Annual Computational Neuroscience Meeting (CNS) - Invited talk

Paolo Bonifazi

2016

Invited talk | Complex networks reveal structural-functional brain resting-state subnetworks: identification, description and application as biomarkers

Neurogune, third Basque Neuroscience. - Invited talk

Bonifazi P, Diez I, Escudero I, Mateos B, Muñoz MA, Stramaglia S and Cortes JM.

Oral presentation | Structural-functional brain resting-state subnetworks: identification, description and application as biomarkers

Simplifying Complex Biological Systems - Oral presentation

Bonifazi P, Diez I, Escudero I, Mateos B, Muñoz MA, Stramaglia S and Cortes JM

Oral presentation | Structural-functional brain resting-state subnetworks: identification, description and application as biomarkers

QBio 2016, QUANTITATIVE BIOMEDICINE FOR HEALTH AND DISEASE - Oral presentation

Bonifazi P, Diez I, Escudero I, Mateos B, Muñoz MA, Stramaglia S and Cortes JM