Francisco Borrego

Ikerbasque Research Professor, IIS Biobizkaia

Ikerbasque Research Professor at Biobizkaia Health Research Institute.

Research line:

Immunology.

Previous research experience in United States: National Institute of Allergy and Infectious Diseases (NIAID-NIHD) and Food and Drug Administration (FDA).

Doctor in Medicine in 1994 from University of Cordoba.

2024

Article / Activated NK cells with a predominance of inhibitory receptors and a decidual-like phenotype expand after autologous HSCT in children with tumors.

Gabirel Astarloa-Pando, Diego Polanco-Alonso, Ane Orrantia, Ainhoa Amarilla-Irusta, Silvia Pérez-Fernández, Raquel Pérez-Garay, Arrate Sevilla, Víctor Sandá, Ainara Lopez-Pardo, Aritz Tijero, José J. Úriz, Mercedes Rey, Itizar Astigarraga, Bárbara Manzanares-Martin, Laura Amo, Olatz Zenarruzabeitia, Francisco Borrego.

Article / Degranulation assay to evaluate NK cell natural and antibody-dependent cell-mediated cytotoxicity against A549 tumor spheroids

Methods in Cell Biology

Lopez-Pardo, A.; Amarilla-Irusta, A.; Sandá, V.; Stan-Fontoba, M.; Borrego, F.; Amo, L.

Article / CD151 identifies an NK cell subset that is enriched in COVID-19 patients and correlates with disease severity

Journal of Infection

Amarilla-Irusta, A.; Zenarruzabeitia, O.; Sevilla, A.; Sandá, V.; Lopez-Pardo, A.; Astarloa-Pando, G.; Pérez-Garay, R.; Pérez-Fernández, S.; Meijide, S.; Imaz-Ayo, N.; Arana-Arri, E.; Amo, L.; Borrego, F.

2023

Book / Purification and characterization of kidney-infiltrating leukocytes in a mouse model of lupus nephritis

Methods in Cell Biology

Amo L, Kole HK, Scott B, Borrego F, Qi CF, Wang H, Bolland S.

Article / Turning universal O into rare Bombay type blood.

Nature Communications

Itxaso Anso, Andreas Naegeli, Javier O Cifuente, Ane Orrantia 4, Erica Andersson, Olatz Zenarruzabeitia, Alicia Moraleda-Montoya, Mikel García-Alija, Francisco Corzana, Rafael A Del Orbe, Francisco Borrego, Beatriz Trastoy, Jonathan Sjögren, Marcelo E. Guerin

Article / IL-12/15/18-induced cell death and mitochondrial dynamics of human NK cells.

Frontiers in Immunology

Iñigo Terrén, Víctor Sandá, Ainhoa Amarilla-Irusta, Ainara Lopez-Pardo, Arrate Sevilla, Gabirel Astarloa-Pando, Laura Amo, Olatz Zenarruzabeitia, Luca Scorrano, Francisco Borrego

Article / Human IgMhiCD300a+ B cells are circulating marginal zone memory B cells that respond to pneumococcal polysaccharides and their frequency is decreased in people living with HIV

International Journal of Molecular Sciences

Joana Vitallé, Olatz Zenarruzabeitia, Aitana Merino-Pérez, Iñigo Terrén, Ane Orrantia, Arantza Pacho de Lucas, José A Iribarren, Lucio J García-Fraile, Luz Balsalobre, Laura Amo, Belén de Andrés, Francisco Borrego

Article / Turning universal O into rare Bombay type blood

Nature Communications

Anso, I.; Naegeli, A.; Cifuente, J.O.; Orrantia, A.; Andersson, E.; Zenarruzabeitia, O.; Moraleda-Montoya, A.; García-Alija, M.; Corzana, F.; Del Orbe, R.A.; Borrego, F.; Trastoy, B.; Sjögren, J.; Guerin, M.E.

Article / Human IgMhiCD300a+ B Cells Are Circulating Marginal Zone Memory B Cells That Respond to Pneumococcal Polysaccharides and Their Frequency Is Decreased in People Living with HIV

International Journal of Molecular Sciences

Vitallé, J.; Zenarruzabeitia, O.; Merino-Pérez, A.; Terrén, I.; Orrantia, A.; Pacho de Lucas, A.; Iribarren, J.A.; García-Fraile, L.J.; Balsalobre, L.; Amo, L.; de Andrés, B.; Borrego, F.

Article / IL-12/15/18-induced cell death and mitochondrial dynamics of human NK cells

Frontiers in Immunology

Terrén, I.; Sandá, V.; Amarilla-Irusta, A.; Lopez-Pardo, A.; Sevilla, A.; Astarloa-Pando, G.; Amo, L.; Zenarruzabeitia, O.; Scorrano, L.; Borrego, F.

2022

Chapter / Role of NK cells in tumor progression.

Experientia Supplementum: Interaction of immune cells and cancer cells.

I. Terrén, and F. Borrego.

Article / P815-based redirected degranulation assay to study human NK cell effector functions.

Methods in Cell Biology

I. Terrén, G. Astarloa-Pando, A. Amarilla-Irusta, and F. Borrego.

Article / In vivo expansion of a CD9+ decidual-like NK cell subset following autologous hematopoietic stem cell transplantation.

iScience

A. Orrantia, E. Vázquez-De Luis, G. Astarloa-Pando, I. Terrén, A. Amarilla-Irusta, D. Polanco-Alonso, C. González, A. Uranga, T. Carrascosa, J.J. Mateos-Mazón, J.C. García-Ruiz, S. Callejas, A. Quintas, A. Dopazo, O. Zenarruzabeitia, and F. Borrego.

Article / In vivo expansion of a CD9+ decidual-like NK cell subset following autologous hematopoietic stem cell transplantation

iScience

Orrantia, A.; Vázquez-De Luis, E.; Astarloa-Pando, G.; Terrén, I.; Amarilla-Irusta, A.; Polanco-Alonso, D.; González, C.; Uranga, A.; Carrascosa, T.; Mateos-Mazón, J.J.; García-Ruiz, J.C.; Callejas, S.; Quintas, A.; Dopazo, A.; Zenarruzabeitia, O.; Borrego, F.

Review / Cytokine-induced memory-like NK cells: from the basics to clinical applications.

Frontiers in Immunology

I. Terrén, A. Orrantia, G. Astarloa-Pando, A. Amarilla-Irusta, O. Zenarruzabeitia, and F. Borrego.

Review / Cytokine-Induced Memory-Like NK Cells: From the Basics to Clinical Applications

Frontiers in Immunology

Terrén, I.; Orrantia, A.; Astarloa-Pando, G.; Amarilla-Irusta, A.; Zenarruzabeitia, O.; Borrego, F.

2021

Article / PIPE-cloned human IgE, IgG1 and IgG4 antibodies: New tools for investigating cow’s milk allergy and tolerance.

Allergy

C.L. Pranger, J.F. Singer, V.K. Köhler, I. Pali-Schöll, A. Fiocchi, S.N. Karagiannis, O. Zenarruzabeitia, F. Borrego, and E. Jensen-Jarolim.

Article / Metabolic changes of human cytokine-induced memory-like NK cells.

Scientific Reports

I. Terrén, A. Orrantia, A. Mosteiro, J. Vitallé, O. Zenarruzabeitia, and F. Borrego.

Article / T cell activation, highly armed cytotoxic cells and a shift in monocytes CD300 receptors expression is characteristic of patients with severe COVID-19.

Frontiers in Immunology

O. Zenarruzabeitia, G. Astarloa-Pando, I. Terrén, A. Orrantia, R. Pérez-Garay, I. Seijas-Betolaza, J. Nieto-Arana, N. Imaz-Ayo, S. Pérez-Fernández, E. Arana-Arri, and F. Borrego.

Article / Increased frequency of CTLA-4 and PD-1 expressing regulatory T cells and basophils with activating profile in infants with moderate-to-severe atopic dermatitis hypersensitized to food allergens.

Frontiers in Pediatrics

A. Bilbao, R. Pérez-Garay, I. Rius, A. Irurzun, I. Terrén, A. Orrantia, G. Asstarloa-Pando, F. Borrego, and O. Zenarruzabetia.

Article / NK cell reconstitution after autologous hematopoietic stem cell transplantation: association between NK cell maturation stage and outcome in multiple myeloma.

Frontiers in Immunology

A. Orrantia, I. Terrén, G. Astarloa-Pando, C. González, A. uranga, J.J. Mateos-Mazón, J.C. García-Ruiz, M. Riñón, M. Rey, S. Pérez-Fernández, O. Zenarruzabeitia, and F. Borrego.

Article / Metabolic changes of Interleukin-12/15/18-stimulated human NK cells

Scientific Reports

Terrén, I.; Orrantia, A.; Mosteiro, A.; Vitallé, J.; Zenarruzabeitia, O.; Borrego, F.

Article / Increased Frequency of CTLA-4 and PD-1 Expressing Regulatory T Cells and Basophils With an Activating Profile in Infants With Moderate-to-Severe Atopic Dermatitis Hypersensitized to Food Allergens

Frontiers in Pediatrics

Bilbao, A.; Pérez-Garay, R.; Rius, I.; Irurzun, A.; Terrén, I.; Orrantia, A.; Astarloa-Pando, G.; Borrego, F.; Zenarruzabeitia, O.

Article / NK Cell Reconstitution After Autologous Hematopoietic Stem Cell Transplantation: Association Between NK Cell Maturation Stage and Outcome in Multiple Myeloma

Frontiers in Immunology

Orrantia, A.; Terrén, I.; Astarloa-Pando, G.; González, C.; Uranga, A.; Mateos-Mazón, J.J.; García-Ruiz, J.C.; Riñón, M.; Rey, M.; Pérez-Fernandez, S.; Zenarruzabeitia, O.; Borrego, F.

Article / T Cell Activation, Highly Armed Cytotoxic Cells and a Shift in Monocytes CD300 Receptors Expression Is Characteristic of Patients With Severe COVID-19

Frontiers in Immunology

Zenarruzabeitia, O.; Astarloa-Pando, G.; Terrén, I.; Orrantia, A.; Pérez-Garay, R.; Seijas-Betolaza, I.; Nieto-Arana, J.; Imaz-Ayo, N.; Pérez-Fernández, S.; Arana-Arri, E.; Borrego, F.

Letter / PIPE-cloned human IgE and IgG4 antibodies: New tools for investigating cow's milk allergy and tolerance

Allergy: European Journal of Allergy and Clinical Immunology

Pranger, C.L.; Fazekas-Singer, J.; Köhler, V.K.; Pali-Schöll, I.; Fiocchi, A.; Karagiannis, S.N.; Zenarruzabeitia, O.; Borrego, F.; Jensen-Jarolim, E.

Review / Human NK cells in autologous hematopoietic stem cell transplantation for cancer treatment.

Cancers

A. Orrantia, I. Terrén, G. Astarloa-Pando, O. Zenarruzabeitia, and F. Borrego.

Review / Nanoparticles and trained immunity: glimpse into the future.

Advanced Drug Delivery Reviews

S. Magadán, I. Mikelez-Alonso, F. Borrego, and A. González-Fernández.

Review / Natural killer (NK) cell-based immunotherapies and the many faces of NK cell memory: a look into how nanoparticles enhance NK cell activity.

Advanced Drug Delivery Reviews

I. Mikelez-Alonso, S. Magadán, A. González-Fernández, and F. Borrego.

Review / Células NK memoria: las asesinas naturales también recuerdan.

Inmunología

F. Borrego, I. Terrén.

Review / Natural killer (NK) cell-based immunotherapies and the many faces of NK cell memory: A look into how nanoparticles enhance NK cell activity

Advanced Drug Delivery Reviews

Mikelez-Alonso, I.; Magadán, S.; González-Fernández, Á.; Borrego, F.

Review / Nanoparticles and trained immunity: Glimpse into the future

Advanced Drug Delivery Reviews

Magadán, S.; Mikelez-Alonso, I.; Borrego, F.; González-Fernández, Á.

Review / Human nk cells in autologous hematopoietic stem cell transplantation for cancer treatment

Cancers

Orrantia, A.; Terrén, I.; Astarloa-Pando, G.; Zenarruzabeitia, O.; Borrego, F.

2020

Chapter / Inmunoterapias y biomarcadores

Farreras Rozman, Medicina Interna. XIX Edición.

J. Kalil, P. Giavina-Bianchi, F. Borrego

Chapter / Capítulo 8: Células linfoides innatas: papel en la inmunidad y en las enfermedades inmunomediadas.

Inmunología para reumatólogos. Una visión integradora.

F. Borrego, I. terrén

Article / CFSE dilution to study human T and NK cell proliferation in vitro.

Methods in Enzymology

I. Terrén, A. Orrantia, J. Vitallé, O. Zenarruzabeitia, and F. Borrego.

Article / CD300a identifies a CD4+CD45RA- T cell subset with a higher susceptibility to HIV-1 infection.

AIDS

J. Vitallé, L. Tarancón-Díez, M.R. Jiménez-Leon, I. Terrén, A. Orrantia, C. Roca-Oporto, L. López-Cortés, E. Ruiz-Mateos, O. Zenarruzabeitia, and F. Borrego.

Article / Polyfunctional HIV-1 specific response by CD8+ T lymphocytes expressing high levels of CD300a.

Scientific Reports

J. Vitallé, I. Terrén, L. Gamboa-Urquijo, A. Orrantia, L. Tarancón-Díez, M. Genebat, M. Leal, E. Ruiz-Mateos, F. Borrego, and O. Zenarruzabeitia.

Article / A NKp80-based identification strategy reveals that CD56neg NK cells are not completely dysfunctional in health and disease.

iScience

A. Orrantia, I. Terrén, A. Izquierdo-Lafuente, J.A. Alonso-Cabrera, V. Sandá1, J. Vitallé, S. Moreno, M. Tasias, A. Uranga, C. González, J.J. Mateos, J.C. García-Ruiz, O Zenarruzabeitia, and F. Borrego.

Article / Identification and Functional Analysis of human CD56neg NK cells by Flow Cytometry.

STAR Protocols

A. Orrantia, I. Terrén, J. Vitallé, G. Astarloa-Pando, O. Zenarruzabeitia, and F. Borrego.

Article / Identification and Functional Analysis of Human CD56neg NK Cells by Flow Cytometry

STAR Protocols

Orrantia, A.; Terrén, I.; Vitallé, J.; Astarloa-Pando, G.; Zenarruzabeitia, O.; Borrego, F.

Article / Polyfunctional HIV-1 specific response by CD8+ T lymphocytes expressing high levels of CD300a

Scientific Reports

Vitallé, J.; Terrén, I.; Gamboa-Urquijo, L.; Orrantia, A.; Tarancón-Díez, L.; Genebat, M.; Leal, M.; Ruiz-Mateos, E.; Borrego, F.; Zenarruzabeitia, O.

Article / Modulating NK cell metabolism for cancer immunotherapy

Seminars in Hematology

Terrén, I.; Orrantia, A.; Vitallé, J.; Astarloa-Pando, G.; Zenarruzabeitia, O.; Borrego, F.

Article / A NKp80-Based Identification Strategy Reveals that CD56neg NK Cells Are Not Completely Dysfunctional in Health and Disease

iScience

Orrantia, A.; Terrén, I.; Izquierdo-Lafuente, A.; Alonso-Cabrera, J.A.; Sandá, V.; Vitallé, J.; Moreno, S.; Tasias, M.; Uranga, A.; González, C.; Mateos, J.J.; García-Ruiz, J.C.; Zenarruzabeitia, O.; Borrego, F.

Article / CD300a identifies a CD4+memory T cell subset with a higher susceptibility to HIV-1 infection

AIDS

Vitallé, J.; Tarancón-Díez, L.; Jiménez-Leon, M.R.; Terrén, I.; Orrantia, A.; Roca-Oporto, C.; López-Cortés, L.; Ruiz-Mateos, E.; Zenarruzabeitia, O.; Borrego, F.

Review / Modulating NK cell metabolism for cancer immunotherapy.

Seminars in Hematology

I. Terrén, A. Orrantia, J. Vitallé, G. Astarloa-Pando, O. Zenarruzabeitia, and F. Borrego.

Review / NK cell-based immunotherapy in renal cell carcinoma.

Cancers

I. Terrén, A. Orrantia, I. Mikelez-Alonso, J. Vitallé, Olatz Zenarruzabeitia, and F. Borrego.

Review / The expression and function of CD300 molecules in the main players of allergic responses: mast cells, basophils and eosinophils.

International Journal Molecular of Sciences

J. Vitallé, I. Terrén, A. Orrantia, A. Bilbao, P.M. Gamboa, F. Borrego, and O. Zenarruzabeitia.

Review / The expression and function of CD300 molecules in the main players of allergic responses: Mast cells, basophils and eosinophils

International Journal of Molecular Sciences

Vitallé, J.; Terrén, I.; Orrantia, A.; Bilbao, A.; Gamboa, P.M.; Borrego, F.; Zenarruzabeitia, O.

Review / NK cell-based immunotherapy in renal cell carcinoma

Cancers

Terrén, I.; Orrantia, A.; Mikelez-Alonso, I.; Vitallé, J.; Zenarruzabeitia, O.; Borrego, F.

2019

Article / CD300c co-stimulates IgE-mediated basophils activation and its expression is increased in cow´s milk allergy.

Journal of Allergy and Clinical Immunology

O. Zenarruzabeitia, J. Vitallé, I. Terrén, A. Orrantia, I. Astigarraga, L. Dopazo, C. González, L. Santos-Díez, C. Tutau, P.M. Gamboa, A. Bilbao, and F. Borrego.

Article / Increased expression levels of CD300c on basophils from allergic individuals.

World Allergy Organization Journal

J. Vitallé, I. Terrén, A. Orrantia, A. Segurola, Y. Seras, P.M. Gamboa, F. Borrego, and O. Zenarruzabeitia.

Article / CD300a inhibits CD16-mediated NK cell effector functions in HIV-1 infected patients.

Cellular & Molecular Immunology

J. Vitallé, I. Terrén, A. Orrantia, R. Pérez-Garay, F. Vidal, J.A. Iribarren, C. Rodríguez, A.M. López Lirola, E. Bernal, O. Zenarruzabeitia, and F. Borrego.

Article / CD300a inhibits CD16-mediated NK cell effector functions in HIV-1-infected patients

Cellular and Molecular Immunology

Vitallé, J.; Terrén, I.; Orrantia, A.; Pérez-Garay, R.; Vidal, F.; Iribarren, J.A.; Rodríguez, C.; Lirola, A.M.L.; Bernal, E.; Zenarruzabeitia, O.; Borrego, F.

Article / CD300c costimulates IgE-mediated basophil activation, and its expression is increased in patients with cow's milk allergy

Journal of Allergy and Clinical Immunology

Zenarruzabeitia, O.; Vitallé, J.; Terrén, I.; Orrantia, A.; Astigarraga, I.; Dopazo, L.; Gonzalez, C.; Santos-Díez, L.; Tutau, C.; Gamboa, P.M.; Bilbao, A.; Borrego, F.

Letter / Increased expression levels of CD300c on basophils from allergic individuals

World Allergy Organization Journal

Vitallé, J.; Terrén, I.; Orrantia, A.; Segurola, A.; Seras, Y.; Gamboa, P.M.; Borrego, F.; Zenarruzabeitia, O.

Review / CD300 receptor family in viral infections.

European of Journal of Immunology

Vitallé J, Terrén I, Orrantia A, Zenarruzabeitia O, Borrego F.

Review / NK Cell Metabolism and Tumor Microenvironment.

Frontiers in Immunology

Terrén I, Orrantia A, Vitallé J, Zenarruzabeitia O, Borrego F.

Review / CD300 receptor family in viral infections

European Journal of Immunology

Vitallé, J.; Terrén, I.; Orrantia, A.; Zenarruzabeitia, O.; Borrego, F.

Short Survey / NK cell metabolism and tumor microenvironment

Frontiers in Immunology

Terrén, I.; Orrantia, A.; Vitallé, J.; Zenarruzabeitia, O.; Borrego, F.

2018

Book / Inmunología Tumoral e Inmunoterapia del Cáncer

Francisco Borrego

Chapter / Capítulo 12: Regulación de la citotoxicidad de las células NK.

Inmunología Tumoral e Inmunoterapia del Cáncer.

Borrego, Francisco

Article / Altered expression of CD300a inhibitory receptor on CD4+ T cells from HIV-1 infected patients: association with disease progression markers.

Frontiers in Immunology

Joana Vitallé, Iñigo Terrén, Leire Gamboa-Urquijo, Ane Orrantia, Laura Tarancón-Díez, Miguel Genebat, Ezequiel Ruiz-Mateos, Manuel Leal, Susana García-Obregón, Olatz Zenarruzabeitia, Francisco Borrego.

Article / Identification of a panel of potential serum protein markers in severe sepsis.

Journal of Microbiology, Immunology and Infection

S. Garcia-Obregon, M. Azkargorta, I. Seijas, J. Pilar-Orive, F. Borrego, F. Elortza, M.D. Boyano, and I. Astigarraga.

Article / Implication of interleukin (IL)-12/15/18 and ruxolitinib in the phenotype, proliferation and polyfunctionality of human cytokine-preactivated NK cells.

Frontiers in Immunology

I. Terrén, I. Mikelez, I. Odriozola, A. Gredilla, J. González, A. Orrantia, J. Vitallé, O. Zenarruzabeitia, and F. Borrego.

Article / Long interleukin-22 binding protein isoform-1 is an intracellular activator of the unfolded protein response.

Frontiers in Immunology

P. Gómez, A. Urtasun, A.W. Paton, J.C. Paton, F. Borrego, D. Dersh, A. Yair, I. Alloza, and K. Vandenbroeck.

Article / Long Interleukin-22 Binding Protein Isoform-1 Is an Intracellular Activator of the Unfolded Protein Response

Frontiers in Immunology

Gómez-Fernández, P.; Urtasun, A.; Paton, A.W.; Paton, J.C.; Borrego, F.; Dersh, D.; Argon, Y.; Alloza, I.; Vandenbroeck, K.

Article / Identification of a panel of serum protein markers in early stage of sepsis and its validation in a cohort of patients

Journal of Microbiology, Immunology and Infection

Garcia-Obregon, S.; Azkargorta, M.; Seijas, I.; Pilar-Orive, J.; Borrego, F.; Elortza, F.; Boyano, M.D.; Astigarraga, I.

Article / Altered expression of CD300a inhibitory receptor on CD4+ T cells from human immunodeficiency virus-1-infected patients: Association with disease progression markers

Frontiers in Immunology

Vitallé, J.; Terrén, I.; Gamboa-Urquijo, L.; Orrantia, A.; Tarancón-Díez, L.; Genebat, M.; Ruiz-Mateos, E.; Leal, M.; García-Obregón, S.; Zenarruzabeitia, O.; Borrego, F.

Article / Implication of interleukin-12/15/18 and ruxolitinib in the phenotype, proliferation, and polyfunctionality of human cytokine-preactivated natural killer cells

Frontiers in Immunology

Terrén, I.; Mikelez, I.; Odriozola, I.; Gredilla, A.; González, J.; Orrantia, A.; Vitallé, J.; Zenarruzabeitia, O.; Borrego, F.

2017

Article / Monocytes phenotype and cytokine production in HIV-1 infected patients receiving a modified vaccinia Ankara-based HIV-1 vaccine (MVA-B): relationship to CD300 molecules expression.

Frontiers in Immunology

Joana Vitallé, Olatz Zenarruzabeitia, Iñigo Terrén, Montserrat Plana, Alberto C. Guardo, Lorna Leal, José Peña, Felipe García, Francisco Borrego

Article / OP9 feeder cells are superior for the generation of mature and functional NK cells from umbilical cord hematopoietic progenitors.

Frontiers in Immunology

Lara Herrera, Juan M. Salcedo, Silvia Santos, Miguel A. Vesga, Francisco Borrego, Cristina Eguizabal.

Article / Monocytes phenotype and cytokine production in human immunodeficiency virus-1 infected patients receiving a modified vaccinia ankara-based HIV-1 vaccine: Relationship to CD300 molecules expression

Frontiers in Immunology

Vitallé, J.; Zenarruzabeitia, O.; Terrén, I.; Plana, M.; Guardo, A.C.; Leal, L.; Peña, J.; García, F.; Borrego, F.; Mothe, B.; Cobarsi, P.; Rosàs, M.; Carmen Puertas, M.; Carrillo, J.; Blanco, J.; Martínez-Picado, J.; Clotet, B.; Brander, C.; Climent, N.; Alvarez, C.; Sánchez, S.; León, A.; Pich, J.; Arnaiz, J.A.; Torres, B.; Lucero, C.; Gatell, J.M.; Muñoz-Fernández, M.A.; de Quirós, J.C.L.B.; Jiménez, J.L.; Esteban, M.; Gómez, C.E.; Perdiguero, B.; García-Arriaza, J.; Cepeda, V.; Sánchez-Sorzano, C.O.; Gonzalez, N.; Alcamí, J.; Jiménez, L.; Benito, J.M.; Rallón, N.

Article / OP9 feeder cells are superior to M2-10B4 cells for the generation of mature and functional natural killer cells from umbilical cord hematopoietic progenitors

Frontiers in Immunology

Herrera, L.; Salcedo, J.M.; Santos, S.; Vesga, M.Á.; Borrego, F.; Eguizabal, C.

Article / Natural killer cells to the attack: Combination therapy against neuroblastoma

Clinical Cancer Research

Zenarruzabeitia, O.; Vitallé, J.; Astigarraga, I.; Borrego, F.

Editorial / Natural Killer Cells to the Attack: Combination Therapy Against Neuroblastoma.

Clinical Cancer Research

Zenarruzabeitia O, Vitallé J, Astigarraga I, Borrego F.

Review / Buscando nuevas dianas para el tratamiento de alergias.

Inmunología

Francisco Borrego, Olatz Zenarruzabeitia, Joana Vitallé, Iñigo Terrén, Itziar Astigarraga, Agurtzane Bilbao, Leire Dopazo.

2016

Article / FCRL5 expression distinguishes two distinct subsets of human circulating tissue-like memory B cells

Journal of Immunology

Huifang Li, Francisco Borrego, and Mate Tolnay

Article / The expression and function of human CD300 receptors on human blood circulating mononuclear cells are distinct in neonates and adults.

Scientific Reports

Olatz Zenarruzabeitia, Joana Vitallé, Susana García-Obregón, Itziar Astigarraga, Cristina Eguizabal, Silvia Santos, Venkateswara R. Simhadri, Francisco Borrego

Article / CD300c is uniquely expressed on CD56bright natural killer cells and differs from CD300a upon ligand recognition.

Scientific Reports

M. Dimitrova, O. Zenarruzabeitia, F. Borrego, and V.R. Simhadri.

Article / The expression and function of human CD300 receptors on blood circulating mononuclear cells are distinct in neonates and adults

Scientific Reports

Zenarruzabeitia, O.; Vitallé, J.; García-Obregón, S.; Astigarraga, I.; Eguizabal, C.; Santos, S.; Simhadri, V.R.; Borrego, F.

Article / Fc receptor-like 5 expression distinguishes two distinct subsets of human circulating tissue-like memory b cells

Journal of Immunology

Li, H.; Borrego, F.; Nagata, S.; Tolnay, M.

Article / CD300c is uniquely expressed on CD56bright Natural Killer Cells and differs from CD300a upon ligand recognition

Scientific Reports

Dimitrova, M.; Zenarruzabeitia, O.; Borrego, F.; Simhadri, V.R.

Editorial / NK cell-based cancer immunotherapy

Frontiers in Immunology

Francisco Borrego, Susana Larrucea, Rafael Solana, Raquel Tarazona

Editorial / Editorial: NK cell-based cancer immunotherapy

Frontiers in Immunology

Borrego, F.; Larrucea, S.; Solana, R.; Tarazona, R.

2015

Chapter / Inmunoterapia del cáncer. Realidades y perspectivas.

Elsevier

Alena Gros, Marcela Maus, and Francisco Borrego

Article / A human anti-M2 antibody mediates antibody-dependent cell-mediated cytotoxicity (ADCC) and cytokine secretion by resting and cytokine preactivated natural killer (NK) cells.

PLoS One

V. R. Simhadri, M. Dimitrova, J.L. Mariano, O. Zenarruzabeitia, W. Zhong, T. Ozawa, A. Muraguchi, H. Kishi, M.C. Eichelberger, and F. Borrego.

Article / A human anti-M2 antibody mediates antibody-dependent cell-mediated cytotoxicity (ADCC) and cytokine secretion by resting and cytokine-preactivated natural killer (NK) cells

PLoS ONE

Simhadri, V.R.; Dimitrova, M.; Mariano, J.L.; Zenarruzabeitia, O.; Zhong, W.; Ozawa, T.; Muraguchi, A.; Kishi, H.; Eichelberger, M.C.; Borrego, F.

Review / The biology and disease relevance of CD300a, an inhibitory receptor for phosphatidylserine and phosphatidylethanolamine.

Journal of Immunology

Zenarruzabeitia O, Vitallé J, Eguizabal C, Simhadri VR, Borrego F.

Review / The biology and disease relevance of CD300a, an inhibitory receptor for phosphatidylserine and phosphatidylethanolamine

Journal of Immunology

Zenarruzabeitia, O.; Vitallé, J.; Eguizabal, C.; Simhadri, V.R.; Borrego, F.

2014

Article / Intact IL-12 signaling is necessary for the generation of human NK cells with enhanced effector function after restimulation.

Journal of Allergy and Clinical Immunology

V.R. Simhadri, J.L. Mariano, O. Zenarruzabeitia, C.M. Seroogy, S.M. Holland, H.S. Kuehn, S.D. Rosenzweig, and F. Borrego.

Article / Intact IL-12 signaling is necessary for the generation of human natural killer cells with enhanced effector function after restimulation

Journal of Allergy and Clinical Immunology

Simhadri, V.R.; Mariano, J.L.; Zenarruzabeitia, O.; Seroogy, C.M.; Holland, S.M.; Kuehn, H.S.; Rosenzweig, S.D.; Borrego, F.

Review / Natural killer (NK) cells for immunotherapy: a special case for pluripotent stem cells-derived NK cells.

Frontiers in Immunology

C. Eguizabal, O. Zenarruzabeitia, J. Monge, S. Santos, M. A. Vesga, N. Maruri, A. Arrieta, M. Riñón, E. Tamayo-Orbegozo, L. Amo, S. Larrucea and F. Borrego.

Review / Involvement of platelet-tumor cell interaction in immune evasion. Potential role of podocalyxin-like protein 1.

Frontiers in Oncology

L. Amo, E. Tamayo-Orbegozo, N. Maruri, C. Eguizabal, O. Zenarruzabeitia, M. Riñón, A. Arrieta, S. Santos, J. Monge, M.A. Vesga, F. Borrego, and S. Larrucea.

Short Survey / Natural killer cells for cancer immunotherapy: Pluripotent stem cells-derived NK cells as an immunotherapeutic perspective

Frontiers in Immunology

Eguizabal, C.; Zenarruzabeitia, O.; Monge, J.; Santos, S.; Vesga, M.A.; Maruri, N.; Arrieta, A.; Riñón, M.; Tamayo-Orbegozo, E.; Amo, L.; Larrucea, S.; Borrego, F.

Short Survey / Involvement of platelet-tumor cell interaction in immune evasion. Potential role of podocalyxin-like protein 1

Frontiers in Oncology

Amo, L.; Tamayo-Orbegozo, E.; Maruri, N.; Eguizabal, C.; Zenarruzabeitia, O.; Riñón, M.; Arrieta, A.; Santos, S.; Monge, J.; Vesga, M.A.; Borrego, F.; Larrucea, S.

2013

Article / Membrane-type 6 matrix metalloproteinase regulates the activation-induced down-modulation of CD16 in human primary NK cells.

Journal of Immunology

G. Peruzzi, L. Femnou, A. Gil-Krzewska, F. Borrego, J. Weck, K. Krzewski, and J.E. Coligan.

Article / Membrane-type 6 matrix metalloproteinase regulates the activation-induced downmodulation of CD16 in human primary NK cells

Journal of Immunology

Peruzzi, G.; Femnou, L.; Gil-Krzewska, A.; Borrego, F.; Weck, J.; Krzewski, K.; Coligan, J.E.

Cytokine-trained NK cell therapy: from bench to bedside and back again