Joaquin Castilla

Ikerbasque Research Professor, CIC bioGUNE

Head of the Prion Research Lab at CIC bioGUNE (Bizkaia).

Research line:

Molecular mechanisms involved in the prion transmission between different species. The research implies the study and design of new molecules able to block the prion replication and could be used as therapy.

Award of Royal Academy of Doctors (1997) ; National award for the best thesis of the Animal Health (1998) ; Award of Young Scientific in Virology (2011).

Research experience: More than 10 years of research experience in centers in Europe and USA. Since 2006, group leader of a laboratory in Scripps Research Institute, Florida.

Doctor in Science 1996 from University Autonoma of Madrid.

2024

Article / Classical BSE dismissed as the cause of CWD in Norwegian red deer despite strain similarities between both prion agents

Veterinary research

Marín-Moreno, A.; Benestad, S.L.; Barrio, T.; Pirisinu, L.; Espinosa, J.C.; Tran, L.; Huor, A.; Di Bari, M.A.; Eraña, H.; Maddison, B.C.; D'Agostino, C.; Fernández-Borges, N.; Canoyra, S.; Jerez-Garrido, N.; Castilla, J.; Spiropoulos, J.; Bishop, K.; Gough, K.C.; Nonno, R.; Våge, J.; Andréoletti, O.; Torres, J.M.

Article / A Protein Misfolding Shaking Amplification-based method for the spontaneous generation of hundreds of bona fide prions

Nature Communications

Eraña, H.; Sampedro-Torres-Quevedo, C.; Charco, J.M.; Díaz-Domínguez, C.M.; Peccati, F.; San-Juan-Ansoleaga, M.; Vidal, E.; Gonçalves-Anjo, N.; Pérez-Castro, M.A.; González-Miranda, E.; Piñeiro, P.; Fernández-Veiga, L.; Galarza-Ahumada, J.; Fernández-Muñoz, E.; Perez de Nanclares, G.; Telling, G.; Geijo, M.; Jiménez-Osés, G.; Castilla, J.

2023

Article / An optimized western blot assay provides a comprehensive assessment of the physiological endoproteolytic processing of the prion protein

J Biol Chem.

Ilaria Vanni, Floriana Iacobone, Claudia D'agostino, Matteo Giovannelli, Laura Pirisinu, Hermann Clemens Altmeppen, Joaquín Castilla, Juan María Torres, Umberto Agrimi and Romolo Nonno

Article / Understanding the key features of the spontaneous formation of bona fide prions through a novel methodology that enables their swift and consistent generation

Acta Neuropathologica Communications

Eraña, H.; Díaz-Domínguez, C.M.; Charco, J.M.; Vidal, E.; González-Miranda, E.; Pérez-Castro, M.A.; Piñeiro, P.; López-Moreno, R.; Sampedro-Torres-Quevedo, C.; Fernández-Veiga, L.; Tasis-Galarza, J.; Lorenzo, N.L.; Santini-Santiago, A.; Lázaro, M.; García-Martínez, S.; Gonçalves-Anjo, N.; San-Juan-Ansoleaga, M.; Galarza-Ahumada, J.; Fernández-Muñoz, E.; Giler, S.; Valle, M.; Telling, G.C.; Geijó, M.; Requena, J.R.; Castilla, J.

Article / A tetracationic porphyrin with dual anti-prion activity

iScience

Masone, A.; Zucchelli, C.; Caruso, E.; Lavigna, G.; Eraña, H.; Giachin, G.; Tapella, L.; Comerio, L.; Restelli, E.; Raimondi, I.; Elezgarai, S.R.; De Leo, F.; Quilici, G.; Taiarol, L.; Oldrati, M.; Lorenzo, N.L.; García-Martínez, S.; Cagnotto, A.; Lucchetti, J.; Gobbi, M.; Vanni, I.; Nonno, R.; Di Bari, M.A.; Tully, M.D.; Cecatiello, V.; Ciossani, G.; Pasqualato, S.; Van Anken, E.; Salmona, M.; Castilla, J.; Requena, J.R.; Banfi, S.; Musco, G.; Chiesa, R.

Article / Analysis of a large case series of fatal familial insomnia to determine tests with the highest diagnostic value

Journal of Neuropathology and Experimental Neurology

Kortazar-Zubizarreta, I.; Eraña, H.; Pereda, A.; Charco, J.M.; Manero-Azua, A.; Ruiz-Onandi, R.; Aguirre, U.; Gonzalez-Chinchon, G.; Perez De Nanclares, G.; Castilla, J.

Article / An optimized Western blot assay provides a comprehensive assessment of the physiological endoproteolytic processing of the prion protein

Journal of Biological Chemistry

Vanni, I.; Iacobone, F.; D'Agostino, C.; Giovannelli, M.; Pirisinu, L.; Altmeppen, H.C.; Castilla, J.; Torres, J.M.; Agrimi, U.; Nonno, R.

2022

Article / Analysis of a large case series of Fatal Familial Insomnia to determine tests with the highest diagnostic value

J. Neuropathol. Exp. Neurol.

Izaro Kortazar-Zubizarreta, Hasier Eraña, Arrate Pereda, Jorge M Charco, Africa Manero-Azua, Rebeca Ruiz-Onandi, Urko Aguirre, Gonzalo Gonzalez-Chinchon, Basque Prionopathies Study Group, Guiomar Perez de Nanclares and Joaquín Castilla

Article / An optimized western blot assay provides a comprehensive assessment of the physiological endoproteolytic processing of the prion protein

J Biol Chem

Ilaria Vanni, Floriana Iacobone, Claudia D'agostino, Matteo Giovannelli, Laura Pirisinu, Hermann Clemens Altmeppen, Joaquín Castilla, Juan María Torres, Umberto Agrimi and Romolo Nonno

Article / Bona fide atypical scrapie faithfully reproduced for the first time in a rodent model

Acta Neuropathologica Communications

Vidal, E.; Sánchez-Martín, M.A.; Eraña, H.; Lázaro, S.P.; Pérez-Castro, M.A.; Otero, A.; Charco, J.M.; Marín, B.; López-Moreno, R.; Díaz-Domínguez, C.M.; Geijo, M.; Ordóñez, M.; Cantero, G.; di Bari, M.; Lorenzo, N.L.; Pirisinu, L.; d’Agostino, C.; Torres, J.M.; Béringue, V.; Telling, G.; Badiola, J.J.; Pumarola, M.; Bolea, R.; Nonno, R.; Requena, J.R.; Castilla, J.

Article / Glycans are not necessary to maintain the pathobiological features of bovine spongiform encephalopathy

PLoS Pathogens

Otero, A.; Barrio, T.; Eraña, H.; Charco, J.M.; Betancor, M.; Díaz-Domínguez, C.M.; Marín, B.; Andréoletti, O.; Torres, J.M.; Kong, Q.; Badiola, J.J.; Bolea, R.; Castilla, J.

Article / Description of the first Spanish case of Gerstmann–Sträussler–Scheinker disease with A117V variant: clinical, histopathological and biochemical characterization

Journal of Neurology

Eraña, H.; San Millán, B.; Díaz-Domínguez, C.M.; Charco, J.M.; Rodríguez, R.; Viéitez, I.; Pereda, A.; Yañez, R.; Geijo, M.; Navarro, C.; Perez de Nanclares, G.; Teijeira, S.; Castilla, J.

Article / Blood β-Synuclein and Neurofilament Light Chain During the Course of Prion Disease

Neurology

Halbgebauer, S.; Abu-Rumeileh, S.; Oeckl, P.; Steinacker, P.; Roselli, F.; Wiesner, D.; Mammana, A.; Beekes, M.; Kortazar-Zubizarreta, I.; De Nanclares, G.P.; Capellari, S.; Giese, A.; Castilla, J.; Ludolph, A.C.; Žáková, D.; Parchi, P.; Otto, M.

2021

Chapter / Laboratory Identification of Prion Infections

Encyclopedia of Infection and Immunity

Hasier Eraña, Jorge M. Charco, Miguel A. Pérez-Castro, Carlos M. Díaz-Domínguez, Cristina Sampedro-Torres-Quevedo, Izaro Kortazar-Zubizarreta, Leire Fernández-Veiga, Juan Tasis-Galarza, Joaquín Castilla

Article / Autoantibodies against the prion protein in individuals with PRNP mutations

Neurology

Karl Frontzek, Manfredi Christopher Carta, Marco Losa, Mirka Epskamp, Georg Meisl, Alice Anane, Jean-Philippe Brandel, Ulrike Camenisch, Joaquín Castilla, Stéphane Haik, Tuomas Knowles, Ewald Lindner, Andreas Lutterotti, Eric Vallabh Minikel, Benedetto Ignacio Roiter, Jiri Safar, Raquel Sánchez-Valle, Dana Žáková, Simone Hornemann, and Adriano Aguzzi

Article / Homozygous R136S mutation in PRNP gene causes inherited early onset prion disease

Alzheimer's Research and Therapy

Ximelis, T.; Marín-Moreno, A.; Espinosa, J.C.; Eraña, H.; Charco, J.M.; Hernández, I.; Riveira, C.; Alcolea, D.; González-Roca, E.; Aldecoa, I.; Molina-Porcel, L.; Parchi, P.; Rossi, M.; Castilla, J.; Ruiz-García, R.; Gelpi, E.; Torres, J.M.; Sánchez-Valle, R.

Article / Biosemiotics comprehension of PrP code and prion disease

BioSystems

Coca, J.R.; Eraña, H.; Castilla, J.

Article / Detection of chronic wasting disease in mule and white-tailed deer by RT-QuIC analysis of outer ear

Scientific Reports

Ferreira, N.C.; Charco, J.M.; Plagenz, J.; Orru, C.D.; Denkers, N.D.; Metrick, M.A.; Hughson, A.G.; Griffin, K.A.; Race, B.; Hoover, E.A.; Castilla, J.; Nichols, T.A.; Miller, M.W.; Caughey, B.

Article / Sporadic Creutzfeldt–Jakob disease with extremely long 14-year survival period

European Journal of Neurology

Kortazar-Zubizarreta, I.; Ruiz-Onandi, R.; Pereda, A.; Vado, Y.; González-Chinchon, G.; Eraña, H.; Perez de Nanclares, G.; Castilla, J.

Article / Cerebrospinal fluid and plasma small extracellular vesicles and mirnas as biomarkers for prion diseases

International Journal of Molecular Sciences

López-Pérez, Ó.; Sanz-Rubio, D.; Hernaiz, A.; Betancor, M.; Otero, A.; Castilla, J.; Andréoletti, O.; Badiola, J.J.; Zaragoza, P.; Bolea, R.; Toivonen, J.M.; Martín-Burriel, I.

Article / Improving the pharmacological properties of ciclopirox for its use in congenital erythropoietic porphyria

Journal of Personalized Medicine

Bernardo-Seisdedos, G.; Charco, J.M.; Sanjuan, I.; García-Martínez, S.; Urquiza, P.; Eraña, H.; Castilla, J.; Millet, O.

Article / Prion-associated neurodegeneration causes both endoplasmic reticulum stress and proteasome impairment in a murine model of spontaneous disease

International Journal of Molecular Sciences

Otero, A.; Betancor, M.; Eraña, H.; Borges, N.F.; Lucas, J.J.; Badiola, J.J.; Castilla, J.; Bolea, R.

2020

Article / A Novel, Reliable and Highly Versatile Method to Evaluate Different Prion Decontamination Procedures

Frontiers in Bioengineering and Biotechnology

Eraña, H.; Pérez-Castro, M.Á.; García-Martínez, S.; Charco, J.M.; López-Moreno, R.; Díaz-Dominguez, C.M.; Barrio, T.; González-Miranda, E.; Castilla, J.

Article / Autoantibodies against the prion protein in individuals with PRNP mutations

Neurology

Frontzek, K.; Carta, M.; Losa, M.; Epskamp, M.; Meisl, G.; Anane, A.; Brandel, J.P.; Camenisch, U.; Castilla, J.; Haïk, S.; Knowles, T.; Lindner, E.; Lutterotti, A.; Minikel, E.V.; Roiter, I.; Safar, J.G.; Sanchez-Valle, R.; Žáková, D.; Hornemann, S.; Aguzzi, A.

Article / Evaluation of the Influence of Astrocytes on In Vitro Blood–Brain Barrier Models

ATLA Alternatives to Laboratory Animals

García-Salvador, A.; Domínguez-Monedero, A.; Gómez-Fernández, P.; García-Bilbao, A.; Carregal-Romero, S.; Castilla, J.; Goñi-de-Cerio, F.

Article / Dogs are resistant to prion infection, due to the presence of aspartic or glutamic acid at position 163 of their prion protein

FASEB Journal

Vidal, E.; Fernández-Borges, N.; Eraña, H.; Parra, B.; Pintado, B.; Sánchez-Martín, M.A.; Charco, J.M.; Ordóñez, M.; Pérez-Castro, M.A.; Pumarola, M.; Mathiason, C.K.; Mayoral, T.; Castilla, J.

Review / Detection of pathognomonic biomarker PrPsc and the contribution of cell free-amplification techniques to the diagnosis of prion diseases

Biomolecules

Eraña, H.; Charco, J.M.; González-Miranda, E.; García-Martínez, S.; López-Moreno, R.; Pérez-Castro, M.A.; Díaz-Domínguez, C.M.; García-Salvador, A.; Castilla, J.

2019

Article / A Single Amino Acid Substitution, Found in Mammals with Low Susceptibility to Prion Diseases, Delays Propagation of Two Prion Strains in Highly Susceptible Transgenic Mouse Models

Molecular Neurobiology

Otero, A.; Hedman, C.; Fernández-Borges, N.; Eraña, H.; Marín, B.; Monzón, M.; Sánchez-Martín, M.A.; Nonno, R.; Badiola, J.J.; Bolea, R.; Castilla, J.

Article / Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies

PLoS Pathogens

Eraña, H.; Charco, J.M.; Di Bari, M.A.; Díaz-Domínguez, C.M.; López-Moreno, R.; Vidal, E.; González-Miranda, E.; Pérez-Castro, M.A.; García-Martínez, S.; Bravo, S.; Fernández-Borges, N.; Geijo, M.; D’Agostino, C.; Garrido, J.; Bian, J.; König, A.; Uluca-Yazgi, B.; Sabate, R.; Khaychuk, V.; Vanni, I.; Telling, G.C.; Heise, H.; Nonno, R.; Requena, J.R.; Castilla, J.

Article / Qualitative analysis of the social and family impact of human transmissible spongiform encephalopathies

Revista de Neurologia

Coca, J.R.; Sanz-Molina, L.; Eraña, H.; Castilla, J.

Review / Insights into the Bidirectional Properties of the Sheep–Deer Prion Transmission Barrier

Molecular Neurobiology

Harrathi, C.; Fernández-Borges, N.; Eraña, H.; Elezgarai, S.R.; Venegas, V.; Charco, J.M.; Castilla, J.

2018

Article / Repurposing ciclopirox as a pharmacological chaperone in a model of congenital erythropoietic porphyria

Science Translational Medicine

Urquiza, P.; Laín, A.; Sanz-Parra, A.; Moreno, J.; Bernardo-Seisdedos, G.; Dubus, P.; González, E.; Gutiérrez-De-Juan, V.; García, S.; Eraña, H.; Juan, I.S.; Macías, I.; Ben Bdira, F.; Pluta, P.; Ortega, G.; Oyarzábal, J.; González-Muñiz, R.; Rodríguez-Cuesta, J.; Anguita, J.; Díez, E.; Blouin, J.M.; De Verneuil, H.; Mato, J.M.; Richard, E.; Falcón-Pérez, J.M.; Castilla, J.; Millet, O.

Article / An Amino Acid Substitution Found in Animals with Low Susceptibility to Prion Diseases Confers a Protective Dominant-Negative Effect in Prion-Infected Transgenic Mice

Molecular Neurobiology

Otero, A.; Bolea, R.; Hedman, C.; Fernández-Borges, N.; Marín, B.; López-Pérez, Ó.; Barrio, T.; Eraña, H.; Sánchez-Martín, M.A.; Monzón, M.; Badiola, J.J.; Castilla, J.

Article / iPS Cell Cultures from a Gerstmann-Sträussler-Scheinker Patient with the Y218N PRNP Mutation Recapitulate tau Pathology

Molecular Neurobiology

Matamoros-Angles, A.; Gayosso, L.M.; Richaud-Patin, Y.; di Domenico, A.; Vergara, C.; Hervera, A.; Sousa, A.; Fernández-Borges, N.; Consiglio, A.; Gavín, R.; López de Maturana, R.; Ferrer, I.; López de Munain, A.; Raya, Á.; Castilla, J.; Sánchez-Pernaute, R.; del Río, J.A.

Article / Detection of amyloid fibrils in Parkinson’s disease using plasmonic chirality

Proceedings of the National Academy of Sciences of the United States of America

Kumar, J.; Eraña, H.; López-Martínez, E.; Claes, N.; Martín, V.F.; Solís, D.M.; Bals, S.; Cortajarena, A.L.; Castilla, J.; Liz-Marzán, L.M.

Article / Cofactors influence the biological properties of infectious recombinant prions

Acta Neuropathologica

Fernández-Borges, N.; Di Bari, M.A.; Eraña, H.; Sánchez-Martín, M.; Pirisinu, L.; Parra, B.; Elezgarai, S.R.; Vanni, I.; López-Moreno, R.; Vaccari, G.; Venegas, V.; Charco, J.M.; Gil, D.; Harrathi, C.; D’Agostino, C.; Agrimi, U.; Mayoral, T.; Requena, J.R.; Nonno, R.; Castilla, J.

Article / Recombinant PrPScshares structural features with brain-derived PrPSc: Insights from limited proteolysis

PLoS Pathogens

Sevillano, A.M.; Fernández-Borges, N.; Younas, N.; Wang, F.; R. Elezgarai, S.; Bravo, S.; Vázquez-Fernández, E.; Rosa, I.; Eraña, H.; Gil, D.; Veiga, S.; Vidal, E.; Erickson-Beltran, M.L.; Guitián, E.; Silva, C.J.; Nonno, R.; Ma, J.; Castilla, J.; R. Requena, J.

Note / Behind the potential evolution towards prion resistant species

Prion

Fernández-Borges, N.; Eraña, H.; Castilla, J.

2017

Article / In vitro approach to identify key amino acids in low susceptibility of rabbit prion protein to misfolding

Journal of Virology

Eraña, H.; Fernández-Borges, N.; Elezgarai, S.R.; Harrathi, C.; Charco, J.M.; Chianini, F.; Dagleish, M.P.; Ortega, G.; Millet, Ó.; Castilla, J.

Article / Generation of a new infectious recombinant prion: A model to understand Gerstmann-Sträussler-Scheinker syndrome

Scientific Reports

Elezgarai, S.R.; Fernández-Borges, N.; Eraña, H.; Sevillano, A.M.; Charco, J.M.; Harrathi, C.; Saá, P.; Gil, D.; Kong, Q.; Requena, J.R.; Andréoletti, O.; Castilla, J.

Article / Unraveling the key to the resistance of canids to prion diseases

PLoS Pathogens

Fernández-Borges, N.; Parra, B.; Vidal, E.; Eraña, H.; Sánchez-Martín, M.A.; de Castro, J.; Elezgarai, S.R.; Pumarola, M.; Mayoral, T.; Castilla, J.

Article / Soluble polymorphic bank vole prion proteins induced by co-expression of quiescin sulfhydryl oxidase in E. coli and their aggregation behaviors

Microbial Cell Factories

Abskharon, R.; Dang, J.; Elfarash, A.; Wang, Z.; Shen, P.; Zou, L.S.; Hassan, S.; Wang, F.; Fujioka, H.; Steyaert, J.; Mulaj, M.; Surewicz, W.K.; Castilla, J.; Wohlkonig, A.; Zou, W.Q.

Article / An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein

PLoS ONE

Stincardini, C.; Massignan, T.; Biggi, S.; Elezgarai, S.R.; Sangiovanni, V.; Vanni, I.; Pancher, M.; Adami, V.; Moreno, J.; Stravalaci, M.; Maietta, G.; Gobbi, M.; Negro, A.; Requena, J.R.; Castilla, J.; Nonno, R.; Biasini, E.

Article / Protein misfolding cyclic amplification corroborates the absence of PrPSc accumulation in placenta from foetuses with the ARR/ARQ genotype in natural scrapie

Veterinary Microbiology

Garza, M.C.; Eraña, H.; Castilla, J.; Acín, C.; Vargas, A.; Badiola, J.J.; Monleón, E.

Article / Post-translational modifications in PrP expand the conformational diversity of prions in vivo

Scientific Reports

Aguilar-Calvo, P.; Xiao, X.; Bett, C.; Eraña, H.; Soldau, K.; Castilla, J.; Nilsson, K.P.R.; Surewicz, W.K.; Sigurdson, C.J.

Article / Prion replication without host adaptation during interspecies transmissions

Proceedings of the National Academy of Sciences of the United States of America

Bian, J.; Khaychuk, V.; Angers, R.C.; Fernández-Borges, N.; Vidal, E.; Meyerett-Reid, C.; Kim, S.; Calvi, C.L.; Bartz, J.C.; Hoover, E.A.; Agrimi, U.; Richt, J.A.; Castilla, J.; Telling, G.C.

Review / Recombinant PrP and its contribution to research on transmissible spongiform encephalopathies

Pathogens

Charco, J.M.; Eraña, H.; Venegas, V.; García-Martínez, S.; López-Moreno, R.; González-Miranda, E.; Pérez-Castro, M.Á.; Castilla, J.

Review / Prion-like disorders and Transmissible Spongiform Encephalopathies: An overview of the mechanistic features that are shared by the various disease-related misfolded proteins

Biochemical and Biophysical Research Communications

Eraña, H.; Venegas, V.; Moreno, J.; Castilla, J.

2016

Article / The architecture of prions. How its understanding would provide new therapeutic insights

Swiss Medical Weekly

Hasier Eraña and Joaquín Castilla

Article / A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein

Scientific Reports

Massignan, T.; Cimini, S.; Stincardini, C.; Cerovic, M.; Vanni, I.; Elezgarai, S.R.; Moreno, J.; Stravalaci, M.; Negro, A.; Sangiovanni, V.; Restelli, E.; Riccardi, G.; Gobbi, M.; Castilla, J.; Borsello, T.; Nonno, R.; Biasini, E.

2015

Article / Animal models for prion?like diseases

Virus Research

Natalia Fernández-Borges, Hasier Eraña, Vanesa Venegas, Saioa R. Elezgarai, Chafik Harrathi and Joaquín Castilla

Article / Animal models for prion-like diseases

Virus Research

Fernández-Borges, N.; Eraña, H.; Venegas, V.; Elezgarai, S.R.; Harrathi, C.; Castilla, J.

Article / Transgenic Mouse Bioassay: Evidence That Rabbits Are Susceptible to a Variety of Prion Isolates

PLoS Pathogens

Vidal, E.; Fernández-Borges, N.; Pintado, B.; Eraña, H.; Ordóñez, M.; Márquez, M.; Chianini, F.; Fondevila, D.; Sánchez-Martín, M.A.; Andreoletti, O.; Dagleish, M.P.; Pumarola, M.; Castilla, J.

Article / Transgenic Fatal Familial Insomnia Mice Indicate Prion Infectivity-Independent Mechanisms of Pathogenesis and Phenotypic Expression of Disease

PLoS Pathogens

Bouybayoune, I.; Mantovani, S.; Del Gallo, F.; Bertani, I.; Restelli, E.; Comerio, L.; Tapella, L.; Baracchi, F.; Fernández-Borges, N.; Mangieri, M.; Bisighini, C.; Beznoussenko, G.V.; Paladini, A.; Balducci, C.; Micotti, E.; Forloni, G.; Castilla, J.; Fiordaliso, F.; Tagliavini, F.; Imeri, L.; Chiesa, R.

Article / Human prion protein sequence elements impede cross-species chronic wasting disease transmission

Journal of Clinical Investigation

Kurt, T.D.; Jiang, L.; Fernández-Borges, N.; Bett, C.; Liu, J.; Yang, T.; Spraker, T.R.; Castilla, J.; Eisenberg, D.; Kong, Q.; Sigurdson, C.J.

Article / Susceptibility of european red deer (Cervus elaphus elaphus) to alimentary challenge with bovine spongiform encephalopathy

PLoS ONE

Dagleish, M.P.; Martin, S.; Steele, P.; Finlayson, J.; Eaton, S.L.; Sisó, S.; Stewart, P.; Fernández-Borges, N.; Hamilton, S.; Pang, Y.; Chianini, F.; Reid, H.W.; Goldmann, W.; González, L.; Castilla, J.; Jeffrey, M.

Editorial / Prion-like diseases: Looking for their niche in the realm of infectious diseases

Virus Research

Castilla, J.; Requena, J.R.

2014

Article / Elements modulating the prion species barrier and its passage consequences

PLoS ONE

Torres, J.M.; Espinosa, J.C.; Aguilar-Calvo, P.; Herva, M.E.; Relanõ-Ginés, A.; Villa-Diaz, A.; Morales, M.; Parra, B.; Alamillo, E.; Brun, A.; Castilla, J.; Molina, S.; Hawkins, S.A.C.; Andreoletti, O.

Article / Prion transmission prevented by modifying the β2-α2 loop structure of host PrPC

Journal of Neuroscience

Kurt, T.D.; Bett, C.; Fernández-Borges, N.; Joshi-Barr, S.; Hornemann, S.; Rülicke, T.; Castilla, J.; Wüthrich, K.; Aguzzi, A.; Sigurdson, C.J.

2013

Article / Characterization of the shortest incubation time model for prion diseases

PLoS Pathogens

Michele Angelo Di Bari, Romolo Nonno, Joaquín Castilla, Claudia D’Agostino, Laura Pirisinu, Geraldina Riccardi, Michela Conte, Juergen Richt, Robert Kunkle, Jan Langeveld, Gabriele Vaccari and Umberto Agrimi

Article / BSE induces misfolding of alleged prion resistant species PrPC without altering its pathobiological features

Journal of Neuroscience

Enric Vidal, Natalia Fernández-Borges, Belén Pintado, Martí Pumarola and Joaquín Castilla

Article / Spontaneous generation of infectious prion disease in transgenic mice

Emerging Infectious Diseases

Torres, J.M.; Castilla, J.; Pintado, B.; Gutiérrez-Adan, A.; Andréoletti, O.; Aguilar-Calvo, P.; Arroba, A.I.; Parra-Arrondo, B.; Ferrer, I.; Manzanares, J.; Espinosa, J.C.

Article / Exploring the risks of a putative transmission of BSE to new species

Prion

Vidal, E.; Fernández-Borges, N.; Pintado, B.; Ordóñez, M.; Márquez, M.; Fondevila, D.; Eraña, H.; Torres, J.M.; Pumarola, M.; Castilla, J.

Article / Recombinant human prion protein inhibits prion propagation in vitro

Scientific Reports

Yuan, J.; Zhan, Y.A.; Abskharon, R.; Xiao, X.; Martinez, M.C.; Zhou, X.; Kneale, G.; Mikol, J.; Lehmann, S.; Surewicz, W.K.; Castilla, J.; Steyaert, J.; Zhang, S.; Kong, Q.; Petersen, R.B.; Wohlkonig, A.; Zou, W.Q.

Article / Bovine spongiform encephalopathy induces misfolding of alleged prion-resistant species cellular prion protein without altering its pathobiological features

Journal of Neuroscience

Vidal, E.; Fernández-Borges, N.; Pintado, B.; Ordóñez, M.; Márquez, M.; Fondevila, D.; Torres, J.M.; Pumarola, M.; Castilla, J.

Article / Chronic Wasting Disease in Bank Voles: Characterisation of the Shortest Incubation Time Model for Prion Diseases

PLoS Pathogens

Di Bari, M.A.; Nonno, R.; Castilla, J.; D'Agostino, C.; Pirisinu, L.; Riccardi, G.; Conte, M.; Richt, J.; Kunkle, R.; Langeveld, J.; Vaccari, G.; Agrimi, U.

Note / Prion-resistant or prion-susceptible species, this is the question

Virulence

Chianini, F.; Fernández-Borges, N.; Eraña, H.; Pang, Y.; Vidal, E.; Eaton, S.L.; Finlayson, J.; Dagleish, M.P.; Castilla, J.

Review / Infectivity versus seeding in neurodegenerative diseases sharing a prion-like mechanism

International Journal of Cell Biology

Fernández-Borges, N.; Eraña, H.; Elezgarai, S.R.; Harrathi, C.; Gayosso, M.; Castilla, J.

2012

Article / Prionemia and leuco-platelet associated infectivity in sheep TSE models

Journal of Virology

Caroline Lacroux, Didier Vilette, Natalia Fernández-Borges, Claire Litaise, Severine Lugan, Nathalie Morel, Fabien Corbière, Stephanie Simon, Hugh Simmons, Pierrette Costes, Jean Louis Weisbecker, Isabelle Lantier, Frederic Lantier, Francois Schelcher, Ja

Article / Structure of the Î²2-Î±2 loop and interspecies prion transmission

FASEB J.

Bett C, Fernández-Borges N, Kurt TD, Lucero M, Nilsson KP, Castilla J, Sigurdson CJ.

Article / Desmitificando la existencia de especies resistentes a los priones

Revista de la SEV

Hasier Eraña, Natalia Fernández Borges y Joaquín Castilla

Article / De novo induction of amyloid-β deposition in vivo

Molecular Psychiatry

Morales, R.; Duran-Aniotz, C.; Castilla, J.; Estrada, L.D.; Soto, C.

Article / Structure of the β2-α2 loop and interspecies prion transmission

FASEB Journal

Bett, C.; Fernández-Borges, N.; Kurt, T.D.; Lucero, M.; Nilsson, K.P.R.; Castilla, J.; Sigurdson, C.J.

Article / Rabbits are not resistant to prion infection

Proceedings of the National Academy of Sciences of the United States of America

Chianini, F.; Fernández-Borges, N.; Vidal, E.; Gibbard, L.; Pintado, B.; De Castro, J.; Priola, S.A.; Hamilton, S.; Eaton, S.L.; Finlayson, J.; Pang, Y.; Steele, P.; Reid, H.W.; Dagleish, M.P.; Castilla, J.

Article / Prionemia and leukocyte-platelet-associated infectivity in sheep transmissible spongiform encephalopathy models

Journal of Virology

Lacroux, C.; Vilette, D.; Fernández-Borges, N.; Litaise, C.; Lugan, S.; Morel, N.; Corbière, F.; Simon, S.; Simmons, H.; Costes, P.; Weisbecker, J.L.; Lantier, I.; Lantier, F.; Schelcher, F.; Grassi, J.; Castilla, J.; Andréoletti, O.

Review / Naturally prion resistant mammals: A utopia?

Prion

Fernández-Borges, N.; Chianini, F.; Eraña, H.; Vidal, E.; Eaton, S.L.; Pintado, B.; Finlayson, J.; Dagleish, M.P.; Castilla, J.

2011

Article / De novo induction of amyloid-b deposition in vivo

Molecular Psychiatry

Rodrigo Morales, Claudia Duran-Aniotz, Joaquín Castilla, Lisbell D. Estrada and Claudio Soto

Article / Priones, más de 200 años de historia

Revista de la SEV

Natalia Fernández Borges y Joaquín Castilla

Article / Replicación in vitro de priones. A por la prueba definitiva

CIC Network

Joaquín Castilla

Article / Detection of PrPres in genetically susceptible fetuses from sheep with natural scrapie

PLoS ONE

Garza, M.C.; Fernández-Borges, N.; Bolea, R.; Badiola, J.J.; Castilla, J.; Monleón, E.

Article / Ultra-efficient PrP Sc amplification highlights potentialities and pitfalls of PMCA technology

PLoS Pathogens

Cosseddu, G.M.; Nonno, R.; Vaccari, G.; Bucalossi, C.; Fernandez-Borges, N.; Bari, M.A.; Castilla, J.; Agrimi, U.

Short Survey / Lipids, a missing link in prion propagation

Chemistry and Biology

Castilla, J.; Goñi, F.M.

2010

Article / Mesa redonda: "Un mundo libre de infeccionesâ€.

CIC Network

Joaquín Castilla, Emilio Bouza, José Luis Nieva y Daniel Zulaika

Article / Diálogos científicos con Angelika Schnieke â€œEn un futuro llegaremos a trasplantar órganos de animalesâ€

CIC Network

Joaquín Castilla

Article / Veredicto final: Sólo proteína

Virología (SEV)

Joaquín Castilla

Article / PMCA. A decade of in vitro prion replication

Current Chemical Biology

Fernández-Borges, N.; Castilla, J.

Article / A molecular switch controls interspecies prion disease transmission in mice

Journal of Clinical Investigation

Sigurdson, C.J.; Nilsson, K.P.R.; Hornemann, S.; Manco, G.; Fernández-Borges, N.; Schwarz, P.; Castilla, J.; Wüthrich, K.; Aguzzi, A.

Article / Prion strain mutation determined by prion protein conformational compatibility and primary structure

Science

Angers, R.C.; Kang, H.E.; Napier, D.; Browning, S.; Seward, T.; Mathiason, C.; Balachandran, A.; McKenzie, D.; Castilla, J.; Soto, C.; Jewell, J.; Graham, C.; Hoover, E.A.; Telling, G.C.

Article / Molecular cross talk between misfolded proteins in animal models of alzheimer's and prion diseases

Journal of Neuroscience

Morales, R.; Estrada, L.D.; Diaz-Espinoza, R.; Morales-Scheihing, D.; Jara, M.C.; Castilla, J.; Soto, C.

Estudio de la diversidad de variantes polimórficas de las proteínas del prion de cérvidos, su capacidad de malplegamiento e influencia sobre la emergencia de cepas con características distintivas

UPV-EHU

Carlos Miguel Díaz-Domínguez - Finished

Estudio de la diversidad y estabilidad de diferentes priones recombinantes infecciosos para dilucidar los mecanismos moleculares que rigen el fenómeno de cepa

UPV-EHU

Rafael López Moreno - Finished

Generación de distintas cepas de priones recombinantes como herramienta para el estudio del malplegamiento espontáneo en las enfermedades priónicas

UPV-EHU

Miguel Ángel Pérez Castro - Finished

Adaptación de un sistema de propagación de priones in vitro para el cribado masivo de compuestos específicos frente a las Encefalopatías Espongiformes Transmisibles humanas

UPV-EHU

Ezequiel González Marina - Finished

Estudio de la uroporfirina I como aproximación terapéutica frente a las encefalopatías espongiformes transmisibles

UPV-EHU

Sandra García Martínez - Finished

Desarrollo de un nuevo sistema de cribado masivo basado en la propagación in vitro de priones recombinantes infecciosos para la detección de compuestos con actividad anti-priónica

UPV - EHU

Jorge Moreno Charco - Finished

Influencia de la región N-terminal de la proteína del prion en la susceptibilidad al malplegamiento, mantenimiento de las características de cepa y neurotoxicidad

UPV - EHU

Vanessa Venegas García - Finished

Desarrollo de líneas celulares competentes para la replicación de priones humanos mediante la reprogramación de fibroblastos de pacientes genéticamente susceptibles

UPV-EHU

Lucía Mayela Gayosso Miranda - Finished

Estudio de la susceptibilidad/resistencia del ganado ovino a la infección por priones utilizando modelos de amplificación in vitro

UPV-EHU

Chafik Harrathi - Finished

Estudio de los determinantes moleculares que modulan la resistencia del conejo a la infección por priones utilizando un modelo de propagación in vitro

UPV-EHU

Hasier Eraña Lasagabaster - Finished

Priones recombinantes. Una novedosa estrategia para el estudio de las encefalopatías espongiformes transmisibles

UPV-EHU

Saioa Rodríguez Elezgarai - Finished

2022

Estudio del efecto de las octarepeticiones sobre el malplegamiento espontáneo

UPV-EHU

Desarrollo de una terapia frente a las Enfermedades priónicas basadas en la expresión de proteínas dominantes negativas

UPV-EHU

2020

Estudio del malplegamiento espontáneo in vitro mediado por cofactores basados en estructuras glucídicas

UPV-EHU

2017

Determinación in vitro de los residuos aminoacídicos clave en la barrera de transmisión interespecie entre cérvido y humano en la enfermedad crónica debilitante

UPV-EHU

2016

Efecto del aminoácido 108 de la proteína del prion de ratón y otras especies de mamífero en su capacidad de malplegamiento espontáneo

UPV-EHU

2010

Búsqueda de una PrP dominante negativa humana mediante estudios de replicación in vitro

UPV-EHU

2011

Conferencia invitada - MÃ¡ster en Neurociencias (UPV) - Mal plegamiento proteico: de los priones a otras enfermedades neurodegenerativas

Conferencia invitada - IBMCP - ReplicacioÌn in vitro de priones. FenoÌmenos de infectividad, cepa y barrera de transmisioÌn

Conferencia invitada - Istituto di Ricerche Farmacologiche Mario Negri - In vitro prion replication. Infectivity, strain and transmission barrier phenomena

Conferencia invitada - Institut National de la Research Agronomique (INRA) - In vitro prion replication. Infectivity, strain and transmission barrier phenomena

Conferencia invitada - CIC biomaGUNE (Christmas lecture) - Prions: Minimalist pathogenic agents with maximum complexity

Conferencia invitada (Clausura) - XI Congreso Nacional de VirologÃa - Priones. Dualidad entre una irreductible simplicidad y una compleja estructura

2010

Curso de encefalopatÃas espongiformes transmisibles (Universidad de Zaragoza)

Conferencia invitada - Unidad de BiofÃsica (UPV) - In vitro prion replication. Infectivity, strain and transmission barrier phenomena

Conferencia invitada - Hospital de Cruces - In vitro prion replication. Infectivity, strain and transmission barrier phenomena

Conferencia invitada - Centro Andaluz de BiologÃa del Desarrollo - In vitro prion replication. Infectivity, strain and transmission barrier phenomena

Conferencia invitada - Neuroprion 2010 - In vitro studies for evaluating prion transmission between species

Conferencia invitada - Ciclo de seminarios en VirologÃa Veterinaria del CISA - In vitro prion replication. Infectivity, strain and transmission barrier phenomena

Conferencia invitada - Centro Nacional de BiotecnologÃa (CNB) - In vitro prion replication. Infectivity, strain and transmission barrier phenomena

2019

Oral presentation | Estrategia de Especialización Inteligente RIS3 Euskadi. Plataforma de recursos de investigación en Enfermedades raras en Euskai (IKERR)

VIII Jornada científica sobre Enfermedades raras en Euskadi - Oral presentation

Joaquín Castilla

Oral presentation | A Structural Insight of Infectious Recombinant PrPSc Using FTIR

II CiMUS Annual Workshop - Oral presentation

Yaiza Bugallo-Codeseira, Phillip Pinder, Sonia Veiga, Hasier Eraña, Joaquín Castilla, Michael Beekes, Jesús R. Requena

Oral presentation | TgShM112I mouse, a unique model for a spontaneous, transmissible and atypical ovine prion disease

8th Iberian Prion Congress - Oral presentation

Enric Vidal, Manuel Sánchez-Martín, Sierra Espinar, Hasier Eraña, Jorge M Charco, Miguel A Pérez-Castro, Rafael López-Moreno, Montse Ordóñez, Claudia D’Agostino, Michele A Di Bari, Juan M Torres, Vincent Béringue, Rosa Bolea, Jesús R Requena, Olivier Andr

Oral presentation | A largely scalable new method to produce infectious recombinant prions

8th Iberian Prion Congress - Oral presentation

Hasier Eraña, Jorge M Charco, Michele A Di Bari, Carlos M Díaz-Domínguez, Rafael López-Moreno, Enric Vidal, Ezequiel González-Miranda, Miguel A Pérez-Castro, Sandra García-Martínez, Susana Bravo, Natalia Fernández-Borges, Mariví Geijo, Claudia D Agostino,

Poster presentation | RT-QuIC as an antemortem diagnostic tool to detect chronic wasting disease in deer skin

Prion 2019 - Poster presentation

Natália C. Ferreira, Jorge M. Charco, Michael A. Metrick, Christina D. Orrú, Andrew G. Hughsona, Joaquín Castilla, Michael W. Miller and Byron Caughey

Poster presentation | A First Glimpse of Infectious Recombinant PrPSc Using Solid State NMR

Prion 2019 - Poster presentation

Manuel Martín-Pastor, Hasier Eraña, Giovanni Spagnolli, Ezequiel Fernández-Miranda, Jorge M. Charco, Susana Bravo, Sonia Veiga, Emiliano Biasini, Víctor Sánchez-Pedregal, Joaquín Castilla, Jesús R. Requena

Poster presentation | Un modelo murino transgénico de scrapie atípico

XXXI Reunión de las Sociedad Española de Anatomía Patológica Veterinaria (SEAPV) - Poster presentation

Vidal, E.; Blasco, E.; Sánchez-Martín, M.; Ordóñez, M.; Eraña, H.; Espinar, S.; Charco, J.M.; Méndez, L.; Fondevila, D.; Pumarola, M. y Castilla, J

Poster presentation | Generating models for the study of Congenital Erythropoietic Porphyria using CRISPR/Cas9

The International Congress on Porphyins and Porphyrias - Poster presentation

Immacolata Giordano, Pedro Urquiza, Joaquín Castilla, Óscar Millet, Rosa Barrio and James Sutherland

Poster presentation | Conversion disorder in a possible carrier of fatal familial insomnia

5th Congress of the European Academy of Neurology - Poster presentation

I. Kortazar Zubizarreta, J. Castilla, R. Sánchez-Valle, G. Gónzalez Chincon

Poster presentation | Dogs are resistant to prion infection. Amino acid in position 163 key of such extreme resistance

8th Iberian Prion Congress - Poster presentation

Hasier Eraña, Enric Vidal, Natalia Fernández-Borges, Beatriz Parra, Belén Pintado, Manuel Sánchez-Martín, Jorge M Charco, Montserrat Ordoñez, Miguel A Pérez-Castro, Martí Pumarola, Candace K Mathiason, Tomás Mayoral and Joaquín Castilla

Poster presentation | The impossibility to induce misfolding of chicken PrP suggests that prion diseases may be restricted to mammals

8th Iberian Prion Congress - Poster presentation

Hasier Eraña, Natalia Fernández-Borges, Alicia Otero, Cassard Hervé, Carlos Hedman, Ezequiel González-Miranda, Manuel Sánchez-Martín, Carlos M Díaz-Domínguez, Enric Vidal, Tomás Barrio, Beatriz Parra, Belén Marín, Tomás Mayoral, Juan J Badiola, Rosa Bolea

Poster presentation | Removal of PrPC-attached glycans favors the propagation and transmission of human strains with atypical characteristics

8th Iberian Prion Congress - Poster presentation

Tomás Barrio, Alicia Otero, Hasier Eraña, Jorge M. Charco, Belén Marín, Ezequiel González-Miranda, Qhinzhong Kong, Juan J. Badiola, Rosa Bolea and Joaquín Castilla

2018

Invited talk | Shaken, not sonicated: A strategy to generate large amounts of recombinant bona fide prions for definitive structural studies

Prion 2018 Congress - Invited talk

Hasier Eraña, Jorge M. Charco, Sandra García-Martínez, Rafael López-Moreno, Ezequiel González-Miranda, Miguel Á. Pérez-Castro, Natalia Fernández-Borges, Michele A. Di Bari, Enric Vidal, Jifeng Bian, Haohong Pei, Boran Uluca, Glenn C. Telling, Romolo Nonno

Invited talk | Experimental studies on prion transmission barrier and TSE pathogenesis in large animals

Prion 2018 Congress - Invited talk

Rosa Bolea, Acín C, Marín B, Hedman C, Raksa H, Barrio T, Otero A, López-Pérez O, Monleón E,Martín-Burriel, Monzón M, Garza MC, Filali H,Pitarch JL, Garcés M, Betancor M, GuijarroI M, García M, Moreno B,Vargas A, Vidal E, Pumarola M, Castilla J, Andréolet

Oral presentation | Structural insights from limited proteolysis of two unusual prions

7th Iberian Prion Congress - Oral presentation

Bugallo Y, Shinde K, Bouloukou E, Arce L, Spagnolli G, Eraña H, Telling G, Biasini E, Wille H, Castilla J and Requena JR

Oral presentation | A transgenic mouse model of spontaneous prion disease in sheep

7th Iberian Prion Congress - Oral presentation

Vidal E, Sánchez-Martín M, Ordóñez M, Eraña H, Espinar S, Charco JM, López-Moreno R, Pérez-Castro MA, Méndez L, Pumarola M and Castilla J

Oral presentation | Development of a new HTS system based on the in vitro propagation of recombinant infectious prions for the detection of compounds with anti-prion activity

7th Iberian Prion Congress - Oral presentation

Charco JM, Eraña H, García-Martínez S, González-Miranda E, Pérez-Castro MA, López-Moreno R, Piñeiro P, Shinde KD, Vidal E, Ferreira NC, Fernández-Borges N, Caughey B, Geijó M, Garrido J, Requena JR and Castilla J

Oral presentation | How to manage infectious prions

1st Basque Microbiology Meeting - Oral presentation

Hasier Eraña, Jorge M. Charco, Sandra García-Martínez, Rafael López-Moreno, Ezequiel González-Miranda, Miguel Ángel Pérez-Castro, Carlos Díaz-Domínguez and Joaquín Castilla

Oral presentation | Plegamiento anómalo de proteínas y mecanismo tipo prion en sinucleinopatías

ISAS 2018, II Simposio Internacional sobre Alfa-Sinucleína - Oral presentation

Joaquín Castilla

Poster presentation | New PMCA-based HTS system that uses recombinant infectious prions to detect anti-prion compounds

Prion 2018 Congress - Poster presentation

Jorge M. Charco, Hasier Eraña, Sandra García-Martínez, Ezequiel González-Miranda, Miguel Ángel Pérez-Castro, Rafael López-Moreno, Keshav D. Shinde, Enric Vidal, Natalia Fernández-Borges, Jesús R. Requena and Joaquín Castilla

Poster presentation | Transmission of rare genetic prion disease with 6OPRI to humanized mice

Prion 2018 Congress - Poster presentation

Barrio T, Otero A, Eraña H, Betancor M, Marín B, Charco JM, Monzón M, Acín C, Zou WQ, Badiola JJ, Bolea R, Castilla J

Poster presentation | Characterization of the transmission properties of in vitro generated FFI and CJD178 mouse prions

Prion 2018 Congress - Poster presentation

Masone A, Comerio L, Fernandez-Borges N, Castilla J and Chiesa R

Poster presentation | Glycans are not necessary to maintain the pathobiological features of classical BSE

Prion 2018 Congress - Poster presentation

Otero A, Barrio T, Eraña H, Charco JM, Fernández-Borges N, Marín B, Betancor M, Kong Q, Garza MC, Monzón M, Monleón E, Badiola JJ, Bolea R and Castilla J

Poster presentation | Evaluation of miRNA levels and infectivity of exosomes from plasma and cerebrospinal fluid in ovine scrapie

Prion 2018 Congress - Poster presentation

López-Pérez O, Bolea R, Sanz-Rubio D, Gómez-Redrano S, Otero A, Eraña H, Castilla J, Andreoletti O, Badiola JJ, Toivonen JM, Martín-Burriel I

Poster presentation | A spontaneous misfolding-associated polymorphism in ovine PRNP(M112I) renders ShTg mice highly susceptible to atypical scrapie

Prion 2018 Congress - Poster presentation

Vidal E, Sánchez-Martín M, Ordóñez M, Eraña H, Charco JM, Méndez L, Pumarola M and Castilla J

Poster presentation | Detection of amyloid fibrils using plasmonic chirality

Prion 2018 Congress - Poster presentation

Eraña H, Kumar J, López-Martínez E, Claes N, Martín VF, Solís DM, Bals S, Cortajarena AL, Castilla J, and Liz-Marzán LM

Poster presentation | Detection of amyloid fibrils using plasmonic chirality

Neurogune 2018 - Poster presentation

Eraña H, Kumar J, López-Martínez E, Claes N, Martín VF, Solís DM, Bals S, Cortajarena AL, Castilla J, and Liz-Marzán LM

2017

Invited talk | Priones y enfermedades tipo prión. El mismo mecanismo de propagación es suficiente para considerarlas infecciosas?

LXIX Reunión Anual de la Sociedad Española de Neurología - Invited talk

Joaquín Castilla

Oral presentation | The infectivity of atypical PrPSc is not affected by protease K treatment

6th Iberian Congress on Prions - Oral presentation

Vanni I, Pirisinu L, Marcon S, Di Bari MA, D’Agostino C, Castilla J, Gambetti P, Agrimi U, Nonno R

Oral presentation | Studying the role of PrPC glycosylation in the strain properties and the pathobiological features of BSE

6th Iberian Congress on Prions - Oral presentation

Tomás Barrio, Alicia Otero, Hasier Eraña, Jorge M. Charco, Natalia Fernández-Borges, Belén Marín, Qingzhong Kong, Marta Monzón, Rosa Bolea, Juan José Badiola, Joaquín Castilla

Oral presentation | Generation of a variety of different infectious recombinant prion strains

6th Iberian Congress on Prions - Oral presentation

Hasier Eraña, Natalia Fernández-Borges, Michele A Di Bari, Manuel A Sánchez-Martín, Laura Pirisinu, Beatriz Parra, Saioa R Elezgarai, Ilaria Vanni, Rafael López-Moreno, Gabriele Vaccari, Vanessa Venegas, Jorge M Charco, David Gil, Chafik Harrathi, Claudia

Poster presentation | Identifying novel anti-prion compounds by targeting the cellular prion protein

Neuroprion congress - Poster presentation

Elezgarai SR, Iglesias A, Veiga S, Moreno J, Massignan T, Eraña H, Luotti S, Bonetto V, Barreca ML, Castilla J, Dominguez E, Requena JR and Biasini E

Poster presentation | Prion strain polymorphic inter-conversion by PMCA

Neuroprion congress - Poster presentation

Kramm, C., Bravo-Alegría J., Castilla, J., Langeveld, J.P., Soto, C., Morales, R.

Poster presentation | Pathogenic prion isoforms are linked with the different types of advanced glycation end products

Neuroprion congress - Poster presentation

Yeong-Gon Choi, Jae-Il Kim, Eun-Kyoung Choi, Joaquin Castilla, Yong-Sun Kim

Poster presentation | The role of glycans in the strain properties and the pathobiological features of BSE

Neuroprion congress - Poster presentation

Barrio T, Otero A, Eraña H, Moreno J, Fernández-Borges N, Marín B, Kong Q, Monzón M, Bolea R, Badiola J, Castilla J

Poster presentation | Atypical PrPSc retains high infectivity after protease K treatment

Neuroprion congress - Poster presentation

Vanni I, Pirisinu L, Marcon S, Di Bari MA, D’Agostino C, Castilla J, Gambetti P, Agrimi U, Nonno R

Poster presentation | Testing ovine PRNP genotypes resistance to scrapie based on recombinant

Neuroprion congress - Poster presentation

María Jesús Cano, Dolores Hurtado, Beatriz Parra, Natalia Fernández-Borges, Enrique Anadón, Joaquín Castilla, Tomás Mayoral

Poster presentation | Studying the role of the PrP amino-terminal region in misfolding proneness, strain-like features selection and neurotoxicity

6th Iberian Congress on Prions - Poster presentation

Venegas V, Eraña H, Fernández-Borges N, Sánchez-Martín M, Vidal E, Gil D, Pintado B, Requena JR and Castilla J

2016

Invited talk | Priones y enfermedades tipo prión. En busca de un sitio en el grupo de enfermedades infecciosas

LXVIII Reunión Anual de la Sociedad Española de Neurología - Invited talk

Joaquín Castilla

Oral presentation | Studying the effect of glycosylation in the pathobiological features of BSE

5th Iberian Congress on Prions - Oral presentation

Barrio T, Otero A, Eraña H, Moreno J, Fernández-Borges N, Marín B, Kong Q, Monzón M, Bolea R, Badiola JJ, Castilla J

Oral presentation | Infectious recombinant prions: in vitro generation and propagation of different strains

5th Iberian Congress on Prions - Oral presentation

Castilla J, Fernández-Borges N, Di Bari MA, Eraña H, Sánchez-Martín MA, Elezgarai S, Parra B, Pirisinu L, Harrathi C, Vidal E, Vázquez-Fernández E, Gil D, Agrimi U, Mayoral T, Requena JR and Nonno R

Poster presentation | Effect of substitutions equivalent to bank vole 109I polymorphism in the spontaneous misfolding ability of PrPs from several mammalian species

Neuroprion congress - Poster presentation

Hasier Eraña, Natalia Fernández-Borges, Vanessa Venegas, Jorge Moreno, Michele Angelo Di Bari, Enric Vidal, Alejandro Sevillano, Saioa R. Elezgarai, Juan Carlos Espinosa, Chafik Harrathi, Juan María Torres, Umberto Agrimi, Jesus R. Requena, Romolo Nonno a

Poster presentation | Post-translational modifications in the prion protein determine disease outcome

Neuroprion congress - Poster presentation

Christina Sigurdson, Patricia Aguilar-Calvo, Cyrus Bet, Hasier Eraña, Peter Nilsson, Katrin Soldau, Joaquín Castilla and Witold Surewicz

Poster presentation | A comprehensive study of the potential resistance of the canidae family to prion

Neuroprion congress - Poster presentation

Natalia Fernández-Borges, Beatriz Parra, Manuel Sánchez-Martín, Enric Vidal, Jorge de Castro, Pedro Fernández-Fúnez, Diego E. Rincón-Limas, Martí Pumarola, Tomás Mayoral and Joaquín Castilla

Poster presentation | A new model of spontaneous bovine prion disease

5th Iberian Congress on Prions - Poster presentation

Sánchez M, Vidal E, Ordóñez M, Eraña H, Fernández-Borges N, Harrathi C, Venegas V, Moreno J, Pumarola M and Castilla J

Poster presentation | Identification of pharmacological chaperones for the celular prion protein employing dynamic mass redistribution

5th Iberian Congress on Prions - Poster presentation

Elezgarai SR, Iglesias A, Luotti S, Veiga S, Moreno J, Eraña H, Bonetto V, Castilla J, Barreca ML, Domínguez E, Requena JR and Biasini E

Poster presentation | Studying the role of the PrP amino-terminal region in misfolding proneness and neurotoxicity

5th Iberian Congress on Prions - Poster presentation

Venegas V, Eraña H, Fernández-Borges N, Sánchez-Martín M, Vidal E, Gil D, Pintado B, Requena JR and Castilla J

Poster presentation | iPS cell cultures from a Gerstmann-Sträussler-Scheinker patient with the Y218N PRNP mutation recapitulate Tau pathology

5th Iberian Congress on Prions - Poster presentation

Matamoros-Angles A, Mayela Gayosso L, Richaud-Patin Y4, di Domenico A, Vergara C, Hervera A, Sousa A, Fernández-Borges N, Consiglio A, Gavín R, Lopez de Maturana R, Ferrer I, López de Munain A, Raya A, Castilla J, Sánchez-Pernaute R and del Río JA

Poster presentation | Identification of pharmacological chaperones for the cellular prion protein by dynamic mass redistribution screening

VIII Spanish Drug Discovery Network Meeting - Poster presentation

González-García A, Elezgarai SR, Veiga S, Bonetto V, Barreca ML, Moreno J, García S, Eraña H, Castilla J, Loza M, Biasini E, Domínguez E and Requena JR

2015

Invited talk | Preliminary study of infectivity in peripheral tissues from a transgenic model of spontaneous prion disease

Neuroprion congress - Invited talk

Pirisinu L., Di Bari M., D’Agostino C., Marcon S., Riccardi G., Fernández-Borges N., Sánchez-Martín M., Castilla J., Agrimi U. and Nonno R.

Invited talk | The architecture of recombinant prions is similar to that of brain-derived prions: insights from limited proteolysis

Neuroprion congress - Invited talk

Alejandro Sevillano, Natalia Fernández-Borges, Neelam Younas, Ester Vázquez-Fernández, Romolo Nonno, Joaquín Castilla and Jesús R. Requena

Invited talk | Key steric zipper segments govern conversion by mouse and elk prions

Neuroprion congress - Invited talk

Timothy D Kurt, Lin Jiang, Hasier Eraña, Jun Liu, Joaquín Castilla, David Eisenberg and Christina J Sigurdson

Invited talk | Infectious recombinant prions: in vitro generation and propagation of different strains

Neuroprion congress - Invited talk

Joaquín Castilla

Oral presentation | The architecture of recombinant prions is similar to that of brain-derived prions. Insight from limited proteolysis

4th Iberian Congress on Prions - Oral presentation

Alejandro M. Sevillano, Natalia Fernández-Borges, Neelam Younas, Susana Bravo, Ester Vázquez-Fernández, Saioa R. Elezgarai, Isaac Rosa, Hasier Eraña, Enric Vidal, Romolo Nonno, Joaquín Castilla, Jesús R. Requena

Oral presentation | A comprehensive study of the potential resistance of the canidae family to prion infection

4th Iberian Congress on Prions - Oral presentation

Fernández-Borges, N, Parra, B, Elezgarai, SR, Sánchez-Martín, M, Vidal, E, de Castro, J, Torres, JM, Espinosa JC, Fernández-Fúnez, P, Rincón-Limas, DE, Pumarola, M, Mayoral, T, Castilla, J.

Oral presentation | Effects of N158D canine substitution on prion infected mice

4th Iberian Congress on Prions - Oral presentation

Otero A, Hedman C, Bolea R, Fernández-Borges N, Marín B, López-Pérez O, Barrio T, Sánchez-Martín M, Monzón M, Badiola JJ, Castilla J

Oral presentation | Infectious recombinant prions: in vitro generation and propagation of different strains

4th Iberian Congress on Prions - Oral presentation

Castilla J, Di Bari MA, Sánchez-Martín MA, Eraña H, Vidal E, Elezgarai SR, Gil D, Harrathi C, Venegas V, Moreno J, Vázquez-Fernández E, Parra B, Espinosa JC, Surewicz W, Torres JM, Mayoral T, Agrimi U, Requena JR, Nonno R and Fernández-Borges N.

Poster presentation | Efecto protector de la sustitución canina N158D en ratones infectados con enfermedades priónicas

XXVI Reunión de SEAPV - Poster presentation

Otero A, Hedman C, Marín B, Fernández-Borges N, López-Pérez O, Barrio T, Sánchez-Martín M, Monzón M, Bolea R, Badiola JJ, Castilla J

Poster presentation | Infectious recombinant prions: in vitro generation and propagation of different strains

Neuroprion congress - Poster presentation

Fernández-Borges N, Di Bari MA. Sánchez-Martín MA, Eraña H, Vidal E, Venegas, V, Sevillano, AM, Elezgarai SR, Pirisinu L, Vázquez-Fernández E, Harrathi C, Parra B, D'Agostino C, Espinosa JC, Surewicz W, Torres JM, Mayoral T, Agrimi U. Requena JR, Nonno R

Poster presentation | Non-adaptive prion amplification (NAPA): Interspecies prion propagation liberated from the constraints of speciesspecific PrP primary structure

Neuroprion congress - Poster presentation

Jifeng Bian, Vadim Khaychuk, Jason Bartz, Joaquín Castilla, Sehun Kim and Glenn Telling

2014

Invited talk | Prion and prion-like diseases. Looking for their niche in the realm of infectious diseases

XIIIth International Nidovirus Symposium - Invited talk

Joaquín Castilla

Invited talk | Generation of a new mouse model showing fast, spontaneous and highly transmissible prion disease

The Twelfth Annual CJD Foundation Family Conference - Invited talk

Joaquín Castilla

Oral presentation | Generation of a new mouse model showing fast, spontaneous and highly transmissible prion disease

Neuroprion congress - Oral presentation

Natalia Fernández-Borges, Hasier Eraña, María V Geijo, Belén Pintado, Alejandro Sevillano, Enric Vidal, Saioa R Elezgarai, Chafik Harrathi, Juan Rodríguez, Manuel A Sánchez-Martín, Olivier Andrèoletti, Jesús R Requena, Ramón A Juste and Joaquín Castilla

Oral presentation | A proposed mechanism for the promotion of prion conversion involving a strictly conserved tyrosine residue in the ?2-?2 loop of PrPC

Neuroprion congress - Oral presentation

Timothy D Kurt, Cyrus Bett, Natalia Fernández-Borges, Lin Jiang, Shivanjali Joshi-Barr, Simone Hornemann, Thomas Rülicke, David Eisenberg, Joaquín Castilla, Kurt Wüthrich, Adriano Aguzzi and Christina J Sigurdson

Oral presentation | Effects if N159D mutation on prion transmission in mice

III Iberian Prion Congress - Oral presentation

Otero A, Hedman C, Fernández-Borges N, López-Pérez O, Barrio T, Filali H, Sánchez-Martín M, Monzón M, Badiola JJ, Bolea R and Castilla J

Oral presentation | Infectious recombinant prions: in vitro generation and propagation of different strains

III Iberian Prion Congress - Oral presentation

Fernández-Borges N, Di Bari MA, Sánchez-Martín MA, Eraña H, Vidal E, Elezgarai SR, Gil D, Vázquez-Fernández E, Harrathi C, Parra B, Espinosa JC, Surewicz W, Torres JM, Mayoral T, Agrimi U, Requena JR, Nonno R, Castilla J

Oral presentation | Experimental in vivo evidence of rabbit interspecies prion strain vulnerability

III Iberian Prion Congress - Oral presentation

Vidal, E., Fernández-Borges, N., Pintado, B., Eraña, H., Ordóñez, M., Márquez, M., Chianini, F., Fondevilla, D., Sánchaz-Martín, MA., Andreoletti, O., Dagleish, MP., Pumarola, M. and Castilla, J

Poster presentation | Transgenic Fatal Familial Insomnia Mice Indicate Prion-independent Mechanisms of Pathogenesis and Phenotypic Expression of Disease. Neuroprion congress

Neuroprion congress - Poster presentation

Ihssane Bouybayoune, Susanna Mantovani, Federico del Gallo, Ilaria Bertani, Laura Tapella, Liliana Comerio, Elena Restelli, Susanna Bianchi, Natalia Fernández-Borges, Michela Mangieri, Cinzia Bisighini, Galina Beznusenko, Alessandra Paladini, Claudia Bald

Poster presentation | Transgenic mice expressing the CJD178 and FFI mutatins do not develop spontaneous prion infectivity

Neuroprion congress - Poster presentation

Liliana Comerio, Laura Tapella, Natalia Fernández-Borges, Ihssane Bouybayoune, Susanna Mantovani, Ilaria Bertani, Joaquín Castilla and Roberto Chiesa

Poster presentation | Characterization mesenchymal stem cells obtained from peripheral blood and bone marrow of naturally infected sheep with classical scrapie

Neuroprion congress - Poster presentation

Diego R Mediano, David Sanz, Ana R Remacha, Francisco Vázquez, Belén Marín, Natalia Fernández-Borges, Joaquín Castilla, Juan José Badiola, Pilar Zaragoza, Clementina Rodellar, Rosa Bolea and Inmaculada Martín-Burriel

Poster presentation | Transgenic mice overexpressing rabbit prion protein are susceptible to BSE, BASE and scrapie prion strains but resistant to CWD and atypical scrapie

Neuroprion congress - Poster presentation

Natalia Fernández-Borges, Enric Vidal, Belén Pintado, Hasier Eraña, Montserrat Ordoñez, Mercedes Márquez, Francesca Chianini, Dolors Fondevila, Manuel A Sánchez-Martín, Olivier Andrèoletti, Mark P Dagleish, Martí Pumarola and Joaquín Castilla

Poster presentation | Transgenic mice expressing bank vole prion protein spontaneously produce transmissible prions indistinguishable from an inherited human prion disease

Neuroprion congress - Poster presentation

Romolo Nonno, Laura Pirisinu, Michele A Di Bari, Natalia Fernández-Borges, Manuel A Sánchez-Martín, Enric Vidal, Claudia D´Agostino, Stefano Marcon, Geraldina Riccardi, Pierluigi Gambetti, Joaquín Castilla and Umberto Agrimi

Poster presentation | Detección de la proteína prión en placentas procedentes de fetos que presentan el haplotipo ARK

XXVI Congreso de la SEAPV - Poster presentation

Garza MC, Castilla J, Acín C, Marín B, Badiola JJ, Monleón E.

Poster presentation | Characterization of autologous mesenchymal stem cells in sheep naturally infected with scrapie, a natural animal model of prion diseases

III Iberian Prion Congress - Poster presentation

Mediano, D., Sanz-Rubio, D., Vázquez, F., Marín, B., Fernández-Borges, N., Castilla, J., Badiola, JJ., Zaragoza, P., Bolea, R. and Martín-Burriel, I

Poster presentation | Generation of a new spontaneous prion mouse model shwoing a reduced PrPSc neurotoxicity

III Iberian Prion Congress - Poster presentation

Venegas-García V, Fernández-Borges N, Eraña H, Sánchez-Martín M, Vidal E, Pintado B, Requena J and Castilla J

Poster presentation | Characterization of the cellular prion protein in human neurons derived from pluripotent stem cells and in induced neurons

Neurogune - Poster presentation

Gayosso L., López de Maturana R., Giorgetti A., López de Munain A., Castilla J. and Sánchez-Pernaute R.

2013

Oral presentation | Highly infectious recombinant prions. A new challenge for understanding how prions work

6th ELETTRA-SISSA Workshop - Oral presentation

Joaquín Castilla

Oral presentation | Deciphering the molecular mechanisms involved in rabbit resistance to prions: search of the key amino acids by in vitro replication techniques

XII Congreso Nacional de Virología - Oral presentation

H. Eraña, N. Fernández-Borges, S. R. Elezgarai, S. Veiga, E. Vázquez, C. Harrathi, G. Ortega, M. Gayosso-Miranda, O.Millet, W. Surewicz, J.R. Requena and J. Castilla

Oral presentation | Developing and testing new models for studying current and future therapies

CJD 2013 and the Eleventh Annual CJD Foundation Family Conference - Oral presentation

Joaquín Castilla

Oral presentation | Recombinant prions. A new method for studying prions

Asian Pacific Prion Symposium - Oral presentation

Joaquín Castilla, Saioa Rodríguez-Elezgarai, Hasier Eraña, Ester Vázquez-Fernández, Beatriz Parra, Chafik Harrathi, Mayela Gayosso-Miranda, Jana Alonso, Michele Angelo Di Bari, Manuel A. Sánchez-Martín, Enric Vidal, Umberto Agrimi, Tomás Mayoral, Olivier

Oral presentation | Bexarotene as a possible drug for the treatment of prion disease

II Congreso ibérico de priones - Oral presentation

Alejandro Sevillano, Isabel Rodríguez Caamaño, Natalia Fernández-Borges, Manuel Sánchez Martín

Oral presentation | Towards gaining insight into the molecular mechanisms involved in rabbit low-susceptibility to prions by in vitro approaches

II Congreso ibérico de priones - Oral presentation

Hasier Eraña, Natalia Fernández-Borges, Saioa R. Elezgarai, Sonia Veiga, Enric Vidal, Ester Vázquez, Chafik Harrathi, Gabriel Ortega, Belén Pintado, Francesca Chianini, Mark P. Dagleish, Oscar Millet, Jesús R. Requena and Joaquín Castilla

Oral presentation | Generation of human recombinant prions. Model for understanding the Gerstmann–Sträussler–Scheinker syndrome

II Congreso ibérico de priones - Oral presentation

Saioa R. Elezgarai, Natalia Fernández-Borges, Hasier Eraña, Ester Vázquez, Chafik Harrathi, Sonia Veiga, Isidre Ferrer, Larisa Cervenakova, Paula Saá, Witold Surewicz, Qingzhong Kong, Olivier Andreoletti, Jesús R. Requena and Joaquín Castilla

Poster presentation | Aglycosylated recombinant prion protein inhibits prion propagation in vitro

Neuroprion congress - Poster presentation

Jue Yuan, Yi-An Zhan, Romany Abskharon, Xiangzhu Xiao, Manuel Camacho Martínez, Geoff Kneale, Mikol Jacqueline, Sylvain Lehmann, Joaquín Castilla, Qingzhong Kong, Robert B. Petersen, Alexandre Wohlkonig, Wen-Quan Zou

Poster presentation | Generation of human recombinant prions. Model for understanding the Gerstmann–Sträussler–Scheinker syndrome

XII Congreso Nacional de Virología - Poster presentation

S.R. Elezgarai, N. Fernández-Borges, H. Eraña, E. Vázquez, C. Harrati, S. Veiga, L. Cervenakova, P. Saá, W. Surewicz, O. Andreoletti, J.R. Requena and J. Castilla

Poster presentation | Generation of human recombinant prions. Model for understanding the Gerstmann–Sträussler–Scheinker syndrome

NeuroGUNE 2013 - Poster presentation

S.R. Elezgarai, N. Fernández-Borges, H. Eraña, E. Vázquez, C. Harrati and J. Castilla

Poster presentation | In vitro studies of the sheep-deer transmission barrier

II Congreso ibérico de priones - Poster presentation

Chafik Harrathi, Hasier Eraña, Natalia Fernández-Borges, Saioa R. Elezgarai, Sonia Veiga, Ester Vázquez, Juan Carlos Espinosa, Olivier Andreoletti, Juan María Torres, Jesús R. Requena and Joaquín Castilla

Poster presentation | Characterization of bone marrow derived mesenchymal stem cells obtained from scrapie sheep

II Congreso ibérico de priones - Poster presentation

Diego R. Mediano, David Sanz, Francisco Vázquez, Belén Marín, Natalia Fernández-Borges, Joaquín Castilla, Juan J Badiola, Pilar Zaragoza, Rosa Bolea, Martín-Burriel Inmaculada

Poster presentation | Study of prion resistance using a TSE resistant-associated mutant in transgenic mouse models

II Congreso ibérico de priones - Poster presentation

Otero A., Hedman C., Fernández-Borges N., López O., Filali H., Sánchez Martín M., Bolea R., Badiola JJ. and Castilla J.

2012

Oral presentation | Highly infectious recombinant prions: a new challenge for understanding how prions work

Neuroprion congress - Oral presentation

Joaquín Castilla, Natalia Fernández-Borges, Ester Vázquez-Fernández, Saioa Rodríguez-Elezgarai, Beatriz Parra, Jana Alonso, Michele Angelo Di Bari, Manuel A. Sánchez-Martín, Hasier Eraña, Chafik Harrathi, Mayela Gayosso-Miranda, Enric Vidal, Um

Oral presentation | A rationale design of a prion resistant animal model based on Nature observation

5th ELETTRA-SISSA Workshop - Oral presentation

Joaquín Castilla

Oral presentation | Recombinant prions. A new method for studying prions

I Congreso ibérico de priones - Oral presentation

Joaquín Castilla, Ester Vázquez-Fernández, Saioa Rodríguez-Elezgarai, Hasier Eraña, Beatriz Parra, Chafik Harrathi, Mayela Gayosso-Miranda, Jana Alonso, Michele Angelo Di Bari, Manuel A. Sánchez-Martín, Enric Vidal, Umberto Agrimi, Tomás Mayoral, Olivier

Poster presentation | A reasoned design of a prion resistant animal model based on observations of nature

Neuroprion congress - Poster presentation

Natalia Fernández-Borges, Beatriz Parra, Saioa Rodríguez-Elezgarai, Enric Vidal, Hasier Eraña, Chafik Harrathi, Mayela Gayosso-Miranda, Manuel Sánchez-Martín, Ester Vázquez, Martí Pumarola, Jesús Requena, Tomás Mayoral and Joaquín Castilla

Poster presentation | Shattering the myth of rabbit resistance to prion infection

Neuroprion congress - Poster presentation

N. Fernández-Borges, F. Chianini, E. Vidal, L. Gibbard, B. Pintado, J. de Castro, S.A. Priola, S. Hamilton, S.L. Eaton, J. Finlayson, Y. Pang, P. Steele, H.W. Reid, M.P. Dagleish and J. Castilla

Poster presentation | In vivo and in vitro studies of prion transmission barrier

Neuroprion congress - Poster presentation

Enric Vidal, Natalia Fernández-Borges, Mercedes Márquez, Juan M. torres, Martí Pumarola, Glenn Telling, Belén Pintado and Joaquín Castilla

2011

Invited talk | In vitro studies for evaluating prion transmission between species

Transmissible Spongiform Encephalopathies Conference - Invited talk

Joaquín Castilla

Invited talk | Priones. Dualidad entre una irreductible simplicidad y una compleja estructura

XI Congreso Nacional de Virología - Invited talk

Joaquín Castilla

Invited talk | Developing a prion susceptible human neuronal cell line based on reprogramming fibroblasts from CJD affected patients

CJD 2011 and the Ninth Annual CJD Foundation Family Conference - Invited talk

Joaquín Castilla

Invited talk | Mal plegamiento proteico en enfermedades neurológicas: de los priones a otras enfermedades neurodegenerativas

IV Simposium sobre transtornos cognitivos en la enfermedad de Parkinson - Invited talk

Joaquín Castilla

Invited talk | Mal plegamiento proteico en enfermedades neurológicas: de los priones a otras enfermedades neurodegenerativas

Simposium sobre trastornos cognitivos en la enfermedad de Parkinson - Invited talk

Joaquín Castilla

Oral presentation | In vivo and in vitro studies of prion transmission barrier

II Congreso Nacional de Priones - Oral presentation

Vidal E., Fernández-Borges N., Torres JM., Pumarola M., Telling G., Pintado B., Castilla J.

Oral presentation | Lessons from Nature: Prion resistant species and their mechanisms

II Congreso Nacional de Priones - Oral presentation

Natalia Fernández-Borges, Beatriz Parra, Saioa Rodríguez-Elezgarai, Enric Vidal, Manuel Sánchez Martí, Jorge de Castro, Ester Vázquez, Martí Pumarola, Jesús Requena, Tomás Mayoral and Joaquín Castilla

Poster presentation | Failure of prions from â€œrigid loopâ€ equine PrP transgenic mice to adapt across a species barrier

Neuroprion congress - Poster presentation

Jifeng Bian, Joaquín Castilla, Rachel Angers, Natalia Fernández-Borges, Glenn C. Telling

Poster presentation | Comparative study of BSE behavior in the boTg110 mice model after in vivo and in vitro passage through C57 and VM inbred mice

Neuroprion congress - Poster presentation

Vidal, E., Fernández-Borges, N., Fondevila, D., Torres, JM., Pumarola, M. and Castilla, J.

Poster presentation | Detection of PrPSc in fetal tissues from natural scrapie infected ewes

Neuroprion congress - Poster presentation

Garza MC., Fernández-Borges N., Acín C., Badiola JJ., Castilla J. and Monleón E.

Poster presentation | Prions in the Ocean: A Natural Case of Prion Disease in Dolphins

Neuroprion congress - Poster presentation

Manuel V. Camacho, Diego Morales-Schehing, Natalia Fernández-Borges, Joaquín Castilla, Daniel Cowan and Claudio Soto

Poster presentation | In vitro prion transmission studies. A switch to a recombinant PrPSc world

Neuroprion congress - Poster presentation

Natalia Fernández-Borges, Ester Vázquez-Fernández, Saioa Rodríguez-Elezgarai, Binbin Gong, Beatriz Parra, Jana Alonso, Manuel A. Sánchez-Martín, Hasier Eraña, Chafik Harrathi, Mayela Gayosso, Enric Vidal, Tomás Mayoral, Jesús R. Requena and Joaqu

Poster presentation | Landing in a new recombinant world

II Congreso Nacional de Priones - Poster presentation

Chafik Harrathi, Hasier Eraña, Saioa Rodríguez-Elezgarai, Ester Vázquez-Fernández, Natalia Fernández-Borges, Jesús R. Requena and Joaquín Castilla

2010

Oral presentation | In vitro studies for evaluating prion transmission between species

Neuroprion congress - Oral presentation

J. Castilla

Oral presentation | Are rabbits really resistant?

Neuroprion congress - Oral presentation

F. Chianini, N. Fernandez-Borges, L. Gibbard, J. de Castro, S. Priola, S.L. Eaton, J. Finlayson, Y. Pang, S. Hamilton, P. Steele, K. McNally, H.W. Reid, M.P. Dagleish and J. Castilla

Oral presentation | Studying the transmission barrier by in vitro prion replication

I Congreso Nacional de Priones - Oral presentation

J. Castilla

Oral presentation | Searching for Custom Dominant Negative PrPs by In Vitro Prion Replication Studies

The Eighth Annual CJD Foundation Family Conference - Oral presentation

J. Castilla

Poster presentation | Neuropathological and molecular characterization of rabbit in vitro adapted BSE upon inoculation in bovine PrP transgenic mouse model

Neuroprion congress - Poster presentation

Vidal E., Fernández-Borges N., Márquez M., Fondevila D., Torres J.M., Pintado B., Pumarola M. and Castilla J.

Poster presentation | Diferenciación de “cepas” priónicas mediante estudio histológico e inmunohistoquíco

I Congreso Nacional de Priones - Poster presentation

Vidal E., Estévez J., Brugnolaro C., Fernández-Borges N., Molin J., Marco P., Rabanal R.M., Fondevila D., Castilla J. y Pumarola M

Poster presentation | Neuropathological and molecular characterization of BSE prions amplified in vitro from rabbit normal brain homogenate upon intracerebral inoculation in a bovinised mouse model (BoTg110)

I Congreso Nacional de Priones - Poster presentation

Vidal E., Fernández-Borges N., Marquez M., Fondevila D., Torres J.M., Pintado B., Pumarola M. and Castilla J.

Poster presentation | Identification of prnp gene polymorphisms in Spanish sheep and their association with classical and/or atypical scrapie

I Congreso Nacional de Priones - Poster presentation

L. Hurtado, M. Hernández, C. LÃ²pez-Maroto, J. Castilla, E. Anadon and T. Mayoral

2009

Conference Paper | In vitro studies of the transmission barrier

Prion - Conference Paper

Fernández-Borges, N.; De Castro, J.; Castilla, J.

Oral presentation | Generation of new prion species by in vitro prion replication

Neuroprion congress - Oral presentation

Natalia Fernández-Borges, Francesca Chianini, Suzette A. Priola, Glenn Telling, Enric.Vidal, Jorge de Castro, Louise Gibbard, Rachel Angers, Hugh W. Reid, Kristin McNally, Scott Hamilton, Tanya Seward, Martí Pumarola, Mark P. Dagleish and Joaquín Ca

Poster presentation | Modulated conversion of PrPC into PrPSc in sheep by PMCA based on prnp genotype

Neuroprion congress - Poster presentation

T. Huélamo, J. Castilla, M.J. Nevado, M. Vigo, C. Gómez-Tejedor & T. Mayoral.

2005

Oral presentation | A Structural Insight of Infectious Recombinant PrPSc Using FTIR

8th Iberian Prion Congress - Oral presentation

Yaiza B Codeseira, Phillip Pinder, Sonia Veiga, Hasier Eraña, Joaquín Castilla, Michael Beekes and Jesús R Requena