Charles Lawrie

Ikerbasque Research Professor, Biogipuzkoa Health Research Institute

Director of Oncology research area at Biogipuzkoa Health Research Institute.

Research line:

Use of primarily genomics techniques to identify genes/microRNAs involved in cancer pathology and their potential as biomarkers.

Previous research experience in commercial and academic departments in UK. Comes from Nuffield Department of Clinical Laboratory Sciences, University of Oxford.

Doctor in biological sciences from the University of Oxford in 2000. Over 10 years in commercial and academic departments in UK.

Publicaciones
Congresos y Proceedings

2024

Article / Rapid noninvasive lung cancer screening via discriminative wavenumbers in Raman spectroscopy

Microchemical Journal

Harun Hano, Beatriz Suárez, Jose Manuel Amigo, Charles Lawrie, Andreas Seifert

Article / Power of Light: Raman Spectroscopy and Machine Learning for the Detection of Lung Cancer

ACS Omega

Hano, H.; Lawrie, C.H.; Suarez, B.; Paredes Lario, A.; Elejoste Echeverría, I.; Gómez Mediavilla, J.; Crespo Cruz, M.I.; Lopez, E.; Seifert, A.

Article / Non-coding RNA and gene expression analyses of papillary renal neoplasm with reverse polarity (PRNRP) reveal distinct pathological mechanisms from other renal neoplasms

Pathology

Nemours, S.; Armesto, M.; Arestín, M.; Manini, C.; Giustetto, D.; Sperga, M.; Pivovarcikova, K.; Pérez-Montiel, D.; Hes, O.; Michal, M.; López, J.I.; Lawrie, C.H.

Article / Efficient enrichment of free target sequences in an integrated microfluidic device for point-of-care detection systems

Nanomedicine: Nanotechnology, Biology, and Medicine

Erice, E.; Mitxelena-Iribarren, O.; Arana, S.; Lawrie, C.H.; Mujika, M.

Article / Identification of miRNAs and Their Target Genes Associated with Sunitinib Resistance in Clear Cell Renal Cell Carcinoma Patients

International Journal of Molecular Sciences

Armesto, M.; Nemours, S.; Arestín, M.; Bernal, I.; Solano-Iturri, J.D.; Manrique, M.; Basterretxea, L.; Larrinaga, G.; Angulo, J.C.; Lecumberri, D.; Iturregui, A.M.; López, J.I.; Lawrie, C.H.

Article / Shape-Specific Gold Nanoparticles for Multiplex Biosensing Applications

ACS Omega

Zhang, S.; Zhang, Y.; Jiang, J.; Charconnet, M.; Peng, Y.; Zhang, L.; Lawrie, C.H.

Article / Optical biosensor based on the dual-functional gold nanoparticles for rapid and accurate multiplex detection of influenza A and B viruses

Sensing and Bio-Sensing Research

Zhang, Y.; Zhang, S.; Wang, H.; Charconnet, M.; Jiang, J.; Peng, Y.; Zhang, L.; Lawrie, C.H.

Article / Predicting Survival of Metastatic Clear Cell Renal Cell Cancer Treated with VEGFR-TKI-Based Sequential Therapy

Cancers

Angulo, J.C.; Larrinaga, G.; Lecumberri, D.; Iturregui, A.M.; Solano-Iturri, J.D.; Lawrie, C.H.; Armesto, M.; Dorado, J.F.; Nunes-Xavier, C.E.; Pulido, R.; Manini, C.; López, J.I.

Article / Fusion of Raman and FTIR Spectroscopy Data Uncovers Physiological Changes Associated with Lung Cancer

International Journal of Molecular Sciences

Hano, H.; Suarez, B.; Lawrie, C.H.; Seifert, A.

Review / Engineering nanoparticles for cancer immunotherapy: Current achievements, key considerations and future perspectives

Chemical Engineering Journal

Farooq, M.U.; Lawrie, C.H.; Deng, N.N.

2023

Article / Progress in the blood-based diagnosis of oesophageal squamous cell carcinoma (ESCC) using microRNAs

British Journal of Cancer

Lawrie, C.H

Article / Investigating the role of miRNAs in sunitinib resistance in clear cell renal cell carcinoma (ccRCC)

Cancers

María Armesto, Stéphane Nemours, Iraide Bernal, Manuel Manrique, Jose Ignacio Lopez, Charles H. Lawrie

Article / Non-coding RNA and Gene expression analyses of Papillary Renal Neoplasm with Reverse Polarity (PRNRP) reveal distinct pathological mechanisms from other Renal Neoplasms

Pathology

Stéphane Nemours, María Armesto, María Arestín, Claudia Manini, Doriana Giustetto, Maris Sperga, Kristyna Pivovarcikova, Delia Pérez-Montiel, Ondrej Hes, Michal Michal, José I. López, Charles H. Lawrie

Article / Targeting oncogenic functions of miR-301a in head and neck squamous cell carcinoma by PI3K/PTEN and MEK/ERK pathways

Biomedicine and Pharmacotherapy

Granda-Díaz, R.; Manterola, L.; Hermida-Prado, F.; Rodríguez, R.; Santos, L.; García-de-la-Fuente, V.; Fernández, M.T.; Corte-Torres, M.D.; Rodrigo, J.P.; Álvarez-Teijeiro, S.; Lawrie, C.H.; Garcia-Pedrero, J.M.

Article / Validation of Rapid and Economic Colorimetric Nanoparticle Assay for SARS-CoV-2 RNA Detection in Saliva and Nasopharyngeal Swabs

Biosensors

Armesto, M.; Charconnet, M.; Marimón, J.M.; Fernández Regueiro, C.L.; Jia, J.; Yan, T.; Sorarrain, A.; Grzelczak, M.; Sanromán, M.; Vicente, M.; Klempa, B.; Zubiria, J.; Peng, Y.; Zhang, L.; Zhang, J.; Lawrie, C.H.

Note / Progress in the blood-based diagnosis of oesophageal squamous cell carcinoma (ESCC) using microRNAs: Comment on Komatsu et al. (BJC (2011) 105, 104–111)

British Journal of Cancer

Lawrie, C.H.

Review / The role of microRNAs in the toxic mechanisms of furan and 3-MCPD and links to cancer risk–a review

Food Additives and Contaminants - Part A

Tivanello, R.G.; Lawrie, C.H.; Bragotto, A.P.A.

2022

Chapter / Circulating microRNAs as cancer biomarkers in liquid biopsies

MicroRNA Cancer Regulation: Vol II

Suarez, B, Sole, C, Marquez, M., Nanetti, F. and Lawrie, C.H

Article / Differential Effects of HIF2α Antagonist and HIF2α Silencing in Renal Cancer and Sensitivity to Repurposed Drugs

BMC Cancer

Esther Arnaiz, Ana Miar, Esther Bridges, Naveen Prasad, Stephanie Hatch, Charles H. Lawrie*, Adrian L. Harris

Article / MicroRNAs in metastasis and the tumour microenvironment

International Journal of Molecular Sciences

Sole, C and Lawrie, C.H

Article / Stromal Oncostatin M axis promotes breast cancer progression by reprogramming the tumor microenvironment

Journal of Clinical Investigation

A. M. Araujo, A. Abaurrea, P. Azcoaga, J. I. López-Velazco, R. Rezola; I. Osorio-Querejeta, F. Valdés-Mora, J. M. Flores, L. Jenkins,P. Fernandez-Nogueira, N. Ferrari, N. Martín-Martín, A. Tzankov, S. Eppenberger-Castori, I. Alvarez-Lopez, A.Urruticoechea, P. Bragado, N. Coleman, A. Carracedo, D. Gallego-Ortega, F. Calvo, C. M. Isacke, M. M. Caffarel*, C. H. Lawrie.*corresponding author

Article / Integrated mRNA and miRNA transcriptomic analyses reveals divergent mechanisms of sunitinib resistance in clear cell renal cell carcinoma (ccRCC)

Cancers

María Armesto, Maitane Marquez, María Arestin, Peio Errarte, Ane Rubio, Lorea Manterola, Jose I. López and Charles H. Lawrie

Article / A decision tree-based method for the refinement of variants in FFPE DNA sequencing data

NAR Genomics and Bioinformatics

Tellaetxe, M, Calvo, B., Lawrie, C.H.

Article / High SOX9 Maintains Glioma Stem Cell Activity through a Regulatory Loop Involving STAT3 and PML

International Journal of Molecular Sciences

Aldaz, P. ;Martín-Martín, N. ;Saenz-Antoñanzas, A. ;Carrasco-Garcia, E. ;Álvarez-Satta, M. ;Elúa-Pinin, A. ;Pollard, S.M. ;Lawrie, C.H. ;Moreno-Valladares, M. ;Samprón, N. ;Hench, J. ;Lovell-Badge, R. ;Carracedo, A. ;Matheu, A.

Article / High SOX9 Maintains Glioma Stem Cell Activity through a Regulatory Loop Involving STAT3 and PML

International Journal of Molecular Sciences

Aldaz, P.; Martín‐martín, N.; Saenz‐antoñanzas, A.; Carrasco‐garcia, E.; Álvarez‐satta, M.; Elúa‐pinin, A.; Pollard, S.M.; Lawrie, C.H.; Moreno‐valladares, M.; Samprón, N.; Hench, J.; Lovell‐badge, R.; Carracedo, A.; Matheu, A.

Article / Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment

Journal of Clinical Investigation

Araujo, A.M.; Abaurrea, A.; Azcoaga, P.; López-Velazco, J.I.; Manzano, S.; Rodriguez, J.; Rezola, R.; Egia-Mendikute, L.; Valdés-Mora, F.; Flores, J.M.; Jenkins, L.; Pulido, L.; Osorio-Querejeta, I.; Fernández-Nogueira, P.; Ferrari, N.; Viera, C.; Martín-Martín, N.; Tzankov, A.; Eppenberger-Castori, S.; Alvarez-Lopez, I.; Urruticoechea, A.; Bragado, P.; Coleman, N.; Palazón, A.; Carracedo, A.; Gallego-Ortega, D.; Calvo, F.; Isacke, C.M.; Caffarel, M.M.; Lawrie, C.H.

Article / SOX9 Triggers Different Epithelial to Mesenchymal Transition States to Promote Pancreatic Cancer Progression

Cancers

Carrasco-Garcia, E.; Lopez, L.; Moncho-Amor, V.; Carazo, F.; Aldaz, P.; Collado, M.; Bell, D.; Gaafar, A.; Karamitopoulou, E.; Tzankov, A.; Hidalgo, M.; Rubio, Á.; Serrano, M.; Lawrie, C.H.; Lovell-Badge, R.; Matheu, A.

Review / Clear Cell Renal Cell Carcinomas with Aggressive Behavior Display Low Intratumor Heterogeneity at the Histological Level

Current Urology Reports

Manini, C.; López-Fernández, E.; Lawrie, C.H.; Laruelle, A.; Angulo, J.C.; López, J.I.

2021

Article / Therapeutic pretargeting with ultra-small nanoparticles: Boron carbon dots as drug candidates for boron neutron capture therapy

J. Mater. Chem. B

I. V. J. Feiner, K. R. Pulagam, C. Simó, K. Zamacola, V. Gómez-Vallejo, N. Herrero-Álvarez, U. Cossío, Z. Baz, M. M. Caffarel, C. H. Lawrie, D. J. Vugts, L. Rejc, J. Llop.

Article / Heparin length in the coating of extremely small iron oxide nanoparticles regulates in vivo theranostic applications

Nanoscale

H. Groult, S. Carregal-Romero, D. Castejón, M. Azkargorta, A.B. Miguel Coello, K. R. Pulagam, V. Gómez-Vallejo, R. Cousin, M.M. Caffarel, C. H. Lawrie, J. Llop, J-M. Piot, F. Elortza, T. Maugard, J. Ruiz-Cabello, I. Fruitier-Arnaudin.

Article / Ideafix: A decision tree-based method for the refinement of variants in FFPE DNA sequencing data

NAR Genomics and Bioinformatics

Tellaetxe-Abete, M.; Calvo, B.; Lawrie, C.

Article / Integrated mrna and mirna transcriptomic analyses reveals divergent mechanisms of sunitinib resistance in clear cell renal cell carcinoma (Ccrcc)

Cancers

Armesto, M.; Marquez, M.; Arestin, M.; Errarte, P.; Rubio, A.; Manterola, L.; López, J.I.; Lawrie, C.H.

Article / Heparin length in the coating of extremely small iron oxide nanoparticles regulates: In vivo theranostic applications

Nanoscale

Groult, H.; Carregal-Romero, S.; Castejón, D.; Azkargorta, M.; Miguel-Coello, A.B.; Pulagam, K.R.; Gómez-Vallejo, V.; Cousin, R.; Muñoz-Caffarel, M.; Lawrie, C.H.; Llop, J.; Piot, J.M.; Elortza, F.; Maugard, T.; Ruiz-Cabello, J.; Fruitier-Arnaudin, I.

Article / Pre-targeting with ultra-small nanoparticles: Boron carbon dots as drug candidates for boron neutron capture therapy

Journal of Materials Chemistry B

Feiner, I.V.J.; Pulagam, K.R.; Uribe, K.B.; Passannante, R.; Simó, C.; Zamacola, K.; Gómez-Vallejo, V.; Herrero-Álvarez, N.; Cossío, U.; Baz, Z.; Caffarel, M.M.; Lawrie, C.H.; Vugts, D.J.; Rejc, L.; Llop, J.

Review / Micrornas in metastasis and the tumour microenvironment

International Journal of Molecular Sciences

Solé, C.; Lawrie, C.H.

2020

Chapter / MicroRNA in Human Malignancies

Massimo Negrini, George Calin, Carlo Croce, Robin James James Sulit

Carla Sole & Charles H. Lawrie

Article / Circular RNAs

Advances in Clinical Chemistry.

Sole, C and Lawrie, C.H

Article / Identification of recurrent microRNA binding site mutations in follicular lymphoma cases include mutations in BCL2 and EZH2 genes

Blood Cancer Journal

Erika Larrea, Marta Fernandez-Mercado, Izaskun Ceberio, José Afonso Guerra-Assunção, Jun Wang, Ibai Goicoechea, Anton Enright, J. Okosun, J. Fitzgibbon, CH. Lawrie

Article / An integrative omics approach reveals involvement of BRCA1 in the hepatic metastatic progression of colorectal cancer

Gastroenterology

Gerovska D, Larrinaga G, Solano-Iturri, Márques J, Garcia Gallastegi J, Khatib A-M, Stüler K, Armesto M, Lawrie C.H., Badiola I, Araúzo-Bravo MJ

Article / The urinary transcriptome as a source of biomarkers for prostate cancer

Cancers

Solé, C.; Goicoechea, I.; Goñi, A.; Schramm, M.; Armesto, M.; Arestin, M.; Manterola, L.; Tellaetxe, M.; Alberdi, A.; Nogueira, L.; Roumiguie, M.; López, J.I.; Jaka, J.P.S.; Urruticoechea, A.; Vergara, I.; Loizaga-Iriarte, A.; Unda, M.; Carracedo, A.; Malavaud, B.; Lawrie, C.H.

Article / Therapeutic Pretargeting with Gold Nanoparticles as Drug Candidates for Boron Neutron Capture Therapy

Particle and Particle Systems Characterization

Feiner, I.V.J.; Pulagam, K.R.; Gómez-Vallejo, V.; Zamacola, K.; Baz, Z.; Caffarel, M.M.; Lawrie, C.H.; Ruiz-de-Angulo, A.; Carril, M.; Llop, J.

Article / Identification of recurrent mutations in the microrna‐binding sites of b‐cell lymphoma‐ associated genes in follicular lymphoma

International Journal of Molecular Sciences

Larrea, E.; Fernandez‐mercado, M.; Guerra‐assunção, J.A.; Wang, J.; Goicoechea, I.; Gaafar, A.; Ceberio, I.; Lobo, C.; Okosun, J.; Enright, A.J.; Fitzgibbon, J.; Lawrie, C.H.

Article / An integrative omics approach reveals involvement of BRCA1 in hepatic metastatic progression of colorectal cancer

Cancers

Gerovska, D.; Larrinaga, G.; Solano-Iturria, J.D.; Márquez, J.; Gallastegi, P.G.; Khatib, A.M.; Poschmann, G.; Stühler, K.; Armesto, M.; Lawrie, C.H.; Badiola, I.; Araúzo-Bravo, M.J.

Article / Serum levels of hsa-miR-16-5p, hsa-miR-29a-3p, hsa-miR-150-5p, hsa-miR-155-5p and hsa-miR-223-3p and subsequent risk of chronic lymphocytic leukemia in the EPIC study

International Journal of Cancer

Casabonne, D.; Benavente, Y.; Seifert, J.; Costas, L.; Armesto, M.; Arestin, M.; Besson, C.; Hosnijeh, F.S.; Duell, E.J.; Weiderpass, E.; Masala, G.; Kaaks, R.; Canzian, F.; Chirlaque, M.D.; Perduca, V.; Mancini, F.R.; Pala, V.; Trichopoulou, A.; Karakatsani, A.; La Vecchia, C.; Sánchez, M.J.; Tumino, R.; Gunter, M.J.; Amiano, P.; Panico, S.; Sacerdote, C.; Schmidt, J.A.; Boeing, H.; Schulze, M.B.; Barricarte, A.; Riboli, E.; Olsen, A.; Tjønneland, A.; Vermeulen, R.; Nieters, A.; Lawrie, C.H.; de Sanjosé, S.

Article / Characterization of a new small-molecule inhibitor of HDAC6 in glioblastoma

Cell Death and Disease

Auzmendi-Iriarte, J.; Saenz-Antoñanzas, A.; Mikelez-Alonso, I.; Carrasco-Garcia, E.; Tellaetxe-Abete, M.; Lawrie, C.H.; Sampron, N.; Cortajarena, A.L.; Matheu, A.

Review / MicroRNAs and metastasis

Cancers

Solé, C.; Lawrie, C.H.

2019

Article / Sequential treatment of metastatic renal cancer in a complex evolving landscape

Annals of Translational Medicine

Angulo, J.C., Lawrie, C.H., López, J.I.

Article / CircRNAs and Cancer

Advances in Clinical Chemistry

Sole, C and Lawrie, C.H

Article / The circulating transcriptome as a source of biomarkers for melanoma

Cancers

Solé, C.; Tramonti, D.; Schramm, M.; Goicoechea, I.; Armesto, M.; Hernandez, L.I.; Manterola, L.; Fernandez-Mercado, M.; Mujika, K.; Tuneu, A.; Jaka, A.; Tellaetxe, M.; Friedländer, M.R.; Estivill, X.; Piazza, P.; Ortiz-Romero, P.L.; Middleton, M.R.; Lawrie, C.H.

Review / The circulating transcriptome as a source of cancer liquid biopsy biomarkers

Seminars in Cancer Biology

Sole, C.; Arnaiz, E.; Manterola, L.; Otaegui, D.; Lawrie, C.H.

Review / CircRNAs and cancer: Biomarkers and master regulators

Seminars in Cancer Biology

Arnaiz, E.; Sole, C.; Manterola, L.; Iparraguirre, L.; Otaegui, D.; Lawrie, C.H.

2018

Article / Spatial intratumoural heterogeneity in the expression of GIT1 is associated with poor prognostic outcome in oestrogen receptor positive (ER+) breast cancer patients with synchronous lymph node metastases

F1000

Ibai Goicoechea, Ricardo Rezola, María Arestin, María M. Caffarel, Ana Rosa Cortazar, Lorea Manterola, Marta Fernandez-Mercado,María Armesto,Carla Sole, Erika Larrea, Angela M. Araujo, Nerea Ancizar, Arrate Plazaola, Ander Urruticoechea, Lawrie, C.H.

Article / Spatial intratumoural heterogeneity in the expression of GIT1 is associated with poor prognostic outcome in oestrogen receptor positive breast cancer patients with synchronous lymph node metastases

F1000Research

Lawrie, C.H.; Goicoechea, I.; Rezola, R.; Arestin, M.; Caffarel, M.M.; Cortazar, A.R.; Manterola, L.; Fernandez-Mercado, M.; Armesto, M.; Sole, C.; Larrea, E.; Araujo, A.M.; Ancizar, N.; Plazaola, A.; Urruticoechea, A.; Carracedo, A.; Ruiz, I.; Alvarez Lopez, I.

Article / Mutational profiling can identify laryngeal dysplasia at risk of progression to invasive carcinoma

Scientific Reports

Manterola, L.; Aguirre, P.; Larrea, E.; Arestín, M.; Gaafar, A.; Elorriaga, K.; Goicoechea, I.; Armesto, M.; Fernández-Mercado, M.; Zabalza, I.; López-Duque, J.C.; Larruskain, E.; Sistiaga, J.A.; Landa, M.; Zabala, A.; Santaolalla, F.; Municio, J.A.; Ispizua, Á.; García-Pedrero, J.M.; Rodrigo, J.P.; Lawrie, C.H.

Article / Potential impact of PD-L1 (SP-142) immunohistochemical heterogeneity in clear cell renal cell carcinoma immunotherapy

Pathology Research and Practice

López, J.I.; Pulido, R.; Cortés, J.M.; Angulo, J.C.; Lawrie, C.H.

Article / The role of chemically modified dna in discrimination of single-point mutation through plasmon-based colorimetric assays

ACS Applied Nano Materials

Sanroman-Iglesias, M.; Lawrie, C.H.; Liz-Marzan, L.M.; Grzelczak, M.

Article / Loss of PD-L1 (SP-142) expression characterizes renal vein tumor thrombus microenvironment in clear cell renal cell carcinoma

Annals of Diagnostic Pathology

López, J.I.; Pulido, R.; Lawrie, C.H.; Angulo, J.C.

Article / High levels of intratumor heterogeneity characterize the expression of epithelial-mesenchymal transition markers in high-grade clear cell renal cell carcinoma

Annals of Diagnostic Pathology

Guarch, R.; Lawrie, C.H.; Larrinaga, G.; Angulo, J.C.; Pulido, R.; López, J.I.

Article / Noncoding RNA Expression and Targeted Next-Generation Sequencing Distinguish Tubulocystic Renal Cell Carcinoma (TC-RCC) from Other Renal Neoplasms

Journal of Molecular Diagnostics

Lawrie, C.H.; Armesto, M.; Fernandez-Mercado, M.; Arestín, M.; Manterola, L.; Goicoechea, I.; Larrea, E.; Caffarel, M.M.; Araujo, A.M.; Sole, C.; Sperga, M.; Alvarado-Cabrero, I.; Michal, M.; Hes, O.; López, J.I.

Review / MicroRNAs as Biomarkers of B-cell Lymphoma

Biomarker Insights

Solé, C.; Arnaiz, E.; Lawrie, C.H.

2017

Article / Frequent deregulation of miR-196 in head and neck cancers leads to pleiotropic effects in the tumour cells and surrounding stromal fibroblasts

Scientific Reports

Álvarez-Teijeiro, S., Menéndez, S.T., Ángeles Villaronga, M., Rodrigo, J.P., Manterola, L., de Villalaín, L., de Vicente, J.C., Alonso-Durán, L., Fernández, M.P., Lawrie,C.H., García-Pedrero J.M.

Article / The expression of angiotensin-regulating enzymes predicts prognosis in renal cell carcinoma

PLoS ONE

Errarte, P., López, J.I., Beitia, M., Manterola, L.,, Lawrie, C.H., Perez, I., Larrinaga, G.

Article / miRNA in Hematological Cancers: molecular mechanism and biomarkers potential

Cancer Letters

Sole, C., Larrea, E., de Pinto, G., Lawrie, C.H

Article / SOX9 regulates epithelial to mesenchymal transition and self-renewal to promote metastasis and chemoresistance

Cancer Research

Estefania Carrasco-Garcia, Sara Arevalo, Lidia Lopez, Veronica Moncho-Amor, Paula Aldaz, Manuel Collado, Donald Bell, Ayman Gaafar, Eva Diamantis, Alexander Tzankov, Manuel Hidalgo, Manuel Serrano, Charles H. Lawrie Robin Lovell-Badge,& Ander Matheu

Article / Detection of mutations in cancer DNA using short blocking probes: a comparative study in solution and on the surface

Nanoscale

Aboudzadeh, M.A., Sanroman-Iglesias, M., Lawrie, C.H., Grzelczak, M. Liz-Marzán, L., Schäfer, T.

Article / Blocking probe as a potential tool for detection of single nucleotide DNA mutations: Design and performance

Nanoscale

Aboudzadeh, M.A.; Sanromán-Iglesias, M.; Lawrie, C.H.; Grzelczak, M.; Liz-Marzán, L.M.; Schäfer, T.

Article / Dysregulation of miR-196b in head and neck cancers leads to pleiotropic effects in the tumor cells and surrounding stromal fibroblasts

Scientific Reports

Álvarez-Teijeiro, S.; Menéndez, S.T.; Villaronga, M.Á.; Rodrigo, J.P.; Manterola, L.; De Villalaín, L.; De Vicente, J.C.; Alonso-Durán, L.; Fernández, M.P.; Lawrie, C.H.; García-Pedrero, J.M.

Article / Expression and activity of angiotensin-regulating enzymes is associated with prognostic outcome in clear cell renal cell carcinoma patients

PLoS ONE

Errarte, P.; Beitia, M.; Perez, I.; Manterola, L.; Lawrie, C.H.; Solano-Iturri, J.D.; Calvete-Candenas, J.; Unda, M.; López, J.I.; Larrinaga, G.

Article / Nanoparticle-Based Discrimination of Single-Nucleotide Polymorphism in Long DNA Sequences

Bioconjugate Chemistry

Sanromán-Iglesias, M.; Lawrie, C.H.; Liz-Marzán, L.M.; Grzelczak, M.

Review / miRNAs in B-cell lymphoma: Molecular mechanisms and biomarker potential

Cancer Letters

Solé, C.; Larrea, E.; Di Pinto, G.; Tellaexte, M.; Lawrie, C.H.

2016

Article / DNMT1 expression is associated with cell cycle gene sets and mitotic bodies in diffuse large B-cell lymphoma

Leukemia and Lymphoma

Loo, S.K., Ch'ng, E.S, Lawrie, C.H.,, Arestin, M., Gaafar, A., Salzihan, M., Salleh, M., Banham, A.H., Pedersen, L.M., Møller, M.B., Green, T.M., Wong, K.K.

Article / MicroRNA expression in B-cell lymphomas

MicroRNA

Sole, C., Larrea, E., Manterola, L., Goicoechea, I., Armesto,M., Arestin, M., Caffarel, M., Araujo, A., Araiz, M., Fernandez, M., Lawrie, CH,

Article / Challenges, opportunities and recommendations when using miRNA in liquid biopsies as disease biomarkers

Journal of Biotechnology and Biomedical Engineering

Fernandez, M., Lawrie,C.H

Article / Multi-site tumor sampling (MSTS) improves the performance of histological detection of intratumor heterogeneity in clear cell renal cell carcinoma (CCRCC)

F1000 Research

Guarch, R., Cortés,J.M, Lawrie, C.H.,* López, J.I.,

Article / High levels of SOX9 induce gastric cancer progression through a regulatory loop with WNT canonical signaling

Cancer Research

Santos, J.C, Carrasco-Garcia, E., Garcia-Puga, M., Aldaz, P., Montes, Fernandez-Reyes, M., Lawrie, C.H.,, Araúzo-Bravo, M.J., Ribeiro, M.L, Matheu, M.

Article / Sensitivity Limit of Nanoparticle Biosensors in the Discrimination of Single Nucleotide Polymorphism

ACS Sensors

Sanromán-Iglesias, M.; Lawrie, C.H.; Schäfer, T.; Grzelczak, M.; Liz-Marzán, L.M.

Article / Stratification and therapeutic potential of PML in metastatic breast cancer

Nature Communications

Martín-Martín, N.; Piva, M.; Urosevic, J.; Aldaz, P.; Sutherland, J.D.; Fernández-Ruiz, S.; Arreal, L.; Torrano, V.; Cortazar, A.R.; Planet, E.; Guiu, M.; Radosevic-Robin, N.; Garcia, S.; Macías, I.; Salvador, F.; Domenici, G.; Rueda, O.M.; Zabala-Letona, A.; Arruabarrena-Aristorena, A.; Zúñiga-García, P.; Caro-Maldonado, A.; Valcárcel-Jiménez, L.; Sánchez-Mosquera, P.; Varela-Rey, M.; Martínez-Chantar, M.L.; Anguita, J.; Ibrahim, Y.H.; Scaltriti, M.; Lawrie, C.H.; Aransay, A.M.; Iovanna, J.L.; Baselga, J.; Caldas, C.; Barrio, R.; Serra, V.; Dm Vivanco, M.; Matheu, A.; Gomis, R.R.; Carracedo, A.

Article / SOX9 elevation acts with canonical WNT signaling to drive gastric cancer progression

Cancer Research

Santos, J.C.; Carrasco-Garcia, E.; Garcia-Puga, M.; Aldaz, P.; Montes, M.; Fernandez-Reyes, M.; De Oliveira, C.C.; Lawrie, C.H.; Arauzo-Bravo, M.J.; Ribeiro, M.L.; Matheu, A.

Article / Multi-site tumor sampling (MSTS) improves the performance of histological detection of intratumor heterogeneity in clear cell renal cell carcinoma (CCRCC)

F1000Research

Guarch, R.; Cortés, J.M.; Lawrie, C.H.; López, J.I.

Note / MicroRNA master regulator of hematopoiesis may also hold the key to B-cell lymphoma pathogenesis and therapy

Translational Cancer Research

Lawrie, C.H.

Review / New concepts in cancer biomarkers: Circulating miRNAs in liquid biopsies

International Journal of Molecular Sciences

Larrea, E.; Sole, C.; Manterola, L.; Goicoechea, I.; Armesto, M.; Arestin, M.; Caffarel, M.M.; Araujo, A.M.; Araiz, M.; Fernandez-Mercado, M.; Lawrie, C.H.

2015

Article / Transcriptional-Repression by a novel HDAC4-RelB-p52 complex regulates Multiple Myeloma Survival and growth

Nature Comm.

Vallabhapurapu, S.D., Noothi, S.K., Pullum, D., Lawrie, C.H., Pallapati, R., Potluri,V., Kuntzen, C., Plas, D.R., Orlowski, R., Chesi, M., Kuehl, W.M., Bergsagel, L.P., Karin, M., & Vallabhapurapu, S.

Article / MicroRNAs as B-Cell lymphoma biomarkers

Journal of Blood and Lymphatic Cancer: Targets and Therapy

Manterola, L., Fernandez-Mercado, M., Larrea, E., Goicoechea, I., Arestin, M., Armesto,M., Hernandez, L., Lawrie, CH,

Article / Conjugated Polymers As Molecular Gates for Light-Controlled Release of Gold Nanoparticles

ACS Applied Materials and Interfaces

Sanromán-Iglesias, M.; Zhang, K.A.I.; Chuvilin, A.; Lawrie, C.H.; Grzelczak, M.; Liz-Marzán, L.M.

Article / Low HIP1R mRNA and protein expression are associated with worse survival in diffuse large B-cell lymphoma patients treated with R-CHOP

Experimental and Molecular Pathology

Wong, K.K.; Ch'ng, E.S.; Loo, S.K.; Husin, A.; Muruzabal, M.A.; Møller, M.B.; Pedersen, L.M.; Pomposo, M.P.; Gaafar, A.; Banham, A.H.; Green, T.M.; Lawrie, C.H.

Article / The circulating transcriptome as a source of non-invasive cancer biomarkers: Concepts and controversies of non-coding and coding RNA in body fluids

Journal of Cellular and Molecular Medicine

Fernandez-Mercado, M.; Manterola, L.; Larrea, E.; Goicoechea, I.; Arestin, M.; Armesto, M.; Otaegui, D.; Lawrie, C.H.

Article / MicroRNAs in lymphoma: Regulatory role and biomarker potential

Current Genomics

Fernandez-Mercado, M.; Manterola, L.; Lawrie, C.H.

Note / Written in Blood: Kissing Disease miRNAs Could Predict Outcome of Patients With Chronic Lymphocytic Leukaemia

EBioMedicine

Lawrie, C.H.

2014

Chapter / MicroRNAs as key regulators of oncogenesis.

Lawrie, C.H.

Chapter / Applied RNAi: From Fundamental Research to Therapeutic Applications

Otaegui, D and Lawrie, C.H.

Chapter / Topics in Anti-Cancer Research (Volume 3)

Carrasco, E., Sampron, N., Aldaz, P., Arrizabalaga, O., Vilauna, J., Barrena, C., Ruiz, I., Arrazola, M., Lawrie, C.H., Matheu, A.

Article / Reciprocal expression of the endocytic protein HIP1R and its repressor FOXP1 predicts outcome in R-CHOP-treated diffuse large B-cell lymphoma patients

Leukemia

Wong, K.K.; Gascoyne, D.M.; Brown, P.J.; Soilleux, E.J.; Snell, C.; Chen, H.; Lyne, L.; Lawrie, C.H.; Gascoyne, R.D.; Pedersen, L.M.; Møller, M.B.; Pulford, K.; Murphy, D.; Green, T.M.; Banham, A.H.

Article / Targeted next-generation sequencing and non-coding RNA expression analysis of clear cell papillary renal cell carcinoma suggests distinct pathological mechanisms from other renal tumour subtypes

Journal of Pathology

Lawrie, C.H.; Larrea, E.; Larrinaga, G.; Goicoechea, I.; Arestin, M.; Fernandez-Mercado, M.; Hes, O.; Cáceres, F.; Manterola, L.; Lõpez, J.I.

2013

Chapter / Advances in Virus Research.

Armesto, M and Lawrie, C.H.

Article / MicroRNAs in hematological malignancies

Blood Reviews

Lawrie, C.H.

Review / Therapeutic strategies targeting Glioblastoma stem cells

Recent Patents on Anti-Cancer Drug Discovery

Carrasco-Garcia, E.; Sampron, N.; Aldaz, P.; Arrizabalaga, O.; Villanua, J.; Barrena, C.; Ruiz, I.; Arrazola, M.; Lawrie, C.; Matheu, A.

Review / MicroRNAs and lymphomagenesis: A functional review

British Journal of Haematology

Lawrie, C.H.

2012

Book / Hematology: Science and Practice.

Lawrie, C.H.

Lawrie, C.H. (Editor)

Chapter / Hematology: Science and Practice.

Lawrie, C.H.

Article / MicroRNAs: back to basics

Myeloid disorders in Practice

Lawrie, C.H.

Article / Inter- and intra-observational variability in immunohistochemistry: A multicentre analysis of diffuse large B-cell lymphoma staining

Histopathology

Lawrie, C.H.; Ballabio, E.; Soilleux, E.; Sington, J.; Hatton, C.S.R.; Dirnhofer, S.; Tzankov, A.

Letter / Bortezomib action in multiple myeloma: MicroRNA-mediated synergy (and miR-27a/CDK5 driven sensitivity)?

Blood Cancer Journal

Ballabio, E.; Armesto, M.; Breeze, C.E.; Manterola, L.; Arestin, M.; Tramonti, D.; Hatton, C.S.R.; Lawrie, C.H.

Letter / Primary cutaneous anaplastic large cell lymphoma shows a distinct miRNA expression profile and reveals differences from tumor-stage mycosis fungoides

Experimental Dermatology

Benner, M.F.; Ballabio, E.; Van Kester, M.S.; Saunders, N.J.; Vermeer, M.H.; Willemze, R.; Lawrie, C.H.; Tensen, C.P.

2011

Article / Identification and characterization of peripheral T-cell lymphoma-associated SEREX antigen

PLoS ONE

Cooper, CD*,Lawrie CH*, Liggins, A, Collins, G, Pulford, K, Banham, AH

2024

Conference paper | Raman spectroscopy detects biochemical signatures in non-small cell lung cancer

H. Hano, B. Suarez, C. H. Lawrie, and A. Seifert

Conference Paper | Raman Spectroscopy Detects Biochemical Signatures in Non-Small Cell Lung Cancer

International Conference on Optical MEMS and Nanophotonics - Conference Paper

Hano, H.; Suarez, B.; Lawrie, C.H.; Seifert, A.

Oral presentation | CAR T therapy monitored by Raman spectroscopy: temporal trajectories of therapeutic response

ETPN2024 – European Technology Platform Nanomedicine - Oral presentation

J. Plou, C. H. Lawrie, and A. Seifert

Poster presentation | Non-invasive lung cancer detection by multivariate analysis of vibrational spectroscopy data

ETPN2024 – European Technology Platform Nanomedicine - Poster presentation

H. Hano, B. Suarez, C. H. Lawrie, and A. Seifert

2022

Poster presentation | Improving anti-PD1 immunotherapy through targeting the HIF/hypoxia axis of clear cell renal cell carcinoma

ASEICA International Congress – Asociación Española de Investigación sobre el Cáncer - Poster presentation

M. Márquez López, E. Arnaitz González, C. Solé Cañadas, B. Suárez Álvarez, M. Armesto Álvarez, A. Seifert, C. Lawrie