Iban Ubarretxena Belandia

Ikerbasque Research Professor, Director at Biofisika Institute (UPV/EHU, CSIC)

Scientific Director and Group Leader at Biofisika Institute (UPV/EHU, CSIC).

Research line:

Structural Biology of Neurodegenerative Disorders; cryo-EM of Macromolecular Complexes; Membrane Enzymology.

National Science Foundation CAREER award (USA).

Post-doctoral Fellow at Yale University (USA) and MRC Laboratory of Molecular Biology (UK).

PhD in Biochemistry.

2024

Article / Cryo-EM structure of the Rev1-Polζ holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis

Nature Structural and Molecular Biology

Radhika Malik, Robert E Johnson, Iban Ubarretxena-Belandia, Louise Prakash, Satya Prakash , Aneel K Aggarwal

Article / Purification of Functional Recombinant Human Mitochondrial Hsp60

Methods in Enzymology

Weiss C., González-Berruezo A., Seraidy S., Parnas A., Tascón I., Ubarretxena-Belandia I., Azem A.

Article / Cryo-EM structure of the Rev1–Polζ holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis

Nature Structural and Molecular Biology

Malik, R.; Johnson, R.E.; Ubarretxena-Belandia, I.; Prakash, L.; Prakash, S.; Aggarwal, A.K.

Article / Purification of functional recombinant human mitochondrial Hsp60

Methods in Enzymology

Weiss, C.; Berruezo, A.G.; Seraidy, S.; Parnas, A.; Tascón, I.; Ubarretxena-Belandia, I.; Azem, A.

2023

Article / Structural and functional insights into the delivery of a bacterial Rhs pore-forming toxin to the membrane

Nature Communications

Amaia González-Magaña, Igor Tascón, Jon Altuna-Alvarez, María Queralt-Martín, Jake Colautti, Carmen Velázquez, Maialen Zabala, Jessica Rojas-Palomino, Marité Cárdenas , Antonio Alcaraz, John C Whitney, Iban Ubarretxena-Belandia, David Albesa-Jové

Article / Structural and functional insights into the delivery of a bacterial Rhs pore-forming toxin to the membrane

Nature Communications

González-Magaña, A.; Tascón, I.; Altuna-Alvarez, J.; Queralt-Martín, M.; Colautti, J.; Velázquez, C.; Zabala, M.; Rojas-Palomino, J.; Cárdenas, M.; Alcaraz, A.; Whitney, J.C.; Ubarretxena-Belandia, I.; Albesa-Jové, D.

2022

Article / Cryo-EM structure of translesion DNA synthesis polymerase zeta with a base pair mismatch

Nature Communications

Radhika Malik, Robert E Johnson, Louise Prakash, Satya Prakash, Iban Ubarretxena-Belandia, Aneel K Aggarwal

Article / Cryo-EM structure of translesion DNA synthesis polymerase ζ with a base pair mismatch

Nature Communications

Malik, R.; Johnson, R.E.; Prakash, L.; Prakash, S.; Ubarretxena-Belandia, I.; Aggarwal, A.K.

2021

Article / Conformational plasticity underlies membrane fusion induced by an HIV sequence juxtaposed to the lipid envelope

Scientific Reports

Igor de la Arada, Johana Torralba, Igor Tascón, Adai Colom, Iban Ubarretxena‑Belandia, José L. R. Arrondo, Beatriz Apellániz4 & José L. Nieva

Article / Conformational plasticity underlies membrane fusion induced by an HIV sequence juxtaposed to the lipid envelope

Scientific Reports

de la Arada, I.; Torralba, J.; Tascón, I.; Colom, A.; Ubarretxena-Belandia, I.; Arrondo, J.L.R.; Apellániz, B.; Nieva, J.L.

2020

Article / Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin

Nature Communications

Gomez-Llorente, Y.; Jebara, F.; Patra, M.; Malik, R.; Nisemblat, S.; Chomsky-Hecht, O.; Parnas, A.; Azem, A.; Hirsch, J.A.; Ubarretxena-Belandia, I.

Article / Structure and mechanism of B-family DNA polymerase ζ specialized for translesion DNA synthesis

Nature Structural and Molecular Biology

Malik, R.; Kopylov, M.; Gomez-Llorente, Y.; Jain, R.; Johnson, R.E.; Prakash, L.; Prakash, S.; Ubarretxena-Belandia, I.; Aggarwal, A.K.

Article / Substrate interaction inhibits γ-secretase production of amyloid-β peptides

Chemical Communications

Zhao, J.; Xiao, Y.; Liu, X.; Kim, S.; Wu, X.; Barros, M.; Zhuang, R.; Hou, X.; Zhang, Y.; Robakis, N.K.; Li, Y.M.; Dordick, J.S.; Ubarretxena-Belandia, I.; Wang, C.

Article / Presenilin1 familial Alzheimer disease mutants inactivate EFNB1-and BDNF-dependent neuroprotection against excitotoxicity by affecting neuroprotective complexes of N-methyl-d-Aspartate receptor

Brain Communications

Al Rahim, M.; Yoon, Y.; Dimovasili, C.; Shao, Z.; Huang, Q.; Zhang, E.; Kezunovic, N.; Chen, L.; Schaffner, A.; Huntley, G.W.; Ubarretxena-Belandia, I.; Georgakopoulos, A.; Robakis, N.K.

Review / Substrate–Enzyme Interactions in Intramembrane Proteolysis: γ-Secretase as the Prototype

Frontiers in Molecular Neuroscience

Liu, X.; Zhao, J.; Zhang, Y.; Ubarretxena-Belandia, I.; Forth, S.; Lieberman, R.L.; Wang, C.

2019

Article / CD46 facilitates entry and dissemination of human cytomegalovirus

Nature Communications

Stein, K.R.; Gardner, T.J.; Hernandez, R.E.; Kraus, T.A.; Duty, J.A.; Ubarretxena-Belandia, I.; Moran, T.M.; Tortorella, D.

Article / Cryo-EM structure and dynamics of eukaryotic DNA polymerase δ holoenzyme

Nature Structural and Molecular Biology

Jain, R.; Rice, W.J.; Malik, R.; Johnson, R.E.; Prakash, L.; Prakash, S.; Ubarretxena-Belandia, I.; Aggarwal, A.K.

Biochemical and structural characterization of di-aspartyl intramembrane proteases

City University of New York

Celia Torres-Arancivia - Finished

Structural and biochemical characterization of Rhomboid intramembrane proteases

City University of New York

Jose Chavez - Finished

Design and validation of an open-source modular microplate photoirradiation system for high-through experiments in photobiology

Icahn School of Medicine at Mount Sinai

Suzanna Katz - Finished

Developing novel strategies to target LRRK2 in the fight against Parkinson

Icahn School of Medicine at Mount Sinai

Adam Schaffner - Finished

Iban Ubarretxena Belandia

Ikerbasque Research Professor, Director at Biofisika Institute (UPV/EHU, CSIC)

2024

2023

2022

2021

2020

2019

2018

2006