José Luis Zugaza

Ikerbasque Research Professor, UPV/EHU and Achucarro Basque Center for Neuroscience

Ikerbasque Research Professor at the Department of Genetics, Physical Anthropology and Animal Genetics, Faculty of Science and Technology, University of the Basque Contry, UPV/EHU and Achucarro Basque Center for Neuroscience.

Research line:

Cell signaling in cancer and neurodegeneration.

Previous research experience in centers in United Kingdom, France and Spain.

Doctor in Pharmacy (1993) from the University of Santiago de Compostela.

2024

Review / The importance of muscle glycogen phosphorylase in glial cells function

Biochemical Society Transactions

Llavero, F.; Zugaza, J.L.

2023

Article / P-Rex1 is a novel substrate of the E3 ubiquitin ligase Malin associated with Lafora disease

Neurobiology of Disease

Kumarasinghe, L.; Garcia-Gimeno, M.A.; Ramirez, J.; Mayor, U.; Zugaza, J.L.; Sanz, P.

Article / Amyloid β1–42 Oligomers Induce Galectin–1<sup>S8</sup> O–GlcNAcylation Leading to Microglia Migration

Cells

Arrazola Sastre, A.; Luque Montoro, M.; Llavero, F.; Zugaza, J.L.

2022

Article / Recombinant Integrin β1 Signal Peptide Blocks Gliosis Induced by Aβ Oligomers

International Journal of Molecular Sciences

Ortiz‐sanz, C.; Llavero, F.; Zuazo‐ibarra, J.; Balantzategi, U.; Quintela‐lópez, T.; Wyssenbach, A.; Capetillo‐zarate, E.; Matute, C.; Alberdi, E.; Zugaza, J.L.

Article / Identification of Potential Muscle Biomarkers in McArdle Disease: Insights from Muscle Proteome Analysis

International Journal of Molecular Sciences

García-Consuegra, I.; Asensio-Peña, S.; Garrido-Moraga, R.; Pinós, T.; Domínguez-González, C.; Santalla, A.; Nogales-Gadea, G.; Serrano-Lorenzo, P.; Andreu, A.L.; Arenas, J.; Zugaza, J.L.; Lucia, A.; Martín, M.A.

Article / Amyloid β / PKC-dependent alterations in NMDA receptor composition are detected in early stages of Alzheimer´s disease

Cell Death and Disease

Ortiz-Sanz, C.; Balantzategi, U.; Quintela-López, T.; Ruiz, A.; Luchena, C.; Zuazo-Ibarra, J.; Capetillo-Zarate, E.; Matute, C.; Zugaza, J.L.; Alberdi, E.

2021

Article / The tyrosine phosphatase hPTPRβ controls the early signals and dopaminergic cells viability via the P2X7 receptor

International Journal of Molecular Sciences

Bernal, F.L.; Montoro, M.L.; Sastre, A.A.; Lacerda, H.M.; Zugaza, J.L.

Article / Exercise training effects on natural killer cells: a preliminary proteomics and systems biology approach

Exercise immunology review

Llavero, F.; Alejo, L.B.; Fiuza-Luces, C.; López Soto, A.; Valenzuela, P.L.; Castillo-García, A.; Morales, J.S.; Fernández, D.; Aldazabal, I.P.; Ramírez, M.; Santos-Lozano, A.; Zugaza, J.L.; Lucia, A.

Editorial / Cell signaling in neurodegeneration

International Journal of Molecular Sciences

Zugaza, J.L.

Review / Small gtpases of the rab and arf families: Key regulators of intracellular trafficking in neurodegeneration

International Journal of Molecular Sciences

Sastre, A.A.; Montoro, M.L.; Lacerda, H.M.; Llavero, F.; Zugaza, J.L.

Review / Small GTPases of the Rab and Arf Families: Key Regulators of Intracellular Trafficking in Neurodegeneration

International journal of molecular sciences

Arrazola Sastre, A.; Luque Montoro, M.; Lacerda, H.M.; Llavero, F.; Zugaza, J.L.

Review / Future avenues for Alzheimer's disease detection and therapy: liquid biopsy, intracellular signaling modulation, systems pharmacology drug discovery

Neuropharmacology

Hampel, H.; Vergallo, A.; Caraci, F.; Cuello, A.C.; Lemercier, P.; Vellas, B.; Giudici, K.V.; Baldacci, F.; Hänisch, B.; Haberkamp, M.; Broich, K.; Nisticò, R.; Emanuele, E.; Llavero, F.; Zugaza, J.L.; Lucía, A.; Giacobini, E.; Lista, S.

Review / Small GTPases of the Ras superfamily and glycogen phosphorylase regulation in T cells

Small GTPases

Llavero, F.; Arrazola Sastre, A.; Luque Montoro, M.; Martín, M.A.; Arenas, J.; Lucia, A.; Zugaza, J.L.

2020

Article / Successful aging: Insights from proteome analyses of healthy centenarians

Aging

Santos-Lozano, A.; Valenzuela, P.L.; Llavero, F.; Lista, S.; Carrera-Bastos, P.; Hampel, H.; Pareja-Galeano, H.; Gálvez, B.G.; López, J.A.; Vázquez, J.; Emanuele, E.; Zugaza, J.L.; Lucia, A.

Article / Early Effects of Aβ Oligomers on Dendritic Spine Dynamics and Arborization in Hippocampal Neurons

Frontiers in Synaptic Neuroscience

Ortiz-Sanz, C.; Gaminde-Blasco, A.; Valero, J.; Bakota, L.; Brandt, R.; Zugaza, J.L.; Matute, C.; Alberdi, E.

Review / Small gtpases of the ras and rho families switch on/off signaling pathways in neurodegenerative diseases

International Journal of Molecular Sciences

Sastre, A.A.; Montoro, M.L.; Gálvez-Martín, P.; Lacerda, H.M.; Lucia, A.; Llavero, F.; Zugaza, J.L.

Review / Small GTPases of the Ras and Rho Families Switch on/off Signaling Pathways in Neurodegenerative Diseases

International journal of molecular sciences

Arrazola Sastre, A.; Luque Montoro, M.; Gálvez-Martín, P.; Lacerda, H.M.; Lucia, A.M.; Llavero, F.; Zugaza, J.L.

Review / An overview of international regulatory frameworks for mesenchymal stromal cell-based medicinal products: From laboratory to patient

Medicinal Research Reviews

López-Beas, J.; Guadix, J.A.; Clares, B.; Soriano-Ruiz, J.L.; Zugaza, J.L.; Gálvez-Martín, P.

2019

Article / Epidermal growth factor receptor controls glycogen phosphorylase in T cells through small GTPases of the RAS family

Journal of Biological Chemistry

Llavero, F.; Montoro, M.L.; Sastre, A.A.; Fernández-Moreno, D.; Lacerda, H.M.; Parada, L.A.; Lucia, A.; Zugaza, J.L.

Review / Mcardle disease: New insights into its underlying molecular mechanisms

International Journal of Molecular Sciences

Llavero, F.; Sastre, A.A.; Montoro, M.L.; Gálvez, P.; Lacerda, H.M.; Parada, L.A.; Zugaza, J.L.

Review / Principal criteria for evaluating the quality, safety and efficacy of hMSC-based products in clinical practice: Current approaches and challenges

Pharmaceutics

Guadix, J.A.; López-Beas, J.; Clares, B.; Soriano-Ruiz, J.L.; Zugaza, J.L.; Gálvez-Martín, P.

2018

Article / Inhibition of Casein Kinase 2 protects oligodendrocytes from excitotoxicity by attenuating JNK/p53 signaling cascade

Frontiers In Molecular Neuroscience

Canedo-Antelo M, Serrano MP, Manterola A, Ruiz A, Llavero F, Mato S, Zugaza JL, Pérez-Cerdá F, Matute C, Sanchez-Gómez MV

Article / Inhibition of Casein Kinase 2 Protects Oligodendrocytes From Excitotoxicity by Attenuating JNK/p53 Signaling Cascade

Frontiers in Molecular Neuroscience

Canedo-Antelo, M.; Serrano, M.P.; Manterola, A.; Ruiz, A.; Llavero, F.; Mato, S.; Zugaza, J.L.; Pérez-Cerdá, F.; Matute, C.; Sánchez-Gómez, M.V.

Article / PLAGL1 gene function during hepatoma cells proliferation

Oncotarget

Vega-Benedetti, A.F.; Saucedo, C.N.; Zavattari, P.; Vanni, R.; Royo, F.; Llavero, F.; Zugaza, J.L.; Parada, L.A.

Article / Muscle molecular adaptations to endurance exercise training are conditioned by glycogen availability: a proteomics-based analysis in the McArdle mouse model

Journal of Physiology

Fiuza-Luces, C.; Santos-Lozano, A.; Llavero, F.; Campo, R.; Nogales-Gadea, G.; Díez-Bermejo, J.; Baladrón, C.; González-Murillo, Á.; Arenas, J.; Martín, M.A.; Andreu, A.L.; Pinós, T.; Gálvez, B.G.; López, J.A.; Vázquez, J.; Zugaza, J.L.; Lucia, A.

Review / Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors

Nature Reviews Cardiology

Fiuza-Luces, C.; Santos-Lozano, A.; Joyner, M.; Carrera-Bastos, P.; Picazo, O.; Zugaza, J.L.; Izquierdo, M.; Ruilope, L.M.; Lucia, A.

2017

Article / TIAM1 variants improve clinical outcome in neuroblastoma

Oncotarget

Sanmartín, E.; Yáñez, Y.; Fornés-Ferrer, V.; Zugaza, J.L.; Cañete, A.; Castel, V.; de Mora, J.F.

Review / Characteristics, applications and prospects of mesenchymal stem cells in cell therapy

Medicina Clinica

Guadix, J.A.; Zugaza, J.L.; Gálvez-Martín, P.

Review / PLAGL1: an important player in diverse pathological processes

Journal of Applied Genetics

Vega-Benedetti, A.F.; Saucedo, C.; Zavattari, P.; Vanni, R.; Zugaza, J.L.; Parada, L.A.

2016

Article / Lck/PLC? control migration and proliferation of interleukin (IL)-2-stimulated T cells via the Rac1 GTPase/glycogen phosphorylase pathway

Cellular Signalling

Llavero F, Artaso A, Lacerda HM, Parada LP, Zugaza JL

Article / Amyloid ?-induced astrogliosis is mediated by ?1 integrin via NADPH oxidase 2 in Alzheimer´s disease

Aging Cell

Wyssenbach A., Quintela T., Llavero F., Zugaza JL., Matute C., Alberdi E.

Article / Amyloid β-induced astrogliosis is mediated by β1-integrin via NADPH oxidase 2 in Alzheimer's disease

Aging Cell

Wyssenbach, A.; Quintela, T.; Llavero, F.; Zugaza, J.L.; Matute, C.; Alberdi, E.

Article / Lck/PLCγ control migration and proliferation of interleukin (IL)-2-stimulated T cells via the Rac1 GTPase/glycogen phosphorylase pathway

Cellular Signalling

Llavero, F.; Artaso, A.; Lacerda, H.M.; Parada, L.A.; Zugaza, J.L.

Article / Rac1/p21-activated kinase pathway controls retinoblastoma protein phosphorylation and E2F transcription factor activation in B lymphocytes

FEBS Journal

Zaldua, N.; Llavero, F.; Artaso, A.; Gálvez, P.; Lacerda, H.M.; Parada, L.A.; Zugaza, J.L.

Review / Mesenchymal Stem Cells as Therapeutics Agents: Quality and Environmental Regulatory Aspects

Stem Cells International

Galvez-Martin, P.; Sabata, R.; Verges, J.; Zugaza, J.L.; Ruiz, A.; Clares, B.

2015

Article / Guanine nucleotide exchange factor ?PIX leads to activation of the Rac 1 GTPase/Glycogen phosphorylase pathway in Interleukin (IL)-2-stimulated T cells.

Journal of Biological Chemistry

Llavero F, Urzelai B, Osinalde N, Gálvez P, Lacerda HM, Parada LA, Zugaza JL

Article / You have full text access to this contentRac1/p21-activated kinase pathway controls RB phosphorylation and E2F transcription factor activation in B-lymphocytes

The FEBS Journal

Zaldua N, Llavero F, Artaso A, Gálvez P, Lacerda HM, Parada LA, Zugaza JL

Article / Expression of the DYRK1A gene correlates with its 3D positioning in the interphase nucleus of Down syndrome cells

Chromosome Research

Paz, N.; Felipe-Blanco, I.; Royo, F.; Zabala, A.; Guerra-Merino, I.; García-Orad, Á.; Zugaza, J.L.; Parada, L.A.

Article / H-Chain Ferritin: A Natural Nuclei Targeting and Bioactive Delivery Nanovector

Advanced Healthcare Materials

Zhang, L.; Li, L.; Di Penta, A.; Carmona, U.; Yang, F.; Schöps, R.; Brandsch, M.; Zugaza, J.L.; Knez, M.

Article / Guanine nucleotide exchange factor αPIX leads to activation of the Rac 1 GTPase/glycogen phosphorylase pathway in interleukin (IL)-2-stimulated T cells

Journal of Biological Chemistry

Llavero, F.; Urzelai, B.; Osinalde, N.; Gálvez, P.; Lacerda, H.M.; Parada, L.A.; Zugaza, J.L.

2013

Article / Genome-Wide Analysis of DNA copy number changes in liver steatosis

British Journal of Medicine & Medical Research

Royo F, Zabala A, Paz N, Acquadro F, Echevarria JJ, Zabalza I, cigudosa JC, Zugaza JL, Parada LA

Article / ATP Antagonizes Thrombin-Induced Signal Transduction through 12(S)-HETE and cAMP

PLoS ONE

Burzaco, J.; Conde, M.; Parada, L.A.; Zugaza, J.L.; Dehaye, J.P.; Marino, A.

Article / Combined Fluorescent-Chromogenic In Situ Hybridization for Identification and Laser Microdissection of Interphase Chromosomes

PLoS ONE

Paz, N.; Zabala, A.; Royo, F.; García-Orad, A.; Zugaza, J.L.; Parada, L.A.

Article / 1–42 β-amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death

Translational Psychiatry

Manterola, L.; Hernando-Rodríguez, M.; Ruiz, A.; Apraiz, A.; Arrizabalaga, O.; Vellón, L.; Alberdi, E.; Cavaliere, F.; Lacerda, H.M.; Jimenez, S.; Parada, L.A.; Matute, C.; Zugaza, J.L.

2012

Book / Las GTPasas de la Familia Rho en la Proliferación linfocitaria

Editorial Académica Española

Onetsine Arrizabalaga, Ana María Zubiaga, josé Luis Zugaza

Article / Rac1 protein regulates glycogen phosphorylase activation and controls interleukin (IL)-2-dependent T cell proliferation

Journal of Biological Chemistry

Arrizabalaga, O.; Lacerda, H.M.; Zubiaga, A.M.; Zugaza, J.L.

2023

Conference Paper | High performance photonics-based biosensing platform for Covid detection

Proceedings of SPIE - The International Society for Optical Engineering - Conference Paper

Castaño, A.; Zugaza, J.L.; Zubia, J.; Arrizabalaga, O.

2019

Oral presentation | Is the expression of muscle glycogen phosphorylase tissue.specific?. New perspectives

The 24th International Annual Congress of the World Muscle Society - Oral presentation

Llavero F., Arrazola A., Luque M., Scalco R., Pizzamiglio C., Pattni J., Chatfield S., Quinlivan R., Martin M.A., Arenas J., Lucia A., Zugaza J.L.

Poster presentation | Integrin ?1 signal peptide, a new molecular tool to prevent A?-oligomer/Integrin ?1 signalling in astrocytes

XIV European Meeting on Glial Cells in Health and Disease - Poster presentation

Ortiz-Sanz C., Llavero F. , Quintela-López T., Luque M. , A. Wyssenbach M., Matute C., Zugaza J.L., Alberdi E.

Poster presentation | Natural history of McArdle disease in a cohort of 220 patients

The 24th International Annual Congress of the World Muscle Society - Poster presentation

Quinlivan R., Pietrusz C., Pizzamiglio C., Pattni J., Mahroo O., Khan K., Elliott P., Patasin M., Chatfield S., Lucia A, Zugaza J.L., Llavero F., Godfrey R.

2017

Invited talk | VIII Congreso Internacional de Glucogenosis

VIII Congreso Internacional de Glucogenosis - Invited talk

Zugaza JL

2014

Oral presentation | P2X7 receptor stimulation in neurons mediates different pathway activation in the presence or absence of calcium

XXXVII Congreso SEBBM - Oral presentation

Urcelai B, Llavero F, Zugaza JL

Poster presentation | IL-2 requires p56lck/PLCg/nPKCs pathway to induce Rac1/PYGM activation in T cells/

XXXVII SEBBM - Poster presentation

Llavero F, Urcelai B, Zugaza JL

Poster presentation | Overexpression of constitutively active forms of small GTPases of the Rho family modify neuronal morphology

Neurogune 2nd edition - Poster presentation

Ortiz C, Ruiz A, Llavero F, Matute C, Zugaza JL, Alberdi E