Juan Anguita

Ikerbasque Research Professor, CIC bioGUNE

He leads the Macrophage and Tick Vaccine Lab at CIC bioGUNE.

Research line:

Proinflammatory signals in response to infectious agents. Macrophage function. Antimicrobials and Immunomodulators. Tick Immunity.

Postdoctoral Fellow at Yale U. School of Med. Assistant Professor at UNC Charlotte and UMass Amherst. Associate Professor at UMass Amherst from 2009.

Doctor in Animal Health from the Veterinary School of the University of León, Spain.

Publications
Congresses & Proceedings

2024

Article / An in vitro analysis of the interaction between infliximab and granulocyte–monocyte apheresis

Gastroenterologia y Hepatologia

Rodríguez-Lago, I.; Abecia, L.; Seoane, I.; Anguita, J.; Cabriada, J.L.

Article / Akkermansia muciniphila-induced trained immune phenotype increases bacterial intracellular survival and attenuates inflammation

Communications Biology

Peña-Cearra, A.; Palacios, A.; Pellon, A.; Castelo, J.; Pasco, S.T.; Seoane, I.; Barriales, D.; Martin, J.E.; Pascual-Itoiz, M.Á.; Gonzalez-Lopez, M.; Martín-Ruiz, I.; Macías-Cámara, N.; Gutiez, N.; Araujo-Aris, S.; Aransay, A.M.; Rodríguez, H.; Anguita, J.; Abecia, L.

Article / Novel TLR4-Activating Vaccine Adjuvant Enhances the Production of Enterococcus faecium-binding Antibodies

Journal of Medicinal Chemistry

Franco, A.R.; Sadones, O.; Romerio, A.; Artusa, V.; Shaik, M.M.; Pasco, S.T.; Italia, A.; D’Amato, S.; Anguita, J.; Huebner, J.; Romero-Saavedra, F.; Peri, F.

Article / Vibrational spectroscopy coupled with machine learning sheds light on the cellular effects induced by rationally designed TLR4 agonists

Talanta

Ami, D.; Franco, A.R.; Artusa, V.; Romerio, A.; Shaik, M.M.; Italia, A.; Anguita, J.; Pasco, S.; Mereghetti, P.; Peri, F.; Natalello, A.

Article / IFNAR(-/-) Mice Constitute a Suitable Animal Model for Epizootic Hemorrhagic Disease Virus Study and Vaccine Evaluation

International Journal of Biological Sciences

Jiménez-Cabello, L.; Utrilla-Trigo, S.; Benavides-Silván, J.; Anguita, J.; Calvo-Pinilla, E.; Ortego, J.

2023

Article / Immunization with a small fragment of the Schmallenberg virus nucleoprotein highly conserved across the Orthobunyaviruses of the Simbu serogroup reduces viremia in SBV challenged IFNAR-/- mice

Vaccine

Guerra, G.S.; Barriales, D.; Lorenzo, G.; Moreno, S.; Anguita, J.; Brun, A.; Abrescia, N.G.A.

Article / New Glucosamine-Based TLR4 Agonists: Design, Synthesis, Mechanism of Action, and In Vivo Activity as Vaccine Adjuvants

Journal of Medicinal Chemistry

Romerio, A.; Gotri, N.; Franco, A.R.; Artusa, V.; Shaik, M.M.; Pasco, S.T.; Atxabal, U.; Matamoros-Recio, A.; Mínguez-Toral, M.; Zalamea, J.D.; Franconetti, A.; Abrescia, N.G.A.; Jimenez-Barbero, J.; Anguita, J.; Martín-Santamaría, S.; Peri, F.

Article / Mitochondrial dysfunction promotes microbial composition that negatively impacts on ulcerative colitis development and progression

npj Biofilms and Microbiomes

Peña-Cearra, A.; Song, D.; Castelo, J.; Palacios, A.; Lavín, J.L.; Azkargorta, M.; Elortza, F.; Fuertes, M.; Pascual-Itoiz, M.A.; Barriales, D.; Martín-Ruiz, I.; Fullaondo, A.; Aransay, A.M.; Rodríguez, H.; Palm, N.W.; Anguita, J.; Abecia, L.

Article / Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology

Juárez-Fernández, M.; Goikoetxea-Usandizaga, N.; Porras, D.; García-Mediavilla, M.V.; Bravo, M.; Serrano-Maciá, M.; Simón, J.; Delgado, T.C.; Lachiondo-Ortega, S.; Martínez-Flórez, S.; Lorenzo, Ó.; Rincón, M.; Varela-Rey, M.; Abecia, L.; Rodríguez, H.; Anguita, J.; Nistal, E.; Martínez-Chantar, M.L.; Sánchez-Campos, S.

Article / The Ixodes ricinus salivary gland proteome during feeding and B. Afzelii infection: New avenues for an anti-tick vaccine

Vaccine

Klouwens, M.J.; Trentelman, J.J.A.; Barriales, D.; Ersoz, J.I.; Azkargorta, M.; Elortza, F.; Šíma, R.; Hajdušek, O.; Lavin, J.L.; Tomás Cortazar, J.; Escobes Corcuera, I.; Colstrup, E.; Nayak, A.; Martín Ruíz, I.; Rodriguez, H.; Nijhof, A.M.; Anguita, J.; Hovius, J.W.R.

Article / Development of synthetic, self-adjuvanting, and self-assembling anticancer vaccines based on a minimal saponin adjuvant and the tumor-associated MUC1 antigen

Chemical Science

Pifferi, C.; Aguinagalde, L.; Ruiz-De-Angulo, A.; Sacristán, N.; Baschirotto, P.T.; Poveda, A.; Jiménez-Barbero, J.; Anguita, J.; Fernández-Tejada, A.

Article / Dome1-JAK-STAT signaling between parasite and host integrates vector immunity and development

Science

Rana, V.S.; Kitsou, C.; Dutta, S.; Ronzetti, M.H.; Zhang, M.; Bernard, Q.; Smith, A.A.; Tomás-Cortázar, J.; Yang, X.; Wu, M.J.; Kepple, O.; Li, W.; Dwyer, J.E.; Matias, J.; Baljinnyam, B.; Oliver, J.D.; Rajeevan, N.; Pedra, J.H.F.; Narasimhan, S.; Wang, Y.; Munderloh, U.; Fikrig, E.; Simeonov, A.; Anguita, J.; Pal, U.

Article / Mitochondrial dysfunction-associated microbiota establishes a transmissible refractory response to anti-TNF therapy during ulcerative colitis

Gut Microbes

Peña-Cearra, A.; Castelo, J.; Lavín, J.L.; Gonzalez-Lopez, M.; Pascual-Itoiz, M.A.; Fuertes, M.; Gutiérrez de Juan, V.; Bárcena, L.; Martín-Ruiz, I.; Pellón, A.; Seoane, I.; Barriales, D.; Palacios, A.; Fullaondo, A.; Rodríguez-Lago, I.; Martinez-Chantar, M.L.; Aransay, A.M.; Rodriguez, H.; Anguita, J.; Abecia, L.

2022

Article / Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals

Hepatology

Goikoetxea-Usandizaga, N.; Serrano-Maciá, M.; Delgado, T.C.; Simón, J.; Fernández Ramos, D.; Barriales, D.; Cornide, M.; Jiménez, M.; Pérez-Redondo, M.; Lachiondo-Ortega, S.; Rodríguez-Agudo, R.; Bizkarguenaga, M.; Zalamea, J.D.; Pasco, S.T.; Caballero-Díaz, D.; Alfano, B.; Bravo, M.; González-Recio, I.; Mercado-Gómez, M.; Gil-Pitarch, C.; Mabe, J.; Gracia-Sancho, J.; Abecia, L.; Lorenzo, Ó.; Martín-Sanz, P.; Abrescia, N.G.A.; Sabio, G.; Rincón, M.; Anguita, J.; Miñambres, E.; Martín, C.; Berenguer, M.; Fabregat, I.; Casado, M.; Peralta, C.; Varela-Rey, M.; Martínez-Chantar, M.L.

Article / Identification of novel conserved Ixodes vaccine candidates; a promising role for non-secreted salivary gland proteins

Vaccine

Trentelman, J.J.A.; de Vogel, F.A.; Colstrup, E.; Sima, R.; Coumou, J.; Koetsveld, J.; Klouwens, M.J.; Nayak, A.; Ersoz, J.; Barriales, D.; Tomás-Cortázar, J.; Narasimhan, S.; Hajdusek, O.; Anguita, J.; Hovius, J.W.

Article / Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage

Nature Communications

González-Recio, I.; Simón, J.; Goikoetxea-Usandizaga, N.; Serrano-Maciá, M.; Mercado-Gómez, M.; Rodríguez-Agudo, R.; Lachiondo-Ortega, S.; Gil-Pitarch, C.; Fernández-Rodríguez, C.; Castellana, D.; Latasa, M.U.; Abecia, L.; Anguita, J.; Delgado, T.C.; Iruzubieta, P.; Crespo, J.; Hardy, S.; Petrov, P.D.; Jover, R.; Avila, M.A.; Martín, C.; Schaeper, U.; Tremblay, M.L.; Dear, J.W.; Masson, S.; McCain, M.V.; Reeves, H.L.; Andrade, R.J.; Lucena, M.I.; Buccella, D.; Martínez-Cruz, L.A.; Martínez-Chantar, M.L.

Article / Mitochondrial complex I dysfunction alters the balance of soluble and membrane-bound TNF during chronic experimental colitis

Scientific Reports

Peña-Cearra, A.; Pascual-Itoiz, M.A.; Lavín, J.L.; Fuertes, M.; Martín-Ruiz, I.; Castelo, J.; Palacios, A.; Barriales, D.; Fullaondo, A.; Aransay, A.M.; Rodríguez, H.; Anguita, J.; Abecia, L.

Article / Novel Oxime-Derivatized Synthetic Triterpene Glycosides as Potent Saponin Vaccine Adjuvants

Frontiers in Immunology

Fuentes, R.; Aguinagalde, L.; Pifferi, C.; Plata, A.; Sacristán, N.; Castellana, D.; Anguita, J.; Fernández-Tejada, A.

Article / Uneven metabolic and lipidomic profiles in recovered COVID-19 patients as investigated by plasma NMR metabolomics

NMR in Biomedicine

Bizkarguenaga, M.; Bruzzone, C.; Gil-Redondo, R.; SanJuan, I.; Martin-Ruiz, I.; Barriales, D.; Palacios, A.; Pasco, S.T.; González-Valle, B.; Laín, A.; Herrera, L.; Azkarate, A.; Vesga, M.A.; Eguizabal, C.; Anguita, J.; Embade, N.; Mato, J.M.; Millet, O.

Article / A structurally unique Fusobacterium nucleatum tannase provides detoxicant activity against gallotannins and pathogen resistance

Microbial Biotechnology

Mancheño, J.M.; Atondo, E.; Tomás-Cortázar, J.; Luís Lavín, J.; Plaza-Vinuesa, L.; Martín-Ruiz, I.; Barriales, D.; Palacios, A.; Daniel Navo, C.; Sampedro, L.; Peña-Cearra, A.; Ángel Pascual-Itoiz, M.; Castelo, J.; Carreras-González, A.; Castellana, D.; Pellón, A.; Delgado, S.; Ruas-Madiedo, P.; de las Rivas, B.; Abecia, L.; Muñoz, R.; Jiménez-Osés, G.; Anguita, J.; Rodríguez, H.

2021

Article / Borrelia burgdorferi infection induces long-term memory-like responses in macrophages with tissue-wide consequences in the heart

PLoS Biology

Barriales, D.; Martín-Ruiz, I.; Carreras-González, A.; Montesinos-Robledo, M.; Azkargorta, M.; Iloro, I.; Escobés, I.; Martín-Mateos, T.; Atondo, E.; Palacios, A.; Gonzalez-Lopez, M.; Bárcena, L.; Cortázar, A.R.; Cabrera, D.; Peña-Cearra, A.; van Liempd, S.M.; Falcón-Pérez, J.M.; Pascual-Itoiz, M.A.; Flores, J.M.; Abecia, L.; Pellon, A.; Martínez-Chantar, M.L.; Aransay, A.M.; Pascual, A.; Elortza, F.; Berra, E.; Lavín, J.L.; Rodríguez, H.; Anguita, J.

Article / BpOmpW Antigen Stimulates the Necessary Protective T-Cell Responses Against Melioidosis

Frontiers in Immunology

Tomás-Cortázar, J.; Bossi, L.; Quinn, C.; Reynolds, C.J.; Butler, D.K.; Corcoran, N.; Murchú, M.; McMahon, E.; Singh, M.; Rongkard, P.; Anguita, J.; Blanco, A.; Dunachie, S.J.; Altmann, D.; Boyton, R.J.; Arnold, J.; Giltaire, S.; McClean, S.

Article / Peripheral blood mononuclear cells (PBMC) microbiome is not affected by colon microbiota in healthy goats

Animal Microbiome

Peña-Cearra, A.; Belanche, A.; Gonzalez-Lopez, M.; Lavín, J.L.; Pascual-Itoiz, M.Á.; Jiménez, E.; Rodríguez, H.; Aransay, A.M.; Anguita, J.; Yáñez-Ruiz, D.R.; Abecia, L.

Article / Oral vaccination stimulates neutrophil functionality and exerts protection in a Mycobacterium avium subsp. paratuberculosis infection model

npj Vaccines

Ladero-Auñon, I.; Molina, E.; Oyanguren, M.; Barriales, D.; Fuertes, M.; Sevilla, I.A.; Luo, L.; Arrazuria, R.; De Buck, J.; Anguita, J.; Elguezabal, N.

Article / Probing an Ixodes ricinus salivary gland yeast surface display with tick-exposed human sera to identify novel candidates for an anti-tick vaccine

Scientific Reports

Trentelman, J.J.A.; Tomás-Cortázar, J.; Knorr, S.; Barriales, D.; Hajdusek, O.; Sima, R.; Ersoz, J.I.; Narasimhan, S.; Fikrig, E.; Nijhof, A.M.; Anguita, J.; Hovius, J.W.

Article / Aspergillus fumigatus fumagillin contributes to host cell damage

Journal of Fungi

Guruceaga, X.; Perez-Cuesta, U.; Pellon, A.; Cendon-Sanchez, S.; Pelegri-Martinez, E.; Gonzalez, O.; Hernando, F.L.; Mayayo, E.; Anguita, J.; Alonso, R.M.; Keller, N.P.; Ramirez-Garcia, A.; Rementeria, A.

Article / A Catalogus Immune Muris of the mouse immune responses to diverse pathogens

Cell Death and Disease

Barlier, C.; Barriales, D.; Samosyuk, A.; Jung, S.; Ravichandran, S.; Medvedeva, Y.A.; Anguita, J.; del Sol, A.

Article / Identification and characterization of immunodominant proteins from tick tissue extracts inducing a protective immune response against Ixodes ricinus in cattle

Vaccines

Knorr, S.; Reissert-Oppermann, S.; Tomás-Cortázar, J.; Barriales, D.; Azkargorta, M.; Iloro, I.; Elortza, F.; Pinecki-Socias, S.; Anguita, J.; Hovius, J.W.; Nijhof, A.M.

Article / Anti-miR-518d-5p overcomes liver tumor cell death resistance through mitochondrial activity

Cell Death and Disease

Fernández-Tussy, P.; Rodríguez-Agudo, R.; Fernández-Ramos, D.; Barbier-Torres, L.; Zubiete-Franco, I.; Davalillo, S.L.d.; Herraez, E.; Goikoetxea-Usandizaga, N.; Lachiondo-Ortega, S.; Simón, J.; Lopitz-Otsoa, F.; Juan, V.G.d.; McCain, M.V.; Perugorria, M.J.; Mabe, J.; Navasa, N.; Rodrigues, C.M.P.; Fabregat, I.; Boix, L.; Sapena, V.; Anguita, J.; Lu, S.C.; Mato, J.M.; Banales, J.M.; Villa, E.; Reeves, H.L.; Bruix, J.; Reig, M.; Marin, J.J.G.; Delgado, T.C.; Martínez-Chantar, M.L.

Article / Boosting mitochondria activity by silencing MCJ overcomes cholestasis-induced liver injury

JHEP Reports

Iruzubieta, P.; Goikoetxea-Usandizaga, N.; Barbier-Torres, L.; Serrano-Maciá, M.; Fernández-Ramos, D.; Fernández-Tussy, P.; Gutiérrez-de-Juan, V.; Lachiondo-Ortega, S.; Simon, J.; Bravo, M.; Lopitz-Otsoa, F.; Robles, M.; Ferre-Aracil, C.; Varela-Rey, M.; Elguezabal, N.; Calleja, J.L.; Lu, S.C.; Milkiewicz, M.; Milkiewicz, P.; Anguita, J.; Monte, M.J.; Marin, J.J.G.; López-Hoyos, M.; Delgado, T.C.; Rincón, M.; Crespo, J.; Martínez-Chantar, M.L.

Article / Bovine Neutrophils Release Extracellular Traps and Cooperate With Macrophages in Mycobacterium avium subsp. paratuberculosis clearance In Vitro

Frontiers in Immunology

Ladero-Auñon, I.; Molina, E.; Holder, A.; Kolakowski, J.; Harris, H.; Urkitza, A.; Anguita, J.; Werling, D.; Elguezabal, N.

Article / Replacing the Rhamnose-Xylose Moiety of QS-21 with Simpler Terminal Disaccharide Units Attenuates Adjuvant Activity in Truncated Saponin Variants

Chemistry - A European Journal

Fuentes, R.; Ruiz-de-Angulo, A.; Sacristán, N.; Navo, C.D.; Jiménez-Osés, G.; Anguita, J.; Fernández-Tejada, A.

Article / The commensal bacterium Lactiplantibacillus plantarum imprints innate memory-like responses in mononuclear phagocytes

Gut Microbes

Pellon, A.; Barriales, D.; Peña-Cearra, A.; Castelo-Careaga, J.; Palacios, A.; Lopez, N.; Atondo, E.; Pascual-Itoiz, M.A.; Martín-Ruiz, I.; Sampedro, L.; Gonzalez-Lopez, M.; Bárcena, L.; Martín-Mateos, T.; Landete, J.M.; Prados-Rosales, R.; Plaza-Vinuesa, L.; Muñoz, R.; de las Rivas, B.; Rodríguez, J.M.; Berra, E.; Aransay, A.M.; Abecia, L.; Lavín, J.L.; Rodríguez, H.; Anguita, J.

2020

Article / Mesoporous silica nanoparticles as a potential platform for vaccine development against tuberculosis

Pharmaceutics

Montalvo-Quirós, S.; Vallet-Regí, M.; Palacios, A.; Anguita, J.; Prados-Rosales, R.C.; González, B.; Luque-Garcia, J.L.

Article / Generation, establishment and characterization of a pluripotent stem cell line (CVTTHi001-A) from primary fibroblasts isolated from a patient with activated PI3 kinase delta syndrome (APDS2)

Stem Cell Research

Inglés-Ferrándiz, M.; Martin-Inaraja, M.; Herrera, L.; Villaverde, M.; Santos, S.; Vesga, M.A.; Garreta, E.; Martín-Ruiz, I.; Aransay, A.M.; Anguita, J.; Barreña, B.; Allende, L.M.; Gonzalez-Granado, L.I.; Eguizabal, C.

Article / A combined transcriptomic approach to identify candidates for an anti-tick vaccine blocking B. afzelii transmission

Scientific Reports

Trentelman, J.J.A.; Sima, R.; Krezdorn, N.; Tomás-Cortázar, J.; Barriales, D.; Takumi, K.; Butler, J.M.; Sprong, H.; Klouwens, M.J.; Urbanova, V.; Mahmood, S.; Winter, P.; Kopacek, P.; Anguita, J.; Hajdusek, O.; Hovius, J.W.

Article / Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation

Nature Communications

Barbier-Torres, L.; Fortner, K.A.; Iruzubieta, P.; Delgado, T.C.; Giddings, E.; Chen, Y.; Champagne, D.; Fernández-Ramos, D.; Mestre, D.; Gomez-Santos, B.; Varela-Rey, M.; de Juan, V.G.; Fernández-Tussy, P.; Zubiete-Franco, I.; García-Monzón, C.; González-Rodríguez, Á.; Oza, D.; Valença-Pereira, F.; Fang, Q.; Crespo, J.; Aspichueta, P.; Tremblay, F.; Christensen, B.C.; Anguita, J.; Martínez-Chantar, M.L.; Rincón, M.

Article / The mitochondrial negative regulator MCJ modulates the interplay between microbiota and the host during ulcerative colitis

Scientific Reports

Pascual-Itoiz, M.A.; Peña-Cearra, A.; Martín-Ruiz, I.; Lavín, J.L.; Simó, C.; Rodríguez, H.; Atondo, E.; Flores, J.M.; Carreras-González, A.; Tomás-Cortázar, J.; Barriales, D.; Palacios, A.; García-Cañas, V.; Pellón, A.; Fullaondo, A.; Aransay, A.M.; Prados-Rosales, R.; Martín, R.; Anguita, J.; Abecia, L.

Article / Chemical synthesis and immunological evaluation of new generation multivalent anticancer vaccines based on a Tn antigen analogue

Chemical Science

Pifferi, C.; Ruiz-De-Angulo, A.; Goyard, D.; Tiertant, C.; Sacristán, N.; Barriales, D.; Berthet, N.; Anguita, J.; Renaudet, O.; Fernández-Tejada, A.

Article / Ixodes scapularis saliva components that elicit responses associated with acquired tick-resistance

Ticks and Tick-borne Diseases

Narasimhan, S.; Kurokawa, C.; Diktas, H.; Strank, N.O.; Černý, J.; Murfin, K.; Cao, Y.; Lynn, G.; Trentleman, J.; Wu, M.J.; DePonte, K.; Kantor, F.; Anguita, J.; Hovius, J.; Fikrig, E.

Article / Antimycobacterial Effect of Selenium Nanoparticles on Mycobacterium tuberculosis

Frontiers in Microbiology

Estevez, H.; Palacios, A.; Gil, D.; Anguita, J.; Vallet-Regi, M.; González, B.; Prados-Rosales, R.; Luque-Garcia, J.L.

Article / Exploiting structure-activity relationships of QS-21 in the design and synthesis of streamlined saponin vaccine adjuvants

Chemical Communications

Ghirardello, M.; Ruiz-De-Angulo, A.; Sacristan, N.; Barriales, D.; Jiménez-Barbero, J.; Poveda, A.; Corzana, F.; Anguita, J.; Fernández-Tejada, A.

Editorial / Editorial: Macrophage Metabolism and Immune Responses

Frontiers in Immunology

Rodríguez, H.; Prados-Rosales, R.; Lavín, J.L.; Mazzone, M.; Anguita, J.

2019

Article / Gut microbiome and serum metabolome analyses identify molecular biomarkers and altered glutamate metabolism in fibromyalgia

EBioMedicine

Clos-Garcia, M.; Andrés-Marin, N.; Fernández-Eulate, G.; Abecia, L.; Lavín, J.L.; van Liempd, S.; Cabrera, D.; Royo, F.; Valero, A.; Errazquin, N.; Vega, M.C.G.; Govillard, L.; Tackett, M.R.; Tejada, G.; Gónzalez, E.; Anguita, J.; Bujanda, L.; Orcasitas, A.M.C.; Aransay, A.M.; Maíz, O.; López de Munain, A.; Falcón-Pérez, J.M.

Article / Adult peripheral blood and umbilical cord blood NK cells are good sources for effective CAR therapy against CD19 positive leukemic cells

Scientific Reports

Herrera, L.; Santos, S.; Vesga, M.A.; Anguita, J.; Martin-Ruiz, I.; Carrascosa, T.; Juan, M.; Eguizabal, C.

Article / miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease

Molecular Metabolism

Fernández-Tussy, P.; Fernández-Ramos, D.; Lopitz-Otsoa, F.; Simón, J.; Barbier-Torres, L.; Gomez-Santos, B.; Nuñez-Garcia, M.; Azkargorta, M.; Gutiérrez-de Juan, V.; Serrano-Macia, M.; Rodríguez-Agudo, R.; Iruzubieta, P.; Anguita, J.; Castro, R.E.; Champagne, D.; Rincón, M.; Elortza, F.; Arslanow, A.; Krawczyk, M.; Lammert, F.; Kirchmeyer, M.; Behrmann, I.; Crespo, J.; Lu, S.C.; Mato, J.M.; Varela-Rey, M.; Aspichueta, P.; Delgado, T.C.; Martínez-Chantar, M.L.

Article / Mycobacterium tuberculosis extracellular vesicle-associated lipoprotein LpqH as a potential biomarker to distinguish paratuberculosis infection or vaccination from tuberculosis infection

BMC Veterinary Research

Palacios, A.; Sampedro, L.; Sevilla, I.A.; Molina, E.; Gil, D.; Azkargorta, M.; Elortza, F.; Garrido, J.M.; Anguita, J.; Prados-Rosales, R.

Article / Regulation of macrophage activity by surface receptors contained within Borrelia burgdorferi-enriched phagosomal fractions

PLoS Pathogens

Gonzalez, A.C.; Barriales, D.; Palacios, A.; Robledo, M.M.; Navasa, N.; Azkargorta, M.; Cearra, A.P.; Cortazar, J.T.; Escobes, I.; Pascual-Itoiz, M.A.; Hradiska, J.; Kopecky, J.; Carton, D.G.; Rosales, R.P.; Abecia, L.; Atondo, E.; Martin, I.; Pellon, A.; Elortza, F.; Rodriguez, H.; Anguita, J.

Review / The Mycobacterium tuberculosis capsule: A cell structure with key implications in pathogenesis

Biochemical Journal

Kalscheuer, R.; Palacios, A.; Anso, I.; Cifuente, J.; Anguita, J.; Jacobs, W.R.; Guerin, M.E.; Prados-Rosales, R.

Review / Counterattacking the tick bite: Towards a rational design of anti-tick vaccines targeting pathogen transmission

Parasites and Vectors

Rego, R.O.M.; Trentelman, J.J.A.; Anguita, J.; Nijhof, A.M.; Sprong, H.; Klempa, B.; Hajdusek, O.; Tomás-Cortázar, J.; Azagi, T.; Strnad, M.; Knorr, S.; Sima, R.; Jalovecka, M.; Fumačová Havlíková, S.; Ličková, M.; Sláviková, M.; Kopacek, P.; Grubhoffer, L.; Hovius, J.W.

Review / Bacterial tannases: classification and biochemical properties

Applied Microbiology and Biotechnology

de las Rivas, B.; Rodríguez, H.; Anguita, J.; Muñoz, R.

2018

Book / Borrelia burgdorferi: Methods and Protocols in Methods in Molecular Biology

O. Buyuktanir and U. Pal

Anguita, J., Carreras-González, A., Navasa, N.

Book / Clinical Immunology 5th Ed.

Rich, Shearer, Fleisher, Schoroeder, Weyand, Frew

Navasa, N., Fikrig, E., Anguita, J.

Article / Repurposing ciclopirox as a pharmacological chaperone in a model of congenital erythropoietic porphyria

Science Translational Medicine

Urquiza, P.; Laín, A.; Sanz-Parra, A.; Moreno, J.; Bernardo-Seisdedos, G.; Dubus, P.; González, E.; Gutiérrez-De-Juan, V.; García, S.; Eraña, H.; Juan, I.S.; Macías, I.; Ben Bdira, F.; Pluta, P.; Ortega, G.; Oyarzábal, J.; González-Muñiz, R.; Rodríguez-Cuesta, J.; Anguita, J.; Díez, E.; Blouin, J.M.; De Verneuil, H.; Mato, J.M.; Richard, E.; Falcón-Pérez, J.M.; Castilla, J.; Millet, O.

Article / Preliminary Evaluation of Tick Protein Extracts and Recombinant Ferritin 2 as Anti-tick Vaccines Targeting Ixodes ricinus in Cattle

Frontiers in Physiology

Knorr, S.; Anguita, J.; Cortazar, J.T.; Hajdusek, O.; Kopáček, P.; Trentelman, J.J.; Kershaw, O.; Hovius, J.W.; Nijhof, A.M.

Article / A multi-omic analysis reveals the regulatory role of CD180 during the response of macrophages to Borrelia burgdorferi article

Emerging Microbes and Infections

Carreras-González, A.; Navasa, N.; Martín-Ruiz, I.; Lavín, J.L.; Azkargorta, M.; Atondo, E.; Barriales, D.; Macías-Cámara, N.; Pascual-Itoiz, M.A.; Sampedro, L.; Tomás-Cortázar, J.; Peña-Cearra, A.; Pellón, A.; Prados-Rosales, R.; Abecia, L.; Elortza, F.; Aransay, A.M.; Rodríguez, H.; Anguita, J.

Article / MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis

Cell Death and Disease

Fernández-Ramos, D.; Fernández-Tussy, P.; Lopitz-Otsoa, F.; Gutiérrez-de-Juan, V.; Navasa, N.; Barbier-Torres, L.; Zubiete-Franco, I.; Simón, J.; Fernández, A.F.; Arbelaiz, A.; Aransay, A.M.; Lavín, J.L.; Beraza, N.; Perugorria, M.J.; Banales, J.M.; Villa, E.; Fraga, M.F.; Anguita, J.; Avila, M.A.; Berasain, C.; Iruzibieta, P.; Crespo, J.; Lu, S.C.; Varela-Rey, M.; Mato, J.M.; Delgado, T.C.; Martínez-Chantar, M.L.

Article / CD8 T cell responses to an immunodominant epitope within the nonstructural protein NS1 provide wide immunoprotection against bluetongue virus in IFNAR-/- mice

Journal of Virology

Marín-López, A.; Calvo-Pinilla, E.; Barriales, D.; Lorenzo, G.; Brun, A.; Anguita, J.; Ortego, J.

Article / Microglial immune response is impaired against the neurotropic fungus Lomentospora prolificans

Cellular Microbiology

Pellon, A.; Ramirez-Garcia, A.; Guruceaga, X.; Zabala, A.; Buldain, I.; Antoran, A.; Anguita, J.; Rementeria, A.; Matute, C.; Hernando, F.L.

Article / Plasticity in early immune evasion strategies of a bacterial pathogen

Proceedings of the National Academy of Sciences of the United States of America

Bernard, Q.; Smith, A.A.; Yang, X.; Koci, J.; Foor, S.D.; Cramer, S.D.; Zhuang, X.; Dwyer, J.E.; Lin, Y.P.; Mongodin, E.F.; Marques, A.; Leong, J.M.; Anguita, J.; Pal, U.

Article / Identification of a highly active tannase enzyme from the oral pathogen Fusobacterium nucleatum subsp. polymorphum

Microbial Cell Factories

Tomás-Cortázar, J.; Plaza-Vinuesa, L.; de las Rivas, B.; Lavín, J.L.; Barriales, D.; Abecia, L.; Mancheño, J.M.; Aransay, A.M.; Muñoz, R.; Anguita, J.; Rodríguez, H.

Letter / Quantum DNA Sequencing: A Peek Into a Dystopic Future?

BioEssays

Lavín, J.L.; Anguita, J.

2017

Article / Role of aramchol in steatohepatitis and fibrosis in mice

Hepatology Communications

Iruarrizaga-Lejarreta, M.; Varela-Rey, M.; Fernández-Ramos, D.; Martínez-Arranz, I.; Delgado, T.C.; Simon, J.; Gutiérrez-de Juan, V.; delaCruz-Villar, L.; Azkargorta, M.; Lavin, J.L.; Mayo, R.; Van Liempd, S.M.; Aurrekoetxea, I.; Buqué, X.; Delle Cave, D.; Peña, A.; Rodríguez-Cuesta, J.; Aransay, A.M.; Elortza, F.; Falcón-Pérez, J.M.; Aspichueta, P.; Hayardeny, L.; Noureddin, M.; Sanyal, A.J.; Alonso, C.; Anguita, J.; Martínez-Chantar, M.L.; Lu, S.C.; Mato, J.M.

Article / MTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

Nature

Zabala-Letona, A.; Arruabarrena-Aristorena, A.; Martín-Martín, N.; Fernandez-Ruiz, S.; Sutherland, J.D.; Clasquin, M.; Tomas-Cortazar, J.; Jimenez, J.; Torres, I.; Quang, P.; Ximenez-Embun, P.; Bago, R.; Ugalde-Olano, A.; Loizaga-Iriarte, A.; Lacasa-Viscasillas, I.; Unda, M.; Torrano, V.; Cabrera, D.; Van Liempd, S.M.; Cendon, Y.; Castro, E.; Murray, S.; Revandkar, A.; Alimonti, A.; Zhang, Y.; Barnett, A.; Lein, G.; Pirman, D.; Cortazar, A.R.; Arreal, L.; Prudkin, L.; Astobiza, I.; Valcarcel-Jimenez, L.; Zuñiga-García, P.; Fernandez-Dominguez, I.; Piva, M.; Caro-Maldonado, A.; Sánchez-Mosquera, P.; Castillo-Martín, M.; Serra, V.; Beraza, N.; Gentilella, A.; Thomas, G.; Azkargorta, M.; Elortza, F.; Farràs, R.; Olmos, D.; Efeyan, A.; Anguita, J.; Muñoz, J.; Falcón-Pérez, J.M.; Barrio, R.; Macarulla, T.; Mato, J.M.; Martinez-Chantar, M.L.; Cordon-Cardo, C.; Aransay, A.M.; Marks, K.; Baselga, J.; Tabernero, J.; Nuciforo, P.; Manning, B.D.; Marjon, K.; Carracedo, A.

Article / The immunosuppressive effect of the tick protein, Salp15, is long-lasting and persists in a murine model of hematopoietic transplant

Scientific Reports

Tomás-Cortázar, J.; Martín-Ruiz, I.; Barriales, D.; Pascual-Itoiz, M.Á.; De Juan, V.G.; Caro-Maldonado, A.; Merino, N.; Marina, A.; Blanco, F.J.; Flores, J.M.; Sutherland, J.D.; Barrio, R.; Rojas, A.; Martínez-Chantar, M.L.; Carracedo, A.; Simó, C.; García-Cañas, V.; Abecia, L.; Lavín, J.L.; Aransay, A.M.; Rodríguez, H.; Anguita, J.

Article / The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury

Nature Communications

Barbier-Torres, L.; Iruzubieta, P.; Fernández-Ramos, D.; Delgado, T.C.; Taibo, D.; Guitiérrez-De-Juan, V.; Varela-Rey, M.; Azkargorta, M.; Navasa, N.; Fernández-Tussy, P.; Zubiete-Franco, I.; Simon, J.; Lopitz-Otsoa, F.; Lachiondo-Ortega, S.; Crespo, J.; Masson, S.; McCain, M.V.; Villa, E.; Reeves, H.; Elortza, F.; Lucena, M.I.; Hernández-Alvarez, M.I.; Zorzano, A.; Andrade, R.J.; Lu, S.C.; Mato, J.M.; Anguita, J.; Rincón, M.; Martínez-Chantar, M.L.

Article / Mechanistic Insights into the Cholesterol-dependent Binding of Perfringolysin O-based Probes and Cell Membranes

Scientific Reports

Johnson, B.B.; Breña, M.; Anguita, J.; Heuck, A.P.

Article / Enhanced control of Mycobacterium tuberculosis extrapulmonary dissemination in mice by an arabinomannan-protein conjugate vaccine

PLoS Pathogens

Prados-Rosales, R.; Carreño, L.; Cheng, T.; Blanc, C.; Weinrick, B.; Malek, A.; Lowary, T.L.; Baena, A.; Joe, M.; Bai, Y.; Kalscheuer, R.; Batista-Gonzalez, A.; Saavedra, N.A.; Sampedro, L.; Tomás, J.; Anguita, J.; Hung, S.C.; Tripathi, A.; Xu, J.; Glatman-Freedman, A.; Jacobs, W.R.; Chan, J.; Porcelli, S.A.; Achkar, J.M.; Casadevall, A.

2016

Article / Stratification and therapeutic potential of PML in metastatic breast cancer

Nature Communications

Martín-Martín, N.; Piva, M.; Urosevic, J.; Aldaz, P.; Sutherland, J.D.; Fernández-Ruiz, S.; Arreal, L.; Torrano, V.; Cortazar, A.R.; Planet, E.; Guiu, M.; Radosevic-Robin, N.; Garcia, S.; Macías, I.; Salvador, F.; Domenici, G.; Rueda, O.M.; Zabala-Letona, A.; Arruabarrena-Aristorena, A.; Zúñiga-García, P.; Caro-Maldonado, A.; Valcárcel-Jiménez, L.; Sánchez-Mosquera, P.; Varela-Rey, M.; Martínez-Chantar, M.L.; Anguita, J.; Ibrahim, Y.H.; Scaltriti, M.; Lawrie, C.H.; Aransay, A.M.; Iovanna, J.L.; Baselga, J.; Caldas, C.; Barrio, R.; Serra, V.; Dm Vivanco, M.; Matheu, A.; Gomis, R.R.; Carracedo, A.

Article / Characterization of a Chikungunya virus strain isolated from banked patients' sera

Virology Journal

Chalaem, P.; Chusri, S.; Fernandez, S.; Chotigeat, W.; Anguita, J.; Pal, U.; Promnares, K.

Article / Cross-Species Interferon Signaling Boosts Microbicidal Activity within the Tick Vector

Cell Host and Microbe

Smith, A.A.; Navasa, N.; Yang, X.; Wilder, C.N.; Buyuktanir, O.; Marques, A.; Anguita, J.; Pal, U.

Article / Fine-Tuning of CD8+ T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus

Immunity

Champagne, D.P.; Hatle, K.M.; Fortner, K.A.; D'Alessandro, A.; Thornton, T.M.; Yang, R.; Torralba, D.; Tomás-Cortázar, J.; Jun, Y.W.; Ahn, K.H.; Hansen, K.C.; Haynes, L.; Anguita, J.; Rincon, M.

2015

Article / Ikaros mediates the DNA methylation-independent silencing of MCJ/DNAJC15 gene expression in macrophages

Scientific Reports

Navasa, N.; Martin-Ruiz, I.; Atondo, E.; Sutherland, J.D.; Angel Pascual-Itoiz, M.; Carreras-González, A.; Izadi, H.; Tomás-Cortázar, J.; Ayaz, F.; Martin-Martin, N.; Torres, I.M.; Barrio, R.; Carracedo, A.; Olivera, E.R.; Rincón, M.; Anguita, J.

Article / Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1

Hepatology

Barbier-Torres, L.; Beraza, N.; Fernández-Tussy, P.; Lopitz-Otsoa, F.; Fernández-Ramos, D.; Zubiete-Franco, I.; Varela-Rey, M.; Delgado, T.C.; Gutiérrez, V.; Anguita, J.; Pares, A.; Banales, J.M.; Villa, E.; Caballería, J.; Alvarez, L.; Lu, S.C.; Mato, J.M.; Martínez-Chantar, M.L.

Article / Regulation of oxidative stress by methylation-controlled j protein controls macrophage responses to inflammatory insults

Journal of Infectious Diseases

Navasa, N.; Martín, I.; Iglesias-Pedraz, J.M.; Beraza, N.; Atondo, E.; Izadi, H.; Ayaz, F.; Fernández-Alvarez, S.; Hatle, K.; Som, A.; Dienz, O.; Osborne, B.A.; Martínez-Chantar, M.L.; Rincón, M.; Anguita, J.

Letter / Serum C3 enhances complement receptor 3-mediated phagocytosis of Borrelia burgdorferi

International Journal of Biological Sciences

Hawley, K.L.; Olson, C.M.; Carreras-González, A.; Navasa, N.; Anguita, J.

2014

Article / ANTIDotE: Anti-tick vaccines to prevent tick-borne diseases in Europe

Parasites and Vectors

Sprong, H.; Trentelman, J.; Seemann, I.; Grubhoffer, L.; Rego, R.O.M.; Hajdušek, O.; Kopáček, P.; Šíma, R.; Nijhof, A.M.; Anguita, J.; Winter, P.; Rotter, B.; Havlíková, S.; Klempa, B.; Schetters, T.P.; Hovius, J.W.R.

2013

Article / CD14 targets complement receptor 3 to lipid rafts during phagocytosis of Borrelia burgdorferi

International Journal of Biological Sciences

Hawley, K.L.; Martín-Ruiz, I.; Iglesias-Pedraz, J.M.; Berwin, B.; Anguita, J.

Article / MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations

Molecular and Cellular Biology

Hatle, K.M.; Gummadidala, P.; Navasa, N.; Bernardo, E.; Dodge, J.; Silverstrim, B.; Fortner, K.; Burg, E.; Suratt, B.T.; Hammer, J.; Radermacher, M.; Taatjes, D.J.; Thornton, T.; Anguita, J.; Rincon, M.

Review / Borrelia burgdorferi and tick proteins supporting pathogen persistence in the vector

Future Microbiology

Kung, F.; Anguita, J.; Pal, U.

2012

Article / Identification of synthetic host defense peptide mimics that exert dual antimicrobial and anti-inflammatory activities

Clinical and Vaccine Immunology

Som, A.; Navasa, N.; Percher, A.; Scott, R.W.; Tew, G.N.; Anguita, J.

2023

Conference organization | 44 Congreso de la Sociedad Española de Inmunología

Juan Anguita

Oral presentation | Impacto de la inmunidad entrenada en la patología cardiaca asociada a la enfermedad de Lyme

44 Congreso de la Sociedad Española de Inmunología - Oral presentation

Juan Anguita

2022

Invited talk | Inmunidad Innata Entrenada en Homeostasis y Enfermedad: El Papel de la Microbiota

Juan Anguita