Beatriz Trastoy

Ikerbasque Research Fellow, Biobizkaia

Ikerbasque Research Fellow at Biobizkaia Health Research Institute.

Research line:

Structural Glycoimmunology.

“Ramon y Cajal” Fellowship (2022-2025, MICINN, Spain), “Marie Skłodowska-Curie Individual Fellowship” (2019-2021, European Commission) and “Juan de la Cierva-Incorporación” (2016-2018, MICINN, Spain).

Previous research experience at CIC bioGUNE (Spain), Institute of Human Virology, University of Maryland, School of Medicine (USA), and Institute of General Organic Chemistry, Spanish National Research Council (CSIC, Spain).

Doctor in Chemistry from Autonomous University of Madrid (2011).

Publications

2024

Article / Human gut microbes express functionally distinct endoglycosidases to metabolize the same N-glycan substrate

Nature Communications

Sastre, D.E.; Sultana, N.; V. A. S. Navarro, M.; Huliciak, M.; Du, J.; Cifuente, J.O.; Flowers, M.; Liu, X.; Lollar, P.; Trastoy, B.; Guerin, M.E.; Sundberg, E.J.

2023

Article / Turning universal O into rare Bombay type blood

Nature Communications

Anso, I.; Naegeli, A.; Cifuente, J.O.; Orrantia, A.; Andersson, E.; Zenarruzabeitia, O.; Moraleda-Montoya, A.; García-Alija, M.; Corzana, F.; Del Orbe, R.A.; Borrego, F.; Trastoy, B.; Sjögren, J.; Guerin, M.E.

Article / Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases

Nature Communications

Trastoy, B.; Du, J.J.; Cifuente, J.O.; Rudolph, L.; García-Alija, M.; Klontz, E.H.; Deredge, D.; Sultana, N.; Huynh, C.G.; Flowers, M.W.; Li, C.; Sastre, D.E.; Wang, L.X.; Corzana, F.; Mallagaray, A.; Sundberg, E.J.; Guerin, M.E.

Article / SigH stress response mediates killing of Mycobacterium tuberculosis by activating nitronaphthofuran prodrugs via induction of Mrx2 expression

Nucleic Acids Research

Cioetto-Mazzabò, L.; Boldrin, F.; Beauvineau, C.; Speth, M.; Marina, A.; Namouchi, A.; Segafreddo, G.; Cimino, M.; Favre-Rochex, S.; Balasingham, S.; Trastoy, B.; Munier-Lehmann, H.; Griffiths, G.; Gicquel, B.; Guerin, M.E.; Manganelli, R.; Alonso-Rodríguez, N.

Review / Modulating antibody effector functions by Fc glycoengineering

Biotechnology Advances

García-Alija, M.; van Moer, B.; Sastre, D.E.; Azzam, T.; Du, J.J.; Trastoy, B.; Callewaert, N.; Sundberg, E.J.; Guerin, M.E.

2022

Article / Mechanism of cooperative N-glycan processing by the multi-modular endoglycosidase EndoE

Nature Communications

García-Alija, M.; Du, J.J.; Ordóñez, I.; Diz-Vallenilla, A.; Moraleda-Montoya, A.; Sultana, N.; Huynh, C.G.; Li, C.; Donahue, T.C.; Wang, L.X.; Trastoy, B.; Sundberg, E.J.; Guerin, M.E.

Review / Sculpting therapeutic monoclonal antibody N-glycans using endoglycosidases

Current Opinion in Structural Biology

Trastoy, B.; Du, J.J.; García-Alija, M.; Li, C.; Klontz, E.H.; Wang, L.X.; Sundberg, E.J.; Guerin, M.E.