Koen Vandenbroeck

Ikerbasque Research Professor, UPV/EHU and Biobizkaia

Head of the Inflammation & Biomarkers laboratory in Biobizkaia Health Research Institute, and associated professor at UPV/EHU.

Research line:

Omics approaches to identify mechanisms and biomarkers of autoimmune disease and stroke.

1999 Teva and Marion Hoechst Roussel Young Investigator Award for Multiple Sclerosis Research; 2002 ISICR Milstein Young Investigator Award.

10 years of research experience in centres in Belgium (Rega Institute for Medical Research), Italy (San Raffaele Scientific Institute - DIBIT) and UK (Queen's University of Belfast).

Doctor in Molecular Biology 1993 from the Katholieke Universiteit Leuven, Belgium.

Publicaciones
Congresos y Proceedings

2022

Article / Identification of the genetic mechanism that associates L3MBTL3 to multiple sclerosis

Human Molecular Genetics

Alcina, A.; Fedetz, M.; Vidal-Cobo, I.; Andres-Leon, E.; Garcia-Sanchez, M.I.; Barroso-Del-Jesus, A.; Eichau, S.; Gil-Varea, E.; Villar, L.M.; Saiz, A.; Leyva, L.; Vandenbroeck, K.; Otaegui, D.; Izquierdo, G.; Comabella, M.; Urcelay, E.; Matesanz, F.

Article / Genomic Multiple Sclerosis Risk Variants Modulate the Expression of the ANKRD55–IL6ST Gene Region in Immature Dendritic Cells

Frontiers in Immunology

Mena, J.; Alloza, I.; Tulloch Navarro, R.; Aldekoa, A.; Díez García, J.; Villanueva Etxebarria, A.; Lindskog, C.; Antigüedad, A.; Boyero, S.; Mendibe-Bilbao, M.d.M.; Álvarez de Arcaya, A.; Sánchez Menoyo, J.L.; Midaglia, L.; Villarrubia, N.; Malhotra, S.; Montalban, X.; Villar, L.M.; Comabella, M.; Vandenbroeck, K.

Review / Pathophysiology of Atherosclerosis

International Journal of Molecular Sciences

Jebari-Benslaiman, S.; Galicia-García, U.; Larrea-Sebal, A.; Olaetxea, J.R.; Alloza, I.; Vandenbroeck, K.; Benito-Vicente, A.; Martín, C.

2021

Article / Novel transcript discovery expands the repertoire of pathologically-associated, long non-coding rnas in vascular smooth muscle cells

International Journal of Molecular Sciences

Bennett, M.; Ulitsky, I.; Alloza, I.; Vandenbroeck, K.; Miscianinov, V.; Mahmoud, A.D.; Ballantyne, M.; Rodor, J.; Baker, A.H.

2020

Article / A new risk variant for multiple sclerosis at 11q23.3 locus is associated with expansion of CXCR5+ circulating regulatory T cells

J. Clin. Med.

Gil-Varea E., Fedetz M., Eixarch H., Spataro N., Villar L.M., Urcelay E., Saiz A., Fernández O., Leyva L., Ramió-Torrentà L., Vandenbroeck K., Otaegui D., Castillo-Triviño T., Izquierdo G., Malhotra S., Bosch E., Navarro A., Alcina A., Montalban X., Matesanz F. and Comabella M.

Article / The rare IL22RA2 signal peptide coding variant rs28385692 decreases secretion of IL-22BP isoform-1, -2 and -3 and is associated with risk for multiple sclerosis

Cells

Gómez-Fernández P., Lopez de Lapuente Portilla A., Astobiza I., Mena J., Urtasun A., Altmann V., Matesanz F., Otaegui D., Urcelay E., Antigüedad A., Malhotra S., Montalban X., Castillo-Triviño T., Espino-Paisán L., Aktas O., Buttmann M., Chan A., Fontaine B., Gourraud P.A., Hecker M., Hoffjan S., Kubisch C., Kümpfel T., Luessi F., Zettl U.K., Zipp F., Alloza I., Comabella M., Lill C.M. and Vandenbroeck K.

Article / Birc6 is associated with vulnerability of carotid atherosclerotic plaque

International Journal of Molecular Sciences

Alloza, I.; Salegi, A.; Mena, J.; Navarro, R.T.; Martin, C.; Aspichueta, P.; Salazar, L.M.; Carpio, J.U.; Cagigal, P.D.L.H.; Vega, R.; Triviño, J.C.; Freijo, M.D.M.; Vandenbroeck, K.

Article / Cholesterol efflux efficiency of reconstituted HDL is affected by nanoparticle lipid composition

Biomedicines

Jebari-Benslaiman, S.; Uribe, K.B.; Benito-Vicente, A.; Galicia-Garcia, U.; Larrea-Sebal, A.; Alloza, I.; Vandenbroeck, K.; Ostolaza, H.; Martín, C.

Article / NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients

Brain

Malhotra, S.; Costa, C.; Eixarch, H.; Keller, C.W.; Amman, L.; Martínez-Banaclocha, H.; Midaglia, L.; Sarró, E.; Machín-Díaz, I.; Villar, L.M.; Triviño, J.C.; Oliver-Martos, B.; Parladé, L.N.; Calvo-Barreiro, L.; Matesanz, F.; Vandenbroeck, K.; Urcelay, E.; Martínez-Ginés, M.L.; Tejeda-Velarde, A.; Fissolo, N.; Castilló, J.; Sanchez, A.; Robertson, A.A.B.; Clemente, D.; Prinz, M.; Pelegrin, P.; Lünemann, J.D.; Espejo, C.; Montalban, X.; Comabella, M.

Article / A new risk variant for multiple sclerosis at 11q23.3 locus is associated with expansion of CXCR5+ circulating regulatory T cells

Journal of Clinical Medicine

Gil-Varea, E.; Fedetz, M.; Eixarch, H.; Spataro, N.; Villar, L.M.; Urcelay, E.; Saiz, A.; Fernández, Ó.; Leyva, L.; Ramió-Torrentà, L.; Vandenbroeck, K.; Otaegui, D.; Castillo-Triviño, T.; Izquierdo, G.; Malhotra, S.; Bosch, E.; Navarro, A.; Alcina, A.; Montalban, X.; Matesanz, F.; Comabella, M.

Article / The Rare IL22RA2 Signal Peptide Coding Variant rs28385692 Decreases Secretion of IL-22BP Isoform-1, -2 and -3 and Is Associated with Risk for Multiple Sclerosis

Cells

Gómez-Fernández, P.; Lopez de Lapuente Portilla, A.; Astobiza, I.; Mena, J.; Urtasun, A.; Altmann, V.; Matesanz, F.; Otaegui, D.; Urcelay, E.; Antigüedad, A.; Malhotra, S.; Montalban, X.; Castillo-Triviño, T.; Espino-Paisán, L.; Aktas, O.; Buttmann, M.; Chan, A.; Fontaine, B.; Gourraud, P.A.; Hecker, M.; Hoffjan, S.; Kubisch, C.; Kümpfel, T.; Luessi, F.; Zettl, U.K.; Zipp, F.; Alloza, I.; Comabella, M.; Lill, C.M.; Vandenbroeck, K.

2019

Article / Interactome of the Autoimmune Risk Protein ANKRD55

Frontiers in Immunology

Ugidos, N.; Mena, J.; Baquero, S.; Alloza, I.; Azkargorta, M.; Elortza, F.; Vandenbroeck, K.

Article / Exome sequencing in multiple sclerosis families identifies 12 candidate genes and nominates biological pathways for the genesis of disease

PLoS Genetics

Vilariño-Güell, C.; Zimprich, A.; Martinelli-Boneschi, F.; Herculano, B.; Wang, Z.; Matesanz, F.; Urcelay, E.; Vandenbroeck, K.; Leyva, L.; Gris, D.; Massaad, C.; Quandt, J.A.; Traboulsee, A.L.; Encarnacion, M.; Bernales, C.Q.; Follett, J.; Yee, I.M.; Criscuoli, M.G.; Deutschländer, A.; Reinthaler, E.M.; Zrzavy, T.; Mascia, E.; Zauli, A.; Esposito, F.; Alcina, A.; Izquierdo, G.; Espino-Paisán, L.; Mena, J.; Antigüedad, A.; Urbaneja-Romero, P.; Ortega-Pinazo, J.; Song, W.; Sadovnick, A.D.

Article / Pharmacological targeting of the er-resident chaperones GRP94 or cyclophilin b induces secretion of IL-22 binding protein isoform-1 (IL-22bpi1)

International Journal of Molecular Sciences

Gómez-Fernández, P.; Urtasun, A.; Astobiza, I.; Mena, J.; Alloza, I.; Vandenbroeck, K.

2018

Article / Characterization of carotid smooth muscle cells during phenotypic transition

Cells

Haize Goikuria, Mª del Mar Freijo, Reyes Vega Manrique, Maria Sastre, Elena Elizagaray, Ana Lorenzo, Koen Vandenbroeck and Iraide Alloza

Article / Long Interleukin-22 Binding Protein Isoform-1 Is an Intracellular Activator of the Unfolded Protein Response

Frontiers in Immunology

Gómez-Fernández, P.; Urtasun, A.; Paton, A.W.; Paton, J.C.; Borrego, F.; Dersh, D.; Argon, Y.; Alloza, I.; Vandenbroeck, K.

Article / Characterization of carotid smooth muscle cells during phenotypic transition

Cells

Goikuria, H.; del Mar Freijo, M.; Manrique, R.V.; Sastre, M.; Elizagaray, E.; Lorenzo, A.; Vandenbroeck, K.; Alloza, I.

Note / The era of GWAS is over – Yes

Multiple Sclerosis Journal

Vandenbroeck, K.

Short Survey / Inflammation in human carotid atheroma plaques

Cytokine and Growth Factor Reviews

Goikuria, H.; Vandenbroeck, K.; Alloza, I.

2017

Article / RNAseq based transcriptomics study of SMCs from carotid atherosclerotic plaque: BMP2 and IDs proteins are crucial regulators of plaque stability

Scientific Reports

Alloza, I.; Goikuria, H.; Idro, J.L.; Triviño, J.C.; Fernández Velasco, J.M.; Elizagaray, E.; García-Barcina, M.; Montoya-Murillo, G.; Sarasola, E.; Vega Manrique, R.; Freijo, M.D.M.; Vandenbroeck, K.

Article / Response to interferon-beta treatment in multiple sclerosis patients: A genome-wide association study

Pharmacogenomics Journal

Mahurkar, S.; Moldovan, M.; Suppiah, V.; Sorosina, M.; Clarelli, F.; Liberatore, G.; Malhotra, S.; Montalban, X.; Antigüedad, A.; Krupa, M.; Jokubaitis, V.G.; McKay, F.C.; Gatt, P.N.; Fabis-Pedrini, M.J.; Martinelli, V.; Comi, G.; Lechner-Scott, J.; Kermode, A.G.; Slee, M.; Taylor, B.V.; Vandenbroeck, K.; Comabella, M.; Boneschi, F.M.; King, C.

2016

Article / Analysis of plasminogen genetic variants in multiple sclerosis patients

G3: Genes, Genomes, Genetics

Sadovnick, A.D.; Traboulsee, A.L.; Bernales, C.Q.; Ross, J.P.; Forwell, A.L.; Yee, I.M.; Guillot-Noel, L.; Fontaine, B.; Cournu-Rebeix, I.; Alcina, A.; Fedetz, M.; Izquierdo, G.; Matesanz, F.; Hilven, K.; Dubois, B.; Goris, A.; Astobiza, I.; Alloza, I.; Antigüedad, A.; Vandenbroeck, K.; Akkad, D.A.; Aktas, O.; Blaschke, P.; Buttmann, M.; Chan, A.; Epplen, J.T.; Gerdes, L.A.; Kroner, A.; Kubisch, C.; Kümpfel, T.; Lohse, P.; Rieckmann, P.; Zettl, U.K.; Zipp, F.; Bertram, L.; Lill, C.M.; Fernandez, O.; Urbaneja, P.; Leyva, L.; Alvarez-Cermeño, J.C.; Arroyo, R.; Garagorri, A.M.; García-Martínez, A.; Villar, L.M.; Urcelay, E.; Malhotra, S.; Montalban, X.; Comabella, M.; Berger, T.; Fazekas, F.; Reindl, M.; Schmied, M.C.; Zimprich, A.; Vilariño-Güell, C.

Article / Novel insights into the multiple sclerosis risk gene ANKRD55

Journal of Immunology

De Lapuente, A.L.; Feliu, A.; Ugidos, N.; Mecha, M.; Mena, J.; Astobiza, I.; Riera, J.; Carillo-Salinas, F.; Comabella, M.; Montalban, X.; Alloza, I.; Guaza, C.; Vandenbroeck, K.

Review / A role for autophagy in carotid atherosclerosis

European Stroke Journal

Alloza, I.; Goikuria, H.; Freijo, M.d.M.; Vandenbroeck, K.

2015

Article / Pharmacogenomic study in patients with multiple sclerosis Responders and nonresponders to IFN-β

Neurology: Neuroimmunology and NeuroInflammation

Bustamante, M.F.; Morcillo-Suárez, C.; Malhotra, S.; Rio, J.; Leyva, L.; Fernández, O.; Zettl, U.K.; Killestein, J.; Brassat, D.; García-Merino, J.A.; Sánchez, A.J.; Urcelay, E.; Alvarez-Lafuente, R.; Villar, L.M.; Alvarez-Cermeño, J.C.; Farré, X.; Lechner-Scott, J.; Vandenbroeck, K.; Rodríguez-Antigüedad, A.; Drulovic, J.S.; Boneschi, F.M.; Chan, A.; Oksenberg, J.; Navarro, A.; Montalban, X.; Comabella, M.

Article / A functional variant that affects exon-skipping and protein expression of SP140 as genetic mechanism predisposing to multiple sclerosis

Human Molecular Genetics

Matesanz, F.; Potenciano, V.; Fedetz, M.; Ramos-Mozo, P.; del Mar Abad-Grau, M.; Karaky, M.; Barrionuevo, C.; Izquierdo, G.; Ruiz-Peña, J.L.; García-Sánchez, M.I.; Lucas, M.; Fernández, Ó.; Leyva, L.; Otaegui, D.; Muñoz-Culla, M.; Olascoaga, J.; Vandenbroeck, K.; Alloza, I.; Astobiza, I.; Antigüedad, A.; Villar, L.M.; Álvarez-Cermeño, J.C.; Malhotra, S.; Comabella, M.; Montalban, X.; Saiz, A.; Blanco, Y.; Arroyo, R.; Varadé, J.; Urcelay, E.; Alcina, A.

Article / Cell-specific effects in different immune subsets associated with SOCS1 genotypes in multiple sclerosis

Multiple Sclerosis

Lopez De Lapuente, A.; Pinto-Medel, M.J.; Astobiza, I.; Alloza, I.; Comabella, M.; Malhotra, S.; Montalban, X.; Zettl, U.K.; Rodríguez-Antigüedad, A.; Fernández, O.; Vandenbroeck, K.

Article / Genome-wide significant association with seven novel multiple sclerosis risk loci

Journal of Medical Genetics

Lill, C.M.; Luessi, F.; Alcina, A.; Sokolova, E.A.; Ugidos, N.; de la Hera, B.; Guillot-Noël, L.; Malhotra, S.; Reinthaler, E.; Schjeide, B.M.M.; Mescheriakova, J.Y.; Mashychev, A.; Wohlers, I.; Akkad, D.A.; Aktas, O.; Alloza, I.; Antigüedad, A.; Arroyo, R.; Astobiza, I.; Blaschke, P.; Boyko, A.N.; Buttmann, M.; Chan, A.; Dörner, T.; Epplen, J.T.; Favorova, O.O.; Fedetz, M.; Fernández, O.; García-Martínez, A.; Gerdes, L.A.; Graetz, C.; Hartung, H.P.; Hoffjan, S.; Izquierdo, G.; Korobko, D.S.; Kroner, A.; Kubisch, C.; Kümpfel, T.; Leyva, L.; Lohse, P.; Malkova, N.A.; Montalban, X.; Popova, E.V.; Rieckmann, P.; Rozhdestvenskii, A.S.; Schmied, C.; Smagina, I.V.; Tsareva, E.Y.; Winkelmann, A.; Zettl, U.K.; Binder, H.; Cournu-Rebeix, I.; Hintzen, R.; Zimprich, A.; Comabella, M.; Fontaine, B.; Urcelay, E.; Vandenbroeck, K.; Filipenko, M.; Matesanz, F.; Zipp, F.; Bertram, L.

2014

Article / Autophagic marker MAP1LC3B expression levels are associated with carotid atherosclerosis symptomatology

PLoS ONE

Swaminathan, B.; Goikuria, H.; Vega, R.; Rodríguez-Antigüedad, A.; López Medina, A.; Del Mar Freijo, M.; Vandenbroeck, K.; Alloza, I.

Article / Human endogenous retrovirus HERV-Fc1 association with multiple sclerosis susceptibility: A meta-analysis

PLoS ONE

De La Hera, B.; Varadé, J.; García-Montojo, M.; Alcina, A.; Fedetz, M.; Alloza, I.; Astobiza, I.; Leyva, L.; Fernández, O.; Izquierdo, G.; Antigüedad, A.; Arroyo, R.; Álvarez-Lafuente, R.; Vandenbroeck, K.; Matesanz, F.; Urcelay, E.

2013

Article / A trifluoromethyl analogue of celecoxib exerts beneficial effects in neuroinflammation

PLoS ONE

Di Penta, A.; Chiba, A.; Alloza, I.; Wyssenbach, A.; Yamamura, T.; Villoslada, P.; Miyake, S.; Vandenbroeck, K.

Article / TNFRSF1A polymorphisms rs1800693 and rs4l49584 in patients with multiple sclerosis

Neurology

Comabella, M.; Caminero, A.B.; Malhotra, S.; Agulló, L.; Fernández, O.; Reverter, F.; Vandenbroeck, K.; Rodríguez-Antiguedad, A.; Matesanz, F.; Izquierdo, G.; Urcelay, E.; López-Larios, A.; Sánchez, A.; Otero, S.; Tintoré, M.; Montalban, X.

Article / Fine Mapping and Functional Analysis of the Multiple Sclerosis Risk Gene CD6

PLoS ONE

Swaminathan, B.; Cuapio, A.; Alloza, I.; Matesanz, F.; Alcina, A.; García-Barcina, M.; Fedetz, M.; Fernández, O.; Lucas, M.; Órpez, T.; Pinto-Medel, M.J.; Otaegui, D.; Olascoaga, J.; Urcelay, E.; Ortiz, M.A.; Arroyo, R.; Oksenberg, J.R.; Antigüedad, A.; Tolosa, E.; Vandenbroeck, K.

Article / Oxidative Stress and Proinflammatory Cytokines Contribute to Demyelination and Axonal Damage in a Cerebellar Culture Model of Neuroinflammation

PLoS ONE

di Penta, A.; Moreno, B.; Reix, S.; Fernandez-Diez, B.; Villanueva, M.; Errea, O.; Escala, N.; Vandenbroeck, K.; Comella, J.X.; Villoslada, P.

Article / Genome-wide significant association of ANKRD55 rs6859219 and multiple sclerosis risk

Journal of Medical Genetics

Lill, C.M.; Schjeide, B.M.M.; Graetz, C.; Liu, T.; Damotte, V.; Akkad, D.A.; Blaschke, P.; Gerdes, L.A.; Kroner, A.; Luessi, F.; Cournu-Rebeix, I.; Hoffjan, S.; Winkelmann, A.; Touze, E.; Pico, F.; Corcia, P.; Otaegui, D.; Antigüedad, A.; Alcina, A.; Comabella, M.; Montalban, X.; Olascoaga, J.; Matesanz, F.; Dörner, T.; Li, S.C.; Steinhagen-Thiessen, E.; Lindenberger, U.; Chan, A.; Rieckmann, P.; Hartung, H.P.; Aktas, O.; Lohse, P.; Buttmann, M.; Kümpfel, T.; Kubisch, C.; Zettl, U.K.; Epplen, J.T.; Fontaine, B.; Zipp, F.; Vandenbroeck, K.; Bertram, L.

Article / MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis

Brain

Lill, C.M.; Schjeide, B.M.M.; Graetz, C.; Ban, M.; Alcina, A.; Ortiz, M.A.; Pérez, J.; Damotte, V.; Booth, D.; Lopez De Lapuente, A.; Broer, L.; Schilling, M.; Akkad, D.A.; Aktas, O.; Alloza, I.; Antigüedad, A.; Arroyo, R.; Blaschke, P.; Buttmann, M.; Chan, A.; Compston, A.; Cournu-Rebeix, I.; Dörner, T.; Epplen, J.T.; Fernández, O.; Gerdes, L.A.; Guillot-Noël, L.; Hartung, H.P.; Hoffjan, S.; Izquierdo, G.; Kemppinen, A.; Kroner, A.; Kubisch, C.; Kümpfel, T.; Li, S.C.; Lindenberger, U.; Lohse, P.; Lubetzki, C.; Luessi, F.; Malhotra, S.; Mescheriakova, J.; Montalban, X.; Papeix, C.; Paredes, L.F.; Rieckmann, P.; Steinhagen-Thiessen, E.; Winkelmann, A.; Zettl, U.K.; Hintzen, R.; Vandenbroeck, K.; Stewart, G.; Fontaine, B.; Comabella, M.; Urcelay, E.; Matesanz, F.; Sawcer, S.; Bertram, L.; Zipp, F.

Article / Identification of a functional variant in the KIF5A-CYP27B1-METTL1-FAM119B locus associated with multiple sclerosis

Journal of Medical Genetics

Alcina, A.; Fedetz, M.; Fernández, O.; Saiz, A.; Izquierdo, G.; Lucas, M.; Leyva, L.; García-León, J.A.; Abad-Grau, M.d.M.; Alloza, I.; Antigüedad, A.; Garcia-Barcina, M.J.; Vandenbroeck, K.; Varadé, J.; de la Hera, B.; Arroyo, R.; Comabella, M.; Montalban, X.; Petit-Marty, N.; Navarro, A.; Otaegui, D.; Olascoaga, J.; Blanco, Y.; Urcelay, E.; Matesanz, F.

2012

Article / Allelic combinations of immune-response genes as possible composite markers of IFN-β efficacy in multiple sclerosis patients

Pharmacogenomics

Kulakova, O.G.; Tsareva, E.Y.; Boyko, A.N.; Shchur, S.G.; Gusev, E.I.; Lvovs, D.; Favorov, A.V.; Vandenbroeck, K.; Favorova, O.O.

Article / Closing the case of APOE in multiple sclerosis: No association with disease risk in over 29 000 subjects

Journal of Medical Genetics

Lill, C.M.; Liu, T.; Schjeide, B.M.M.; Roehr, J.T.; Akkad, D.A.; Damotte, V.; Alcina, A.; Ortiz, M.A.; Arroyo, R.; de Lapuente, A.L.; Blaschke, P.; Winkelmann, A.; Gerdes, L.A.; Luessi, F.; Fernadez, O.; Izquierdo, G.; Antigüedad, A.; Hoffjan, S.; Cournu-Rebeix, I.; Gromöller, S.; Faber, H.; Liebsch, M.; Meissner, E.; Chanvillard, C.; Touze, E.; Pico, F.; Corcia, P.; Dörner, T.; Steinhagen-Thiessen, E.; Baeckman, L.; Heekeren, H.R.; Li, S.C.; Lindenberger, U.; Chan, A.; Hartung, H.P.; Aktas, O.; Lohse, P.; Kümpfel, T.; Kubisch, C.; Epplen, J.T.; Zettl, U.K.; Fontaine, B.; Vandenbroeck, K.; Matesanz, F.; Urcelay, E.; Bertram, L.; Zipp, F.; Bahlo, M.; Booth, D.R.; Broadley, S.A.; Brown, M.A.; Browning, B.L.; Browning, S.R.; Butzkueven, H.; Carroll, W.M.; Cox, M.B.; Chapman, C.; Clarke, G.; Danoy, P.; Drysdale, K.; Field, J.; Foote, S.J.; Greer, J.M.; Griffiths, L.R.; Jensen, C.J.; Johnson, L.J.; Kermode, A.G.; Heard, R.N.; Kilpatrick, T.J.; Lechner-Scott, J.; Marriott, M.; Mason, D.; Moscato, P.; Pender, M.P.; Perreau, V.M.; Rubio, J.P.; Scott, R.J.; Slee, M.; Stankovich, J.; Stewart, G.J.; Tajouri, L.; Taylor, B.V.; Wiley, J.; Wilkins, E.J.

Article / ANKRD55 and DHCR7 are novel multiple sclerosis risk loci

Genes and Immunity

Alloza, I.; Otaegui, D.; De Lapuente, A.L.; Antigüedad, A.; Varadé, J.; Nú̃ez, C.; Arroyo, R.; Urcelay, E.; Fernandez, O.; Leyva, L.; Fedetz, M.; Izquierdo, G.; Lucas, M.; Oliver-Martos, B.; Alcina, A.; Saiz, A.; Blanco, Y.; Comabella, M.; Montalban, X.; Olascoaga, J.; Matesanz, F.; Vandenbroeck, K.

Article / Analysis of the IL28RA locus as genetic risk factor for multiple sclerosis

Journal of Neuroimmunology

Lopez de Lapuente, A.; Alloza, I.; Goertsches, R.; Zettl, U.K.; Urcelay, E.; Arroyo, R.; Comabella, M.; Montalban, X.; Antigüedad, A.; Vandenbroeck, K.

Article / A 4-trifluoromethyl analogue of celecoxib inhibits arthritis by suppressing innate immune cell activation

Arthritis Research and Therapy

Chiba, A.; Mizuno, M.; Tomi, C.; Tajima, R.; Alloza, I.; di Penta, A.; Yamamura, T.; Vandenbroeck, K.; Miyake, S.

Article / Replication study of 10 genes showing evidence for association with multiple sclerosis: Validation of TMEM39A, IL12B and CLBL genes

Multiple Sclerosis Journal

Varadé, J.; Comabella, M.; Ortiz, M.A.; Arroyo, R.; Fernández, O.; Pinto-Medel, M.J.; Fedetz, M.; Izquierdo, G.; Lucas, M.; Gómez, C.L.; Rabasa, A.C.; Alcina, A.; Matesanz, F.; Alloza, I.; Antigüedad, A.; García-Barcina, M.; Otaegui, D.; Olascoaga, J.; Saiz, A.; Blanco, Y.; Montalbán, X.; Vandenbroeck, K.; Urcelay, E.

Article / Chitinase 3-like 1 plasma levels are increased in patients with progressive forms of multiple sclerosis

Multiple Sclerosis Journal

Cantó, E.; Reverter, F.; Morcillo-Suárez, C.; Matesanz, F.; Fernández, O.; Izquierdo, G.; Vandenbroeck, K.; Rodríguez-Antigüedad, A.; Urcelay, E.; Arroyo, R.; Otaegui, D.; Olascoaga, J.; Saiz, A.; Navarro, A.; Sanchez, A.; Domínguez, C.; Caminero, A.; Horga, A.; Tintoré, M.; Montalban, X.; Comabella, M.

Article / A cytokine gene screen uncovers SOCS1 as genetic risk factor for multiple sclerosis

Genes and Immunity

Vandenbroeck, K.; Alvarez, J.; Swaminathan, B.; Alloza, I.; Matesanz, F.; Urcelay, E.; Comabella, M.; Alcina, A.; Fedetz, M.; Ortiz, M.A.; Izquierdo, G.; Fernandez, O.; Rodriguez-Ezpeleta, N.; Matute, C.; Caillier, S.; Arroyo, R.; Montalban, X.; Oksenberg, J.R.; Antigüedad, A.; Aransay, A.

Article / Allelic combinations of immune-response genes associated with glatiramer acetate treatment response in Russian multiple sclerosis patients

Pharmacogenomics

Tsareva, E.Y.; Kulakova, O.G.; Boyko, A.N.; Shchur, S.G.; Lvovs, D.; Favorov, A.V.; Gusev, E.I.; Vandenbroeck, K.; Favorova, O.O.

Review / Cytokine gene polymorphisms and human autoimmune disease in the era of genome-wide association studies

Journal of Interferon and Cytokine Research

Vandenbroeck, K.

2011

Article / IL28B polymorphisms are not associated with the response to interferon-beta in multiple sclerosis

Journal of Neuroimmunology

Malhotra, S.; Morcillo-Suárez, C.; Brassat, D.; Goertsches, R.; Lechner-Scott, J.; Urcelay, E.; Fernández, O.; Drulovic, J.; García-Merino, A.; Martinelli Boneschi, F.; Chan, A.; Vandenbroeck, K.; Navarro, A.; Bustamante, M.F.; Río, J.; Akkad, D.A.; Giacalone, G.; Sánchez, A.J.; Leyva, L.; Alvarez-Lafuente, R.; Zettl, U.K.; Oksenberg, J.; Montalban, X.; Comabella, M.

Article / Pharmacogenomics and multiple sclerosis: Moving toward individualized medicine

Current Neurology and Neuroscience Reports

Comabella, M.; Vandenbroeck, K.

Article / Replication of top markers of a genome-wide association study in multiple sclerosis in Spain

Genes and Immunity

Cavanillas, M.L.; Fernández, O.; Comabella, M.; Alcina, A.; Fedetz, M.; Izquierdo, G.; Lucas, M.; Cénit, M.C.; Arroyo, R.; Vandenbroeck, K.; Alloza, I.; García-Barcina, M.; Antigüedad, A.; Leyva, L.; Gómez, C.L.; Olascoaga, J.; Otaegui, D.; Blanco, Y.; Saiz, A.; Montalbán, X.; Matesanz, F.; Urcelay, E.

Article / Validation of IRF5 as multiple sclerosis risk gene: Putative role in interferon beta therapy and human herpes virus-6 infection

Genes and Immunity

Vandenbroeck, K.; Alloza, I.; Swaminathan, B.; Antigüedad, A.; Otaegui, D.; Olascoaga, J.; Barcina, M.G.; De Las Heras, V.; Bartolomé, M.; Fernández-Arquero, M.; Arroyo, R.; Alvarez-Lafuente, R.; Cénit, M.C.; Urcelay, E.

Article / The endoplasmic reticulum protein folding factory and its chaperones: New targets for drug discovery?

British Journal of Pharmacology

McLaughlin, M.; Vandenbroeck, K.

2010

Chapter / Tratado de Esclerosis Multiple

Pablo Villoslada

Vandenbroeck K. and Alloza I.

Article / Validation of the CD6 and TNFRSF1A loci as risk factors for multiple sclerosis in Spain

Journal of Neuroimmunology

Swaminathan, B.; Matesanz, F.; Cavanillas, M.L.; Alloza, I.; Otaegui, D.; Olascoaga, J.; Cénit, M.C.; Heras, V.d.l.; Barcina, M.G.; Arroyo, R.; Alcina, A.; Fernandez, O.; Antigüedad, A.; Urcelay, E.; Vandenbroeck, K.

Article / Inhibition of secretion of interleukin (IL)-12/IL-23 family cytokines by 4-trifluoromethyl-celecoxib is coupled to degradation via the endoplasmic reticulum stress protein HERP

Journal of Biological Chemistry

McLaughlin, M.; Alloza, I.; Quoc, H.P.; Scott, C.J.; Hirabayashi, Y.; Vandenbroeck, K.

Article / The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis

Genes and Immunity

Alcina, A.; Vandenbroeck, K.; Otaegui, D.; Saiz, A.; Gonzalez, J.R.; Fernandez, O.; Cavanillas, M.L.; Cénit, M.C.; Arroyo, R.; Alloza, I.; García-Barcina, M.; Antigüedad, A.; Leyva, L.; Izquierdo, G.; Lucas, M.; Fedetz, M.; Pinto-Medel, M.J.; Olascoaga, J.; Blanco, Y.; Comabella, M.; Montalban, X.; Urcelay, E.; Matesanz, F.

Review / Single-nucleotide polymorphisms in response to interferon-beta therapy in multiple sclerosis

Journal of Interferon and Cytokine Research

Vandenbroeck, K.; Comabella, M.

Review / IFN-β pharmacogenomics in multiple sclerosis

Pharmacogenomics

Vandenbroeck, K.; Urcelay, E.; Comabella, M.

2009

Article / Special Report: United Europeans for development of pharmacogenomics in multiple sclerosis network

Pharmacogenomics

Vandenbroeck K., Comabella M., Tolosa E., Goertsches R., Brassat D., Hintzen R., Infante-Duarte C., Favorov A., Escorza S., Palacios R., Oksenberg J.R. and Villoslada P

Article / Genetic polymorphisms, their allele combinations and interferon-beta treatment response in Irish multiple sclerosis patients

Pharmacogenomics

O' Doherty C., Favorov A., Heggarty S., Graham C., Favorova O., Ochs M., Hawkins S., Hutchinson M., O' Rourke K. and Vandenbroeck K.

Article / Genetic polymorphisms, their allele combinations and IFN-β treatment response in Irish multiple sclerosis patients

Pharmacogenomics

O'Doherty, C.; Favorov, A.; Heggarty, S.; Graham, C.; Favorova, O.; Ochs, M.; Hawkins, S.; Hutchinson, M.; O'Rourke, K.; Vandenbroeck, K.

Article / United Europeans for development of pharmacogenomics in multiple sclerosis network

Pharmacogenomics

Vandenbroeck, K.; Comabella, M.; Tolosa, E.; Goertsches, R.; Brassat, D.; Hintzen, R.; Infante-Duarte, C.; Favorov, A.; Escorza, S.; Palacios, R.; Oksenberg, J.R.; Villoslada, P.

Short Survey / IL7RA polymorphisms and chronic inflammatory arthropathies

Tissue Antigens

O'Doherty, C.; Alloza, I.; Rooney, M.; Vandenbroeck, K.

2008

Article / IL7RA polymorphisms and susceptibility to multiple sclerosis

New England Journal of Medicine

O' Doherty C., Kantarci O.H. and Vandenbroeck K.

Article / Crossed signals: the role of interleukin (IL)-12, -17, -23, and -27 in autoimmunity

Rheumatology

Paunovic V., Carroll H.P., Vandenbroeck K. and Gadina M.

Article / Pharmacogenomics of the response to IFN-beta in multiple sclerosis: ramifications from the first genome-wide screen

Pharmacogenomics

Vandenbroeck K. and Matute C.

2020

Poster presentation | Improved transcriptome annotation expands the long non-coding RNA repertoire in basal and stressed vascular smooth muscle cells

RNA 2020, 25th Annual Meeting of the RNA Society - Poster presentation

Bennett M.A., Ulitsky I., Alloza I., Vandenbroeck K., Rodor J., Baker A.H.