Jesús Jiménez-Barbero

Ikerbasque Research Professor, Scientific Director CIC bioGUNE

Scientific Director at CIC bioGUNE.

Research line:

NMR & molecular recognition.

Royal Society of Chemistry of Spain, Janssen-Cilag Award in Organic Chemistry (2003), Bruker NMR Prize of the Spanish Royal Society of Chemistry (2008), International Whistler Award in Carbohydrate Chemistry (2010).

Previous research experience at University of Zurich (Switzerland), National Institute for Medical Research, Mill Hill (United Kingdom), Carnegie Mellon University (United States), IQOG-CSIC (Spain) and CIB-CSIC (Spain).

Doctor in Organic Chemistry, University Autonoma of Madrid and IQOG-CSIC (1987).

2024

Article / Structures of the Inhibitory Receptor Siglec-8 in Complex with a High-Affinity Sialoside Analogue and a Therapeutic Antibody

JACS Au

Maria Pia Lenza, Unai Atxabal, Corwin Nycholat, Iker Oyenarte, Antonio Franconetti, Jon Imanol Quintana, Sandra Delgado, Reyes Núñez-Franco, Carmen Teresa Garnica Marroquín, Helena Coelho, Luca Unione, Gonzalo Jiménez-Oses, Filipa Marcelo, Mario Schubert, James C Paulson 2, Jesús Jiménez-Barbero, June Ereño-Orbea

Article / Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b

Nature Communications

Maria Pia Lenza, Leire Egia-Mendikute, Asier Antoñana-Vildosola, Cátia O. Soares, Helena Coelho, Francisco Corzana, Alexandre Bosch, Prodhi Manisha, Jon Imanol Quintana, Iker Oyenarte, Luca Unione, María Jesús Moure, Mikel Azkargorta, Unai Atxabal, Klaudia Sobczak, Felix Elortza, James D. Sutherland, Rosa Barrio, Filipa Marcelo, Jesús Jiménez-Barbero, Asis Palazon & June Ereño-Orbea

Article / Unraveling molecular recognition of glycan ligands by Siglec-9 via NMR spectroscopy and molecular dynamics modeling.

ACS Chemical Biology

Unai Atxabal, Corwin Nycholat, Johannes Pröpster, Andrea Fernández, Iker Oyenarte, Maria Pia Lenza, Antonio Franconetti, Cátia O. Soares, Helena Coelho, Filipa Marcelo, Mario Schubert, James C. Paulson, Jesús Jiménez-Barbero, and June Ereño-Orbea

Article / Enzymatic bioconversion of beechwood xylan into the antioxidant 2′-O-α-(4-O-methyl-D-glucuronosyl)-xylobiose

Biomass Conversion and Biorefinery

Miguez, N.; Fernandez-Polo, D.; Santos-Moriano, P.; Rodríguez-Colinas, B.; Poveda, A.; Jimenez-Barbero, J.; Ballesteros, A.O.; Plou, F.J.

Article / Illuminating a Solvent-Dependent Hierarchy for Aromatic CH/π Complexes with Dynamic Covalent Glyco-Balances

JACS Au

Díaz-Casado, L.; Villacampa, A.; Corzana, F.; Jiménez-Barbero, J.; Gómez, A.M.; Santana, A.G.; Asensio, J.L.

Article / A Multidisciplinary Structural Approach to the Identification of the Haemophilus influenzae Type b Capsular Polysaccharide Protective Epitope

ACS Central Science

Nonne, F.; Iacono, L.D.; Bertuzzi, S.; Unione, L.; Proietti, D.; Norais, N.; Margarit, I.; Adamo, R.; Jiménez-Barbero, J.; Carboni, F.; Romano, M.R.

Article / Dissecting the Conformational Stability of a Glycan Hairpin

Journal of the American Chemical Society

Yadav, N.; Djalali, S.; Poveda, A.; Ricardo, M.G.; Seeberger, P.H.; Jiménez-Barbero, J.; Delbianco, M.

Article / Strategy for the Enzymatic Acylation of the Apple Flavonoid Phloretin Based on Prior α-Glucosylation

Journal of Agricultural and Food Chemistry

Gonzalez-Alfonso, J.L.; Alonso, C.; Poveda, A.; Ubiparip, Z.; Ballesteros, A.O.; Desmet, T.; Jiménez-Barbero, J.; Coderch, L.; Plou, F.J.

Article / Unraveling Molecular Recognition of Glycan Ligands by Siglec-9 via NMR Spectroscopy and Molecular Dynamics Modeling

ACS Chemical Biology

Atxabal, U.; Nycholat, C.; Pröpster, J.M.; Fernández, A.; Oyenarte, I.; Lenza, M.P.; Franconetti, A.; Soares, C.O.; Coelho, H.; Marcelo, F.; Schubert, M.; Paulson, J.C.; Jiménez-Barbero, J.; Ereño-Orbea, J.

Article / Evolution of human H3N2 influenza virus receptor specificity has substantially expanded the receptor-binding domain site

Cell Host and Microbe

Thompson, A.J.; Wu, N.C.; Canales, A.; Kikuchi, C.; Zhu, X.; de Toro, B.F.; Cañada, F.J.; Worth, C.; Wang, S.; McBride, R.; Peng, W.; Nycholat, C.M.; Jiménez-Barbero, J.; Wilson, I.A.; Paulson, J.C.

Article / The impact of glycosylation on the structure, function, and interactions of CD14

Glycobiology

Quintana, J.I.; Delgado, S.; Rábano, M.; Azkargorta, M.; Florencio-Zabaleta, M.; Unione, L.; dM Vivanco, M.; Elortza, F.; Jiménez-Barbero, J.; Ardá, A.

Article / Antigenic determinants driving serogroup-specific antibody response to Neisseria meningitidis C, W, and Y capsular polysaccharides: Insights for rational vaccine design

Carbohydrate Polymers

Pietri, G.P.; Bertuzzi, S.; Karnicar, K.; Unione, L.; Lisnic, B.; Malic, S.; Miklic, K.; Novak, M.; Calloni, I.; Santini, L.; Usenik, A.; Romano, M.R.; Adamo, R.; Jonjic, S.; Turk, D.; Jiménez-Barbero, J.; Lenac Rovis, T.

Article / Disentangling Glycan-Protein Interactions: Nuclear Magnetic Resonance (NMR) to the Rescue

Journal of Visualized Experiments

Bertuzzi, S.; Poveda, A.; Ardá, A.; Gimeno, A.; Jiménez-Barbero, J.

Article / Quantifying Siglec-sialylated ligand interactions: a versatile 19F-T2 CPMG filtered competitive NMR displacement assay

Chemical Science

Atxabal, U.; Fernández, A.; Moure, M.J.; Sobczak, K.; Nycholat, C.; Almeida-Marrero, V.; Oyenarte, I.; Paulson, J.C.; Escosura, A.d.l.; Torres, T.; Reichardt, N.C.; Jiménez-Barbero, J.; Ereño-Orbea, J.

Article / Nanotechnology-assisted intracellular delivery of antibody as a precision therapy approach for KRAS-driven tumors

Journal of Controlled Release

López-Estévez, A.M.; Sanjurjo, L.; Turrero, Á.; Arriaga, I.; Abrescia, N.G.A.; Poveda, A.; Jiménez-Barbero, J.; Vidal, A.; Torres, D.; Alonso, M.J.

Article / Solid-Phase-Supported Chemoenzymatic Synthesis and Analysis of Chondroitin Sulfate Proteoglycan Glycopeptides

Angewandte Chemie - International Edition

Lin, P.h.; Xu, Y.; Bali, S.K.; Kim, J.; Gimeno, A.; Roberts, E.T.; James, D.; Almeida, N.M.S.; Loganathan, N.; Fan, F.; Wilson, A.K.; Jonathan Amster, I.; Moremen, K.W.; Liu, J.; Jiménez-Barbero, J.; Huang, X.

Article / Insights into the transglucosylation activity of α-glucosidase from Schwanniomyces occidentalis

Applied Microbiology and Biotechnology

Merdzo, Z.; Narmontaite, E.; Gonzalez-Alfonso, J.L.; Poveda, A.; Jimenez-Barbero, J.; Plou, F.J.; Fernández-Lobato, M.

Article / Different roles of the heterodimer architecture of galectin-4 in selective recognition of oligosaccharides and lipopolysaccharides having ABH antigens

Journal of Biological Chemistry

Quintana, J.I.; Massaro, M.; Cagnoni, A.J.; Nuñez-Franco, R.; Delgado, S.; Jiménez-Osés, G.; Mariño, K.V.; Rabinovich, G.A.; Jiménez-Barbero, J.; Ardá, A.

Article / Exploring galectin interactions with human milk oligosaccharides and blood group antigens identifies BGA6 as a functional galectin-4 ligand

Journal of Biological Chemistry

Cagnoni, A.J.; Massaro, M.; Cutine, A.M.; Gimeno, A.; Pérez-Sáez, J.M.; Manselle Cocco, M.N.; Maller, S.M.; Di Lella, S.; Jiménez-Barbero, J.; Ardá, A.; Rabinovich, G.A.; Mariño, K.V.

Article / Insights into the recognition of hypermucoviscous Klebsiella pneumoniae clinical isolates by innate immune lectins of the Siglec and galectin families

Frontiers in Immunology

Campanero-Rhodes, M.A.; Martí, S.; Hernández-Ortiz, N.; Cubero, M.; Ereño-Orbea, J.; Ardá, A.; Jiménez-Barbero, J.; Ardanuy, C.; Solís, D.

Article / Unprecedented selectivity for homologous lectin targets: differential targeting of the viral receptors L-SIGN and DC-SIGN

Chemical Science

Delaunay, C.; Pollastri, S.; Thepaut, M.; Cavazzoli, G.; Belvisi, L.; Bouchikri, C.; Labiod, N.; Lasala, F.; Gimeno, A.; Franconetti, A.; Jimenez-Barbero, J.; Arda, A.; Delgado, R.; Bernardi, A.; Fieschi, F.

Article / Opposed Aromatic Surfaces Behave as Independent Binding Sites for Carbohydrate Stacking: Analysis of Sandwich-like CH/π/CH Complexes

JACS Au

Díaz-Casado, L.; Mann, E.; Jiménez-Moreno, E.; Villacampa, A.; Montalvillo-Jiménez, L.; Sánchez-García, C.; Corzana, F.; Jiménez-Barbero, J.; Gómez, A.M.; Santana, A.G.; Asensio, J.L.

Article / Glycosylium Ions in Superacid Mimic the Transition State of Enzyme Reactions

Journal of the American Chemical Society

Armand, M.; Nin-Hill, A.; Ardá, A.; Berrino, E.; Désiré, J.; Martin-Mingot, A.; Michelet, B.; Jiménez-Barbero, J.; Blériot, Y.; Rovira, C.; Thibaudeau, S.

Article / Unveiling the GT114 family: Structural characterization of A075L, a glycosyltransferase from Paramecium bursaria chlorella virus-1 (PBCV-1)

Protein Science

Laugieri, M.E.; Speciale, I.; Gimeno, A.; Lin, S.; Byers, B.W.; Poveda, A.; Núñez-Franco, R.; Iturrioz, I.; Moure, M.J.; Jiménez-Osés, G.; Russo-Krauss, I.; Notaro, A.; Van Etten, J.L.; Lowary, T.L.; Jimenez-Barbero, J.; De Castro, C.; Tonetti, M.; Rojas, A.L.

Editorial / The power lies in the glycans

eLife

Unione, L.; Jiménez-Barbero, J.

Review / Influence of Selective Deoxyfluorination on the Molecular Structure of Type-2 N-Acetyllactosamine

Journal of Organic Chemistry

Kurfirt, M.; St’astna, L.C.; Dracinsky, M.; Pohl, R.; Cisarova, I.; Jan, S.; Baka, M.; Hamala, V.; Canada, F.J.; Arda, A.; Jimenez-Barbero, J.; Karban, J.

Review / NMR investigations of glycan conformation, dynamics, and interactions

Progress in Nuclear Magnetic Resonance Spectroscopy

Angulo, J.; Ardá, A.; Bertuzzi, S.; Canales, A.; Ereño-Orbea, J.; Gimeno, A.; Gomez-Redondo, M.; Muñoz-García, J.C.; Oquist, P.; Monaco, S.; Poveda, A.; Unione, L.; Jiménez-Barbero, J.

2023

Article / Total Synthesis and Structural Studies of Zwitterionic Bacteroides fragilis Polysaccharide A1 Fragments

J Am Chem Soc

Wang Z, Poveda A, Zhang Q, Unione L, Overkleeft HS, van der Marel GA, Jimenez-Barbero J, Codée JDC

Article / Molecular Recognition of Glycan-Bearing Glycomacromolecules Presented at Membrane Surfaces by Lectins: An NMR View

ACS Omega

Lete, M.G.; Hoffmann, M.; Schomann, N.; Martínez-Castillo, A.; Peccati, F.; Konietzny, P.B.; Delgado, S.; Snyder, N.L.; Jiménez-Oses, G.; Abrescia, N.G.A.; Ardá, A.; Hartmann, L.; Jiménez-Barbero, J.

Article / New Glucosamine-Based TLR4 Agonists: Design, Synthesis, Mechanism of Action, and In Vivo Activity as Vaccine Adjuvants

Journal of Medicinal Chemistry

Romerio, A.; Gotri, N.; Franco, A.R.; Artusa, V.; Shaik, M.M.; Pasco, S.T.; Atxabal, U.; Matamoros-Recio, A.; Mínguez-Toral, M.; Zalamea, J.D.; Franconetti, A.; Abrescia, N.G.A.; Jimenez-Barbero, J.; Anguita, J.; Martín-Santamaría, S.; Peri, F.

Article / Development of synthetic, self-adjuvanting, and self-assembling anticancer vaccines based on a minimal saponin adjuvant and the tumor-associated MUC1 antigen

Chemical Science

Pifferi, C.; Aguinagalde, L.; Ruiz-De-Angulo, A.; Sacristán, N.; Baschirotto, P.T.; Poveda, A.; Jiménez-Barbero, J.; Anguita, J.; Fernández-Tejada, A.

Article / Identification of a new DC-SIGN binding pentamannoside epitope within the complex structure of Candida albicans mannan

The Cell Surface

Krylov, V.B.; Gómez-Redondo, M.; Solovev, A.S.; Yashunsky, D.V.; Brown, A.J.P.; Stappers, M.H.T.; Gow, N.A.R.; Ardá, A.; Jiménez-Barbero, J.; Nifantiev, N.E.

Article / Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b

Nature Communications

Lenza, M.P.; Egia-Mendikute, L.; Antoñana-Vildosola, A.; Soares, C.O.; Coelho, H.; Corzana, F.; Bosch, A.; Manisha, P.; Quintana, J.I.; Oyenarte, I.; Unione, L.; Moure, M.J.; Azkargorta, M.; Atxabal, U.; Sobczak, K.; Elortza, F.; Sutherland, J.D.; Barrio, R.; Marcelo, F.; Jiménez-Barbero, J.; Palazon, A.; Ereño-Orbea, J.

Article / Synthesis of a glycan hairpin

Nature Chemistry

Fittolani, G.; Tyrikos-Ergas, T.; Poveda, A.; Yu, Y.; Yadav, N.; Seeberger, P.H.; Jiménez-Barbero, J.; Delbianco, M.

Article / KR-12 Derivatives Endow Nanocellulose with Antibacterial and Anti-Inflammatory Properties: Role of Conjugation Chemistry

ACS Applied Materials and Interfaces

Blasi-Romero, A.; Ångström, M.; Franconetti, A.; Muhammad, T.; Jiménez-Barbero, J.; Göransson, U.; Palo-Nieto, C.; Ferraz, N.

Article / SARS-CoV-2 Spike N-Terminal Domain Engages 9-O-Acetylated α2-8-Linked Sialic Acids

ACS Chemical Biology

Tomris, I.; Unione, L.; Nguyen, L.; Zaree, P.; Bouwman, K.M.; Liu, L.; Li, Z.; Fok, J.A.; Ríos Carrasco, M.; van der Woude, R.; Kimpel, A.L.M.; Linthorst, M.W.; Kilavuzoglu, S.E.; Verpalen, E.C.J.M.; Caniels, T.G.; Sanders, R.W.; Heesters, B.A.; Pieters, R.J.; Jiménez-Barbero, J.; Klassen, J.S.; Boons, G.J.; de Vries, R.P.

Article / Highly Diastereoselective Multicomponent Synthesis of Spirocyclopropyl Oxindoles Enabled by Rare-Earth Metal Salts

Organic Letters

Tallarida, M.A.; Olivito, F.; Navo, C.D.; Algieri, V.; Jiritano, A.; Costanzo, P.; Poveda, A.; Moure, M.J.; Jiménez-Barbero, J.; Maiuolo, L.; Jiménez-Osés, G.; De Nino, A.

Article / Biomimetic Tweezers for N-Glycans: Selective Recognition of the Core GlcNAc2 Disaccharide of the Sialylglycopeptide SGP

Chemistry - A European Journal

Milanesi, F.; Unione, L.; Ardá, A.; Nativi, C.; Jiménez-Barbero, J.; Roelens, S.; Francesconi, O.

Article / Revealing the Specificity of Human H1 Influenza A Viruses to Complex N-Glycans

JACS Au

Canales, A.; Sastre, J.; Orduña, J.M.; Spruit, C.M.; Pérez-Castells, J.; Domínguez, G.; Bouwman, K.M.; van der Woude, R.; Cañada, F.J.; Nycholat, C.M.; Paulson, J.C.; Boons, G.J.; Jiménez-Barbero, J.; de Vries, R.P.

Article / NMR Investigation of Protein-Carbohydrate Interactions: The Recognition of Glycans by Galectins Engineered with Fluorotryptophan Residues

Chemistry - A European Journal

Lete, M.G.; Franconetti, A.; Bertuzzi, S.; Delgado, S.; Azkargorta, M.; Elortza, F.; Millet, O.; Jiménez-Osés, G.; Arda, A.; Jiménez-Barbero, J.

Article / Structures of the Inhibitory Receptor Siglec-8 in Complex with a High-Affinity Sialoside Analogue and a Therapeutic Antibody

JACS Au

Lenza, M.P.; Atxabal, U.; Nycholat, C.; Oyenarte, I.; Franconetti, A.; Quintana, J.I.; Delgado, S.; Núñez-Franco, R.; Garnica Marroquín, C.T.; Coelho, H.; Unione, L.; Jiménez-Oses, G.; Marcelo, F.; Schubert, M.; Paulson, J.C.; Jiménez-Barbero, J.; Ereño-Orbea, J.

Article / Synthetic Zwitterionic Streptococcus pneumoniae Type 1 Oligosaccharides Carrying Labile O-Acetyl Esters

Angewandte Chemie - International Edition

Wang, Z.; Gimeno, A.; Lete, M.G.; Overkleeft, H.S.; van der Marel, G.A.; Chiodo, F.; Jiménez-Barbero, J.; Codée, J.D.C.

Article / Targeting the Spike: Repurposing Mithramycin and Dihydroergotamine to Block SARS-CoV-2 Infection

ACS Omega

Stagnoli, S.; Macari, G.; Corsi, P.; Capone, B.; Vidaurrazaga, A.; Ereño-Orbea, J.; Ardá, A.; Polticelli, F.; Jiménez-Barbero, J.; Abrescia, N.G.; Coluzza, I.

Review / Exploring multivalent carbohydrate-protein interactions by NMR

Chemical Society Reviews

Quintana, J.I.; Atxabal, U.; Unione, L.; Ardá, A.; Jiménez-Barbero, J.

2022

Article / Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods

Frontiers in Microbiology

Stagnoli, S.; Peccati, F.; Connell, S.R.; Martinez-Castillo, A.; Charro, D.; Millet, O.; Bruzzone, C.; Palazon, A.; Ardá, A.; Jiménez-Barbero, J.; Ereño-Orbea, J.; Abrescia, N.G.A.; Jiménez-Osés, G.

Article / The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes

Communications Biology

Mercado-Gómez, M.; Prieto-Fernández, E.; Goikoetxea-Usandizaga, N.; Vila-Vecilla, L.; Azkargorta, M.; Bravo, M.; Serrano-Maciá, M.; Egia-Mendikute, L.; Rodríguez-Agudo, R.; Lachiondo-Ortega, S.; Lee, S.Y.; Eguileor Giné, A.; Gil-Pitarch, C.; González-Recio, I.; Simón, J.; Petrov, P.; Jover, R.; Martínez-Cruz, L.A.; Ereño-Orbea, J.; Delgado, T.C.; Elortza, F.; Jiménez-Barbero, J.; Nogueiras, R.; Prevot, V.; Palazon, A.; Martínez-Chantar, M.L.

Article / Immobilization of Biantennary N-Glycans Leads to Branch Specific Epitope Recognition by LSECtin

ACS Central Science

Bertuzzi, S.; Peccati, F.; Serna, S.; Artschwager, R.; Notova, S.; Thépaut, M.; Jiménez-Osés, G.; Fieschi, F.; Reichardt, N.C.; Jiménez-Barbero, J.; Ardá, A.

Article / The SARS-CoV-2 Spike Glycoprotein Directly Binds Exogeneous Sialic Acids: A NMR View

Angewandte Chemie - International Edition

Unione, L.; Moure, M.J.; Lenza, M.P.; Oyenarte, I.; Ereño-Orbea, J.; Ardá, A.; Jiménez-Barbero, J.

Article / Atomic and Specificity Details of Mucin 1 O-Glycosylation Process by Multiple Polypeptide GalNAc-Transferase Isoforms Unveiled by NMR and Molecular Modeling

JACS Au

Coelho, H.; Rivas, M.D.L.; Grosso, A.S.; Diniz, A.; Soares, C.O.; Francisco, R.A.; Dias, J.S.; Compañon, I.; Sun, L.; Narimatsu, Y.; Vakhrushev, S.Y.; Clausen, H.; Cabrita, E.J.; Jiménez-Barbero, J.; Corzana, F.; Hurtado-Guerrero, R.; Marcelo, F.

Article / Oligosaccharide Presentation Modulates the Molecular Recognition of Glycolipids by Galectins on Membrane Surfaces

Pharmaceuticals

Lete, M.G.; Franconetti, A.; Delgado, S.; Jiménez-Barbero, J.; Ardá, A.

Article / Unveiling the role of pyrylium frameworks on π-stacking interactions: a combined ab initio and experimental study

Physical Chemistry Chemical Physics

Núñez-Franco, R.; Jiménez-Osés, G.; Jiménez-Barbero, J.; Cabrera-Escribano, F.; Franconetti, A.

Article / Synthesis, conformational analysis and glycosidase inhibition of bicyclic nojirimycin C-glycosides based on an octahydrofuro[3,2-b]pyridine motif

Carbohydrate Research

Désiré, J.; Foucart, Q.; Poveda, A.; Gourlaouen, G.; Shimadate, Y.; Kise, M.; Proceviat, C.; Ashmus, R.; Vocadlo, D.J.; Jiménez-Barbero, J.; Kato, A.; Blériot, Y.

2021

Article / Minimal epitope for Mannitou IgM on paucimannose-carrying glycoproteins

Glycobiology

Robakiewicz, S.; Bridot, C.; Serna, S.; Gimeno, A.; Echeverria, B.; Delgado, S.; De Ruyck, J.; Semwal, S.; Charro, D.; Dansercoer, A.; Verstraete, K.; Azkargorta, M.; Van Noort, K.; Wilbers, R.H.P.; Savvides, S.N.; Abrescia, N.G.A.; Arda, A.; Reichardt, N.C.; Jiménez-Barbero, J.; Bouckaert, J.

Article / Cross‐linking effects dictate the preference of galectins to bind lacnac‐decorated hpma copolymers

International Journal of Molecular Sciences

Bertuzzi, S.; Gimeno, A.; Martinez‐castillo, A.; Lete, M.G.; Delgado, S.; Airoldi, C.; Tavares, M.R.; Bláhová, M.; Chytil, P.; Křen, V.; Abrescia, N.G.A.; Ardá, A.; Bojarová, P.; Jiménez‐barbero, J.

Article / Polyglucosylation of Rutin Catalyzed by Cyclodextrin Glucanotransferase from Geobacillus sp.: Optimization and Chemical Characterization of Products

Industrial and Engineering Chemistry Research

González-Alfonso, J.L.; Poveda, A.; Arribas, M.; Hirose, Y.; Fernández-Lobato, M.; Olmo Ballesteros, A.; Jiménez-Barbero, J.; Plou, F.J.

Article / Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease

European Journal of Medicinal Chemistry

Cotrina, E.Y.; Santos, L.M.; Rivas, J.; Blasi, D.; Leite, J.P.; Liz, M.A.; Busquets, M.A.; Planas, A.; Prohens, R.; Gimeno, A.; Jiménez-Barbero, J.; Gales, L.; Llop, J.; Quintana, J.; Cardoso, I.; Arsequell, G.

Article / Sulfation Code and Conformational Plasticity of l -Iduronic Acid Homo-Oligosaccharides Mimic the Biological Functions of Heparan Sulfate

ACS Chemical Biology

Shanthamurthy, C.D.; Gimeno, A.; Leviatan Ben-Arye, S.; Kumar, N.V.; Jain, P.; Padler-Karavani, V.; Jimenez-Barbero, J.; Kikkeri, R.

Article / The Flexibility of Oligosaccharides Unveiled Through Residual Dipolar Coupling Analysis

Frontiers in Molecular Biosciences

Poveda, A.; Fittolani, G.; Seeberger, P.H.; Delbianco, M.; Jiménez-Barbero, J.

Article / Elucidating the Structural and Minimal Protective Epitope of the Serogroup X Meningococcal Capsular Polysaccharide

Frontiers in Molecular Biosciences

Pietri, G.P.; Tontini, M.; Brogioni, B.; Oldrini, D.; Robakiewicz, S.; Henriques, P.; Calloni, I.; Abramova, V.; Santini, L.; Malić, S.; Miklić, K.; Lisnic, B.; Bertuzzi, S.; Unione, L.; Balducci, E.; de Ruyck, J.; Romano, M.R.; Jimenez-Barbero, J.; Bouckaert, J.; Jonjic, S.; Rovis, T.L.; Adamo, R.

Article / Kinetic Studies of Acetyl Group Migration between the Saccharide Units in an Oligomannoside Trisaccharide Model Compound and a Native Galactoglucomannan Polysaccharide

ChemBioChem

Lassfolk, R.; Bertuzzi, S.; Ardá, A.; Wärnå, J.; Jiménez-Barbero, J.; Leino, R.

Article / Epitope Recognition of a Monoclonal Antibody Raised against a Synthetic Glycerol Phosphate Based Teichoic Acid

ACS Chemical Biology

Berni, F.; Kalfopoulou, E.; Gimeno Cardells, A.M.; Carboni, F.; Van Der Es, D.; Romero-Saavedra, F.; Laverde, D.; Miklic, K.; Malic, S.; Rovis, T.L.; Jonjic, S.; Ali, S.; Overkleeft, H.S.; Hokke, C.H.; Van Diepen, A.; Adamo, R.; Jiménez-Barbero, J.; Van Der Marel, G.A.; Huebner, J.; Codée, J.D.C.

Article / Selective 13C-Labels on Repeating Glycan Oligomers to Reveal Protein Binding Epitopes through NMR: Polylactosamine Binding to Galectins

Angewandte Chemie - International Edition

Moure, M.J.; Gimeno, A.; Delgado, S.; Diercks, T.; Boons, G.J.; Jiménez-Barbero, J.; Ardá, A.

Article / Enzymatic Synthesis of Phloretin α-Glucosides Using a Sucrose Phosphorylase Mutant and its Effect on Solubility, Antioxidant Properties and Skin Absorption

Advanced Synthesis and Catalysis

Gonzalez-Alfonso, J.L.; Ubiparip, Z.; Jimenez-Ortega, E.; Poveda, A.; Alonso, C.; Coderch, L.; Jimenez-Barbero, J.; Sanz-Aparicio, J.; Ballesteros, A.O.; Desmet, T.; Plou, F.J.

Article / The two domains of human galectin-8 bind sialyl-and fucose-containing oligosaccharides in an independent manner. A 3D view by using NMR

RSC Chemical Biology

Gómez-Redondo, M.; Delgado, S.; Núñez-Franco, R.; Jiménez-Osés, G.; Ardá, A.; Jiménez-Barbero, J.; Gimeno, A.

Article / Glycosyl Oxocarbenium Ions: Structure, Conformation, Reactivity, and Interactions

Accounts of Chemical Research

Franconetti, A.; Ardá, A.; Asensio, J.L.; Blériot, Y.; Thibaudeau, S.; Jiménez-Barbero, J.

Article / Structural Insights into the Molecular Recognition Mechanism of the Cancer and Pathogenic Epitope, LacdiNAc by Immune-Related Lectins

Chemistry - A European Journal

Lima, C.D.L.; Coelho, H.; Gimeno, A.; Trovão, F.; Diniz, A.; Dias, J.S.; Jiménez-Barbero, J.; Corzana, F.; Carvalho, A.L.; Cabrita, E.J.; Marcelo, F.

Article / Galectin-4 N-Terminal Domain: Binding Preferences Toward A and B Antigens With Different Peripheral Core Presentations

Frontiers in Chemistry

Quintana, J.I.; Delgado, S.; Núñez-Franco, R.; Cañada, F.J.; Jiménez-Osés, G.; Jiménez-Barbero, J.; Ardá, A.

Article / Exploration of galectin ligands displayed on gram-negative respiratory bacterial pathogens with different cell surface architectures

Biomolecules

Campanero-Rhodes, M.A.; Kalograiaki, I.; Euba, B.; Llobet, E.; Ardá, A.; Jiménez-Barbero, J.; Garmendia, J.; Solís, D.

Article / Synthesis and chelation study of a fluoroionophore and a glycopeptide based on an aza crown iminosugar structure

Carbohydrate Research

Bordes, A.; Poveda, A.; Fontelle, N.; Ardá, A.; Guillard, J.; Ruan, Y.B.; Marrot, J.; Imaeda, S.; Kato, A.; Désiré, J.; Xie, J.; Jiménez-Barbero, J.; Blériot, Y.

Article / Targeting the CRD F-face of Human Galectin-3 and Allosterically Modulating Glycan Binding by Angiostatic PTX008 and a Structurally Optimized Derivative

ChemMedChem

Miller, M.C.; Zheng, Y.; Suylen, D.; Ippel, H.; Cañada, F.J.; Berbís, M.A.; Jiménez-Barbero, J.; Tai, G.; Gabius, H.J.; Mayo, K.H.

Article / Single-Step Glycosylations with 13C-Labelled Sulfoxide Donors: A Low-Temperature NMR Cartography of the Distinguishing Mechanistic Intermediates

Chemistry - A European Journal

Santana, A.G.; Montalvillo-Jiménez, L.; Díaz-Casado, L.; Mann, E.; Jiménez-Barbero, J.; Gómez, A.M.; Asensio, J.L.

Article / Insight into the Ferrier Rearrangement by Combining Flash Chemistry and Superacids

Angewandte Chemie - International Edition

Bhuma, N.; Lebedel, L.; Yamashita, H.; Shimizu, Y.; Abada, Z.; Ardá, A.; Désiré, J.; Michelet, B.; Martin-Mingot, A.; Abou-Hassan, A.; Takumi, M.; Marrot, J.; Jiménez-Barbero, J.; Nagaki, A.; Blériot, Y.; Thibaudeau, S.

Article / Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate

Emerging Microbes and Infections

Prieto-Fernández, E.; Egia-Mendikute, L.; Vila-Vecilla, L.; Bosch, A.; Barreira-Manrique, A.; Lee, S.Y.; García-del Río, A.; Antoñana-Vildosola, A.; Jiménez-Lasheras, B.; Moreno-Cugnon, L.; Jiménez-Barbero, J.; Berra, E.; Ereño-Orbea, J.; Palazon, A.

Article / Recent advances in the application of NMR methodologies to analyze the conformation, dynamics, and interactions of saccharides

Carbohydrate Chemistry

Arda, A.; Atxabal, U.; Bertuzzi, S.; Canales, A.; Cañada, F.J.; Gimeno, A.; Ereño-Orbea, J.; De Toro, B.F.; Franconetti, A.; Gómez-Redondo, M.; Lete, M.G.; Lenza, M.P.; Martínez, J.D.; Moure, M.J.; Poveda, A.; Quintana, J.I.; Valverde, P.; Jiménez-Barbero, J.

Review / NMR of glycoproteins: profiling, structure, conformation and interactions

Current Opinion in Structural Biology

Unione, L.; Ardá, A.; Jiménez-Barbero, J.; Millet, O.

2020

Chapter / Carbohydrate Chemistry - Chemical and Biological Approaches. VOLUME 44

ROYAL SOCIETY OF CHEMISTRY (UK)

A. Arda, U. Atxabal, S. Bertuzzi, A. Gimeno, J. Ereño-Orbea, A. Franconetti, M. Gómez-Redondo, M. G. Lete, M. P. Lenza, J. D. Martínez, M. J. Moure, A. Poveda, J. I. Quintana, P. Valverde, J. Jiménez-Barbero

Chapter / NMR in chemical biology

E. Cabrita (Royal Society of Chemistry, UK)

Ana Ardá, Sara Bertuzzi, Ilaria Calloni, Angeles Canales, F. Javier Cañada, June Ereño-Orbea, Beatriz Fernández de Toro, Ana Gimeno, Helena Coelho, Maria Pia Lenza, Marta G. Lete, Javier López-Ogalla, Filipa Marcelo, J. Daniel Martínez, Ana Poveda, Jon I.

Chapter / Translational Glycobiology in Human Health and Disease

L. Joshi, M. Kilkoyne. Elsevier

Antonio Franconetti, Marcos Gómez, Ana Ardá, Ana Poveda, and Jesús Jiménez-Barbero

Article / Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins

Angewandte Chemie - International Edition

Lenza, M.P.; Oyenarte, I.; Diercks, T.; Quintana, J.I.; Gimeno, A.; Coelho, H.; Diniz, A.; Peccati, F.; Delgado, S.; Bosch, A.; Valle, M.; Millet, O.; Abrescia, N.G.A.; Palazón, A.; Marcelo, F.; Jiménez-Osés, G.; Jiménez-Barbero, J.; Ardá, A.; Ereño-Orbea, J.

Article / Exploiting structure-activity relationships of QS-21 in the design and synthesis of streamlined saponin vaccine adjuvants

Chemical Communications

Ghirardello, M.; Ruiz-De-Angulo, A.; Sacristan, N.; Barriales, D.; Jiménez-Barbero, J.; Poveda, A.; Corzana, F.; Anguita, J.; Fernández-Tejada, A.

Article / An Assay for Screening Potential Drug Candidates for Alzheimer's Disease That Act as Chaperones of the Transthyretin and Amyloid-β Peptides Interaction

Chemistry - A European Journal

Cotrina, E.Y.; Gimeno, A.; Llop, J.; Jiménez-Barbero, J.; Quintana, J.; Prohens, R.; Cardoso, I.; Arsequell, G.

Article / Fluorinated Carbohydrates as Lectin Ligands: Simultaneous Screening of a Monosaccharide Library and Chemical Mapping by 19F NMR Spectroscopy

Journal of Organic Chemistry

Martínez, J.D.; Manzano, A.I.; Calviño, E.; Diego, A.D.; Rodriguez De Francisco, B.; Romanò, C.; Oscarson, S.; Millet, O.; Gabius, H.J.; Jiménez-Barbero, J.; Cañada, F.J.

Article / Unravelling the Time Scale of Conformational Plasticity and Allostery in Glycan Recognition by Human Galectin-1

Chemistry - A European Journal

Bertuzzi, S.; Gimeno, A.; Núñez-Franco, R.; Bernardo-Seisdedos, G.; Delgado, S.; Jiménez-Osés, G.; Millet, O.; Jiménez-Barbero, J.; Ardá, A.

Article / Mono- and Di-Fucosylated Glycans of the Parasitic Worm S. mansoni are Recognized Differently by the Innate Immune Receptor DC-SIGN

Chemistry - A European Journal

Srivastava, A.D.; Unione, L.; Wolfert, M.A.; Valverde, P.; Ardá, A.; Jiménez-Barbero, J.; Boons, G.J.

Article / Dissection of the key steps of amyloid-β peptide 1–40 fibrillogenesis

International Journal of Biological Macromolecules

Leite, J.P.; Gimeno, A.; Taboada, P.; Jiménez-Barbero, J.J.; Gales, L.

Article / Structure of a protective epitope reveals the importance of acetylation of Neisseria meningitidis serogroup A capsular polysaccharide

Proceedings of the National Academy of Sciences of the United States of America

Henriques, P.; Lucia Dello Iacono, ; Gimeno, A.; Biolchi, A.; Maria Rosaria Romano, ; Arda, A.; Bernardes, G.J.L.; Jimenez-Barbero, J.; Berti, F.; Rappuoli, R.; Adamo, R.

Article / Isolation and characterization of an exopolymer produced by Bacillus licheniformis: In vitro antiviral activity against enveloped viruses

Carbohydrate Polymers

Sánchez-León, E.; Bello-Morales, R.; López-Guerrero, J.A.; Poveda, A.; Jiménez-Barbero, J.; Gironès, N.; Abrusci, C.

Article / Synthesis of long-chain alkyl glucosides via reverse hydrolysis reactions catalyzed by an engineered β-glucosidase

Enzyme and Microbial Technology

Thenchartanan, P.; Pitchayatanakorn, P.; Wattana-Amorn, P.; Ardá, A.; Svasti, J.; Jiménez-Barbero, J.; Kongsaeree, P.T.

Article / Complete Dynamic Reconstruction of C60, C70, and (C59N)2Encapsulation into an Adaptable Supramolecular Nanocapsule

Journal of the American Chemical Society

Garciá-Simón, C.; Colomban, C.; Çetin, Y.A.; Gimeno, A.; Pujals, M.; Ubasart, E.; Fuertes-Espinosa, C.; Asad, K.; Chronakis, N.; Costas, M.; Jiménez-Barbero, J.; Feixas, F.; Ribas, X.

Article / Structural Basis of Noscapine Activation for Tubulin Binding

Journal of Medicinal Chemistry

Oliva, M.A.; Prota, A.E.; Rodríguez-Salarichs, J.; Bennani, Y.L.; Jiménez-Barbero, J.; Bargsten, K.; Canales, Á.; Steinmetz, M.O.; Díaz, J.F.

Article / The interaction of fluorinated glycomimetics with dc-sign: Multiple binding modes disentangled by the combination of NMR methods and MD simulations

Pharmaceuticals

Martínez, J.D.; Infantino, A.S.; Valverde, P.; Diercks, T.; Delgado, S.; Reichardt, N.C.; Ardá, A.; Cañada, F.J.; Oscarson, S.; Jiménez-Barbero, J.

Article / Synthesis and Structural Analysis of Aspergillus fumigatus Galactosaminogalactans Featuring α-Galactose, α-Galactosamine and α-N-Acetyl Galactosamine Linkages

Angewandte Chemie - International Edition

Zhang, Y.; Gómez-Redondo, M.; Jiménez-Osés, G.; Arda, A.; Overkleeft, H.S.; van der Marel, G.A.; Jiménez-Barbero, J.; Codée, J.D.C.

Article / Dissecting the Essential Role of Anomeric β-Triflates in Glycosylation Reactions

Journal of the American Chemical Society

Santana, A.G.; Montalvillo-Jiménez, L.; Díaz-Casado, L.; Corzana, F.; Merino, P.; Cañada, F.J.; Jiménez-Osés, G.; Jiménez-Barbero, J.; Gómez, A.M.; Asensio, J.L.

Article / Chemoenzymatic synthesis of 3-deoxy-3-fluoro-l-fucose and its enzymatic incorporation into glycoconjugates

Chemical Communications

Valverde, P.; Vendeville, J.B.; Hollingsworth, K.; Mattey, A.P.; Keenan, T.; Chidwick, H.; Ledru, H.; Huonnic, K.; Huang, K.; Light, M.E.; Turner, N.; Jiménez-Barbero, J.; Galan, M.C.; Fascione, M.A.; Flitsch, S.; Turnbull, W.B.; Linclau, B.

Article / Structure-Guided Design of a Group B Streptococcus Type III Synthetic Glycan-Conjugate Vaccine

Chemistry (Weinheim an der Bergstrasse, Germany)

Oldrini, D.; Del Bino, L.; Arda, A.; Carboni, F.; Henriques, P.; Angiolini, F.; Quintana, J.I.; Calloni, I.; Romano, M.R.; Berti, F.; Jimenez-Barbero, J.; Margarit, I.; Adamo, R.

Article / Structure-Guided Design of a Group B Streptococcus Type III Synthetic Glycan–Conjugate Vaccine

Chemistry - A European Journal

Oldrini, D.; del Bino, L.; Arda, A.; Carboni, F.; Henriques, P.; Angiolini, F.; Quintana, J.I.; Calloni, I.; Romano, M.R.; Berti, F.; Jimenez-Barbero, J.; Margarit, I.; Adamo, R.

Article / An Epoxide Intermediate in Glycosidase Catalysis

ACS Central Science

Sobala, L.F.; Speciale, G.; Zhu, S.; Raich, L.; Sannikova, N.; Thompson, A.J.; Hakki, Z.; Lu, D.; Shamsi Kazem Abadi, S.; Lewis, A.R.; Rojas-Cervellera, V.; Bernardo-Seisdedos, G.; Zhang, Y.; Millet, O.; Jiménez-Barbero, J.; Bennet, A.J.; Sollogoub, M.; Rovira, C.; Davies, G.J.; Williams, S.J.

Article / Selective Synthesis of Galactooligosaccharides Containing β(1→3) Linkages with β-Galactosidase from Bifidobacterium bifidum (Saphera)

Journal of Agricultural and Food Chemistry

Füreder, V.; Rodriguez-Colinas, B.; Cervantes, F.V.; Fernandez-Arrojo, L.; Poveda, A.; Jimenez-Barbero, J.; Ballesteros, A.O.; Plou, F.J.

Article / Calorimetric Studies of Binary and Ternary Molecular Interactions between Transthyretin, Aβ Peptides, and Small-Molecule Chaperones toward an Alternative Strategy for Alzheimer's Disease Drug Discovery

Journal of Medicinal Chemistry

Cotrina, E.Y.; Gimeno, A.; Llop, J.; Jiménez-Barbero, J.; Quintana, J.; Valencia, G.; Cardoso, I.; Prohens, R.; Arsequell, G.

Article / Synthesis, Conformational Analysis, and Complexation Study of an Iminosugar-Aza-Crown, a Sweet Chiral Cyclam Analog

Organic Letters

Bordes, A.; Poveda, A.; Troadec, T.; Franconetti, A.; Ardá, A.; Perrin, F.; Ménand, M.; Sollogoub, M.; Guillard, J.; Désiré, J.; Tripier, R.; Jiménez-Barbero, J.; Blériot, Y.

Article / Discovering Biomolecules with Huisgenase Activity: Designed Repeat Proteins as Biocatalysts for (3 + 2) Cycloadditions

Journal of the American Chemical Society

Rivilla, I.; Odriozola-Gimeno, M.; Aires, A.; Gimeno, A.; Jiménez-Barbero, J.; Torrent-Sucarrat, M.; Cortajarena, A.L.; Cossío, F.P.

Article / Oral Treatment with Iododiflunisal Delays Hippocampal Amyloid-β Formation in a Transgenic Mouse Model of Alzheimer's Disease: A Longitudinal in vivo Molecular Imaging Study

Journal of Alzheimer's Disease

Rejc, L.; Gómez-Vallejo, V.; Rios, X.; Cossío, U.; Baz, Z.; Mujica, E.; Gião, T.; Cotrina, E.Y.; Jiménez-Barbero, J.; Quintana, J.; Arsequell, G.; Cardoso, I.; Llop, J.

Editorial / Scientific Response to the Coronavirus Crisis in Spain: Collaboration and Multidisciplinarity

ACS Chemical Biology

Millet, O.; Cortajarena, A.L.; Salvatella, X.; Kiessling, L.L.; Jiménez-Barbero, J.

Review / Current Status on Therapeutic Molecules Targeting Siglec Receptors

Cells

Lenza, M.P.; Atxabal, U.; Oyenarte, I.; Jiménez-Barbero, J.; Ereño-Orbea, J.

Review / Bacterial polysaccharides: conformation, dynamics and molecular recognition by antibodies

Drug Discovery Today: Technologies

Gómez-Redondo, M.; Ardá, A.; Gimeno, A.; Jiménez-Barbero, J.

Review / Molecular Recognition in C-Type Lectins: The Cases of DC-SIGN, Langerin, MGL, and L-Sectin

ChemBioChem

Valverde, P.; Martínez, J.D.; Cañada, F.J.; Ardá, A.; Jiménez-Barbero, J.

Review / Targeting Galectins With Glycomimetics

Frontiers in Chemistry

Bertuzzi, S.; Quintana, J.I.; Ardá, A.; Gimeno, A.; Jiménez-Barbero, J.

Review / Fluorinated carbohydrates as chemical probes for molecular recognition studies. Current status and perspectives

Chemical Society Reviews

Jiménez-Barbero, J.; Linclau, B.; Ardá, A.; Reichardt, N.C.; Sollogoub, M.; Unione, L.; Vincent, S.P.

Review / Glycan structures and their interactions with proteins. A NMR view

Current Opinion in Structural Biology

Gimeno, A.; Valverde, P.; Ardá, A.; Jiménez-Barbero, J.

2019

Article / Experimental and theoretical study of the role of CH/? interactions in the aminolysis reaction of acetyl galactoside.

Carbohydr Res.

Cuétara-Guadarrama F, Hernández-Huerta E, Rojo-Portillo T, Reyes-López E, Jiménez-Barbero J, Cuevas G.

Article / Impact of Aromatic Stacking on Glycoside Reactivity: Balancing CH/? and Cation/? Interactions for the Stabilization of Glycosyl-Oxocarbenium Ions.

J Am Chem Soc

Montalvillo-Jiménez L, Santana AG, Corzana F, Jiménez-Osés G, Jiménez-Barbero J, Gómez AM, Asensio JL.

Article / Glycoprofile Analysis of an Intact Glycoprotein As Inferred by NMR Spectroscopy

ACS Central Science

Unione, L.; Lenza, M.P.; Ardá, A.; Urquiza, P.; Laín, A.; Falcón-Pérez, J.M.; Jiménez-Barbero, J.; Millet, O.

Article / Regioselective Glycosylation Strategies for the Synthesis of Group Ia and Ib Streptococcus Related Glycans Enable Elucidating Unique Conformations of the Capsular Polysaccharides

Chemistry - A European Journal

Del Bino, L.; Calloni, I.; Oldrini, D.; Raso, M.M.; Cuffaro, R.; Ardá, A.; Codée, J.D.C.; Jiménez-Barbero, J.; Adamo, R.

Article / Experimental and theoretical study of the role of CH/π interactions in the aminolysis reaction of acetyl galactoside

Carbohydrate Research

Cuétara-Guadarrama, F.; Hernández-Huerta, E.; Rojo-Portillo, T.; Reyes-López, E.; Jiménez-Barbero, J.; Cuevas, G.

Article / Radiochemical examination of transthyretin (TTR) brain penetration assisted by iododiflunisal, a TTR tetramer stabilizer and a new candidate drug for AD

Scientific Reports

Rios, X.; Gómez-Vallejo, V.; Martín, A.; Cossío, U.; Morcillo, M.Á.; Alemi, M.; Cardoso, I.; Quintana, J.; Jiménez-Barbero, J.; Cotrina, E.Y.; Valencia, G.; Arsequell, G.; Llop, J.

Article / Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties

Scientific Reports

Cochet, F.; Facchini, F.A.; Zaffaroni, L.; Billod, J.M.; Coelho, H.; Holgado, A.; Braun, H.; Beyaert, R.; Jerala, R.; Jimenez-Barbero, J.; Martin-Santamaria, S.; Peri, F.

Article / The Plasticity of the Carbohydrate Recognition Domain Dictates the Exquisite Mechanism of Binding of Human Macrophage Galactose-Type Lectin

Chemistry - A European Journal

Diniz, A.; Coelho, H.; Dias, J.S.; van Vliet, S.J.; Jiménez-Barbero, J.; Corzana, F.; Cabrita, E.J.; Marcelo, F.

Article / Structural and Computational Analysis of 2-Halogeno-Glycosyl Cations in the Presence of a Superacid: An Expansive Platform

Angewandte Chemie - International Edition

Lebedel, L.; Ardá, A.; Martin, A.; Désiré, J.; Mingot, A.; Aufiero, M.; Aiguabella Font, N.; Gilmour, R.; Jiménez-Barbero, J.; Blériot, Y.; Thibaudeau, S.

Article / Synthetic, Zwitterionic Sp1 Oligosaccharides Adopt a Helical Structure Crucial for Antibody Interaction

ACS Central Science

Zhang, Q.; Gimeno, A.; Santana, D.; Wang, Z.; Valdés-Balbin, Y.; Rodríguez-Noda, L.M.; Hansen, T.; Kong, L.; Shen, M.; Overkleeft, H.S.; Vérez-Bencomo, V.; Van Der Marel, G.A.; Jiménez-Barbero, J.; Chiodo, F.; Codée, J.D.C.

Article / Impact of Aromatic Stacking on Glycoside Reactivity: Balancing CH/πand Cation/πInteractions for the Stabilization of Glycosyl-Oxocarbenium Ions

Journal of the American Chemical Society

Montalvillo-Jiménez, L.; Santana, A.G.; Corzana, F.; Jiménez-Osés, G.; Jiménez-Barbero, J.; Gómez, A.M.; Asensio, J.L.

Article / Novel NMR Avenues to Explore the Conformation and Interactions of Glycans

ACS Omega

Valverde, P.; Quintana, J.I.; Santos, J.I.; Ardá, A.; Jiménez-Barbero, J.

Article / Molecular Insights into DC-SIGN Binding to Self-Antigens: The Interaction with the Blood Group A/B Antigens

ACS Chemical Biology

Valverde, P.; Delgado, S.; Martínez, J.D.; Vendeville, J.B.; Malassis, J.; Linclau, B.; Reichardt, N.C.; Cañada, F.J.; Jiménez-Barbero, J.; Ardá, A.

Article / Conformational Behavior of D-Lyxose in Gas and Solution Phases by Rotational and NMR Spectroscopies

Journal of Physical Chemistry Letters

Calabrese, C.; Écija, P.; Compañón, I.; Vallejo-López, M.; Cimas, Á.; Parra, M.; Basterretxea, F.J.; Santos, J.I.; Jiménez-Barbero, J.; Lesarri, A.; Corzana, F.; Cocinero, E.J.

Article / Minimizing the Entropy Penalty for Ligand Binding: Lessons from the Molecular Recognition of the Histo Blood-Group Antigens by Human Galectin-3

Angewandte Chemie - International Edition

Gimeno, A.; Delgado, S.; Valverde, P.; Bertuzzi, S.; Berbís, M.A.; Echavarren, J.; Lacetera, A.; Martín-Santamaría, S.; Surolia, A.; Cañada, F.J.; Jiménez-Barbero, J.; Ardá, A.

Article / Peptidoglycan recognition by wheat germ agglutinin. A view by NMR

Natural Product Communications

El Biari, K.; Gaudioso, Á.; Carmen Fernández-Alonso, M.; Jiménez-Barbero, J.; Javier Cañada, F.

Article / Synthesis, Profiling, and Bioactive Conformation of trans-Cyclopropyl Epothilones

Helvetica Chimica Acta

Kuzniewski, C.N.; Glauser, S.; Gaugaz, F.Z.; Schiess, R.; Rodríguez-Salarichs, J.; Vetterli, S.; Horlacher, O.P.; Gertsch, J.; Redondo-Horcajo, M.; Canales, A.; Jiménez-Barbero, J.; Díaz, J.F.; Altmann, K.H.

Article / The N-glycan structures of the antigenic variants of chlorovirus PBCV-1 major capsid protein help to identify the virus-encoded glycosyltransferases

Journal of Biological Chemistry

Speciale, I.; Duncan, G.A.; Unione, L.; Agarkova, I.V.; Garozzo, D.; Jimenez-Barbero, J.; Lin, S.; Lowary, T.L.; Molinaro, A.; Noel, E.; Laugieri, M.E.; Tonetti, M.G.; Van Etten, J.L.; De Castro, C.

Article / Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage

Journal of the American Chemical Society

Companión, I.; Guerreiro, A.; Mangini, V.; Castro-López, J.; Escudero-Casao, M.; Avenoza, A.; Busto, J.H.; Castillón, S.; Jiménez-Barbero, J.; Asensio, J.L.; Jiménez-Osés, G.; Boutureira, O.; Peregrina, J.M.; Hurtado-Guerrero, R.; Fiammengo, R.; Bernardes, G.J.L.; Corzana, F.

Article / Novel Dextran-Supported Biological Probes Decorated with Disaccharide Entities for Investigating the Carbohydrate–Protein Interactions of Gal-3

ChemBioChem

Rahkila, J.; Ekholm, F.S.; Ardá, A.; Delgado, S.; Savolainen, J.; Jiménez-Barbero, J.; Leino, R.

Article / Unraveling sugar binding modes to DC-SIGN by employing fluorinated carbohydrates

Molecules

Daniel Martínez, J.; Valverde, P.; Delgado, S.; Romanò, C.; Linclau, B.; Reichardt, N.C.; Oscarson, S.; Ardá, A.; Jiménez-Barbero, J.; Javier Cañada, F.

Note / In My Element: Fluorine

Chemistry - A European Journal

Jiménez-Barbero, J.

Review / Glycans in drug discovery

MedChemComm

Valverde, P.; Ardá, A.; Reichardt, N.C.; Jiménez-Barbero, J.; Gimeno, A.

2018

Article / The Conformation of the Mannopyranosyl Phosphate Repeating Unit of the Capsular Polysaccharide of Neisseria meningitidis Serogroup A and Its Carba?Mimetic

Eur J Org Chem

I Carloni, L Unione, G Jiménez?Osés, F Corzana, L Del Bino, A Corrado, O Pitirollo, C Colombo, L Lay, R Adamo, J Jiménez?Barbero

Article / From 1,4-Disaccharide to 1,3-Glycosyl Carbasugar: Synthesis of a Bespoke Inhibitor of Family GH99 Endo-α-mannosidase

Organic Letters

Lu, D.; Zhu, S.; Sobala, L.F.; Bernardo-Seisdedos, G.; Millet, O.; Zhang, Y.; Jiménez-Barbero, J.; Davies, G.J.; Sollogoub, M.

Article / Avenues to Characterize the Interactions of Extended N-Glycans with Proteins by NMR Spectroscopy: The Influenza Hemagglutinin Case

Angewandte Chemie - International Edition

Fernández de Toro, B.; Peng, W.; Thompson, A.J.; Domínguez, G.; Cañada, F.J.; Pérez-Castells, J.; Paulson, J.C.; Jiménez-Barbero, J.; Canales, Á.

Article / Structure and N-acetylglucosamine binding of the distal domain of mouse adenovirus 2 fibre

Journal of General Virology

Singh, A.K.; Nguyen, T.H.; Vidovszky, M.Z.; Harrach, B.; Benko, M.; Kirwan, A.; Joshi, L.; Kilcoyne, M.; Berbis, M.Á.; Cañada, F.J.; Jiménez-Barbero, J.; Menéndez, M.; Wilson, S.S.; Bromme, B.A.; Smith, J.G.; Van Raaij, M.J.

Article / Molecular Recognition of a Thomsen–Friedenreich Antigen Mimetic Targeting Human Galectin-3

ChemMedChem

Santarsia, S.; Grosso, A.S.; Trovão, F.; Jiménez-Barbero, J.; Carvalho, A.L.; Nativi, C.; Marcelo, F.

Article / Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4

ACS Central Science

De Las Rivas, M.; Paul Daniel, E.J.; Coelho, H.; Lira-Navarrete, E.; Raich, L.; Compañón, I.; Diniz, A.; Lagartera, L.; Jiménez-Barbero, J.; Clausen, H.; Rovira, C.; Marcelo, F.; Corzana, F.; Gerken, T.A.; Hurtado-Guerrero, R.

Article / The Conformation of the Mannopyranosyl Phosphate Repeating Unit of the Capsular Polysaccharide of Neisseria meningitidis Serogroup A and Its Carba-Mimetic

European Journal of Organic Chemistry

Calloni, I.; Unione, L.; Jiménez-Osés, G.; Corzana, F.; Del Bino, L.; Corrado, A.; Pitirollo, O.; Colombo, C.; Lay, L.; Adamo, R.; Jiménez-Barbero, J.

Article / Water Sculpts the Distinctive Shapes and Dynamics of the Tumor-Associated Carbohydrate Tn Antigens: Implications for Their Molecular Recognition

Journal of the American Chemical Society

Bermejo, I.A.; Usabiaga, I.; Compañón, I.; Castro-López, J.; Insausti, A.; Fernández, J.A.; Avenoza, A.; Busto, J.H.; Jiménez-Barbero, J.; Asensio, J.L.; Peregrina, J.M.; Jiménez-Osés, G.; Hurtado-Guerrero, R.; Cocinero, E.J.; Corzana, F.

Article / Environmental Effects Determine the Structure of Potential β-Amino Acid Based Foldamers

Chemistry - A European Journal

Sussman, F.; Sánchez-Pedregal, V.M.; Estévez, J.C.; Balo, R.; Jiménez-Barbero, J.; Ardá, A.; Gimeno, A.; Royo, M.; Villaverde, M.C.; Estévez, R.J.

Article / Efficient α-Glucosylation of Epigallocatechin Gallate Catalyzed by Cyclodextrin Glucanotransferase from Thermoanaerobacter Species

Journal of Agricultural and Food Chemistry

Gonzalez-Alfonso, J.L.; Leemans, L.; Poveda, A.; Jimenez-Barbero, J.; Ballesteros, A.O.; Plou, F.J.

Article / Structural Analysis of a GalNAc-T2 Mutant Reveals an Induced-Fit Catalytic Mechanism for GalNAc-Ts

Chemistry - A European Journal

de las Rivas, M.; Coelho, H.; Diniz, A.; Lira-Navarrete, E.; Compañón, I.; Jiménez-Barbero, J.; Schjoldager, K.T.; Bennett, E.P.; Vakhrushev, S.Y.; Clausen, H.; Corzana, F.; Marcelo, F.; Hurtado-Guerrero, R.

Article / The Stabilization of Glycosyl Cations Through Cooperative Noncovalent Interactions: A Theoretical Perspective

ChemPhysChem

Franconetti, A.; Jiménez-Barbero, J.; Cabrera-Escribano, F.

Article / Co-administration of Antimicrobial Peptides Enhances Toll-like Receptor 4 Antagonist Activity of a Synthetic Glycolipid

ChemMedChem

Facchini, F.A.; Coelho, H.; Sestito, S.E.; Delgado, S.; Minotti, A.; Andreu, D.; Jiménez-Barbero, J.; Peri, F.

Article / Exploring the role of solvent on carbohydrate−aryl interactions by diffusion NMR-based studies

ACS Omega

Jütten, L.; Ramírez-Gualito, K.; Weilhard, A.; Albrecht, B.; Cuevas, G.; Fernandez-Alonso, M.d.C.; Jimenez-Barbero, J.; Schlörer, N.E.; Diaz, D.

Article / Zwitterionic Polysaccharides of Shigella sonnei: Synthetic Study toward a Ready-for-Oligomerization Building Block Made of Two Rare Amino Sugars

Synthesis (Germany)

Pfister, H.B.; Paoletti, J.; Poveda, A.; Jimenez-Barbero, J.; Mulard, L.A.

Article / The recognition of glycans by protein receptors. Insights from NMR spectroscopy

Chemical Communications

Ardá, A.; Jiménez-Barbero, J.

2017

Book / Specialist Periodical Reports: Carbohydrate Chemistry

AP Rauter, TK LIndhorst, Y Queneau

Ana Ardá, Helena Coelho, Beatriz Fernández de Toro, Silvia Galante, Ana Gimeno, Ana Poveda, Javier Sastre, Luca Unione, Pablo Valverde, F. Javier Cañada, Jesús Jiménez-Barbero1

Chapter / NMR in Glycoscience and Glycotechnology

NMR in Glycoscience and Glycotechnology

A Canales, J Jimenez-Barbero

Article / Contribution of shape and charge to the inhibition of a family GH99 endo-?-1,2-mannanase.

J Am Chem Soc

Petricevic M, Sobala LF, Fernandes P, Raich L, Thompson AJ, Bernardo-Seisdedos G, Millet O, Zhu S, Sollogoub M, Jimenez-Barbero J, Rovira C, Davies GJ, Williams SJ.

Article / Mechanistic Insight into the Binding of Multivalent Pyrrolidines to ?-Mannosidases.

Chem Eur J

Mirabella S, D'Adamio G, Matassini C, Goti A, Delgado S, Gimeno A, Robina I, Moreno-Vargas AJ, Šesták S, Jiménez-Barbero J, Cardona F.

Article / The Use of Fluoroproline in MUC1 Antigen Enables Efficient Detection of Antibodies in Patients with Prostate Cancer

Journal of the American Chemical Society

Somovilla, V.J.; Bermejo, I.A.; Albuquerque, I.S.; Martínez-Sáez, N.; Castro-López, J.; García-Martín, F.; Compañón, I.; Hinou, H.; Nishimura, S.I.; Jiménez-Barbero, J.; Asensio, J.L.; Avenoza, A.; Busto, J.H.; Hurtado-Guerrero, R.; Peregrina, J.M.; Bernardes, G.J.L.; Corzana, F.

Article / Hidden α-helical propensity segments within disordered regions of the transcriptional activator CHOP

PLoS ONE

Canales, Á.; Rösinger, M.; Sastre, J.; Felli, I.C.; Jiménez-Barbero, J.; Giménez-Gallego, G.; Fernández-Tornero, C.

Article / The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences

Nature Communications

Rivas, M.D.L.; Lira-Navarrete, E.; Daniel, E.J.P.; Companõn, I.; Coelho, H.; Diniz, A.; Jiménez-Barbero, J.; Peregrina, J.M.; Clausen, H.; Corzana, F.; Marcelo, F.; Jiménez-Osés, G.; Gerken, T.A.; Hurtado-Guerrero, R.

Article / Breaking the Limits in Analyzing Carbohydrate Recognition by NMR Spectroscopy: Resolving Branch-Selective Interaction of a Tetra-Antennary N-Glycan with Lectins

Angewandte Chemie - International Edition

Canales, A.; Boos, I.; Perkams, L.; Karst, L.; Luber, T.; Karagiannis, T.; Domínguez, G.; Cañada, F.J.; Pérez-Castells, J.; Häussinger, D.; Unverzagt, C.; Jiménez-Barbero, J.

Article / Mechanistic Insight into the Binding of Multivalent Pyrrolidines to α-Mannosidases

Chemistry - A European Journal

Mirabella, S.; D'Adamio, G.; Matassini, C.; Goti, A.; Delgado, S.; Gimeno, A.; Robina, I.; Moreno-Vargas, A.J.; Šesták, S.; Jiménez-Barbero, J.; Cardona, F.

Article / Protein–Glycan Quinary Interactions in Crowding Environment Unveiled by NMR Spectroscopy

Chemistry - A European Journal

Diniz, A.; Dias, J.S.; Jiménez-Barbero, J.; Marcelo, F.; Cabrita, E.J.

Article / Insights on the Interaction between Transthyretin and Aβ in Solution. A Saturation Transfer Difference (STD) NMR Analysis of the Role of Iododiflunisal

Journal of Medicinal Chemistry

Gimeno, A.; Santos, L.M.; Alemi, M.; Rivas, J.; Blasi, D.; Cotrina, E.Y.; Llop, J.; Valencia, G.; Cardoso, I.; Quintana, J.; Arsequell, G.; Jiménez-Barbero, J.

Article / Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin

Cell Chemical Biology

Sáez-Calvo, G.; Sharma, A.; Balaguer, F.d.A.; Barasoain, I.; Rodríguez-Salarichs, J.; Olieric, N.; Muñoz-Hernández, H.; Berbís, M.Á.; Wendeborn, S.; Peñalva, M.A.; Matesanz, R.; Canales, Á.; Prota, A.E.; Jímenez-Barbero, J.; Andreu, J.M.; Lamberth, C.; Steinmetz, M.O.; Díaz, J.F.

Article / Interactions between a heparin trisaccharide library and FGF-1 analyzed by NMR methods

International Journal of Molecular Sciences

García-Jiménez, M.J.; Gil-Caballero, S.; Canales, Á.; Jiménez-Barbero, J.; de Paz, J.L.; Nieto, P.M.

Article / NMR and Molecular Recognition of N-Glycans: Remote Modifications of the Saccharide Chain Modulate Binding Features

ACS Chemical Biology

Gimeno, A.; Reichardt, N.C.; Cañada, F.J.; Perkams, L.; Unverzagt, C.; Jiménez-Barbero, J.; Ardá, A.

Article / Fluoroacetamide Moieties as NMR Spectroscopy Probes for the Molecular Recognition of GlcNAc-Containing Sugars: Modulation of the CH–π Stacking Interactions by Different Fluorination Patterns

Chemistry - A European Journal

Unione, L.; Alcalá, M.; Echeverria, B.; Serna, S.; Ardá, A.; Franconetti, A.; Cañada, F.J.; Diercks, T.; Reichardt, N.; Jiménez-Barbero, J.

Article / Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling

Chemistry - A European Journal

Marín-Ramos, N.I.; Piñar, C.; Vázquez-Villa, H.; Martín-Fontecha, M.; González, Á.; Canales, Á.; Algar, S.; Mayo, P.P.; Jiménez-Barbero, J.; Gajate, C.; Mollinedo, F.; Pardo, L.; Ortega-Gutiérrez, S.; Viso, A.; López-Rodríguez, M.L.

Article / Direct Enzymatic Branch-End Extension of Glycocluster-Presented Glycans: An Effective Strategy for Programming Glycan Bioactivity

Chemistry - A European Journal

Bayón, C.; He, N.; Deir-Kaspar, M.; Blasco, P.; André, S.; Gabius, H.J.; Rumbero, Á.; Jiménez-Barbero, J.; Fessner, W.D.; Hernáiz, M.J.

Article / Contribution of shape and charge to the inhibition of a family GH99 endo-α-1,2-mannanase

Journal of the American Chemical Society

Petricevic, M.; Sobala, L.F.; Fernandes, P.Z.; Raich, L.; Thompson, A.J.; Bernardo-Seisdedos, G.; Millet, O.; Zhu, S.; Sollogoub, M.; Jiménez-Barbero, J.; Rovira, C.; Davies, G.J.; Williams, S.J.

Article / Role of the sugar moiety on the opioid receptor binding and conformation of a series of enkephalin neoglycopeptides

Bioorganic and Medicinal Chemistry

Rosa, M.; Gonzalez-Nunez, V.; Barreto-Valer, K.; Marcelo, F.; Sánchez-Sánchez, J.; Calle, L.P.; Arévalo, J.C.; Rodríguez, R.E.; Jiménez-Barbero, J.; Arsequell, G.; Valencia, G.

Article / Recent advances in the application of NMR methods to uncover the conformation and recognition features of glycans

Carbohydrate Chemistry

Ardá, A.; Coelho, H.; De Toro, B.F.; Galante, S.; Gimeno, A.; Poveda, A.; Sastre, J.; Unione, L.; Valverde, P.; Javier Cañada, F.; Jiménez-Barbero, J.

Review / Glycans in infectious diseases. A molecular recognition perspective

Current Medicinal Chemistry

Unione, L.; Gimeno, A.; Valverde, P.; Calloni, I.; Coelho, H.; Mirabella, S.; Poveda, A.; Ardá, A.; Jiménez-Barbero, J.

2016

Book / Reference Module in Chemistry, Molecular Sciences and Chemical Engineering,

Reedijk, J.

A. Lacetera, S. Galante, J. Jiménez-Barbero, S. Martín-Santamaría

Article / Novel vaccines targeting dendritic cells by coupling allergoids to nonoxidized mannan enhance allergen uptake and induce functional regulatory T cells through programmed death ligand 1.

J Allergy Clin Immunol.

Sirvent S, Soria I, Cirauqui C, Cases B, Manzano AI, Diez-Rivero CM, Reche PA, López-Relaño J, Martínez-Naves E, Cañada FJ, Jiménez-Barbero J, Subiza J, Casanovas M, Fernández-Caldas E, Subiza JL, Palomares O.

Article / Diastereomeric Glycosyl Sulfoxides Display Different Recognition Features versus E. coli β-Galactosidase

European Journal of Organic Chemistry

Colomer, J.P.; Fernández de Toro, B.; Cañada, F.J.; Corzana, F.; Jiménez Barbero, J.; Canales, Á.; Varela, O.

Article / Structural and Biochemical Characterization of the Interaction of Tubulin with Potent Natural Analogues of Podophyllotoxin

Journal of Natural Products

Antúnez-Mojica, M.; Rodríguez-Salarichs, J.; Redondo-Horcajo, M.; León, A.; Barasoain, I.; Canales, Á.; Cañada, F.J.; Jiménez-Barbero, J.; Alvarez, L.; Díaz, J.F.

Article / Unraveling the Conformational Landscape of Ligand Binding to Glucose/Galactose-Binding Protein by Paramagnetic NMR and MD Simulations

ACS Chemical Biology

Unione, L.; Ortega, G.; Mallagaray, A.; Corzana, F.; Pérez-Castells, J.; Canales, A.; Jiménez-Barbero, J.; Millet, O.

Article / Intra- and intermolecular interactions of human galectin-3: Assessment by full-assignment-based NMR

Glycobiology

Ippel, H.; Miller, M.C.; Vértesy, S.; Zheng, Y.; Cañada, F.J.; Suylen, D.; Umemoto, K.; Romanò, C.; Hackeng, T.; Tai, G.; Leffler, H.; Kopitz, J.; André, S.; Kübler, D.; Jiménez-Barbero, J.; Oscarson, S.; Gabius, H.J.; Mayo, K.H.

Article / Synthesis, biological profiling and determination of the tubulin-bound conformation of 12-aza-epothilones (azathilones)

Molecules

Jantsch, A.; Nieto, L.; Gertsch, J.; Rodríguez-Salarichs, J.; Matesanz, R.; Jiménez-Barbero, J.; Díaz, J.F.; Canales, Á.; Altmann, K.H.

Article / Detailed Investigation of the Immunodominant Role of O-Antigen Stoichiometric O-Acetylation as Revealed by Chemical Synthesis, Immunochemistry, Solution Conformation and STD-NMR Spectroscopy for Shigella flexneri 3a

Chemistry - A European Journal

Boutet, J.; Blasco, P.; Guerreiro, C.; Thouron, F.; Dartevelle, S.; Nato, F.; Cañada, F.J.; Ardá, A.; Phalipon, A.; Jiménez-Barbero, J.; Mulard, L.A.

Article / Design of α-S-Neoglycopeptides Derived from MUC1 with a Flexible and Solvent-Exposed Sugar Moiety

Journal of Organic Chemistry

Rojas-Ocáriz, V.; Compañón, I.; Aydillo, C.; Castro-Loṕez, J.; Jiménez-Barbero, J.; Hurtado-Guerrero, R.; Avenoza, A.; Zurbano, M.M.; Peregrina, J.M.; Busto, J.H.; Corzana, F.

Article / Mechanism of sulfur transfer across protein-protein interfaces: The cysteine desulfurase model system

ACS Catalysis

Fernández, F.J.; Ardá, A.; López-Estepa, M.; Aranda, J.; Peña-Soler, E.; Garces, F.; Round, A.; Campos-Olivas, R.; Bruix, M.; Coll, M.; Tuñón, I.; Jiménez-Barbero, J.; Vega, M.C.

Article / Finding the Right Candidate for the Right Position: A Fast NMR-Assisted Combinatorial Method for Optimizing Nucleic Acids Binders

Journal of the American Chemical Society

Jiménez-Moreno, E.; Montalvillo-Jiménez, L.; Santana, A.G.; Gómez, A.M.; Jiménez-Osés, G.; Corzana, F.; Bastida, A.; Jiménez-Barbero, J.; Canada, F.J.; Gómez-Pinto, I.; González, C.; Asensio, J.L.

Article / Acetylated Trivalent Mannobioses: Chemical Modification, Structural Elucidation, and Biological Evaluation

ChemMedChem

Rahkila, J.; Panchadhayee, R.; Ardá, A.; Jiménez-Barbero, J.; Savolainen, J.; Leino, R.

Article / Quillaja saponin variants with central glycosidic linkage modifications exhibit distinct conformations and adjuvant activities

Chemical Science

Walkowicz, W.E.; Fernández-Tejada, A.; George, C.; Corzana, F.; Jiménez-Barbero, J.; Ragupathi, G.; Tan, D.S.; Gin, D.Y.

Article / Mucin architecture behind the immune response: Design, evaluation and conformational analysis of an antitumor vaccine derived from an unnatural MUC1 fragment

Chemical Science

Martínez-Sáez, N.; Supekar, N.T.; Wolfert, M.A.; Bermejo, I.A.; Hurtado-Guerrero, R.; Asensio, J.L.; Jiménez-Barbero, J.; Busto, J.H.; Avenoza, A.; Boons, G.J.; Peregrina, J.M.; Corzana, F.

Article / Catching elusive glycosyl cations in a condensed phase with HF/SbF5 superacid

Nature Chemistry

Martin, A.; Arda, A.; Désiré, J.; Martin-Mingot, A.; Probst, N.; Sinaÿ, P.; Jiménez-Barbero, J.; Thibaudeau, S.; Blériot, Y.

Article / Conformational flexibility around the Gal-β-(1 → 3)-Glc linkage: Experimental evidence for the existence of the anti-ψ conformation in aqueous solution

Carbohydrate Research

Vidal, P.; Jiménez-Barbero, J.; Espinosa, J.F.

2015

Book / Carbohydrates in Drug Design and Discovery

Jesus Jimenez-Barbero, F. Javier Canada and Sonsoles Martin-Santamaria

Book / Carbohydrate Chemistry: State of the Art and Challenges for Drug Development

L Cipolla

Ángeles Canales, Javier Sastre-Martinez, Luca Unione, M C Fernández-Alonso, Pilar Blasco, F Javier Cañada and Jesús Jiménez-Barbero

Book / Carbohydrates in Drug Design and Discovery

esus Jimenez-Barbero, F. Javier Canada, Sonsoles Martin-Santamaria

Ana Ardá, Angeles Canales, F. Javier Cañada and Jesús Jiménez-Barbero

Chapter / Glycoinformatics

T Luttecke, M Franck

D. Díaz, A. Canales-Mayordomo, F. Javier Cañada, J. Jiménez-Barbero

Article / Chemistry of Lipid?A: At the Heart of Innate Immunity.

Chem. Eur. J.

Molinaro A, Holst O, Di Lorenzo F, Callaghan M, Nurisso A, D'Errico G, Zamyatina A, Peri F, Berisio R, Jerala R, Jiménez-Barbero J, Silipo A, Martín-Santamaría S

Article / The Crystal Structure and Small-Angle X-Ray Analysis of CsdL/TcdA reveal a new tRNA binding motif in the MoeB/E1 superfamily

PLOS ONE

Miguel López-Estepa, Ana Ardá, Martin Savko, Adam Round, William Sephard, Marta Bruix, Miquel Coll, Francisco J Fernández, Jesús Jiménez-Barbero, and M. Cristina Vega

Article / Influence of polar side chains modifications on the dual enkephalinase inhibitory activity and conformation of human opiorphin, a pain perception related peptide

Bioorganic and Medicinal Chemistry Letters

Rosa, M.; Marcelo, F.; Calle, L.P.; Rougeot, C.; Jiménez-Barbero, J.; Arsequell, G.; Valencia, G.

Article / Fluorinated carbohydrates as lectin ligands: 19F-based direct STD monitoring for detection of Anomeric selectivity

Biomolecules

Ribeiro, J.P.; Diercks, T.; Jiménez-Barbero, J.; André, S.; Gabius, H.J.; Cañada, F.J.

Article / The Quest for Anticancer Vaccines: Deciphering the Fine-Epitope Specificity of Cancer-Related Monoclonal Antibodies by Combining Microarray Screening and Saturation Transfer Difference NMR

Journal of the American Chemical Society

Coelho, H.; Matsushita, T.; Artigas, G.; Hinou, H.; Cañada, F.J.; Lo-Man, R.; Leclerc, C.; Cabrita, E.J.; Jiménez-Barbero, J.; Nishimura, S.I.; Garcia-Martín, F.; Marcelo, F.

Article / D - And L -Mannose-Containing glyco-Oligoamides Show Distinct Recognition Properties When Interacting with DNA

European Journal of Organic Chemistry

Blázquez-Sánchez, M.T.; Marcelo, F.; Fernández-Alonso, M.D.C.; Del Villar-Guerra, R.; Samadi, A.; Cañada, F.J.; Jiménez-Barbero, J.; Vicent, C.

Article / Structure and sialyllactose binding of the carboxy-terminal head domain of the fibre from a siadenovirus, Turkey adenovirus 3

PLoS ONE

Singh, A.K.; Berbís, M.Á.; Ballmann, M.Z.; Kilcoyne, M.; Menéndez, M.; Nguyen, T.H.; Joshi, L.; Cañada, F.J.; Jiménez-Barbero, J.; Benko, M.; Harrach, B.; Van Raaij, M.J.

Article / Modulation of the Interaction between a Peptide Ligand and a G Protein-Coupled Receptor by Halogen Atoms

ACS Medicinal Chemistry Letters

Rosa, M.; Caltabiano, G.; Barreto-Valer, K.; Gonzalez-Nunez, V.; Gómez-Tamayo, J.C.; Ardá, A.; Jiménez-Barbero, J.; Pardo, L.; Rodríguez, R.E.; Arsequell, G.; Valencia, G.

Article / Deciphering the Non-Equivalence of Serine and Threonine O-Glycosylation Points: Implications for Molecular Recognition of the Tn Antigen by an anti-MUC1 Antibody

Angewandte Chemie - International Edition

Martínez-Sáez, N.; Castro-Lõpez, J.; Valero-González, J.; Madariaga, D.; Compañõn, I.; Somovilla, V.J.; Salvadõ, M.; Asensio, J.L.; Jiménez-Barbero, J.; Avenoza, A.; Busto, J.H.; Bernardes, G.J.L.; Peregrina, J.M.; Hurtado-Guerrero, R.; Corzana, F.

Article / Monitoring Glycan-Protein Interactions by NMR Spectroscopic Analysis: A Simple Chemical Tag That Mimics Natural CH-π Interactions

Chemistry - A European Journal

Calle, L.P.; Echeverria, B.; Franconetti, A.; Serna, S.; Fernández-Alonso, M.C.; Diercks, T.; Cañada, F.J.; Ardá, A.; Reichardt, N.C.; Jiménez-Barbero, J.

Article / A thorough experimental study of CH/π interactions in water: quantitative structure-stability relationships for carbohydrate/aromatic complexes

Chemical Science

Jiménez-Moreno, E.; Jiménez-Osés, G.; Gómez, A.M.; Santana, A.G.; Corzana, F.; Bastida, A.; Jiménez-Barbero, J.; Asensio, J.L.

Article / Thermodynamic Switch in Binding of Adhesion/Growth Regulatory Human Galectin-3 to Tumor-Associated TF Antigen (CD176) and MUC1 Glycopeptides

Biochemistry

Rodriguez, M.C.; Yegorova, S.; Pitteloud, J.P.; Chavaroche, A.E.; André, S.; Ardá, A.; Minond, D.; Jiménez-Barbero, J.; Gabius, H.J.; Cudic, M.

Article / Antimicrobial peptides: Insights into membrane permeabilization, lipopolysaccharide fragmentation and application in plant disease control

Scientific Reports

Datta, A.; Ghosh, A.; Airoldi, C.; Sperandeo, P.; Mroue, K.H.; Jimenez-Barbero, J.; Kundu, P.; Ramamoorthy, A.; Bhunia, A.

Article / Recent Developments in Synthetic Carbohydrate-Based Diagnostics, Vaccines, and Therapeutics

Chemistry - A European Journal

Fernández-Tejada, A.; Cañada, F.J.; Jiménez-Barbero, J.

Article / Conformational Plasticity in Glycomimetics: Fluorocarbamethyl- L -idopyranosides Mimic the Intrinsic Dynamic Behaviour of Natural Idose Rings

Chemistry - A European Journal

Unione, L.; Xu, B.; Díaz, D.; Martín-Santamaría, S.; Poveda, A.; Sardinha, J.; Rauter, A.P.; Blériot, Y.; Zhang, Y.; Cañada, F.J.; Sollogoub, M.; Jiménez-Barbero, J.

Article / New inhibitors of angiogenesis with antitumor activity in vivo

Journal of Medicinal Chemistry

Marín-Ramos, N.I.; Alonso, D.; Ortega-Gutiérrez, S.; Ortega-Nogales, F.J.; Balabasquer, M.; Vázquez-Villa, H.; Andradas, C.; Blasco-Benito, S.; Pérez-Gómez, E.; Canales, Á.; Jiménez-Barbero, J.; Marquina, A.; Del Prado, J.M.; Sánchez, C.; Martín-Fontecha, M.; López-Rodríguez, M.L.

Article / A Murine Monoclonal Antibody to Glycogen: Characterization of Epitope-Fine Specificity by Saturation Transfer Difference (STD) NMR Spectroscopy and Its Use in Mycobacterial Capsular α-Glucan Research

ChemBioChem

Van De Weerd, R.; Berbís, M.A.; Sparrius, M.; Maaskant, J.J.; Boot, M.; Paauw, N.J.; De Vries, N.; Boon, L.; Baba, O.; Cañada, F.J.; Geurtsen, J.; Jiménez-Barbero, J.; Appelmelk, B.J.

Article / Modulating weak interactions for molecular recognition: A dynamic combinatorial analysis for assessing the contribution of electrostatics to the stability of CH-π bonds in water

Angewandte Chemie - International Edition

Jiménez-Moreno, E.; Gõmez, A.M.; Bastida, A.; Corzana, F.; Jiménez-Oses, G.; Jiménez-Barbero, J.; Asensio, J.L.

Article / Thiodisaccharide Sulfoxides: Absolute Configuration of the SO Sulfur Atom and Influence on the Biological Activity towards the β-Galactosidase from E. coli

European Journal of Organic Chemistry

Colomer, J.P.; Canales Mayordomo, M.Á.; Fernández de Toro, B.; Jiménez-Barbero, J.; Varela, O.

Article / Structural basis of ligand binding to UDP-galactopyranose mutase from Mycobacterium tuberculosis using substrate and tetrafluorinated substrate analogues

Journal of the American Chemical Society

Van Straaten, K.E.; Kuttiyatveetil, J.R.A.; Sevrain, C.M.; Villaume, S.A.; Jiménez-Barbero, J.; Linclau, B.; Vincent, S.P.; Sanders, D.A.R.

Article / Carbohydrate-protein interactions: A 3D view by NMR

RSC Drug Discovery Series

Ardá, A.; Canales, A.; Javier Canãda, F.; Jiménez-Barbero, J.

Article / Structure and function of prokaryotic UDP-glucose pyrophosphorylase, a drug target candidate

Current Medicinal Chemistry

Berbís, M.Á.; Sánchez-Puelles, J.M.; Cañada, F.J.; Jiménez-Barbero, J.

Review / Glycans in Medicinal Chemistry: An Underexploited Resource

ChemMedChem

Fernández-Tejada, A.; Cañada, F.J.; Jiménez-Barbero, J.

2014

Article / Anti-endotoxic activity and structural basis for human MD-2·TLR4 antagonism of tetraacylated lipid A mimetics based on ?GlcN(1?1)?GlcN scaffold.

INNATE IMMUN

Garate JA, Stöckl J, Del Carmen Fernández-Alonso M, Artner D, Haegman M, Oostenbrink C, Jiménez-Barbero J, Beyaert R, Heine H, Kosma P, Zamyatina A

Article / Conformational analysis of peptides and glycopeptides derived from the consensus sequence for β-O-glucosylation

Current Topics in Medicinal Chemistry

Somovilla, V.J.; Martínez-Sáez, N.; Fernández-Tejada, A.; De La Torre, B.G.; Andreu, D.; Jiménez-Barbero, J.; Asensio, J.L.; Avenoza, A.; Busto, J.H.; Corzana, F.; Peregrina, J.M.

Unveiling Heparin & Heparin Sulfate Conformations. A Journey into paramagnetic NMR Analysis.

Paris-Saclay & UPV/EHU

Juan Carlos Jaime Rodríguez - Finished

Understanding and Harnessing Siglec-10-Glycan Interactions

UPV/EHU

Klaudia Sobczak - Finished

Lectin-Glycan Interactions: new NMR insights on the role of dynamics and presentation by using state-of-the-art NMR methodologies

UPV/EHU

Sara Bertuzzi - Finished

NMR and molecular recognition: The interaction of human galectin-4 with the histo blood group antigens and with pathogen-associated molecules

UPV/EHU

Jon Imanol Quintana - Finished

Unravelling molecular recognition events between glycans & proteins using advanced NMR techniques

UPV/EHU

Unai Atxabal - Finished

NMR and molecular recognition: The interaction of human galectin-8 and DC-SIGN with natural glycans and glycomimetics

UPV/EHU

Marcos Gomez Redondo - Finished

Decipherig the recognition features on glycans by human lectins at the molecular level

UPV/EHU

Maria Pia Lenza - Finished

Novel ligand-based 19F-NMR and computational approaches for studying sugar-lectin molecular recognition events

Complutense

Jose Daniel Martínez - Finished

Resonancia Magne?tica Nuclear Aplicada al Estudio sobre el Reconocimiento Molecular de Ligandos con Fucosa Mediado por el Receptor DC-SIGN

Complutense

Pablo Valverde - Finished

Beatriz Fernández de Toro

Complutense

Beatriz Fernández de Toro - Finished

NMR studies of the interactions of glycan antigens with monoclonal antibodies

UPV-EHU

Ilaria Calloni - Finished

Ultrasmall Glyco-Gold Nanoparticles: Synthesis Optimization, Characterization and Applications in Immune-Cell Targeting

UPV-EHU

Valentin Cognet - Finished

Synthesis of N-glycan mimetics and their evaluation as C-type lectin receptor (CLR) antagonists using microarray technology

UPV-EHU

Anna Cioce - Finished

NMR and molecular recognition of compounds related to the immune system

UPV-EHU

Helena Coelho - Finished

Synthesis, screening and use of parasitic P-glycans and mimetics for improved C-type lectin receptor targeting

UPV-EHU

Julie Thanh Pham - Finished

NMR and Molecular Recognition

Complutense

Javier Sastre Martínez - Finished

Sistemas heteroaromáticos de tipo Pirilio: Evaluación de la Interacción anión-pi y aplicación al desarrollo de materiales multifuncionales basados en Quitosano

SEVILLA

A Franconetti - Finished

The Role of Dynamics in Molecular Interactions

COMPLUTENSE MADRID

Luca Unione - Finished

RMN y Reconocimiento Molecular: Relación estructura-actividad de péptidos implicados en el dolor e interacciones proteína-carbohidrato

COMPLUTENSE MADRID

Luis P Calle Jiménez - Finished

2024

NMR & Molecular recognition. UPV/EHU

2022

NMR & MOLECULAR RECOGNITION. UPV/EHU

2021

Course on NMR & MOLECULAR RECOGNITION, UPV/EHU

2020

Course on NMR & MOLECULAR RECOGNITION, UPV/EHU

2019

Course on NMR & MOLECULAR RECOGNITION, UPV/EHU

2018

Course on NMR & MOLECULAR RECOGNITION, UPV/EHU

2017

Master course on NMR & MOLECULAR RECOGNITION, Univ. Valencia

NMR & METABOLOMICS, Univ. Valencia

2016

Master course on NMR & MOLECULAR RECOGNITION, Univ. Rovira Virgili

2015

Master course on NMR & MOLECULAR RECOGNITION, Univ. Valencia

2024

CIC bioGUNE Scientific Director

Head of the "2024 Ayudas Beatriz Galindo" Committee

2023

CIC bioGUNE Scientific Director

2022

CIC bioGUNE Scientific Director

Head of the "2022 Ayudas Beatriz Galindo" Committee

2021

CIC bioGUNE Scientific Director

2020

Head of the "2020 Ayudas Beatriz Galindo" Committee

2019

CIC bioGUNE Scientific Director

2018

CIC bioGUNE Scientific Director

Head of the "2018 Ayudas Beatriz Galindo" Committee

2017

Scientific Director CIC bioGUNE

Head of the Chemistry Panel of State Plan for Research (MINECO)

CIC bioGUNE Scientific Director

2016

CIC bioGUNE Scientific Director

2015

CIC bioGUNE Scientific Director

2023

National Prize "Enrique Moles" in Chemical Sciences & Technology

2019

MEDAL OF RSEQ

2018

Gold Medal of the Royal Society of Chemistry of Spain

2017

ChemPubSoc Fellow

Gamboa-Winkler Award from the Chemical Society of Hungary http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1860-7187/homepage/news/41908.en.html

Member of the European Academy of Sciences

2024

Invited talk | Unlocking the Siglec-Sialic acid axis

7th Iberian Carbohydrate Meeting, Sitges (Spain). - Invited talk

Unai Atxabal; Andrea Fernández, Klaudia Sobczak, Iker Oyenarte, Maria Pia Lenza, Jesús Jiménez Barbero, June Ereño-Orbea.

2023

Invited talk | GLYCAN-LECTIN MOLECULAR RECOGNITION:NEW NMR STARTEGIES AND KEY MOLECULAR MECHANISMS

XIII Jornadas de Carbohidratos, GE HiC, RSEQ - Invited talk

Ana Arda

Invited talk | Unveiling Siglec interactions with glycans and antibodies: a molecular perspective

I GlycoForum La Rioja-Euskadi-Hokkaido - Invited talk

June Ereño-Orbea

Poster presentation | Molecular insights into Galectin-4 binding to oligo- and lipopolysaccharides containing the ABH histo-blood antigens

2023 Carbohydrates Gordon Research Conference - Poster presentation

Jon I. Quintana, Sandra Delgado, Jesús Jiménez-Barbero, Ana Ardá

2022

Poster presentation | Structural insights of the interactions of Siglec-9 with natural and synthetic analogues

NMR summer School-RSEQ - Poster presentation

Atxabal, Unai ;Lenza, Maria Pia ;Oyenarte, Iker ;Nycholat, Corwin ;Paulson, James C ;Schubert, Mario ;Jiménez Barbero, Jesús ;Ereño Orbea, June

2021

Poster presentation | Targeting SARS-CoV-2 spike protein glycans by structural and computational methods

Congress Microscopy at the Frontiers of Science - Poster presentation

Soledad Stagnoli*, Francesca Peccati, Sean R Connell, Ane Martinez-Castillo, Diego Charro, Oscar Millet, Chiara Bruzzone, Asis Palazon, Ana Ardá, Jesús Jiménez-Barbero, June Ereño-Orbea, Nicola GA Abrescia, Gonzalo Jiménez-Osés

Poster presentation | Structural insights of the interactions of Siglec-9 with natural and synthetic analogues

4rd Glycobasque Meeting - Poster presentation

Atxabal, Unai ;Oyenarte, Iker ;Lenza, Maria Pia ;Jimenez Barbero, Jesús ;Ereño Orbea, June

Poster presentation | Deciphering the structural details of the recognition mode of the cancer-asscoaited glycoprotein CD24 by Siglec-10

4rd Glycobasque Meeting - Poster presentation

Sobczak, Klaudia ;Oyenarte, Ike ;Lenza, Maria Pia ;Jimenez Barbero, Jesús ;Ereño Orbea, June

2020

Invited talk | Breaking the limits in Glycan Recognition by NMR

Biennial Meeting of the Chemical Biology Division of RSEQ - Invited talk

J Jimenez-Barbero

2019

Invited talk | Breaking the limits in understanding carbohydrate recognition by NMR

CBM13 - Carbohydrate Bioengineering Meeting - Invited talk

Jesus Jimenez-Barbero

Invited talk | Breaking the limits in understanding carbohydrate recognition by NMR

H-BOND2019 - Invited talk

Jesus Jimenez-Barbero

Invited talk | Breaking the limits in understanding glycan recognition by NMR

EUROISMAR 2019 - Invited talk

J Jimenez-Barbero

Invited talk | Breaking the limits in understanding glycan recognition by NMR

Biennial Meeting of RSEQ - Invited talk

J Jimenez-Barbero

2018

Invited talk | Breaking the limits in glycan recognition by NMR

International Carbohydrate Symposium 2018 - Invited talk

J Jimenez-Barbero

2017

Invited talk | Breaking the limits in Glycan recognition by NMR

Eurocarb2017 - Invited talk

Jiménez-Barbero J

Invited talk | Breaking the limits in Glycan recognition by NMR

Spanish-Japanese Symposium on Modern Synthetic Methodology - Invited talk

Jimenez-Barbero J

Invited talk | Breaking the limits in glycan recognition by NMR

Spanish-German Symposium on Modern Synthetic Methodology - Invited talk

Jimenez-Barbero J

Invited talk | Breaking the limits in Glycan recognition by NMR

NMR: A Tool For Biology VII. - Invited talk

J. Jimenez-Barbero

Invited talk | Breaking the limits in glycan recognition by NMR

Frontiers in Bimolecular NMR - Invited talk

Jimenez-Barbero J

2016

Invited talk | NMR and Molecular Recognition

BIFI International Symposium on Molecular Recogniiton - Invited talk

J Jimenez-Barbero

Invited talk | NMR and Molecular Recognition. GLYCAN-PROTEIN INTERACTIONS

82. International Conference On Magnetic Resonance In Biological Systems - Invited talk

J Jimenez-Barbero

Invited talk | NMR and Molecular Recognition. GLYCAN-PROTEIN INTERACTIONS

Third Iberoamerican Organic Chemistry Symposium (SIBEAQO-III) - Invited talk

Jimenez-Barbero J

2015

Invited talk | NMR and Molecular Recognition

Symposium on Dynamic Constitutional Systems - Invited talk

J Jimenez-Barbero