Ainara Castellanos

Ikerbasque Research Associate, UPV/EHU

Ikerbasque research associate at the Department of Genetics, Physical Anthropology and Animal Physiology of the University of the Basque Country.

Research line:

Functional genetics of complex immune disorders.

Research experience at BioCruces Research Institute, University of Tampere (Finland) and Columbia University (US).

Dr. in Biology (2010) from University of the Basque Country (UPV-EHU).

2024

Article / m<sup>6</sup>A Methylated Long Noncoding RNA LOC339803 Regulates Intestinal Inflammatory Response

Advanced Science

Olazagoitia-Garmendia, A.; Rojas-Márquez, H.; Sebastian-delaCruz, M.; Agirre-Lizaso, A.; Ochoa, A.; Mendoza-Gomez, L.M.; Perugorria, M.J.; Bujanda, L.; Madrigal, A.H.; Santin, I.; Castellanos-Rubio, A.

Article / A novel long non-coding RNA connects obesity to impaired adipocyte function

Molecular Metabolism

Lluch, A.; Latorre, J.; Oliveras-Cañellas, N.; Fernández-Sánchez, A.; Moreno-Navarrete, J.M.; Castells-Nobau, A.; Comas, F.; Buxò, M.; Rodríguez-Hermosa, J.I.; Ballester, M.; Espadas, I.; Martín-Montalvo, A.; Zhang, B.; Zhou, Y.; Burkhardt, R.; Höring, M.; Liebisch, G.; Castellanos-Rubio, A.; Santin, I.; Kar, A.; Laakso, M.; Pajukanta, P.; Olkkonen, V.M.; Fernández-Real, J.M.; Ortega, F.J.

Article / Drug-delivery and biological activity in colorectal cancer of a supramolecular porous material assembled from heptameric chromium-copper-adenine entities

Journal of Materials Chemistry B

Mena-Gutiérrez, S.; Maiza-Razkin, E.; Pascual-Colino, J.; Araúzo-Bravo, M.J.; Beobide, G.; Castillo, O.; Castellanos-Rubio, A.; Gerovska, D.; Luque, A.; Pérez-Yáñez, S.

Short Survey / A Novel, Noninvasive Method to Diagnose Active Eosinophilic Esophagitis, Combining Clinical Data and Oral Cavity RNA Levels

Clinical Gastroenterology and Hepatology

Sebastian-Delacruz, M.; Garcia-Etxebarria, K.; Bilbao, J.r.; Lucendo, A.J.; Bujanda, L.; Castellanos-Rubio, A.

Short Survey / Human Colonic Organ Culture Reveals XPO1-Independent Ability of Salvianolic Acid to Reduce Ulcerative Colitis–Related Inflammation

Gastro Hep Advances

Rojas-Márquez, H.; Olazagoitia-Garmendia, A.; Perugorria, M.J.; Huerta, A.; Bujanda, L.; Castellanos-Rubio, A.

2023

Article / Functional evolutionary convergence of long noncoding RNAs involved in embryonic development

Communications Biology

Olazagoitia-Garmendia, A.; Senovilla-Ganzo, R.; García-Moreno, F.; Castellanos-Rubio, A.

Article / A long non-coding RNA that harbors a SNP associated with type 2 diabetes regulates the expression of TGM2 gene in pancreatic beta cells

Frontiers in Endocrinology

González-Moro, I.; Rojas-Márquez, H.; Sebastian-delaCruz, M.; Mentxaka-Salgado, J.; Olazagoitia-Garmendia, A.; Mendoza, L.M.; Lluch, A.; Fantuzzi, F.; Lambert, C.; Ares Blanco, J.; Marselli, L.; Marchetti, P.; Cnop, M.; Delgado, E.; Fernández-Real, J.M.; Ortega, F.J.; Castellanos-Rubio, A.; Santin, I.

Article / Isoreticular Chemistry and Applications of Supramolecularly Assembled Copper-Adenine Porous Materials

Inorganic Chemistry

Mena-Gutiérrez, S.; Pascual-Colino, J.; Beobide, G.; Castillo, O.; Castellanos-Rubio, A.; Luque, A.; Maiza-Razkin, E.; Mentxaka, J.; Pérez-Yáñez, S.

Letter / Inhibition of YTHDF1 by salvianolic acid overcomes gluten-induced intestinal inflammation

Gut

Olazagoitia-Garmendia, A.; Rojas-Márquez, H.; Del Mar Romero, M.; Ruiz, P.; Agirre-Lizaso, A.; Chen, Y.; Perugorria, M.J.; Herrero, L.; Serra, D.; Luo, C.; Bujanda, L.; He, C.; Castellanos-Rubio, A.

Review / lncRNA involvement in immune-related diseases - from SNP association to implication in pathogenesis and therapeutic potential

Journal of Translational Genetics and Genomics

Bergara-Muguruza, L.; Castellanos-Rubio, A.; Santin, I.; Olazagoitia-Garmendia, A.

2022

Article / Efficient Magneto-Luminescent Nanosystems based on Rhodamine-Loaded Magnetite Nanoparticles with Optimized Heating Power and Ideal Thermosensitive Fluorescence

ACS Applied Materials and Interfaces

Castellanos-Rubio, I.; Barón, A.; Luis-Lizarraga, O.; Rodrigo, I.; de Muro, I.G.; Orue, I.; Martínez-Martínez, V.; Castellanos-Rubio, A.; López-Arbeloa, F.; Insausti, M.

Article / Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells

Gut

Olazagoitia-Garmendia, A.; Zhang, L.; Mera, P.; Godbout, J.K.; Sebastian-Delacruz, M.; Garcia-Santisteban, I.; Mendoza, L.M.; Huerta, A.; Irastorza, I.; Bhagat, G.; Green, P.H.; Herrero, L.; Serra, D.; Rodriguez, J.A.; Verdu, E.F.; He, C.; Bilbao, J.R.; Castellanos-Rubio, A.

2021

Article / Shaping up Zn-Doped Magnetite Nanoparticles from Mono- And Bimetallic Oleates- And Impact of Zn Content, Fe Vacancies, and Morphology on Magnetic Hyperthermia Performance

Chemistry of Materials

Castellanos-Rubio, I.; Arriortua, O.; Marcano, L.; Rodrigo, I.; Iglesias-Rojas, D.; Barón, A.; Olazagoitia-Garmendia, A.; Olivi, L.; Plazaola, F.; Fdez-Gubieda, M.L.; Castellanos-Rubio, A.; Garitaonandia, J.S.; Orue, I.; Insausti, M.

Review / The role of lncrnas in gene expression regulation through mRNA stabilization

Non-coding RNA

Sebastian-Delacruz, M.; Gonzalez-Moro, I.; Olazagoitia-Garmendia, A.; Castellanos-Rubio, A.; Santin, I.

Short Survey / A Novel Noninvasive Method Based on Salivary Inflammatory Biomarkers for the Screening of Celiac Disease

Cellular and Molecular Gastroenterology and Hepatology

Sebastian-delaCruz, M.; Olazagoitia-Garmendia, A.; Huerta Madrigal, A.; Garcia-Etxebarria, K.; Mendoza, L.M.; Fernandez-Jimenez, N.; Garcia Casales, Z.; de la Calle Navarro, E.; Calvo, A.E.; Legarda, M.; Tutau, C.; Irastorza, I.; Bujanda, L.; Bilbao, J.R.; Castellanos-Rubio, A.

2020

Article / The T1D-associated lncRNA Lnc13 modulates human pancreatic ? cell inflammation by allele-specific stabilization of STAT1 mRNA.

PNAS

Gonzalez-Moro I, Olazagoitia-Garmendia A, Colli ML, Cobo-Vuilleumier N, Postler TS, Marselli L, Marchetti P, Ghosh S, Gauthier BR, Eizirik DL, Castellanos-Rubio A, Santin I.

Article / Implication of m6a mrna methylation in susceptibility to inflammatory bowel disease

Epigenomes

Sebastian-Delacruz, M.; Olazagoitia-Garmendia, A.; Gonzalez-Moro, I.; Santin, I.; Garcia-Etxebarria, K.; Castellanos-Rubio, A.

Article / Highly Reproducible Hyperthermia Response in Water, Agar, and Cellular Environment by Discretely PEGylated Magnetite Nanoparticles

ACS Applied Materials and Interfaces

Castellanos-Rubio, I.; Rodrigo, I.; Olazagoitia-Garmendia, A.; Arriortua, O.; Gil De Muro, I.; Garitaonandia, J.S.; Bilbao, J.R.; Fdez-Gubieda, M.L.; Plazaola, F.; Orue, I.; Castellanos-Rubio, A.; Insausti, M.

Article / The T1D-associated lncRNA Lnc13 modulates human pancreatic β cell inflammation by allele-specific stabilization of STAT1 mRNA

Proceedings of the National Academy of Sciences of the United States of America

Gonzalez-Moro, I.; Olazagoitia-Garmendia, A.; Colli, M.L.; Cobo-Vuilleumier, N.; Postler, T.S.; Marselli, L.; Marchetti, P.; Ghosh, S.; Gauthier, B.R.; Eizirik, D.L.; Castellanos-Rubio, A.; Santin, I.

2019

Article / MAGI2 Gene Region and Celiac Disease

Frontiers in Nutrition

Jauregi-Miguel, A.; Santin, I.; Garcia-Etxebarria, K.; Olazagoitia-Garmendia, A.; Romero-Garmendia, I.; Sebastian-delaCruz, M.; Irastorza, I.; Castellanos-Rubio, A.; Bilbao, J.R.

Article / A novel RT-QPCR-based assay for the relative quantification of residue specific m6A RNA methylation

Scientific Reports

Castellanos-Rubio, A.; Santin, I.; Olazagoitia-Garmendia, A.; Romero-Garmendia, I.; Jauregi-Miguel, A.; Legarda, M.; Bilbao, J.R.

2019

Poster presentation | FUNCTIONAL CHARACTERIZATION OF A lncRNA IN THE AUTOIMMUNE DISEASE-ASSOCIATED RGS1 REGION

EHGC 2019 - Poster presentation

Ane Olazagoitia-Garmendia, Nora Fernandez-Jimenez, Jose Ramon Bilbao and Ainara Castellanos-Rubio

Poster presentation | The T1D-associated lncRNA Lnc13 modulates pancreatic ? cell inflammation by allele-specific stabilization of STAT1 and STAT2 mRNA.

EHGC 2019 - Poster presentation

Itziar Gonzalez-Moro, Ane Olazagoitia-Garmendia, Ainara Castellanos-Rubio, Izortze Santin.

Poster presentation | Functional study of the rs6822844 SNP associated with risk to celiac disease in intestinal cells

EHGC 2019 - Poster presentation

Maialen Sebastian-delaCruz, Ane Olazagoitia-Garmendia, Irati Romero-Garmendia, Maria Legarda, Carlos Tutau, Iñaki Irastorza, Ainara Castellanos-Rubio, Jose Ramon Bilbao

Poster presentation | LOC339803 lncRNA mediates susceptibility to intestinal inflammation by allele-specific methylation-dependent gene expression regulation

Cell Symposium in Regulatory RNAs - Poster presentation

Ane Olazagoitia-Garmendia, Maialen Sebastian-delaCruz, Iñaki Irastorza, Izortze Santin, Jose Ramón Bilbao and Ainara Castellanos-Rubio

Poster presentation | LOC339803 lncRNA mediates susceptibility to immune-diseases by tissue-dependent allele-specific gene expression regulation

RNA Regulatory Networks - Poster presentation

Ainara Castellanos-Rubio, Ane Olazagoitia-Garmendia, Izortze Santin, Iñaki Irastorza, Javier Meana and Jose Ramón Bilbao