Amanda Sierra

Ikerbasque Research Professor, UPV/EHU and Achucarro Basque Center for Neuroscience

Group leader of the Laboratory of Glial Cell Biology at Achucarro Basque Center for Neuroscience and the Department of Neuroscience, Faculty of Medicine, at the University of the Basque Country, in Leioa, Bizkaia.

Research line:

Microglial cells at the interplay between phagocytosis and inflammation in the diseased brain. The research involves the study of the cellular and molecular mechanisms involved in the regulation of the efficiency of microglial phagocytosis.

More than 10 years of experience in Neurobiology in research centers in Spain (Cajal Institute) and USA (Rockefeller University, Stony Brook University and Baylor College of Medicine).

Doctor in neurosciences from the Complutense University of Madrid (Spain) in 2003.

2024

Article / Microglia in Health and Diseases: Integrative Hubs of the Central Nervous System (CNS)

Cold Spring Harbor Perspectives in Biology

Sierra, A.; Miron, V.E.; Paolicelli, R.C.; Ransohoff, R.M.

Note / Interferons: Invited guests at the brain's gala banquet

Neuron

Márquez-Ropero, M.; Sierra, A.

2023

Article / Microglia and meningeal macrophages depletion delays the onset of experimental autoimmune encephalomyelitis.

Cell Death Dis

Montilla A, Zabala A, Er-Lukowiak M, Rissiek B, Magnus T, Rodriguez-Iglesias N, Sierra A, Matute C, Domercq M.

Article / Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy

Autophagy

Beccari, S.; Sierra-Torre, V.; Valero, J.; Pereira-Iglesias, M.; García-Zaballa, M.; Soria, F.N.; De Las Heras-Garcia, L.; Carretero-Guillen, A.; Capetillo-Zarate, E.; Domercq, M.; Huguet, P.R.; Ramonet, D.; Osman, A.; Han, W.; Dominguez, C.; Faust, T.E.; Touzani, O.; Pampliega, O.; Boya, P.; Schafer, D.; Mariño, G.; Canet-Soulas, E.; Blomgren, K.; Plaza-Zabala, A.; Sierra, A.

Article / Microglia and meningeal macrophages depletion delays the onset of experimental autoimmune encephalomyelitis

Cell Death and Disease

Montilla, A.; Zabala, A.; Er-Lukowiak, M.; Rissiek, B.; Magnus, T.; Rodriguez-Iglesias, N.; Sierra, A.; Matute, C.; Domercq, M.

Review / Studying Autophagy in Microglia: Overcoming the Obstac

Methods Mol Biol .

Plaza-Zabala A, Sierra A.

2022

Article / Microglial phagocytosis dysfunction during stroke is prevented by rapamycin.

Autophagy (in press)

Beccari S, Sierra-Torre V, Valero J, Garcia-Zaballa M, Carretero-Guillen A, Capetillo-Zarate E, Domercq M, Huguet-Rodriguez PR, Ramonet D, Umekawa T, Osman A, Han W, Dominguez C, Faust T, Touzani O, Boya P, Schaffer D, Mariño G, Canet-Soulas E, Blomgren K,* Plaza-Zabala A, *Sierra A

Article / Susceptibility of Female Mice to the Dietary Omega-3/Omega-6 Fatty-Acid Ratio: Effects on Adult Hippocampal Neurogenesis and Glia

International Journal of Molecular Sciences

Rodríguez-Iglesias, N.; Nadjar, A.; Sierra, A.; Valero, J.

Review / Microglia states and nomenclature: a field at its crossroads

Neuron

Paolicelli R*, *Sierra A, *Stevens B, *Tremblay ME et al.

Review / Microglia states and nomenclature: A field at its crossroads

Neuron

Paolicelli, R.C.; Sierra, A.; Stevens, B.; Tremblay, M.E.; Aguzzi, A.; Ajami, B.; Amit, I.; Audinat, E.; Bechmann, I.; Bennett, M.; Bennett, F.; Bessis, A.; Biber, K.; Bilbo, S.; Blurton-Jones, M.; Boddeke, E.; Brites, D.; Brône, B.; Brown, G.C.; Butovsky, O.; Carson, M.J.; Castellano, B.; Colonna, M.; Cowley, S.A.; Cunningham, C.; Davalos, D.; De Jager, P.L.; de Strooper, B.; Denes, A.; Eggen, B.J.L.; Eyo, U.; Galea, E.; Garel, S.; Ginhoux, F.; Glass, C.K.; Gokce, O.; Gomez-Nicola, D.; González, B.; Gordon, S.; Graeber, M.B.; Greenhalgh, A.D.; Gressens, P.; Greter, M.; Gutmann, D.H.; Haass, C.; Heneka, M.T.; Heppner, F.L.; Hong, S.; Hume, D.A.; Jung, S.; Kettenmann, H.; Kipnis, J.; Koyama, R.; Lemke, G.; Lynch, M.; Majewska, A.; Malcangio, M.; Malm, T.; Mancuso, R.; Masuda, T.; Matteoli, M.; McColl, B.W.; Miron, V.E.; Molofsky, A.V.; Monje, M.; Mracsko, E.; Nadjar, A.; Neher, J.J.; Neniskyte, U.; Neumann, H.; Noda, M.; Peng, B.; Peri, F.; Perry, V.H.; Popovich, P.G.; Pridans, C.; Priller, J.; Prinz, M.; Ragozzino, D.; Ransohoff, R.M.; Salter, M.W.; Schaefer, A.; Schafer, D.P.; Schwartz, M.; Simons, M.; Smith, C.J.; Streit, W.J.; Tay, T.L.; Tsai, L.H.; Verkhratsky, A.; von Bernhardi, R.; Wake, H.; Wittamer, V.; Wolf, S.A.; Wu, L.J.; Wyss-Coray, T.

2021

Article / A two-step model of autophagy: autophagosome formation, degradation and net turnover.

Frontiers in Immunology

Plaza-Zabala A, Sierra-Torre V, Sierra A

Article / Role of mitochondrial dynamics in microglial activation and metabolic switch.

Immunohorizons

Montilla A, Ruiz A, Marquez-Ropero M, Sierra A, Matute C, Domercq M.

Article / Role of Mitochondrial Dynamics in Microglial Activation and Metabolic Switch

ImmunoHorizons

Montilla, A.; Ruiz, A.; Marquez, M.; Sierra, A.; Matute, C.; Domercq, M.

Article / Assessing Autophagy in Microglia: A Two-Step Model to Determine Autophagosome Formation, Degradation, and Net Turnover

Frontiers in Immunology

Plaza-Zabala, A.; Sierra-Torre, V.; Sierra, A.

Editorial / Editorial: Assessing Microglial Function and Identity

Frontiers in Immunology

Sierra, A.; Paolicelli, R.C.

2020

Article / Fast SARS-CoV-2 detection protocol based on RNA precipitation and RT-qPCR in nasopharyngeal swab samples

medRxiv

Xabier Guruceaga, Amanda Sierra, Daniel Marino, Izortze Santin, Jon Ander Nieto-Garai, Jose Ramón Bilbao, Maier Lorizate, Patricia Aspichueta, Adhara Gaminde-Blasco, Adrian Bozal-Leorri, Agustín Marín-Peña, Ainara Castellanos- Rubio, Ainhoa Iglesias-Ara, Aitor Rementeria1D, Ana Bernal-Chico1E,3,7, Andoni Ramirez-Garcia1D, Ane Olazagoitia-Garmendia1C,4, Asier Benito-Vicente1A,8, César Martín1A,8, Eider Bilbao Castellanos1I,10, Eneritz Rueda-Alaña1E,3, Fabio Cavaliere1E,3,7, Guiomar Perez de Nanclares1,9, Igor Aurrekoetxea1F,4, Iraia Garcia-Santisteban1C,4, Irantzu Bernales1H, Itziar Gonzalez-Moro1A,4, Jan Tønnesen1E,3, Jimena Baleriola1B,2,3, Jon Vallejo-Rodríguez1C, Leire Aparicio-Fernandez1D, Leire Martin-Souto1D, Luis Manuel Mendoza1C, Maialen Areitio1D, Maialen Sebastian-delaCruz1C,4, Maren Ortiz- Zarragoitia1I,10, Mari Paz Serrano-Regal1E,3,7, Miren Basaras1D, Nora Fernandez- Jimenez1C,4, Olatz Pampliega1E,3, Santos Alonso Alegre1C, Susi Marcos1, Teresa Fuertes-Mendizabal1G, Unai Galicia-Garcia5,8, Uxue Perez-Cuesta1D, Verónica Torrano1,8, Virginia Sierra-Torre1E,3, Xabier Buqué1F,4 and Ugo Mayor1A,2

Article / Microglial phagocytosis dysfunction is related to local neuronal activity in a genetic model of epilepsy.

Epilepsia

Sierra-Torre V, Plaza-Zabala A, Bonifaci P, Abiega O, Diaz-Aparicio I, Tejelberg S, Lehesjoki AE, Valero J, Sierra A.

Article / Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain

Nature Communications

Madore, C.; Leyrolle, Q.; Morel, L.; Rossitto, M.; Greenhalgh, A.D.; Delpech, J.C.; Martinat, M.; Bosch-Bouju, C.; Bourel, J.; Rani, B.; Lacabanne, C.; Thomazeau, A.; Hopperton, K.E.; Beccari, S.; Sere, A.; Aubert, A.; De Smedt-Peyrusse, V.; Lecours, C.; Bisht, K.; Fourgeaud, L.; Gregoire, S.; Bretillon, L.; Acar, N.; Grant, N.J.; Badaut, J.; Gressens, P.; Sierra, A.; Butovsky, O.; Tremblay, M.E.; Bazinet, R.P.; Joffre, C.; Nadjar, A.; Layé, S.

Article / Microglial phagocytosis dysfunction in the dentate gyrus is related to local neuronal activity in a genetic model of epilepsy

Epilepsia

Sierra-Torre, V.; Plaza-Zabala, A.; Bonifazi, P.; Abiega, O.; Díaz-Aparicio, I.; Tegelberg, S.; Lehesjoki, A.E.; Valero, J.; Sierra, A.

Article / Microglia actively remodel adult hippocampal neurogenesis through the phagocytosis secretome

Journal of Neuroscience

Diaz-Aparicio, I.; Paris, I.; Sierra-Torre, V.; Plaza-Zabala, A.; Rodríguez-Iglesias, N.; Márquez-Ropero, M.; Beccari, S.; Huguet, P.; Abiega, O.; Alberdi, E.; Matute, C.; Bernales, I.; Schulz, A.; Otrokocsi, L.; Sperlagh, B.; Happonen, K.E.; Lemke, G.; Maletic-Savatic, M.; Valero, J.; Sierra, A.

Review / Microglial Corpse Clearance: Lessons From Macrophages

Frontiers in Immunology

Márquez-Ropero, M.; Benito, E.; Plaza-Zabala, A.; Sierra, A.

2019

Article / Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the developing brain

Nat Commun

Madore C, Leyrolle Q, Morel L, Delpech JC, Greenhalgh AD, Lacabanne C, Bosch-Bouju C, Bourel J, Thomazeau A, Hopperton KE, Beccari S, Sere A, Aubert A, De Smedt-Peyrusse V, Lecours C, Bisht K, Fourgeaud L, Gregoire S, Bretillon L, Grant NJ, Badaut J, Gr

Article / C1q is related to microglial phagocytosis in the hippocampus in physiological conditions.

Science Matters

Diaz-Aparicio I, Sierra A.

Article / Reactive Disruption of the Hippocampal Neurogenic Niche After Induction of Seizures by Injection of Kainic Acid in the Amygdala

Frontiers in Cell and Developmental Biology

Muro-García, T.; Martín-Suárez, S.; Espinosa, N.; Valcárcel-Martín, R.; Marinas, A.; Zaldumbide, L.; Galbarriatu, L.; Sierra, A.; Fuentealba, P.; Encinas, J.M.

Editorial / Editorial for the Special Issue: Microglia-Neuron interactions in health and disease - novel perspectives for translational research

Neuroscience

Sierra, A.; Denes, A.

Review / Cien Años de Microglía: Milestones in a Century of Microglial Research

Trends in Neurosciences

Sierra, A.; Paolicelli, R.C.; Kettenmann, H.

Review / Rewiring of memory circuits: Connecting adult newborn neurons with the help of microglia

Frontiers in Cell and Developmental Biology

Rodríguez-Iglesias, N.; Sierra, A.; Valero, J.

2018

Article / ProMoIJ: a new tool for automatic analysis of microglial processes motility.

Glia

Paris I, Escobar L, Savage JC, Hui, CW, Tremblay ME, Sierra A, Valero J

Article / ProMoIJ: A new tool for automatic three-dimensional analysis of microglial process motility

GLIA

Paris, I.; Savage, J.C.; Escobar, L.; Abiega, O.; Gagnon, S.; Hui, C.W.; Tremblay, M.È.; Sierra, A.; Valero, J.

Review / Development and maintenance of the brain's immune toolkit: Microglia and non-parenchymal brain macrophages

Developmental Neurobiology

Lopez-Atalaya, J.P.; Askew, K.E.; Sierra, A.; Gomez-Nicola, D.

2017

Article / Multiple Bellman-Harris branching model provides biological predictors of early stages of adult hippocampal neurogenesis.

BMC Syst Biol

Li B, Sierra A, Semerci F, Deudero JJ, Laitman A, Kimmel M, Maletic-Savatic M.

Article / El sistema de autolimpieza falla en la epilepsia

Mente y Cerebro

Sierra A, Valero J.

Article / Quantifying microglial phagocytosis of apoptotic cells in the brain in health and disease.

Current Protocols in Immunology

Beccari S, Diaz-Aparicio I, Sierra A

Article / A simulation model of neuroprogenitor proliferation dynamics predicts age-related loss of hippocampal neurogenesis but not astrogenesis

Scientific Reports

Beccari, S.; Valero, J.; Maletic-Savatic, M.; Sierra, A.

Article / A standardized protocol for stereotaxic intrahippocampal administration of kainic acid combined with electroencephalographic seizure monitoring in mice

Frontiers in Neuroscience

Bielefeld, P.; Sierra, A.; Encinas, J.M.; Maletic-Savatic, M.; Anderson, A.; Fitzsimons, C.P.

Article / Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

Cell Reports

Askew, K.; Li, K.; Olmos-Alonso, A.; Garcia-Moreno, F.; Liang, Y.; Richardson, P.; Tipton, T.; Chapman, M.A.; Riecken, K.; Beccari, S.; Sierra, A.; Molnár, Z.; Cragg, M.S.; Garaschuk, O.; Perry, V.H.; Gomez-Nicola, D.

Review / Autophagy and microglia: Novel partners in neurodegeneration and aging

International Journal of Molecular Sciences

Plaza-Zabala, A.; Sierra-Torre, V.; Sierra, A.

2016

Article / Lifestyle shapes hippocampal memory function: the dialog between environment, microglia, and adult neurogenesis

ACS Chemical Neuroscience

Valero J, Paris I, Sierra A

Article / The `big-bang´ for modern glial biology: translation and comments on Pío del Río-Hortega 1919 series of papers on microglia.

Glia

Sierra A, de Castro F, del Río-Hortega J, Iglesias-Rozas JR, Garrosa M, Kettenmann H

Article / Hiding the corpses: microglial phagocytosis efficiency determines apoptosis dynamics in health and disease

Neural Regeneration Research

Diaz –Aparicio I, Beccari S, Abiega O, Sierra A

Article / The “Big-Bang” for modern glial biology: Translation and comments on Pío del Río-Hortega 1919 series of papers on microglia

GLIA

Sierra, A.; de Castro, F.; del Río-Hortega, J.; Rafael Iglesias-Rozas, J.; Garrosa, M.; Kettenmann, H.

Article / Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling

PLoS Biology

Abiega, O.; Beccari, S.; Diaz-Aparicio, I.; Nadjar, A.; Layé, S.; Leyrolle, Q.; Gómez-Nicola, D.; Domercq, M.; Pérez-Samartín, A.; Sánchez-Zafra, V.; Paris, I.; Valero, J.; Savage, J.C.; Hui, C.W.; Tremblay, M.È.; Deudero, J.J.P.; Brewster, A.L.; Anderson, A.E.; Zaldumbide, L.; Galbarriatu, L.; Marinas, A.; Vivanco, M.d.M.; Matute, C.; Maletic-Savatic, M.; Encinas, J.M.; Sierra, A.

Review / Clearing the corpses: Regulatory mechanisms, novel tools, and therapeutic potential of harnessing microglial phagocytosis in the diseased brain

Neural Regeneration Research

Diaz-Aparicio, I.; Beccari, S.; Abiega, O.; Sierra, A.

Review / Lifestyle Shapes the Dialogue between Environment, Microglia, and Adult Neurogenesis

ACS Chemical Neuroscience

Valero, J.; Paris, I.; Sierra, A.

2015

Article / From the Cajal alumni Achúcarro and del Río Hortega to the rediscovery of never-resting microglia.

Frontiers in Neuroanatomy

Tremblay ME, Samson L, Sánchez-Zafra V, Sierra A

Article / Longitudinal variations of brain functional connectivity: A case report study based on a mouse model of epilepsy

F1000Research

Erramuzpe, A.; Encinas, J.M.; Sierra, A.; Maletic-Savatic, M.; Brewster, A.L.; Anderson, A.E.; Stramaglia, S.; Cortes, J.M.

Article / Neuronal hyperactivity accelerates depletion of neural stem cells and impairs hippocampal neurogenesis

Cell Stem Cell

Sierra, A.; Martín-Suárez, S.; Valcárcel-Martín, R.; Pascual-Brazo, J.; Aelvoet, S.A.; Abiega, O.; Deudero, J.J.; Brewster, A.L.; Bernales, I.; Anderson, A.E.; Baekelandt, V.; Maletić-Savatić, M.; Encinas, J.M.

Review / From the Cajal alumni Achúcarro and Río-Hortega to the rediscovery of never-resting microglia

Frontiers in Neuroanatomy

Tremblay, M.È.; Lecours, C.; Samson, L.; Sánchez-Zafra, V.; Sierra, A.

2014

Book / Microglia in health and disease

Microglia in Health and Disease

Tremblay, M.È.; Sierra, A.

Article / Accelerated Depletion of Neural Stem Cells and Impairment of Hippocampal neurogenesis by Neuronal Hyperactivity

Cell Stem Cell

Sierra A, Martín-Suárez S, Valcárcel-Martín R, Pascual-Brazo J, Aelvoet S-A, Abiega O, Deudero JJP, Brewster AL, Anderson AE, Baekelandt V, Maleti?-Savati? M, Encinas JM

Editorial / Never-resting microglia: Physiological roles in the healthy brain and pathological implications

Frontiers in Cellular Neuroscience

Sierra, A.; Tremblay, M.E.; Wake, H.

Editorial / Preface

Microglia in Health and Disease

Tremblay, M.È.; Sierra, A.

Editorial / Introduction

Microglia in Health and Disease

Sierra, A.; Tremblay, M.È.

Review / Surveillance, phagocytosis, and inflammation: How never-resting microglia influence adult hippocampal neurogenesis

Neural Plasticity

Sierra, A.; Beccari, S.; Diaz-Aparicio, I.; Encinas, J.M.; Comeau, S.; Tremblay, M.E.

2013

Article / Microglial control of adult hippocampal neurogenesis,memory, and learning: moving forward from the inflammatory paradigm

Neural Plasticity

Sierra A, Beccari S, Diaz I, Encinas JM, Comeau S, Tremblay

Review / A developmental perspective on adult hippocampal neurogenesis

International Journal of Developmental Neuroscience

Encinas, J.M.; Sierra, A.; Valcárcel-Martín, R.; Martín-Suárez, S.

Review / Janus-faced microglia: Beneficial and detrimental consequences of microglial phagocytosis

Frontiers in Cellular Neuroscience

Sierra, A.; Abiega, O.; Shahraz, A.; Neumann, H.

2012

Review / Neural stem cell deforestation as the main force driving the age-related decline in adult hippocampal neurogenesis

Behavioural Brain Research

Encinas, J.M.; Sierra, A.

2011

Article / The role of microglia in the healthy brain

Journal of Neuroscience

Tremblay, M.E.; Stevens, B.; Sierra, A.; Wake, H.; Bessis, A.; Nimmerjahn, A.

Microglial phagocytosis dysfunction from development to neurodegenerative disease

University of the Basque Country EHU/UPV

Sol Beccari - Finished

Microglial phagocytosis of apoptotic cells triggers a neuromodulatory program that supports neurogenesis

Euskal Herriko Unibertsitatea EHU/UPV

Irune Diaz Aparicio - Finished

Microglial phagocytosis/apoptosis uncoupling in epilepsy: mechanisms and detrimental consequences

University of the Basque Country EHU/UPV

Oihane Abiega Etxabe - Finished

2020

Effects of ischemia on autophagy

University of the Basque Country EHU/UPV

2018

Mitochondrial dynamics in phagocytic microglia

University of the Basque Country EHU/UPV

2016

Role of purinergic signaling in microglial phagocytosis in vivo

EHU/UPV

2015

Cellular targets of excitotoxicity in a mouse model of MTLE

EHU/UPV

2012

Microglial phagocytosis and inflammation in a mouse model of MTLE

EHU/UPV

2021

Spanish Confederation of Scientific Societies (COSCE), Life Sciences Section, committee member

Symposium Chair, Spanish Society for Neuroscience meeting

2020

Organizing Committee, EMBL Workshop on Microglia

Invited Host Editor, Frontiers in Immunology, Research Topic “Assesing microglial function and identity”, Eds. A. Sierra, R. Paolicelli.

Symposium Chair, Federation of European Neuroscience Societies meeting (virtual)

2019

Organizing Committee, Symposium 100 years of Microglia, Lausanne University, Switzerland

Instructor, 1st joined ISN/IBRO Basic Neuroscience School: From basic brain functions to neurodegenerative diseases, Sfax, Tunisia

2018

Organizing Committee, 1st Achucarro International Glia School (Bilbao, Spain)

2017

Vicepresident, Spanish Society for Neuroscience

Organizer, “Science is not just for girls: Neuroscience workshop for kids from 0-99. Feb/11: International Day of Women and Girls in Science” (Bilbao)

2016

Program Committee, XII Euroglia Meeting

Instructor, Glial cells in Health and Disease. Cajal – ISN course, Bordeaux, France.

Instructor, Nutrition and Brain Functions. Cajal Summer School, Bordeaux, France.

Organizing and Scientific Committee, III Basque Neuroscience Meeting, Bilbao, Spain

Coordinator (Bilbao), Science dissemination festival Pint of Science

2015

Local Organizing Committee, Euroglia Meeting, Bilbao

Secretary, Spanish Society for Neuroscience

2014

Scientific Committee, II NeuroGune (Basque Neuroscience Meeting), Donostia

Grant reviewer, Hungarian Scientific Research Fund (OTKA); Netherlands Organisation for Scientific Research (NWO); Fonds National de la Recherche, Luxemburg

2013

Organizing and Scientific Committees, I NeuroGune (Basque Neuroscience Meeting), Bilbao

Reviewer, Journal of Visualized Experiments, Journal of Neurochemistry, Frontiers in Neuroscience, Neurobiology of Disease, PLoS ONE

Invited Host Editor, Frontiers in Cellular Neuroscience, Research Topic “Never-resting microglia: physiological roles in the healthy brain and pathological implications”, Eds. Amanda Sierra, Marie-Eve Tremblay and Hiroaki Wake.

Host Editor, book “Microglia in Health and Disease”, Eds. Marie-Eve Tremblay and Amanda Sierra, Springer

2012

Organizer, Workhsop Frontiers in Glial Research, a satellite event to FENS 2012, Barcelona

Host Editor, Frontiers in Neuroscience, research topic "Never-resting microglia: physiological roles in the healthy brain and pathological implications"

Workshop Organizer, Frontiers in Glial Cells, a satellite event to FENS 2012, Barcelona

2011

Symposium chair, "Microglia clearance in health and disease", 10th Euroglia Meeting, Prague, Czech Republic

2019

Invited talk | Clearing the corpses: microglial phagocytosis from neurodegeneration to neurogenesis

Research seminar - Invited talk

Sierra A.

Invited talk | Not just corpse removal: how microglial phagocytosis maintains brain tissue homeostasis.

Glial Cells in Health and Disease symposium - Invited talk

Sierra A.

Invited talk | Microglia in brain physiology

100 years of microglia symposium - Invited talk

Sierra A.

Invited talk | Not just corpse removal: how microglial phagocytosis maintains brain tissue homeostasis

Research Seminar - Invited talk

Sierra A.

2018

Invited talk | Microglial phagocytosis: from neurogenesis to neurodegeneration.

EMBL Workshop on Microglia - Invited talk

Sierra A

Invited talk | Clearing the corpses: do microglia eat enough in the epileptic brain?

Research Seminar - Invited talk

Sierra A

Invited talk | Clearing the corpses: do microglia eat enough in the diseased brain?

Fundación Ramón Areces: The role of astrocytes and microglia in neurodegeneration and cancer n neurodegeneration and cancer - Invited talk

Sierra A

Invited talk | Clearing the corpses: do microglia eat enough in the diseased brain?

XV Curso Nacional de Neurociencia - Invited talk

Sierra A

Invited talk | Clearing the corpses: do microglia eat enough in the epileptic brain?

Roche Pharmaceuticals: Microglia day - Invited talk

Sierra A

Invited talk | Clearing the corpses: microglial phagocytosis from neurodegeneration to neurogenesis.

Research Seminar - Invited talk

Sierra A

Invited talk | Brain scavengers: do microglia eat enough in the diseased brain?"

Research Seminar - Invited talk

Sierra A

2017

Invited talk | Clearing the corpses: Are microglia eating enough in the diseased brain?

Research Seminar - Invited talk

Sierra A

Invited talk | Of ghost cells and ravenous microglia: coupling between apoptosis and microglial phagocytosis in health and disease.

Research Seminar - Invited talk

Sierra A

Invited talk | Clearing the corpses: Are microglia eating enough in the diseased brain?

NeuroMac: Development, function and potential of myeloid cells in the central nervous system - Invited talk

Sierra A

Invited talk | Clearing the corpses: Are microglia eating enough in the diseased brain?

Madrid Meeting DCs and Macrophages. - Invited talk

Sierra A

Invited talk | Principles regulating microglial phagocytosis efficiency

EURON / BSCDB symposium ( - Invited talk

Sierra A

Invited talk | Clearing the corpses: Are microglia eating enough in the diseased brain?

Jacques Monod Conference: Glial cells at the crossroads of innate immunity and brain functions - Invited talk

Sierra A

Invited talk | Microglial dysfunction in epilepsy.

Research Seminars - Invited talk

Sierra A

2016

Invited talk | Remodeling the adult hippocampal neurogenic niche: coupling between newborn cell apoptosis and microglial phagocytosis.

International Society for Neurochemistry and Japanese Society for Neurochemistry joint meeting - Invited talk

Sierra A

Invited talk | Automatic analysis of microglial motility with ImageJ.

Spanish-Portuguese Meeting for Advanced Optical Microscop - Invited talk

Paris I, Escobar L, Nadjar A, Layé S, Leyrolle Q, Savage JC, Hui CW, Trèmblay ME, Sierra A, Valero J

Invited talk | Neuronas muertas y microglía hambrienta: el acoplamiento entre apoptosis y fagocitosis en el cerebro sano y enfermo

IV Biomedical Research Congress. - Invited talk

Sierra A

Invited talk | From brain development to neurodegenerative diseases: are microglia eating enough?

100 year anniversary of Ilya Metchnikoff. - Invited talk

Sierra A

Invited talk | From brain development to neurodegenerative diseases: are microglia eating enough?

Nutribrain Cajal School - Invited talk

Sierra A

Oral presentation | Of ghost cells and ravenous microglia: coupling between apoptosis and phagocytosis in health and disease.

Keystone meeting on Microglia in the Brain, - Oral presentation

Sierra A

2015

Oral presentation | Neuronal hyperactivity triggers microglial phagocytosis-apoptosis uncoupling

2015 Euroglia meeting - Oral presentation

Sierra A

Oral presentation | Microglial phagocytosis-apoptosis coupling: a widespread response disturbed in epilepsy.

XVI Meeting of the Spanish Society for Neuroscience - Oral presentation

49. Abiega O, Beccari S, Diaz-Aparicio I, Brewster AL, Anderson AE, Nadjar A, Leyrolle Q, Layé S, Vivanco MdM, Maletic-Savatic M, Matute C, Encinas JM, Sierra A.

Poster presentation | Microglial phagocytosis-apoptosis coupling: a widespread response disturbed in epilepsy.

IV Venusberg Meeting on Neuroinflammation - Poster presentation

43. Abiega O, Beccari S, Diaz-Aparicio I, Brewster AL, Anderson AE, Nadjar A, Leyrolle Q, Layé S, Vivanco MdM, Maletic-Savatic M, Matute C, Encinas JM, Sierra A.

Poster presentation | Neuronal hyperactivity uncouples microglial phagocitosis and leads to delayed cell clearance and inflammation.

IV Venusberg Meeting on Neuroinflammation - Poster presentation

Diaz-Aparicio I, Abiega O, Beccari S, Sánchez-Zafra V, Nadjar A, Leyrolle Q, Layé S, Vivanco MdM, Maletic-Savatic M, Matute C, Encinas JM, Sierra A.

Poster presentation | Microglial phagocytosis is impaired in chronic mouse and human MTLE and correlates with inflammation.

IV Venusberg Meeting on Neuroinflammation - Poster presentation

Beccari S, Abiega O, Diaz-Aparicio I, Zaldumbide L, Galbarriatu L, Marinas A, Maletic-Savatic M, Matute C, Encinas JM, Sierra A.

Poster presentation | Microglial phagocytosis is impaired in chronic mouse and human MTLE and correlates with inflammation.

2015 Euroglia meeting - Poster presentation

Beccari S, Abiega O, Diaz-Aparicio I, Zaldumbide L, Galbarriatu L, Marinas A, Maletic-Savatic M, Matute C, Encinas JM, Sierra A.

Poster presentation | Microglial phagocytosis-apoptosis coupling: a widespread response disturbed in epilepsy.

2015 Euroglia meeting - Poster presentation

Abiega O, Beccari S, Diaz-Aparicio I, Brewster AL, Anderson AE, Nadjar A, Leyrolle Q, Layé S, Vivanco MdM, Maletic-Savatic M, Matute C, Encinas JM, Sierra A.

Poster presentation | Neuronal hyperactivity uncouples microglial phagocitosis and leads to delayed cell clearance and inflammation.

2015 Euroglia meeting - Poster presentation

45. Diaz-Aparicio I, Abiega O, Beccari S, Sánchez-Zafra V, Nadjar A, Leyrolle Q, Layé S, Vivanco MdM, Maletic-Savatic M, Matute C, Encinas JM, Sierra A.

Poster presentation | Radial neural stem cell activation predicts their decline and the loss of neurogenesis during aging.

2015 Euroglia meeting - Poster presentation

Beccari S, Martin-Suárez S, Encinas JM, Sierra A

Poster presentation | Microglial phagocytosis is impaired in chronic mouse and human MTLE and correlates with inflammation.

XVI Meeting of the Spanish Society for Neuroscience - Poster presentation

50. Beccari S, Abiega O, Diaz-Aparicio I, Zaldumbide L, Galbarriatu L, Marinas A, Maletic-Savatic M, Matute C, Encinas JM, Sierra A

Poster presentation | Neuronal hyperactivity uncouples microglial phagocitosis and leads to delayed cell clearance and inflammation.

XVI Meeting of the Spanish Society for Neuroscience - Poster presentation

51. Diaz-Aparicio I, Abiega O, Beccari S, Sánchez-Zafra V, Nadjar A, Leyrolle Q, Layé S, Vivanco MdM, Maletic-Savatic M, Matute C, Encinas JM, Sierra A.

Poster presentation | Role of P2Y receptor family in microglial phagocytosis: GPR34 and P2Y12

XVI Meeting of the Spanish Society for Neuroscience - Poster presentation

Sánchez-Zafra V, París V, Sierra A.

2014

Oral presentation | Janus-faced microglia: beneficial and detrimental roles of the brain resident macrophages

Madrid Meeting on Macrophages and Dendritic Cells. - Oral presentation

Sierra A

Oral presentation | Microglial phagocytosis is impaired in epilepsy

9th Federation of European Neurosciences Meeting. - Oral presentation

Sierra A

Poster presentation | Uncoupled microglial phagocytosis underlies early pathological changes in hippocampal epilepsy.

EMBL Conference: Microglia, guardians of the brain. - Poster presentation

Abiega O, Beccari S, Encinas JM, Brewster AL, Anderson AE, Maletic-Savatic M, Matute C, Sierra A.

Poster presentation | Adult neurogenesis as a probe to study microglial phagocytosis dynamics in vivo: lessons from the epileptic hippocampus.

Keystone symposia on Adult Neurogenesis - Poster presentation

35. Abiega O, Beccari S, Encinas JM, Brewster AL, Anderson AE, Maletic-Savatic M, Matute C, Sierra A.

2013

Invited talk | Microglial phagocytosis in health and disease

Understanding glial cell functions in the normal and injured CNS, satellite event to ISN 2013 - Invited talk

Sierra A

Invited talk | Microglial phagocytosis shapes adult hippocampal neurogenesis

International Neurochemistry Society Meeting - Invited talk

Sierra A

Invited talk | Apoptosis and phagocytosis in the neurogenesis niche.

2nd Eurogenesis Meeting - Invited talk

31. Sierra A.

Invited talk | Interface between phagocytosis and inflammation: the roles of microglia in the healthy and diseased brain.

Symposium: Nutrition and Inflammation. - Invited talk

A. Sierra

Invited talk | Microglial phagocytosis: moving forward from the inflammatory paradigm.

Berlin Brain Days - Invited talk

A. Sierra

Poster presentation | Acute impairment of microglial phagocytosis in the hippocampus of epileptic mice

3rd Venusberg Meeting on Neuroinflammation - Poster presentation

Abiega O,Encinas JM, Beccari S, Brewster AL, Anderson A, Maletic-Savatic M, Matute, Sierra A

Poster presentation | Desacoplamiento apoptosis-fagocitosis durante la excitotoxicidad asociada a la epilepsia.

XV Meeting of the Spanish Society for Neuroscience - Poster presentation

32. Abiega O, Beccari S, Encinas JM, Brewster AL, Anderson AE, Maletic-Savatic M, Matute C, Sierra A.

2012

Invited talk | Apoptosis and phagocytosis in health and disease

Workshop Frontiers in Glial Research,satellite event of FENS 2012 - Invited talk

Sierra A

Poster presentation | Acute impairment of microglial phagocytosis in the hippocampus of epileptic mice.

Federation of European Neuroscience Societies - Poster presentation

Abiega O, Encinas JM, Maletic-Savatic M, Matute, C, Sierra A

2011

Invited talk | Apoptosis and phagocytosis in the adult neurogenic niche.

41th Program Annual Meeting of the Society for Neuroscience. - Invited talk

Sierra A

Invited talk | Control of adult hippocampal neurogenesis by microglial clearance

10th Euroglia Meeting - Invited talk

Sierra A