Marcos J. Araúzo-Bravo

Ikerbasque Research Professor, Biogipuzkoa Health Research Institute

He leads the Computational Biology and Biomedicine Systems.

Research line:

Computational Biology and Bioinformatics applied to the study of the interaction of –omics networks in the context of regenerative medicine and human diseases.

Previous research experience as Post doctoral fellow at Kyushu Institute of Technology (Japan), funded by the Japan Society for Promotion of Science (JSPS). Researcher at Fujirebio Inc. (Japan). Laboratory leader at the Max Planck Institute for Molecular Biomedicine (Germany).

Doctor in Industrial Technologies (2001) from the Polytechnic University of Cartagena (Spain). Doctor in Information Technology (2003) from the Kyushu Institute of Technology (Japan).

2024

Article / Physical Interventions Restore Physical Frailty and the Expression of CXCL-10 and IL-1β Inflammatory Biomarkers in Old Individuals and Mice

Biomolecules

Marcos-Pérez, D.; Cruces-Salguero, S.; García-Domínguez, E.; Araúzo-Bravo, M.J.; Gómez-Cabrera, M.C.; Viña, J.; Vergara, I.; Matheu, A.

Article / Cell-Free Genic Extrachromosomal Circular DNA Profiles of DNase Knockouts Associated with Systemic Lupus Erythematosus and Relation with Common Fragile Sites

Biomedicines

Gerovska, D.; Fernández Moreno, P.; Zabala, A.; Araúzo-Bravo, M.J.

Article / Transmembrane Protein TMEM230, Regulator of Glial Cell Vascular Mimicry and Endothelial Cell Angiogenesis in High-Grade Heterogeneous Infiltrating Gliomas and Glioblastoma

International Journal of Molecular Sciences

Cocola, C.; Abeni, E.; Martino, V.; Piscitelli, E.; Pelucchi, P.; Mosca, E.; Chiodi, A.; Mohamed, T.; Palizban, M.; Porta, G.; Palizban, H.; Nano, G.; Acquati, F.; Bruno, A.; Greve, B.; Gerovska, D.; Magnaghi, V.; Mazzaccaro, D.; Bertalot, G.; Kehler, J.; Balbino, C.; Arauzo-Bravo, M.J.; Götte, M.; Zucchi, I.; Reinbold, R.A.

Article / Single-cell transcriptomic analysis to identify endomembrane regulation of metalloproteins and motor proteins in autoimmunity

Advances in Protein Chemistry and Structural Biology

Abeni, E.; Cocola, C.; Croci, S.; Martino, V.; Piscitelli, E.; Gualtierotti, R.; Pelucchi, P.; Tria, V.; Porta, G.; Troschel, F.; Greve, B.; Nano, G.; Tomilin, A.; Kehler, J.; Gerovska, D.; Mazzaccaro, D.; Götte, M.; Arauzo-Bravo, M.J.; Carlo, S.; Zucchi, I.; Reinbold, R.

Article / rhBMP-2 induces terminal differentiation of human bone marrow mesenchymal stromal cells only by synergizing with other signals

Stem cell research & therapy

Kathami, N.; Moreno-Vicente, C.; Martín, P.; Vergara-Arce, J.A.; Ruiz-Hernández, R.; Gerovska, D.; Aransay, A.M.; Araúzo-Bravo, M.J.; Camarero-Espinosa, S.; Abarrategi, A.

Article / Galunisertib downregulates mutant type I collagen expression and promotes MSCs osteogenesis in pediatric osteogenesis imperfecta

Biomedicine and Pharmacotherapy

Infante, A.; Alcorta-Sevillano, N.; Macías, I.; Cabodevilla, L.; Medhat, D.; Lafaver, B.; Crawford, T.K.; Phillips, C.L.; Bueno, A.M.; Sagastizabal, B.; Arroyo, M.; Campino, A.; Gerovska, D.; Araúzo-Bravo, M.; Gener, B.; Rodríguez, C.I.

Article / Epigenetics Meets CAR-T-Cell Therapy to Fight Cancer

Cancers

Santourlidis, S.; Araúzo-Bravo, M.J.; Erichsen, L.; Bendhack, M.L.

Article / hTERT Epigenetics Provides New Perspectives for Diagnosis and Evidence-Based Guidance of Chemotherapy in Cancer

International Journal of Molecular Sciences

Santourlidis, S.; Araúzo-Bravo, M.J.; Brodell, R.T.; Hassan, M.; Bendhack, M.L.

Article / Chronic disease incidence explained by stepwise models and co-occurrence among them

iScience

Arróspide Elgarresta, M.; Gerovska, D.; Soto-Gordoa, M.; Jauregui García, M.L.; Merino Hernández, M.L.; Araúzo-Bravo, M.J.

Article / Drug-delivery and biological activity in colorectal cancer of a supramolecular porous material assembled from heptameric chromium-copper-adenine entities

Journal of Materials Chemistry B

Mena-Gutiérrez, S.; Maiza-Razkin, E.; Pascual-Colino, J.; Araúzo-Bravo, M.J.; Beobide, G.; Castillo, O.; Castellanos-Rubio, A.; Gerovska, D.; Luque, A.; Pérez-Yáñez, S.

2023

Article / Prediction of patient admission and readmission in adults from a Colombian cohort with bipolar disorder using artificial intelligence

Front. Psychiatry

Palacios-Ariza MA, Morales-Mendoza E, Murcia J, Arias-Duarte R, Lara-Castellanos G, Cely-Jiménez A, Rincón-Acuña JC*, Araúzo-Bravo MJ*,McDouall J*

Article / Cell-Free Genic Extrachromosomal Circular DNA Profiles of DNase Knockouts Associated with Systemic Lupus Erythematosus and Relation with Common Fragile Sites

Biomedicines

Gerovska D, Fernández Moreno P , Zabala A, Araúzo-Bravo MJ

Article / A distinct circular DNA profile intersects with proteome changes in the genotoxic stress-related hSOD1<sup>G93A</sup> model of ALS

Cell and Bioscience

Gerovska, D.; Noer, J.B.; Qin, Y.; Ain, Q.; Januzi, D.; Schwab, M.; Witte, O.W.; Araúzo-Bravo, M.J.; Kretz, A.

Article / Single-cell RNA sequencing of human non-hematopoietic bone marrow cells reveals a unique set of inter-species conserved biomarkers for native mesenchymal stromal cells

Stem Cell Research and Therapy

Fiévet, L.; Espagnolle, N.; Gerovska, D.; Bernard, D.; Syrykh, C.; Laurent, C.; Layrolle, P.; De Lima, J.; Justo, A.; Reina, N.; Casteilla, L.; Araúzo-Bravo, M.J.; Naji, A.; Pagès, J.C.; Deschaseaux, F.

Article / Systemic Lupus Erythematosus Patients with DNASE1L3·Deficiency Have a Distinctive and Specific Genic Circular DNA Profile in Plasma

Cells

Gerovska, D.; Araúzo-Bravo, M.J.

Article / Skeletal Muscles of Sedentary and Physically Active Aged People Have Distinctive Genic Extrachromosomal Circular DNA Profiles

International Journal of Molecular Sciences

Gerovska, D.; Araúzo-Bravo, M.J.

Article / Consistent DNA Hypomethylations in Prostate Cancer

International Journal of Molecular Sciences

Araúzo-Bravo, M.J.; Erichsen, L.; Ott, P.; Beermann, A.; Sheikh, J.; Gerovska, D.; Thimm, C.; Bendhack, M.L.; Santourlidis, S.

Article / Prediction of patient admission and readmission in adults from a Colombian cohort with bipolar disorder using artificial intelligence

Frontiers in Psychiatry

Palacios-Ariza, M.A.; Morales-Mendoza, E.; Murcia, J.; Arias-Duarte, R.; Lara-Castellanos, G.; Cely-Jiménez, A.; Rincón-Acuña, J.C.; Araúzo-Bravo, M.J.; McDouall, J.

Review / Circular and Circulating DNA in Inflammatory Bowel Disease: From Pathogenesis to Potential Molecular Therapies

Cells

Di Vincenzo, F.; Yadid, Y.; Petito, V.; Emoli, V.; Masi, L.; Gerovska, D.; Araúzo-Bravo, M.J.; Gasbarrini, A.; Regenberg, B.; Scaldaferri, F.

2022

Article / 555 Dermal single-cell atlas: a novel tool to explore fibroblast heterogeneity

Journal of Investigative Dermatology

Ascensión AM , Fuertes-Álvarez S, Araúzo-Bravo MJ, Izeta A

Article / Predictability of COVID-19 Infections Based on Deep Learning and Historical Data

Applied Sciences

Zrieq, R.; Kamel, S.; Boubaker, S.; Algahtani, F.D.; Alzain, M.A.; Alshammari, F.; Aldhmadi, B.K.; Alshammari, F.S.; Araúzo-Bravo, M.J.

Article / The decline in hepatitis B and C in women: A 5-year retrospective case study in Ha’il, Saudi Arabia

Avicenna

Zrieq R, Algahtani FD, Ali RM, Al-Najjar MAA, Suleiman S, Alshammari F, Alsaif B, Araúzo-Bravo MJ

Article / Role of Furin in Colon Cancer Stem Cells Malignant Phenotype and Expression of LGR5 and NANOG in KRAS and BRAF-Mutated Colon Tumors

Cancers (Basel)

Descarpentrie J, Araúzo-Bravo MJ, He Z, François A, González Á, Garcia-Gallastegi P, Badiola I, Evrard S, Pernot S, Creemers JWM, Khatib AM

Article / Lack of evidence for increased transcriptional noise in aged tissues

Elife

Ibañez-Solé O, Ascensión AM, Araúzo-Bravo MJ, Izeta A

Article / Senescence plays a role in myotonic dystrophy type 1

JCI Insight

García-Puga, M.; Saenz-Antoñanzas, A.; Gerenu, G.; Arrieta-Legorburu, A.; Fernández-Torrón, R.; Zulaica, M.; Saenz, A.; Elizazu, J.; Nogales-Gadea, G.; Gadalla, S.M.; Araúzo-Bravo, M.J.; de Munain, A.L.; Matheu, A.

Article / Lack of evidence for increased transcriptional noise in aged tissues

eLife

Ibáñez-Solé, O.; Ascensión, A.M.; Araúzo-Bravo, M.J.; Izeta, A.

Article / The common incidence-age multistep model of neurodegenerative diseases revisited: wider general age range of incidence corresponds to fewer disease steps

Cell and Bioscience

Gerovska, D.; Araúzo-Bravo, M.J.

Article / Differential DNA Methylation of THOR and hTAPAS in the Regulation of hTERT and the Diagnosis of Cancer

Cancers

Ott, P.; Araúzo-Bravo, M.J.; Hoffmann, M.J.; Poyet, C.; Bendhack, M.L.; Santourlidis, S.; Erichsen, L.

Article / Induced Endothelial Cell-Integrated Liver Assembloids Promote Hepatic Maturation and Therapeutic Effect on Cholestatic Liver Fibrosis

Cells

Nam, D.; Park, M.R.; Lee, H.; Bae, S.C.; Gerovska, D.; Araúzo-Bravo, M.J.; Zaehres, H.; Schöler, H.R.; Kim, J.B.

Article / Vaccination Accelerates Liver-Intrinsic Expression of Megakaryocyte-Related Genes in Response to Blood-Stage Malaria

Vaccines

Wunderlich, F.; Delic, D.; Gerovska, D.; Araúzo-Bravo, M.J.

Article / A balanced Oct4 interactome is crucial for maintaining pluripotency

Science Advances

Han, D.; Wu, G.; Chen, R.; Drexler, H.C.A.; MacCarthy, C.M.; Kim, K.P.; Adachi, K.; Gerovska, D.; Mavrommatis, L.; Bedzhov, I.; Araúzo-Bravo, M.J.; Schöler, H.R.

Article / The need to reassess single-cell RNA sequencing datasets: The importance of biological sample processing

F1000Research

Araúzo-Bravo, M.J.; Izeta, A.; Ascensión, A.M.

Article / Triku: A feature selection method based on nearest neighbors for single-cell data

GigaScience

M Ascensión, A.; Ibáñez-SolCrossed D Sign©, O.; Inza, I.; Izeta, A.; Araúzo-Bravo, M.J.

Article / BigMPI4py: Python Module for Parallelization of Big Data Objects Discloses Germ Layer Specific DNA Demethylation Motifs

IEEE/ACM Transactions on Computational Biology and Bioinformatics

Ascension, A.M.; Arauzo-Bravo, M.J.

Review / Epigenetics in the Diagnosis and Therapy of Malignant Melanoma

International Journal of Molecular Sciences

Santourlidis, S.; Schulz, W.A.; Araúzo-Bravo, M.J.; Gerovska, D.; Ott, P.; Bendhack, M.L.; Hassan, M.; Erichsen, L.

Review / Challenges and Opportunities for the Translation of Single-Cell RNA Sequencing Technologies to Dermatology

Life

Ascensión, A.M.; Araúzo-Bravo, M.J.; Izeta, A.

2021

Article / Reiterative infusions of MSCs improve pediatric osteogenesis imperfecta eliciting a pro-osteogenic paracrine response: TERCELOI clinical trial

Clin Transl Med.

Infante A, Gener B, Vázquez M, Olivares N, Arrieta A, Grau G, Llano I, Madero L, Bueno AM, Sagastizabal B, Gerovska D, Araúzo-Bravo MJ, Astigarraga I, Rodríguez CI

Article / Discovery and Proof-of-Concept Study of Nuclease Activity as a Novel Biomarker for Breast Cancer Tumors

Cancers (Basel) .

Hernandez LI, Araúzo-Bravo MJ, Gerovska D, Solaun RR, Machado I, Balian A, Botero J, Jiménez T, Zuriarrain Bergara O, Larburu Gurruchaga L, Urruticoechea A, Hernandez FJ

Article / Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model

Journal of Hepatology

Yang, T.; Poenisch, M.; Khanal, R.; Hu, Q.; Dai, Z.; Li, R.; Song, G.; Yuan, Q.; Yao, Q.; Shen, X.; Taubert, R.; Engel, B.; Jaeckel, E.; Vogel, A.; Falk, C.S.; Schambach, A.; Gerovska, D.; Araúzo-Bravo, M.J.; Vondran, F.W.R.; Cantz, T.; Horscroft, N.; Balakrishnan, A.; Chevessier, F.; Ott, M.; Sharma, A.D.

Article / Human Dermal Fibroblast Subpopulations Are Conserved across Single-Cell RNA Sequencing Studies

Journal of Investigative Dermatology

Ascensión, A.M.; Fuertes-Álvarez, S.; Ibañez-Solé, O.; Izeta, A.; Araúzo-Bravo, M.J.

Article / Geromirs are downregulated in the tumor microenvironment during colon cancer colonization of the liver in a murine metastasis model

International Journal of Molecular Sciences

Gerovska, D.; Garcia-Gallastegi, P.; Crende, O.; Márquez, J.; Larrinaga, G.; Unzurrunzaga, M.; Araúzo-Bravo, M.J.; Badiola, I.

Article / Proprotein convertases blockage up-regulates specifically metallothioneins coding genes in human colon cancer stem cells

Biochimica et Biophysica Acta - Molecular Cell Research

Gerovska, D.; García-Gallastegi, P.; Descarpentrie, J.; Crende, O.; Casado-Andrés, M.; Martín, A.; Eguia, J.; Khatib, A.M.; Araúzo-Bravo, M.J.; Badiola, I.

Article / FOntCell: Fusion of Ontologies of Cells

Frontiers in Cell and Developmental Biology

Cabau-Laporta, J.; Ascensión, A.M.; Arrospide-Elgarresta, M.; Gerovska, D.; Araúzo-Bravo, M.J.

Article / Discovery and proof-of-concept study of nuclease activity as a novel biomarker for breast cancer tumors

Cancers

Hernandez, L.I.; Araúzo-Bravo, M.J.; Gerovska, D.; Solaun, R.R.; Machado, I.; Balian, A.; Botero, J.; Jiménez, T.; Bergara, O.Z.; Gurruchaga, L.L.; Urruticoechea, A.; Hernandez, F.J.

Article / The need to reassess single-cell RNA sequencing datasets: more is not always better

F1000Research

Ascensión, A.M.; Araúzo-Bravo, M.J.; Izeta, A.

Article / Permissive epigenomes endow reprogramming competence to transcriptional regulators

Nature Chemical Biology

Kim, K.P.; Choi, J.; Yoon, J.; Bruder, J.M.; Shin, B.; Kim, J.; Arauzo-Bravo, M.J.; Han, D.; Wu, G.; Han, D.W.; Kim, J.; Cramer, P.; Schöler, H.R.

Review / Genome scale modeling to study the metabolic competition between cells in the tumor microenvironment

Cancers

Frades, I.; Foguet, C.; Cascante, M.; Araúzo-Bravo, M.J.

2020

Chapter / Molecular biomarkers in urologic oncology

Yair Lotan, Nathan Lawrentschuk, and Jack Schalken

Simeon Santourlidis, Marcos J. Araúzo-Bravo, Marcelo Bendhack

Article / BigMPI4py: Python module for parallelization of Big Data objects discloses germ layer specific DNA demethylation motifs

IEEE/ACM Trans Comput Biol Bioinform.

Alex M Ascension, Marcos J Arauzo-Bravo

Article / HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis

Journal of Clinical Investigation

Palomo-Irigoyen, M.; Pérez-Andrés, E.; Iruarrizaga-Lejarreta, M.; Barreira-Manrique, A.; Tamayo-Caro, M.; Vila-Vecilla, L.; Moreno-Cugnon, L.; Beitia, N.; Medrano, D.; Fernández-Ramos, D.; Lozano, J.J.; Okawa, S.; Lavín, J.L.; Martín-Martín, N.; Sutherland, J.D.; de Juan, V.G.; Gonzalez-Lopez, M.; Macías-Cámara, N.; Mosén-Ansorena, D.; Laraba, L.; Oliver Hanemann, C.; Ercolano, E.; Parkinson, D.B.; Schultz, C.W.; Araúzo-Bravo, M.J.; Ascensión, A.M.; Gerovska, D.; Iribar, H.; Izeta, A.; Pytel, P.; Krastel, P.; Provenzani, A.; Seneci, P.; Carrasco, R.D.; Sol, A.D.; Martinez-Chantar, M.L.; Barrio, R.; Serra, E.; Lazaro, C.; Flanagan, A.M.; Gorospe, M.; Ratner, N.; Aransay, A.M.; Carracedo, A.; Varela-Rey, M.; Woodhoo, A.

Article / An integrative omics approach reveals involvement of BRCA1 in hepatic metastatic progression of colorectal cancer

Cancers

Gerovska, D.; Larrinaga, G.; Solano-Iturria, J.D.; Márquez, J.; Gallastegi, P.G.; Khatib, A.M.; Poschmann, G.; Stühler, K.; Armesto, M.; Lawrie, C.H.; Badiola, I.; Araúzo-Bravo, M.J.

Article / SOX9 promotes tumor progression through the axis BMI1-p21<sup>CIP</sup>

Scientific Reports

Aldaz, P.; Otaegi-Ugartemendia, M.; Saenz-Antoñanzas, A.; Garcia-Puga, M.; Moreno-Valladares, M.; Flores, J.M.; Gerovska, D.; Arauzo-Bravo, M.J.; Samprón, N.; Matheu, A.; Carrasco-Garcia, E.

Article / Protective vaccination reshapes hepatic response to blood-stage malaria of genes preferentially expressed by nk cells

Vaccines

Araúzo-Bravo, M.J.; Delic, D.; Gerovska, D.; Wunderlich, F.

Article / Genealogy of the neurodegenerative diseases based on a meta-analysis of age-stratified incidence data

Scientific Reports

Gerovska, D.; Irizar, H.; Otaegi, D.; Ferrer, I.; López de Munain, A.; Araúzo-Bravo, M.J.

Article / Basic Hallmarks of Urothelial Cancer Unleashed in Primary Uroepithelium by Interference with the Epigenetic Master Regulator ODC1

Scientific Reports

Erichsen, L.; Seifert, H.H.; Schulz, W.A.; Hoffmann, M.J.; Niegisch, G.; Araúzo-Bravo, M.J.; Bendhack, M.L.; Poyet, C.; Hermanns, T.; Beermann, A.; Hassan, M.; Theis, L.; Mahmood, W.; Santourlidis, S.

Article / Reprogramming competence of OCT factors is determined by transactivation domains

Science Advances

Kim, K.P.; Wu, Y.; Yoon, J.; Adachi, K.; Wu, G.; Velychko, S.; MacCarthy, C.M.; Shin, B.; Röpke, A.; Arauzo-Bravo, M.J.; Stehling, M.; Han, D.W.; Gao, Y.; Kim, J.; Gao, S.; Schöler, H.R.

Article / Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model

eLife

Lee, H.; Lee, H.Y.; Lee, B.E.; Gerovska, D.; Park, S.Y.; Zaehres, H.; Araúzo-Bravo, M.J.; Kim, J.I.; Ha, Y.; Schöler, H.R.; Kim, J.B.

Article / Vaccination accelerates hepatic erythroblastosis induced by blood-stage malaria

Malaria Journal

Delic, D.; Wunderlich, F.; Al-Quraishy, S.; Abdel-Baki, A.A.S.; Dkhil, M.A.; Araúzo-Bravo, M.J.

2019

Article / Signal Integration and Transcriptional Regulation of the Inflammatory Response Mediated by the GM-/M-CSF Signaling Axis in Human Monocytes

Cell Reports

Rodriguez RM, Suarez-Alvarez B, Lavín JL, Ascensión AM, Gonzalez M, Lozano JJ, Raneros AB, Bulnes PD, Vidal-Castiñeira JR, Huidobro C, Martin-Martin C, Sanz AB, Ruiz-Ortega M, Puig-Kröger A, Corbí AL, Araúzo-Bravo MJ, Aransay AM, Lopez-Larrea C

Article / Oct4 and Hnf4?-induced hepatic stem cells ameliorate chronic liver injury in liver fibrosis model

PLoS One

Park MR, Wong MS, Araúzo-Bravo MJ, Lee H, Nam D, Park SY, Seo HD, Lee SM, Zeilhofer HF, Zaehres H, Schöler HR, Kim JB

Article / The K2P -channel TASK1 affects Oligodendroglial differentiation but not myelin restoration

Glia

Albrecht S, Korr S, Nowack L, Narayanan V, Starost L, Stortz F, Araúzo-Bravo MJ, Meuth SG, Kuhlmann T, Hundehege P

Article / Therapeutic relevance of SOX9 stem cell factor in gastric cancer

Expert Opinion on Therapeutic Targets

Carrasco-Garcia, E.; Álvarez-Satta, M.; García-Puga, M.; Ribeiro, M.L.; Arevalo, S.; Arauzo-Bravo, M.; Matheu, A.

Article / Enhanced Ex Vivo Generation of Erythroid Cells from Human Induced Pluripotent Stem Cells in a Simplified Cell Culture System with Low Cytokine Support

Stem Cells and Development

Bernecker, C.; Ackermann, M.; Lachmann, N.; Rohrhofer, L.; Zaehres, H.; Araúzo-Bravo, M.J.; Van Den Akker, E.; Schlenke, P.; Dorn, I.

Article / Computational analysis of single-cell transcriptomics data elucidates the stabilization of Oct4 expression in the E3.25 mouse preimplantation embryo

Scientific Reports

Gerovska, D.; Araúzo-Bravo, M.J.

Article / Signal Integration and Transcriptional Regulation of the Inflammatory Response Mediated by the GM-/M-CSF Signaling Axis in Human Monocytes

Cell Reports

Rodriguez, R.M.; Suarez-Alvarez, B.; Lavín, J.L.; Ascensión, A.M.; Gonzalez, M.; Lozano, J.J.; Raneros, A.B.; Bulnes, P.D.; Vidal-Castiñeira, J.R.; Huidobro, C.; Martin-Martin, C.; Sanz, A.B.; Ruiz-Ortega, M.; Puig-Kröger, A.; Corbí, A.L.; Araúzo-Bravo, M.J.; Aransay, A.M.; Lopez-Larrea, C.

Article / Oct4 and Hnf4α-induced hepatic stem cells ameliorate chronic liver injury in liver fibrosis model

PLoS ONE

Park, M.R.; Wong, M.S.; Araúzo-Bravo, M.J.; Lee, H.; Nam, D.; Park, S.Y.; Seo, H.D.; Lee, S.M.; Zeilhofer, H.F.; Zaehres, H.; Schöler, H.R.; Kim, J.B.

Article / The K 2P -channel TASK1 affects Oligodendroglial differentiation but not myelin restoration

GLIA

Albrecht, S.; Korr, S.; Nowack, L.; Narayanan, V.; Starost, L.; Stortz, F.; Araúzo-Bravo, M.J.; Meuth, S.G.; Kuhlmann, T.; Hundehege, P.

Article / GABA-B1 Receptor-Null Schwann Cells Exhibit Compromised In Vitro Myelination

Molecular Neurobiology

Faroni, A.; Melfi, S.; Castelnovo, L.F.; Bonalume, V.; Colleoni, D.; Magni, P.; Araúzo-Bravo, M.J.; Reinbold, R.; Magnaghi, V.

2018

Article / 1429 VEGF mediates rejuvenation of aged human skin xenografts in young mice

Journal of Investigative Dermatology

Kerena , Yndriago l , Izeta A , Gerovska D , Araúzo-Bravo MJ , Paus R, Gilhar A

Article / PR-LncRNA signature regulates glioma cell activity through expression of SOX factors

Scientific Reports

Torres-Bayona, S.; Aldaz, P.; Auzmendi-Iriarte, J.; Saenz-Antoñanzas, A.; Garcia, I.; Arrazola, M.; Gerovska, D.; Undabeitia, J.; Querejeta, A.; Egaña, L.; Villanúa, J.; Ruiz, I.; Sarasqueta, C.; Urculo, E.; Araúzo-Bravo, M.J.; Huarte, M.; Samprón, N.; Matheu, A.

Article / Genome-wide hypomethylation of LINE-1 and Alu retroelements in cell-free DNA of blood is an epigenetic biomarker of human aging

Saudi Journal of Biological Sciences

Erichsen, L.; Beermann, A.; Arauzo-Bravo, M.J.; Hassan, M.; Dkhil, M.A.; Al-Quraishy, S.; Hafiz, T.A.; Fischer, J.C.; Santourlidis, S.

Article / Esrrb Unlocks Silenced Enhancers for Reprogramming to Naive Pluripotency

Cell Stem Cell

Adachi, K.; Kopp, W.; Wu, G.; Heising, S.; Greber, B.; Stehling, M.; Araúzo-Bravo, M.J.; Boerno, S.T.; Timmermann, B.; Vingron, M.; Schöler, H.R.

Article / Targeting liver sinusoidal endothelial cells with miR-20a-loaded nanoparticles reduces murine colon cancer metastasis to the liver

International Journal of Cancer

Marquez, J.; Fernandez-Piñeiro, I.; Araúzo-Bravo, M.J.; Poschmann, G.; Stühler, K.; Khatib, A.M.; Sanchez, A.; Unda, F.; Ibarretxe, G.; Bernales, I.; Badiola, I.

Article / Gene expression of the liver of vaccination-protected mice in response to early patent infections of Plasmodium chabaudi blood-stage malaria

Malaria Journal

Al-Quraishy, S.; Dkhil, M.A.; Al-Shaebi, E.M.; Abdel-Baki, A.A.S.; Araúzo-Bravo, M.J.; Delic, D.; Wunderlich, F.

Article / Rules governing the mechanism of epigenetic reprogramming memory

Epigenomics

Luu, P.L.; Gerovska, D.; Schöler, H.R.; Araúzo-Bravo, M.J.

Article / Revised roles of ISL1 in a hES cell-based model of human heart chamber specification

eLife

Quaranta, R.; Fell, J.; Rühle, F.; Rao, J.; Piccini, I.; Araúzo-Bravo, M.J.; Verkerk, A.O.; Stoll, M.; Greber, B.

2017

Article / NaviSE: Superenhancer Navigator integrating epigenomics signal algebr

BMC Bioinformatics

Alex M Ascensión, Mikel Arrospide-Elgarresta, Ander Izeta, Araúzo-Bravo MJ.

Article / GAA deficiency in Pompe disease is alleviated by exon inclusion in iPS-derived skeletal muscle cells

Molecular Therapy - Nucleic Acids

van der Wal E, Bergsma A, van Gestel T, in 't Groen S, Zaehres H, Araúzo-Bravo MJ, Schöler HR, Van der Ploeg A, Pijnappel W

Article / DNA methylation regulates discrimination of enhancers from promoters through a H3K4me1-H3K4me3 seesaw mechanism

BMC Genomics

Sharifi-Zarchi, A.; Gerovska, D.; Adachi, K.; Totonchi, M.; Pezeshk, H.; Taft, R.J.; Schöler, H.R.; Chitsaz, H.; Sadeghi, M.; Baharvand, H.; Araúzo-Bravo, M.J.

Article / NaviSE: Superenhancer navigator integrating epigenomics signal algebra

BMC Bioinformatics

Ascensión, A.M.; Arrospide-Elgarresta, M.; Izeta, A.; Araúzo-Bravo, M.J.

Article / Protective vaccination and blood-stage malaria modify DNA methylation of gene promoters in the liver of Balb/c mice

Parasitology Research

Al-Quraishy, S.; Dkhil, M.A.; Abdel-Baki, A.A.S.; Ghanjati, F.; Erichsen, L.; Santourlidis, S.; Wunderlich, F.; Araúzo-Bravo, M.J.

Article / Astrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant TAU protein

Scientific Reports

Hallmann, A.L.; Araúzo-Bravo, M.J.; Mavrommatis, L.; Ehrlich, M.; Röpke, A.; Brockhaus, J.; Missler, M.; Sterneckert, J.; Schöler, H.R.; Kuhlmann, T.; Zaehres, H.; Hargus, G.

Article / P3BSseq: Parallel processing pipeline software for automatic analysis of bisulfite sequencing data

Bioinformatics

Luu, P.L.; Gerovska, D.; Arrospide-Elgarresta, M.; Retegi-Carrión, S.; Schöler, H.R.; Araúzo-Bravo, M.J.

Article / Changing POU dimerization preferences converts Oct6 into a pluripotency inducer

EMBO Reports

Jerabek, S.; Ng, C.K.L.; Wu, G.; Arauzo-Bravo, M.J.; Kim, K.P.; Esch, D.; Malik, V.; Chen, Y.; Velychko, S.; MacCarthy, C.M.; Yang, X.; Cojocaru, V.; Schöler, H.R.; Jauch, R.

2016

Article / BAF complex enhances reprogramming of adult human fibroblasts

Journal of Stem Cell Research & Therapy

Singhal N, Araúzo-Bravo MJ, Sinn M, Zaehres H

Article / Functional high-resolution time-course expression analysis of human embryonic stem cells undergoing cardiac induction

Genomics Data

Piccini I, Araúzo-Bravo MJ, Seebohm G, Greber B

Article / SOX9 elevation acts with canonical WNT signaling to drive gastric cancer progression

Cancer Research

Santos, J.C.; Carrasco-Garcia, E.; Garcia-Puga, M.; Aldaz, P.; Montes, M.; Fernandez-Reyes, M.; De Oliveira, C.C.; Lawrie, C.H.; Arauzo-Bravo, M.J.; Ribeiro, M.L.; Matheu, A.

Article / Identification and Characterization of the Dermal Panniculus Carnosus Muscle Stem Cells

Stem Cell Reports

Naldaiz-Gastesi, N.; Goicoechea, M.; Alonso-Martín, S.; Aiastui, A.; López-Mayorga, M.; García-Belda, P.; Lacalle, J.; San José, C.; Araúzo-Bravo, M.J.; Trouilh, L.; Anton-Leberre, V.; Herrero, D.; Matheu, A.; Bernad, A.; García-Verdugo, J.M.; Carvajal, J.J.; Relaix, F.; Lopez de Munain, A.; García-Parra, P.; Izeta, A.

Article / Inflammaging and frailty status do not result in an increased extracellular vesicle concentration in circulation

International Journal of Molecular Sciences

Alberro, A.; Sáenz-Cuesta, M.; Muñoz-Culla, M.; Mateo-Abad, M.; Gonzalez, E.; Carrasco-Garcia, E.; Araúzo-Bravo, M.J.; Matheu, A.; Vergara, I.; Otaegui, D.

Article / Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes in Vivo Attenuates Liver Fibrosis

Cell Stem Cell

Song, G.; Pacher, M.; Balakrishnan, A.; Yuan, Q.; Tsay, H.C.; Yang, D.; Reetz, J.; Brandes, S.; Dai, Z.; Pützer, B.M.; Araúzo-Bravo, M.J.; Steinemann, D.; Luedde, T.; Schwabe, R.F.; Manns, M.P.; Schöler, H.R.; Schambach, A.; Cantz, T.; Ott, M.; Sharma, A.D.

Article / Comparative transcriptome analysis in induced neural stem cells reveals defined neural cell identities in vitro and after transplantation into the adult rodent brain

Stem Cell Research

Hallmann, A.L.; Araúzo-Bravo, M.J.; Zerfass, C.; Senner, V.; Ehrlich, M.; Psathaki, O.E.; Han, D.W.; Tapia, N.; Zaehres, H.; Schöler, H.R.; Kuhlmann, T.; Hargus, G.

Article / Blood-stage malaria of Plasmodium chabaudi induces differential Tlr expression in the liver of susceptible and vaccination-protected Balb/c mice

Parasitology Research

Al-Quraishy, S.; Dkhil, M.A.; Alomar, S.; Abdel-Baki, A.A.S.; Delic, D.; Wunderlich, F.; Araúzo-Bravo, M.J.

Article / Distinct Signaling Requirements for the Establishment of ESC Pluripotency in Late-Stage EpiSCs

Cell Reports

Illich, D.J.; Zhang, M.; Ursu, A.; Osorno, R.; Kim, K.P.; Yoon, J.; Araúzo-Bravo, M.J.; Wu, G.; Esch, D.; Sabour, D.; Colby, D.; Grassme, K.S.; Chen, J.; Greber, B.; Höing, S.; Herzog, W.; Ziegler, S.; Chambers, I.; Gao, S.; Waldmann, H.; Schöler, H.R.

Article / Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs

Cell Stem Cell

Rao, J.; Pfeiffer, M.J.; Frank, S.; Adachi, K.; Piccini, I.; Quaranta, R.; Araúzo-Bravo, M.; Schwarz, J.; Schade, D.; Leidel, S.; Schöler, H.R.; Seebohm, G.; Greber, B.

Article / Establishment of feeder-free culture system for human induced pluripotent stem cell on das nanocrystalline graphene

Scientific Reports

Lee, H.; Nam, D.; Choi, J.K.; Araúzo-Bravo, M.J.; Kwon, S.Y.; Zaehres, H.; Lee, T.; Park, C.Y.; Kang, H.W.; Schöler, H.R.; Kim, J.B.

2015

Book / Methods Mol Biol.

Turksen K. and Nagy A.

Araúzo-Bravo MJ.

Article / Oct4-induced oligodendrocyte progenitor cells enhance functional recovery in spinal cord injury model

EMBO Journal

Kim, J.B.; Lee, H.; Araúzo-Bravo, M.J.; Hwang, K.; Nam, D.; Park, M.R.; Zaehres, H.; Park, K.I.; Lee, S.J.

Article / Does mouse embryo primordial germ cell activation start before implantation as suggested by single-cell transcriptomics dynamics?

Molecular Human Reproduction

Gerovska, D.; Araúzo-Bravo, M.J.

Article / Direct Induction of Trophoblast Stem Cells from Murine Fibroblasts

Cell Stem Cell

Kubaczka, C.; Senner, C.E.; Cierlitza, M.; Araúzo-Bravo, M.J.; Kuckenberg, P.; Peitz, M.; Hemberger, M.; Schorle, H.

Article / A mechanism for the segregation of age in mammalian neural stem cells

Science

Moore, D.L.; Pilz, G.A.; Araúzo-Bravo, M.J.; Barral, Y.; Jessberger, S.

Article / Dissecting the role of distinct OCT4-SOX2 heterodimer configurations in pluripotency

Scientific Reports

Tapia, N.; Maccarthy, C.; Esch, D.; Gabriele Marthaler, A.; Tiemann, U.; Araúzo-Bravo, M.J.; Jauch, R.; Cojocaru, V.; Schöler, H.R.

Article / Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein

Stem Cell Reports

Ehrlich, M.; Hallmann, A.L.; Reinhardt, P.; Araúzo-Bravo, M.J.; Korr, S.; Röpke, A.; Psathaki, O.E.; Ehling, P.; Meuth, S.G.; Oblak, A.L.; Murrell, J.R.; Ghetti, B.; Zaehres, H.; Schöler, H.R.; Sterneckert, J.; Kuhlmann, T.; Hargus, G.

Article / Increased robustness of early embryogenesis through collective decision-making by key transcription factors

BMC Systems Biology

Sharifi-Zarchi, A.; Totonchi, M.; Khaloughi, K.; Karamzadeh, R.; Araúzo-Bravo, M.J.; Baharvand, H.; Tusserkani, R.; Pezeshk, H.; Chitsaz, H.; Sadeghi, M.

Article / Universal cardiac induction of human pluripotent stem cells in two and three-dimensional formats: Implications for in vitro maturation

Stem Cells

Zhang, M.; Schulte, J.S.; Heinick, A.; Piccini, I.; Rao, J.; Quaranta, R.; Zeuschner, D.; Malan, D.; Kim, K.P.; Röpke, A.; Sasse, P.; Araúzo-Bravo, M.; Seebohm, G.; Schöler, H.; Fabritz, L.; Kirchhof, P.; Müller, F.U.; Greber, B.

Article / Human primordial germ cell commitment in vitro associates with a unique PRDM14 expression profile

EMBO Journal

Sugawa, F.; Araúzo-Bravo, M.J.; Yoon, J.; Kim, K.P.; Aramaki, S.; Wu, G.; Stehling, M.; Psathaki, O.E.; Hübner, K.; Schöler, H.R.

Article / Hypoxia induces pluripotency in primordial germ cells by HIF1α stabilization and Oct4 deregulation

Antioxidants and Redox Signaling

López-Iglesias, P.; Alcaina, Y.; Tapia, N.; Sabour, D.; Arauzo-Bravo, M.J.; Sainz De La Maza, D.; Berra, E.; O'Mara, A.N.; Nistal, M.; Ortega, S.; Donovan, P.J.; Schöler, H.R.; De Miguel, M.P.

Article / Reactivation of the inactive X chromosome and posttranscriptional reprogramming of Xist in iPSCs

Journal of Cell Science

Kim, J.S.; Choi, H.W.; Araúzo-Bravo, M.J.; Schöler, H.R.; Do, J.T.

Article / Erythroid differentiation of human induced pluripotent stem cells is independent of donor cell type of origin

Haematologica

Dorn, I.; Klich, K.; Arauzo-Bravo, M.J.; Radstaak, M.; Santourlidis, S.; Ghanjati, F.; Radke, T.F.; Psathaki, O.E.; Hargus, G.; Kramer, J.; Einhaus, M.; Kim, J.B.; Kögler, G.; Wernet, P.; Schöler, H.R.; Schlenke, P.; Zaehres, H.

Article / MicroRNA-199a-5p inhibition enhances the liver repopulation ability of human embryonic stem cell-derived hepatic cells

Journal of Hepatology

Möbus, S.; Yang, D.; Yuan, Q.; Lüdtke, T.H.W.; Balakrishnan, A.; Sgodda, M.; Rani, B.; Kispert, A.; Araúzo-Bravo, M.J.; Vogel, A.; Manns, M.P.; Ott, M.; Cantz, T.; Sharma, A.D.

Article / Epigenetic modifications of gene promoter DNA in the liver of adult female mice masculinized by testosterone

Journal of Steroid Biochemistry and Molecular Biology

Dkhil, M.A.; Al-Quraishy, S.; Abdel-Baki, A.A.; Ghanjati, F.; Arauzo-Bravo, M.J.; Delic, D.; Wunderlich, F.

2014

Article / Human bone marrow stromal cells lose immunosuppressive and anti-inflammatory properties upon oncogenic transformation

Stem Cell Reports

Rodriguez, R.; Rosu-Myles, M.; Aráuzo-Bravo, M.; Horrillo, A.; Pan, Q.; Gonzalez-Rey, E.; Delgado, M.; Menendez, P.

Article / Testosterone persistently dysregulates hepatic expression of Tlr6 and Tlr8 induced by Plasmodium chabaudi malaria

Parasitology Research

Al-Quraishy, S.; Dkhil, M.A.; S. Abdel-Baki, A.A.; Araúzo-Bravo, M.J.; Delic, D.; Wunderlich, F.

Article / Origin-dependent neural cell identities in differentiated human iPSCs in vitro and after transplantation into the mouse brain

Cell Reports

Hargus, G.; Ehrlich, M.; Araúzo-Bravo, M.J.; Hemmer, K.; Hallmann, A.L.; Reinhardt, P.; Kim, K.P.; Adachi, K.; Santourlidis, S.; Ghanjati, F.; Fauser, M.; Ossig, C.; Storch, A.; Kim, J.B.; Schwamborn, J.C.; Sterneckert, J.; Schöler, H.R.; Kuhlmann, T.; Zaehres, H.

Article / DNA replication is an integral part of the mouse oocyte's reprogramming machinery

PLoS ONE

Wang, B.; Pfeiffer, M.J.; Schwarzer, C.; Araúzo-Bravo, M.J.; Boiani, M.

Article / Unreserved application of epigenetic methods to define differences of DNA methylation between urinary cellular and cell-free DNA

Cancer Biomarkers

Ghanjati, F.; Beermann, A.; Hermanns, T.; Poyet, C.; Araúzo-Bravo, M.J.; Seifert, H.H.; Schmidtpeter, M.; Goering, W.; Sorg, R.; Wernet, P.; Santourlidis, S.

Article / Nanog induces hyperplasia without initiating tumors

Stem Cell Research

Fischedick, G.; Wu, G.; Adachi, K.; Araúzo-Bravo, M.J.; Greber, B.; Radstaak, M.; Köhler, G.; Tapia, N.; Iacone, R.; Anastassiadis, K.; Schöler, H.R.; Zaehres, H.

Article / A novel feeder-free culture system for expansion of mouse spermatogonial stem cells

Molecules and Cells

Choi, N.Y.; Park, Y.S.; Ryu, J.S.; Lee, H.J.; Araúzo-Bravo, M.J.; Ko, K.; Han, D.W.; Schöler, H.R.; Ko, K.

Article / Direct conversion of mouse fibroblasts into induced neural stem cells

Nature Protocols

Kim, S.M.; Flaßkamp, H.; Hermann, A.; Araúzo-Bravo, M.J.; Lee, S.C.; Lee, S.H.; Seo, E.H.; Lee, S.H.; Storch, A.; Lee, H.T.; Schöler, H.R.; Tapia, N.; Han, D.W.

Development of computational tools for the study of glioblastoma using artificial inteligence technologies