Ugo Mayor

Ikerbasque Research Professor, UPV/EHU

Group leader at the Department of Dept of Biochemistry at the University of the Basque Country UPV/EHU .

Research line:

Biochemical and genetic characterization of ubiquitination pathways in neuronal development, function and disease.

Research experience in the Lund University in Sweden and in the MRC Centre for Protein Engineering, WT CR UK Gurdon Institute and Department of Genetics in Cambridge (UK).

Doctor in Biology (2003) from the University of Cambridge.

Publicaciones

2024

Article / Biotin-Based Strategies to Explore the World of Ubiquitin and Ubiquitin-Like Modifiers

ChemBioChem

Merino-Cacho, L.; Barroso-Gomila, O.; Hernández-Sánchez, S.; Ramirez, J.; Mayor, U.; Sutherland, J.D.; Barrio, R.

Article / Neddylation inhibition prevents acetaminophen-induced liver damage by enhancing the anabolic cardiolipin pathway

Cell Reports Medicine

Gil-Pitarch, C.; Serrano-Maciá, M.; Simon, J.; Mosca, L.; Conter, C.; Rejano-Gordillo, C.M.; Zapata-Pavas, L.E.; Peña-Sanfélix, P.; Azkargorta, M.; Rodríguez-Agudo, R.; Lachiondo-Ortega, S.; Mercado-Gómez, M.; Delgado, T.C.; Porcelli, M.; Aurrekoetxea, I.; Sutherland, J.D.; Barrio, R.; Xirodimas, D.; Aspichueta, P.; Elortza, F.; Martínez-Cruz, L.A.; Nogueiras, R.; Iruzubieta, P.; Crespo, J.; Masson, S.; McCain, M.V.; Reeves, H.L.; Andrade, R.J.; Lucena, M.I.; Mayor, U.; Goikoetxea-Usandizaga, N.; González-Recio, I.; Martínez-Chantar, M.L.

2023

Article / Biotin-based strategies to explore the world of ubiquitin and ubiquitin-like modifiers

Chembiochem

Laura Merino-Cacho, Orhi Barroso-Gomila, Sandra Hernández-Sánchez, Juanma Ramirez, Ugo Mayor, James D Sutherland, Rosa Barrio

Article / Angelman Syndrome causing UBE3A ligase displays predominantly synaptic ubiquitination activity in the mouse brain

Research Square

Unai Alduntzin, Benoit Lectez, Natalia Presa, Nerea Osinalde, Marta Fernandez, Nagore Elu, Juanma Ramirez, Cristina Garcia-Barcena, Kerman Aloria, Andreas Frick, Olga Peñagarikano, Ugo Mayor

Article / Linoleic acid improves PIEZO2 dysfunction in a mouse model of Angelman Syndrome

Nature Communications

Romero, L.O.; Caires, R.; Kaitlyn Victor, A.; Ramirez, J.; Sierra-Valdez, F.J.; Walsh, P.; Truong, V.; Lee, J.; Mayor, U.; Reiter, L.T.; Vásquez, V.; Cordero-Morales, J.F.

Article / P-Rex1 is a novel substrate of the E3 ubiquitin ligase Malin associated with Lafora disease

Neurobiology of Disease

Kumarasinghe, L.; Garcia-Gimeno, M.A.; Ramirez, J.; Mayor, U.; Zugaza, J.L.; Sanz, P.

Article / BioE3 identifies specific substrates of ubiquitin E3 ligases

Nature Communications

Barroso-Gomila, O.; Merino-Cacho, L.; Muratore, V.; Perez, C.; Taibi, V.; Maspero, E.; Azkargorta, M.; Iloro, I.; Trulsson, F.; Vertegaal, A.C.O.; Mayor, U.; Elortza, F.; Polo, S.; Barrio, R.; Sutherland, J.D.

2022

Article / HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress

Cellular and Molecular Life Sciences

Sala-Gaston, J.; Pedrazza, L.; Ramirez, J.; Martinez-Martinez, A.; Rawlins, L.E.; Baple, E.L.; Crosby, A.H.; Mayor, U.; Ventura, F.; Rosa, J.L.

Review / Identification of substrates for human deubiquitinating enzymes (DUBs): An up-to-date review and a case study for neurodevelopmental disorders

Seminars in Cell and Developmental Biology

Elu, N.; Osinalde, N.; Ramirez, J.; Presa, N.; Rodriguez, J.A.; Prieto, G.; Mayor, U.

2021

Book / Libro Blanco de la COVID-19-aren Liburu Zuria

44 autores

Article / Compartment-specific proximity biotinylation: a new approach to identify nuclear export cargos of XPO1

Ekaia

Sendino, M; Ramírez, J; Mayor, Ugo; Prieto, G; Omaetxebarria, M J; Rodríguez, J A

Article / Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via DEPTOR-mTOR axis

Molecular Metabolism

Marina Serrano-Maciá; Jorge Simón; Maria J. González-Rellan; Mikel Azkargorta; Naroa Goikoetxea-Usandizaga; Fernando Lopitz-Otsoa; Diego Saenz De Urturi; Rubén Rodríguez-Agudo; Sofia Lachiondo-Ortega; Maria Mercado-Gomez; Virginia Gutiérrez de Juan; Maider Bizkarguenaga; David Fernández-Ramos; Xabier Buque; Guido A. Baselli; Luca V.C. Valenti; Paula Iruzubieta; Javier Crespo; Erica Villa; Jesus M. Banales; Matias A. Avila; Jose J.G. Marin; Patricia Aspichueta; James Sutherland; Rosa Barrio; Ugo Mayor; Félix Elortza; Dimitris P. Xirodimas; Rubén Nogueiras; Teresa C. Delgado

Article / Identification of proximal SUMO-dependent interactors using SUMO-ID

Nature Communications

Barroso-Gomila, O.; Trulsson, F.; Muratore, V.; Canosa, I.; Merino-Cacho, L.; Cortazar, A.R.; Pérez, C.; Azkargorta, M.; Iloro, I.; Carracedo, A.; Aransay, A.M.; Elortza, F.; Mayor, U.; Vertegaal, A.C.O.; Barrio, R.; Sutherland, J.D.

Article / Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis

Molecular Metabolism

Serrano-Maciá, M.; Simón, J.; González-Rellan, M.J.; Azkargorta, M.; Goikoetxea-Usandizaga, N.; Lopitz-Otsoa, F.; De Urturi, D.S.; Rodríguez-Agudo, R.; Lachiondo-Ortega, S.; Mercado-Gomez, M.; Gutiérrez de Juan, V.; Bizkarguenaga, M.; Fernández-Ramos, D.; Buque, X.; Baselli, G.A.; Valenti, L.V.C.; Iruzubieta, P.; Crespo, J.; Villa, E.; Banales, J.M.; Avila, M.A.; Marin, J.J.G.; Aspichueta, P.; Sutherland, J.; Barrio, R.; Mayor, U.; Elortza, F.; Xirodimas, D.P.; Nogueiras, R.; Delgado, T.C.; Martínez-Chantar, M.L.

Article / A proteomic approach for systematic mapping of substrates of human deubiquitinating enzymes

International Journal of Molecular Sciences

Ramirez, J.; Prieto, G.; Olazabal-Herrero, A.; Borràs, E.; Fernandez-Vigo, E.; Alduntzin, U.; Osinalde, N.; Beaskoetxea, J.; Lectez, B.; Aloria, K.; Rodriguez, J.A.; Paradela, A.; Sabidó, E.; Muñoz, J.; Corrales, F.; Arizmendi, J.M.; Mayor, U.

Article / Solvent-based elimination of organic matter from marine-collected plastics

Environments - MDPI

Mendoza, A.; Kortaberria, G.; Marzo, F.F.; Mayor, U.; Basurko, O.C.; Peña-Rodriguez, C.

Article / The ubiquitin ligase Ariadne-1 regulates neurotransmitter release via ubiquitination of NSF

Journal of Biological Chemistry

Ramírez, J.; Morales, M.; Osinalde, N.; Martínez-Padrón, I.; Mayor, U.; Ferrús, A.

2020

Chapter / Methods Mol Biol

N. Elu, B. Lectez, J. Ramirez, N. Osinalde and Ugo Mayor

Article / Fast SARS-CoV-2 detection protocol based on RNA precipitation and RT-qPCR in nasopharyngeal swab samples

medRxiv

Xabier Guruceaga, Amanda Sierra, Daniel Marino, Izortze Santin, Jon Ander Nieto-Garai, Jose Ramón Bilbao, Maier Lorizate, Patricia Aspichueta, Adhara Gaminde-Blasco, Adrian Bozal-Leorri, Agustín Marín-Peña, Ainara Castellanos- Rubio, Ainhoa Iglesias-Ara, Aitor Rementeria1D, Ana Bernal-Chico1E,3,7, Andoni Ramirez-Garcia1D, Ane Olazagoitia-Garmendia1C,4, Asier Benito-Vicente1A,8, César Martín1A,8, Eider Bilbao Castellanos1I,10, Eneritz Rueda-Alaña1E,3, Fabio Cavaliere1E,3,7, Guiomar Perez de Nanclares1,9, Igor Aurrekoetxea1F,4, Iraia Garcia-Santisteban1C,4, Irantzu Bernales1H, Itziar Gonzalez-Moro1A,4, Jan Tønnesen1E,3, Jimena Baleriola1B,2,3, Jon Vallejo-Rodríguez1C, Leire Aparicio-Fernandez1D, Leire Martin-Souto1D, Luis Manuel Mendoza1C, Maialen Areitio1D, Maialen Sebastian-delaCruz1C,4, Maren Ortiz- Zarragoitia1I,10, Mari Paz Serrano-Regal1E,3,7, Miren Basaras1D, Nora Fernandez- Jimenez1C,4, Olatz Pampliega1E,3, Santos Alonso Alegre1C, Susi Marcos1, Teresa Fuertes-Mendizabal1G, Unai Galicia-Garcia5,8, Uxue Perez-Cuesta1D, Verónica Torrano1,8, Virginia Sierra-Torre1E,3, Xabier Buqué1F,4 and Ugo Mayor1A,2

Article / Multi‐omics integration highlights the role of ubiquitination in ccl4‐induced liver fibrosis

International Journal of Molecular Sciences

Mercado‐gómez, M.; Lopitz‐otsoa, F.; Azkargorta, M.; Serrano‐maciá, M.; Lachiondo‐ortega, S.; Goikoetxea‐usandizaga, N.; Rodríguez‐agudo, R.; Fernández‐ramos, D.; Bizkarguenaga, M.; Gutiérrez‐De Juan, V.; Lectez, B.; Aloria, K.; Arizmendi, J.M.; Simon, J.; Alonso, C.; Lozano, J.J.; Avila, M.A.; Banales, J.M.; Marin, J.J.G.; Beraza, N.; Mato, J.M.; Elortza, F.; Barrio, R.; Sutherland, J.D.; Mayor, U.; Martínez‐chantar, M.L.; Delgado, T.C.

Review / SUMOylation in the control of cholesterol homeostasis

Open Biology

Talamillo, A.; Ajuria, L.; Grillo, M.; Barroso-Gomila, O.; Mayor, U.; Barrio, R.

Review / The role of SUMOylation during development

Biochemical Society Transactions

Talamillo, A.; Barroso-Gomila, O.; Giordano, I.; Ajuria, L.; Grillo, M.; Mayor, U.; Barrio, R.

Review / How to Inactivate Human Ubiquitin E3 Ligases by Mutation

Frontiers in Cell and Developmental Biology

Garcia-Barcena, C.; Osinalde, N.; Ramirez, J.; Mayor, U.

2019

Article / Detailed dissection of UBe3A-mediated DDI1 ubiquitination

Frontiers in Physiology

Elu, N.; Osinalde, N.; Beaskoetxea, J.; Ramirez, J.; Lectez, B.; Aloria, K.; Rodriguez, J.A.; Arizmendi, J.M.; Mayor, U.

Review / Identifying UBE3A substrates to shed light into Angelman syndrome

Ekaia

Ramirez, Juanma; Lectez, Benoit; Osinalde, Nerea; Elu, Nagore; Mayor, Ugo

Review / Searching for Angelman syndrome therapeutical targets: deubiquitinase USP9X in the spotlight

Osagaitz

Nagore Elu, Juanma Ramirez, Benoit Lectez, Nerea Osinalde, Ugo Mayor

Review / Impaired proteostasis in rare neurological diseases

Seminars in Cell and Developmental Biology

Osinalde, N.; Duarri, A.; Ramirez, J.; Barrio, R.; Perez de Nanclares, G.; Mayor, U.

2018

Chapter / BioMed Research International

A. Martinez, J. Ramirez, N. Osinalde, J.M. Arizmendi and Ugo Mayor.

Article / Quantitative proteomics reveals neuronal ubiquitination of Rngo/Ddi1 and several proteasomal subunits by Ube3a, accounting for the complexity of Angelman syndrome

Human Molecular Genetics

Ramirez, J.; Lectez, B.; Osinalde, N.; Sivá, M.; Elu, N.; Aloria, K.; Procházková, M.; Perez, C.; Martínez-Hernández, J.; Barrio, R.; Šašková, K.G.; Arizmendi, J.M.; Mayor, U.

Article / Ubiquitylation Dynamics of the Clock Cell Proteome and TIMELESS during a Circadian Cycle

Cell Reports

Szabó, Á.; Papin, C.; Cornu, D.; Chélot, E.; Lipinszki, Z.; Udvardy, A.; Redeker, V.; Mayor, U.; Rouyer, F.

Review / Neuronal proteomic analysis of the ubiquitinated substrates of the disease-linked E3 ligases parkin and Ube3a

BioMed Research International

Martinez, A.; Ramirez, J.; Osinalde, N.; Arizmendi, J.M.; Mayor, U.

2017

Chapter / Neuromethods

Juanma Ramirez, Nagore Elu, Aitor Martinez, Benoit Lectez, Ugo Mayor

Article / Quantitative proteomic analysis of Parkin substrates in Drosophila neurons

Molecular Neurodegeneration

Martinez, A.; Lectez, B.; Ramirez, J.; Popp, O.; Sutherland, J.D.; Urbé, S.; Dittmar, G.; Clague, M.J.; Mayor, U.

Article / A comprehensive platform for the analysis of ubiquitin-like protein modifications using in vivo biotinylation

Scientific Reports

Pirone, L.; Xolalpa, W.; Sigursson, J.O.; Ramirez, J.; Pérez, C.; González, M.; De Sabando, A.R.; Elortza, F.; Rodriguez, M.S.; Mayor, U.; Olsen, J.V.; Barrio, R.; Sutherland, J.D.

2016

Book / Methods in Molecular Biology : Proteostasis

Rune Matthiesen

Juanma Ramirez, Mingwei Min, Rosa Barrio, Catherine Lindon and Ugo Mayor

Chapter / Methods in Molecular Biology: SUMO

Manuel S. Rodriguez

Lucia Pirone, Wendy Xolalpa, Ugo Mayor, Rosa Barrio and James D. Sutherland

2015

Article / Proteomic analysis of the ubiquitin landscape in the Drosophila embryonic nervous system and the adult photoreceptor cells

PLoS ONE

Ramirez, J.; Martinez, A.; Lectez, B.; Lee, S.Y.; Franco, M.; Barrio, R.; Dittmar, G.; Mayor, U.

Article / USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death

EMBO Reports

Liang, J.R.; Martinez, A.; Lane, J.D.; Mayor, U.; Clague, M.J.; Urbé, S.

2014

Article / Using in vivo biotinylated ubiquitin to describe a mitotic exit ubiquitome from human cells

Molecular and Cellular Proteomics

Min, M.; Mayor, U.; Dittmar, G.; Lindon, C.

Article / Ube3a, the E3 ubiquitin ligase causing Angelman syndrome and linked to autism, regulates protein homeostasis through the proteasomal shuttle Rpn10

Cellular and Molecular Life Sciences

Lee, S.Y.; Ramirez, J.; Franco, M.; Lectez, B.; Gonzalez, M.; Barrio, R.; Mayor, U.

Article / Ubiquitin profiling in liver using a transgenic mouse with biotinylated ubiquitin

Journal of Proteome Research

Lectez, B.; Migotti, R.; Lee, S.Y.; Ramirez, J.; Beraza, N.; Mansfield, B.; Sutherland, J.D.; Martinez-Chantar, M.L.; Dittmar, G.; Mayor, U.

2013

Article / Ubiquitination site preferences in anaphase promoting complex/cyclosome (APC/C) substrates

Open Biology

Min, M.; Mayor, U.; Lindon, C.

Article / Scavenger Receptors Mediate the Role of SUMO and Ftz-f1 in Drosophila Steroidogenesis

PLoS Genetics

Talamillo, A.; Herboso, L.; Pirone, L.; Pérez, C.; González, M.; Sánchez, J.; Mayor, U.; Lopitz-Otsoa, F.; Rodriguez, M.S.; Sutherland, J.D.; Barrio, R.

2012

Chapter / Methods in Molecular Biology: Ubiquitin Family modifiers and the Proteasome

Dohmen, R. JÃ¼rgen; Scheffner, Martin

Ugo Mayor and Junmin Peng

Article / Deciphering tissue-specific ubiquitylation by mass spectrometry

Methods in Molecular Biology

Mayor, U.; Peng, J.

2011

Article / A novel strategy to isolate ubiquitin conjugates reveals wide role for ubiquitination during neural development

Molecular and Cellular Proteomics

Franco, M.; Seyfried, N.T.; Brand, A.H.; Peng, J.; Mayor, U.