Jesús Bañales

Ikerbasque Research Professor, Biogipuzkoa Health Research Institute

Ikerbasque Research Professor and Head of the Liver Diseases Group at the Biogipuzkoa Health Research Institute – Donostia Univ. Hospital in San Sebastian (Spain). Investigator Miguel Servet II and CIBEREHD (ISCIII). He is also Prof. Sciences at the Univ. Navarra (Spain), and Assistant Prof. Medicine/Sciences at Mayo Clinic (Rochester, MN, US) and Univ. Area Andina (Colombia).

Research line:

His multidisciplinary group is chiefly focused on studying the molecular mechanisms involved in liver pathophysiology (i.e. polycystic liver diseases, primary biliary cirrhosis, primary sclerosing cholangitis, non-alcoholic fatty liver disease, fibrosis, cirrhosis, hepatocellular carcinoma and cholangiocarcinoma), and looking for new diagnostic and therapeutic strategies.

Coordinator of the European Network for the Study of Cholangiocarcinoma (ENS-CCA); Vice-Chair of the European COST Action EURO-CHOLANGIONET on Cholangiocarcinoma; Coordinator of the “Cancer Task Force” of the International Primary Sclerosing Cholangitis Study Group (IPSCSG); Steering Committee Member of the Global Cholangiocarcinoma Alliance (GCA); Steering Committee Member of the African Hepatopancreatico-biliary Cancer Consortium (AHPBCC); Coordinator of the Ibero-Latin American Research Network on Cholangiocarcinoma (ILARN-CCA); Member of the Governing Board AEEH (Spanish Association for the Study of the Liver): Member of the EASL Educational Committee (European Association for the Study of the Liver); and Member ERN-Rare Liver Diseases (EU H2020). EASL YI Prize 2018; UEG Rising Start Prize 2018; Miguel Servet II Award 2020 (ISCIII), Nº1 of the Call: 100 points up to 100 and SER Navarra Prize to the Investigation 2020.

Professor Banales is author in >180 research articles published in referent international Journals, has obtained >40 research projects as PI funded by National and International Institutions (including EU Horizon 2020), is inventor of 5 patents (3 licentiated), and is Member of the Editorial Board of Hepatology, Nature Reviews Gastroenterology & Hepatology, Liver Transplantation, Seminars in Liver Diseases, Cells, and Special Section Editor of Journal of Hepatology.

Doctor in Biochemistry (2006) from the University of Navarra (Spain).

2024

Article / Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1

JHEP Reports

Rodríguez-Agudo, R.; González-Recio, I.; Serrano-Maciá, M.; Bravo, M.; Petrov, P.; Blaya, D.; Herranz, J.M.; Mercado-Gómez, M.; Rejano-Gordillo, C.M.; Lachiondo-Ortega, S.; Gil-Pitarch, C.; Azkargorta, M.; Van Liempd, S.M.; Martinez-Cruz, L.A.; Simão, A.L.; Elortza, F.; Martín, C.; Nevzorova, Y.A.; Cubero, F.J.; Delgado, T.C.; Argemi, J.; Bataller, R.; Schoonjans, K.; Banales, J.M.; Castro, R.E.; Sancho-Bru, P.; Avila, M.A.; Julve, J.; Jover, R.; Mabe, J.; Simon, J.; Goikoetxea-Usandizaga, N.; Martínez-Chantar, M.L.

Article / Serum identification of at-risk MASH: The metabolomics-advanced steatohepatitis fibrosis score (MASEF)

Hepatology

Noureddin, M.; Truong, E.; Mayo, R.; Martínez-Arranz, I.; Mincholé, I.; Banales, J.M.; Arrese, M.; Cusi, K.; Arias-Loste, M.T.; Bruha, R.; Romero-Gómez, M.; Iruzubieta, P.; Aller, R.; Ampuero, J.; Calleja, J.L.; Ibañez-Samaniego, L.; Aspichueta, P.; Martín-Duce, A.; Kushner, T.; Ortiz, P.; Harrison, S.A.; Anstee, Q.M.; Crespo, J.; Mato, J.M.; Sanyal, A.J.

Article / Osteopontin characterizes bile duct-associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis

Hepatology

De Muynck, K.; Heyerick, L.; De Ponti, F.F.; Vanderborght, B.; Meese, T.; Van Campenhout, S.; Baudonck, L.; Gijbels, E.; Rodrigues, P.M.; Banales, J.M.; Vesterhuus, M.; Folseraas, T.; Scott, C.L.; Vinken, M.; Van Der Linden, M.; Hoorens, A.; Van Dorpe, J.; Lefere, S.; Geerts, A.; Van Nieuwerburgh, F.; Verhelst, X.; Van Vlierberghe, H.; Devisscher, L.

Article / Fibroblast-Derived Lysyl Oxidase Increases Oxidative Phosphorylation and Stemness in Cholangiocarcinoma

Gastroenterology

Lewinska, M.; Zhuravleva, E.; Satriano, L.; Martinez, M.B.; Bhatt, D.K.; Oliveira, D.V.N.P.; Antoku, Y.; Keggenhoff, F.L.; Castven, D.; Marquardt, J.U.; Matter, M.S.; Erler, J.T.; Oliveira, R.C.; Aldana, B.I.; Al-Abdulla, R.; Perugorria, M.J.; Calvisi, D.F.; Perez, L.A.; Rodrigues, P.M.; Labiano, I.; Banales, J.M.; Andersen, J.B.

Article / TGFβ-induced long non-coding RNA LINC00313 activates Wnt signaling and promotes cholangiocarcinoma

EMBO Reports

Papoutsoglou, P.; Pineau, R.; Leroux, R.; Louis, C.; L’Haridon, A.; Foretek, D.; Morillon, A.; Banales, J.M.; Gilot, D.; Aubry, M.; Coulouarn, C.

Article / SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer

Cell Reports

Lachiondo-Ortega, S.; Rejano-Gordillo, C.M.; Simon, J.; Lopitz-Otsoa, F.; C. Delgado, T.; Mazan-Mamczarz, K.; Goikoetxea-Usandizaga, N.; Zapata-Pavas, L.E.; García-del Río, A.; Guerra, P.; Peña-Sanfélix, P.; Hermán-Sánchez, N.; Al-Abdulla, R.; Fernandez-Rodríguez, C.; Azkargorta, M.; Velázquez-Cruz, A.; Guyon, J.; Martín, C.; Zalamea, J.D.; Egia-Mendikute, L.; Sanz-Parra, A.; Serrano-Maciá, M.; González-Recio, I.; Gonzalez-Lopez, M.; Martínez-Cruz, L.A.; Pontisso, P.; Aransay, A.M.; Barrio, R.; Sutherland, J.D.; Abrescia, N.G.A.; Elortza, F.; Lujambio, A.; Banales, J.M.; Luque, R.M.; Gahete, M.D.; Palazón, A.; Avila, M.A.; Jose, J.J.; De, S.; Daubon, T.; Díaz-Quintana, A.; Díaz-Moreno, I.; Gorospe, M.; Rodríguez, M.S.; Martínez-Chantar, M.L.

Article / The biochemical pattern defines MASLD phenotypes linked to distinct histology and prognosis

Journal of Gastroenterology

Ampuero, J.; Aller, R.; Gallego-Durán, R.; Crespo, J.; Calleja, J.L.; García-Monzón, C.; Gómez-Camarero, J.; Caballería, J.; Lo Iacono, O.; Ibañez, L.; García-Samaniego, J.; Albillos, A.; Francés, R.; Fernández-Rodríguez, C.; Maya-Miles, D.; Diago, M.; Poca, M.; Andrade, R.J.; Latorre, R.; Jorquera, F.; Morillas, R.M.; Escudero, D.; Hernández-Guerra, M.; Pareja-Megia, M.J.; Banales, J.M.; Aspichueta, P.; Benlloch, S.; Rosales, J.M.; Turnes, J.; Romero-Gómez, M.

Article / MCPIP1 Inhibits Hepatic Stellate Cell Activation in Autocrine and Paracrine Manners, Preventing Liver Fibrosis

Cellular and Molecular Gastroenterology and Hepatology

Pydyn, N.; Ferenc, A.; Trzos, K.; Pospiech, E.; Wilamowski, M.; Mucha, O.; Major, P.; Kadluczka, J.; Rodrigues, P.M.; Banales, J.M.; Herranz, J.M.; Avila, M.A.; Hutsch, T.; Malczak, P.; Radkowiak, D.; Budzynski, A.; Jura, J.; Kotlinowski, J.

Article / Comparing Survival of Perihilar Cholangiocarcinoma After R1 Resection Versus Palliative Chemotherapy for Unresected Localized Disease

Annals of Surgical Oncology

van Keulen, A.M.; Buettner, S.; Olthof, P.B.; Klümpen, H.J.; Erdmann, J.I.; Izquierdo-Sanchez, L.; Banales, J.M.; Goeppert, B.; Roessler, S.; Zieniewicz, K.; Lamarca, A.; Valle, J.W.; La Casta, A.; Hoogwater, F.J.H.; Donadon, M.; Scheiter, A.; Marzioni, M.; Adeva, J.; Kiudeliene, E.; Fernández, J.M.U.; Vidili, G.; Mocan, T.; Fabris, L.; Krawczyk, M.; Folseraas, T.; Dopazo, C.; Detry, O.; Voiosu, T.; Scripcariu, V.; Biancaniello, F.; Braconi, C.; Macias, R.I.R.; Groot Koerkamp, B.

Article / Stratified analyses refine association between TLR7 rare variants and severe COVID-19

Human Genetics and Genomics Advances

Boos, J.; van der Made, C.I.; Ramakrishnan, G.; Coughlan, E.; Asselta, R.; Löscher, B.S.; Valenti, L.V.C.; de Cid, R.; Bujanda, L.; Julià, A.; Pairo-Castineira, E.; Baillie, J.K.; May, S.; Zametica, B.; Heggemann, J.; Albillos, A.; Banales, J.M.; Barretina, J.; Blay, N.; Bonfanti, P.; Buti, M.; Fernandez, J.; Marsal, S.; Prati, D.; Ronzoni, L.; Sacchi, N.; Rimoldi, V.; Paraboschi, E.M.; Bandera, A.; Peyvandi, F.; Grasselli, G.; Blasi, F.; Malvestiti, F.; Pelusi, S.; Bianco, C.; Miano, L.; Lombardi, A.; Invernizzi, P.; Gerussi, A.; Citerio, G.; Biondi, A.; Valsecchi, M.G.; Cazzaniga, M.E.; Foti, G.; Beretta, I.; D'Angiò, M.; Bettini, L.R.; Farré, X.; Iraola-Guzmán, S.; Kogevinas, M.; Castaño-Vinyals, G.; Garcia-Etxebarria, K.; Nafria, B.; D'Amato, M.; Palom, A.; Begg, C.; Clohisey, S.; Hinds, C.; Horby, P.; Knight, J.; Ling, L.; Maslove, D.; McAuley, D.; Millar, J.; Montgomery, H.; Nichol, A.; Openshaw, P.J.M.; Pereira, A.C.; Ponting, C.P.; Rowan, K.; Semple, M.G.; Shankar-Hari, M.; Summers, C.; Walsh, T.; Aravindan, L.; Armstrong, R.; Biggs, H.; Boz, C.; Brown, A.; Clark, R.; Coutts, A.; Coyle, J.; Cullum, L.; Das, S.; Day, N.; Donnelly, L.; Duncan, E.; Fawkes, A.; Fineran, P.; Fourman, M.H.; Furlong, A.; Furniss, J.; Gallagher, B.; Gilchrist, T.; Golightly, A.; Griffiths, F.; Hafezi, K.; Hamilton, D.; Hendry, R.; Law, A.

Article / Comparative performance of methylation DNA markers, brushing cytology, and FISH in diagnosing malignant biliary strictures

Hepatology

Banales, J.M.; Lapitz, A.; Fabris, L.

Article / Needs assessment for creation of a platform trial network in metabolic-dysfunction associated steatohepatitis

Communications Medicine

Sena, E.; Tacke, F.; Anstee, Q.M.; Di Prospero, N.; Skalshøi- Kjær, M.; Muñoz-Martínez, S.; Rivera-Esteban, J.; Jiménez-Masip, A.; Bañales, J.M.; Martínez-Gómez, M.; Koenig, F.; Genescà, J.; Ratziu, V.; Pericàs, J.M.

Article / Sensitizing cholangiocarcinoma to chemotherapy by inhibition of the drug-export pump MRP3

Biomedicine and Pharmacotherapy

Asensio, M.; Briz, O.; Herraez, E.; Perez-Silva, L.; Espinosa-Escudero, R.; Bueno-Sacristan, D.; Peleteiro-Vigil, A.; Hammer, H.; Pötz, O.; Kadioglu, O.; Banales, J.M.; Martinez-Chantar, M.L.; Avila, M.A.; Macias, R.I.R.; Efferth, T.; Marin, J.J.G.; Lozano, E.

Letter / Letter to the Editor: Serum Identification of At-Risk MASH: The Metabolomics-Advanced Steatohepatitis Fibrosis Score (MASEF)

Hepatology

Noureddin, M.; Truong, E.; Mayo, R.; Martínez-Arranz, I.; Mincholé, I.; Banales, J.M.; Arrese, M.; Cusi, K.; Arias-Loste, M.T.; Bruha, R.; Romero-Gómez, M.; Iruzubieta, P.; Aller, R.; Ampuero, J.; Calleja, J.L.; Ibañez-Samaniego, L.; Aspichueta, P.; Marín-Duce, A.; Kushner, T.; Ortiz, P.; Harrison, S.A.; Anstee, Q.M.; Crespo, J.; Mato, J.M.; Sanyal, A.J.

Short Survey / Proceedings of the 5th Meeting of Translational Hepatology, organized by the Spanish Association for the Study of the Liver (AEEH)

Gastroenterologia y Hepatologia

Alvarado-Tapias, E.; Maya-Miles, D.; Albillos, A.; Aller, R.; Ampuero, J.; Andrade, R.J.; Arechederra, M.; Aspichueta, P.; Banales, J.M.; Blas-García, A.; Caparros, E.; Cardoso Delgado, T.; Carrillo-Vico, A.; Claria, J.; Cubero, F.J.; Díaz-Ruiz, A.; Fernández-Barrena, M.G.; Fernández-Iglesias, A.; Fernández-Veledo, S.; Francés, R.; Gallego-Durán, R.; Gracia-Sancho, J.; Irimia, M.; Lens, S.; Martínez-Chantar, M.L.; Mínguez, B.; Muñoz-Hernández, R.; Nogueiras, R.; Ramos-Molina, B.; Riveiro-Barciela, M.; Rodríguez-Perálvarez, M.L.; Romero-Gómez, M.; Sabio, G.; Sancho-Bru, P.; Ventura-Cots, M.; Vidal, S.; Gahete, M.D.

2023

Article / Fibroblast-derived lysyl oxidase increases oxidative phosphorylation and stemness in cholangiocarcinoma.

Gastroenterology

Lewinska M, Zhuravleva E, Satriano L, Martinez MB, Bhatt DK, Oliveira DVNP, Antoku Y, Keggenhoff FL, Castven D, Marquardt JU, Matter MS, Erler JT, Oliveira RC, Aldana BI, Al-Abdulla R, Perugorria MJ, Calvisi DF, Perez LA, Rodrigues PM, Labiano I, Banales JM, Andersen JB

Article / A second update on mapping the human genetic architecture of COVID-19

Nature

COVID-19 Host Genetics Initiative

Article / Osteopontin expression characterizes bile duct associated macrophages, correlates with liver fibrosis and represents a novel therapeutic target in primary sclerosing cholangitis

Hepatology

De Muynck K, Heyerick L, De Ponti FF, Vanderborght B, Meese T, Van Campenhout S, Baudonck L, Gijbels E, Rodrigues PM, Banales JM, Vesterhuus M, Karlsen TH, Scott CL, Vinken M, Van der Linden M, Hoorens A, Van Dorpe J, Lefere S, Geerts A, Van Nieuwerburhg F, Verhelst X, Van Vlierberghe H, Devisscher L

Article / Liquid biopsy-based protein biomarkers for risk prediction, early diagnosis, and prognostication of cholangiocarcinoma

Journal of Hepatology

Lapitz, A.; Azkargorta, M.; Milkiewicz, P.; Olaizola, P.; Zhuravleva, E.; Grimsrud, M.M.; Schramm, C.; Arbelaiz, A.; O'Rourke, C.J.; La Casta, A.; Milkiewicz, M.; Pastor, T.; Vesterhus, M.; Jimenez-Agüero, R.; Dill, M.T.; Lamarca, A.; Valle, J.W.; Macias, R.I.R.; Izquierdo-Sanchez, L.; Pérez Castaño, Y.; Caballero-Camino, F.J.; Riaño, I.; Krawczyk, M.; Ibarra, C.; Bustamante, J.; Nova-Camacho, L.M.; Falcon-Perez, J.M.; Elortza, F.; Perugorria, M.J.; Andersen, J.B.; Bujanda, L.; Karlsen, T.H.; Folseraas, T.; Rodrigues, P.M.; Banales, J.M.

Article / Ceramide present in cholangiocarcinoma-derived extracellular vesicle induces a pro-inflammatory state in monocytes

Scientific Reports

Oliviero, B.; Dei Cas, M.; Zulueta, A.; Maiello, R.; Villa, A.; Martinelli, C.; Del Favero, E.; Falleni, M.; Montavoci, L.; Varchetta, S.; Mele, D.; Donadon, M.; Soldani, C.; Franceschini, B.; Maestri, M.; Piccolo, G.; Barabino, M.; Bianchi, P.P.; Banales, J.M.; Mantovani, S.; Mondelli, M.U.; Caretti, A.

Article / Mechanisms by which the cystic fibrosis transmembrane conductance regulator may influence SARS-CoV-2 infection and COVID-19 disease severity

FASEB Journal

Tedbury, P.R.; Manfredi, C.; Degenhardt, F.; Conway, J.; Horwath, M.C.; McCracken, C.; Sorscher, A.J.; Moreau, S.; Wright, C.; Edwards, C.; Brewer, J.; Guarner, J.; de Wit, E.; Williamson, B.N.; Suthar, M.S.; Ong, Y.T.; Roback, J.D.; Alter, D.N.; Holter, J.C.; Karlsen, T.H.; Sacchi, N.; Romero-Gómez, M.; Invernizzi, P.; Fernández, J.; Buti, M.; Albillos, A.; Julià, A.; Valenti, L.; Asselta, R.; Banales, J.M.; Bujanda, L.; de Cid, R.; Franke, A.; Sarafianos, S.G.; Hong, J.S.; Sorscher, E.J.; Ehrhardt, A.

Article / miR-21-5p promotes NASH-related hepatocarcinogenesis

Liver International

Rodrigues, P.M.; Afonso, M.B.; Simão, A.L.; Islam, T.; Gaspar, M.M.; O'Rourke, C.J.; Lewinska, M.; Andersen, J.B.; Arretxe, E.; Alonso, C.; Santos-Laso, Á.; Izquierdo-Sanchez, L.; Jimenez-Agüero, R.; Eizaguirre, E.; Bujanda, L.; Pareja, M.J.; Prip-Buus, C.; Banales, J.M.; Rodrigues, C.M.P.; Castro, R.E.

Article / Effect of Low Testosterone Levels on the Expression of Proliferator-Activated Receptor Alpha in Female Patients with Primary Biliary Cholangitis

Cells

Kempińska-Podhorodecka, A.; Abramczyk, J.; Cielica, E.; Huła, B.; Maciejowska, H.; Banales, J.; Milkiewicz, P.; Milkiewicz, M.

Article / A TGFβ-ECM-integrin signaling axis drives structural reconfiguration of the bile duct to promote polycystic liver disease

Science Translational Medicine

Waddell, S.H.; Yao, Y.; Olaizola, P.; Walker, A.; Jarman, E.J.; Gournopanos, K.; Gradinaru, A.; Christodoulou, E.; Gautier, P.; Boerrigter, M.M.; Cadamuro, M.; Fabris, L.; Drenth, J.P.H.; Kendall, T.J.; Banales, J.M.; Khamseh, A.; Mill, P.; Boulter, L.

Article / A3907, a systemic ASBT inhibitor, improves cholestasis in mice by multiorgan activity and shows translational relevance to humans

Hepatology

Caballero-Camino, F.J.; Rodrigues, P.M.; Wångsell, F.; Agirre-Lizaso, A.; Olaizola, P.; Izquierdo-Sanchez, L.; Perugorria, M.J.; Bujanda, L.; Angelin, B.; Straniero, S.; Wallebäck, A.; Starke, I.; Gillberg, P.G.; Strängberg, E.; Bonn, B.; Mattsson, J.P.; Madsen, M.R.; Hansen, H.H.; Lindström, E.; Åkerblad, P.; Banales, J.M.

Article / Metabolic liver cancer: associations of rare and common germline variants in one-carbon metabolism and DNA methylation genes

Human Molecular Genetics

Antwi, S.O.; Heckman, M.; White, L.; Yan, I.; Sarangi, V.; Lauer, K.P.; Reddy, J.; Ahmed, F.; Veliginti, S.; Mejías Febres, E.D.; Hatia, R.I.; Chang, P.; Izquierdo-Sanchez, L.; Boix, L.; Rojas, A.; Banales, J.M.; Reig, M.; Stål, P.; Gómez, M.R.; Singal, A.G.; Li, D.; Hassan, M.M.; Roberts, L.R.; Patel, T.

Article / Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance

Nature Reviews Gastroenterology and Hepatology

Calvisi, D.F.; Boulter, L.; Vaquero, J.; Saborowski, A.; Fabris, L.; Rodrigues, P.M.; Coulouarn, C.; Castro, R.E.; Segatto, O.; Raggi, C.; van der Laan, L.J.W.; Carpino, G.; Goeppert, B.; Roessler, S.; Kendall, T.J.; Evert, M.; Gonzalez-Sanchez, E.; Valle, J.W.; Vogel, A.; Bridgewater, J.; Borad, M.J.; Gores, G.J.; Roberts, L.R.; Marin, J.J.G.; Andersen, J.B.; Alvaro, D.; Forner, A.; Banales, J.M.; Cardinale, V.; Macias, R.I.R.; Vicent, S.; Chen, X.; Braconi, C.; Verstegen, M.M.A.; Fouassier, L.; Scheiter, A.; Selaru, F.M.; Evert, K.; Utpatel, K.; Broutier, L.; Cadamuro, M.; Huch, M.; Goldin, R.; Gradilone, S.A.; Saito, Y.

Article / Cirrhosis is associated with lower serological responses to COVID-19 vaccines in patients with chronic liver disease

JHEP Reports

Simão, A.L.; Palma, C.S.; Izquierdo-Sanchez, L.; Putignano, A.; Carvalho-Gomes, A.; Posch, A.; Zanaga, P.; Girleanu, I.; Henrique, M.M.; Araújo, C.; Degre, D.; Gustot, T.; Sahuco, I.; Spagnolo, E.; Carvalhana, S.; Moura, M.; Fernandes, D.A.; Banales, J.M.; Romero-Gomez, M.; Trifan, A.; Russo, F.P.; Stauber, R.; Berenguer, M.; Moreno, C.; Gonçalves, J.; Cortez-Pinto, H.; Castro, R.E.

Article / MicroRNA-27a-3p targets FoxO signalling to induce tumour-like phenotypes in bile duct cells

Journal of Hepatology

Duwe, L.; Munoz-Garrido, P.; Lewinska, M.; Lafuente-Barquero, J.; Satriano, L.; Høgdall, D.; Taranta, A.; Nielsen, B.S.; Ghazal, A.; Matter, M.S.; Banales, J.M.; Aldana, B.I.; Gao, Y.T.; Marquardt, J.U.; Roberts, L.R.; Oliveira, R.C.; Koshiol, J.; O'Rourke, C.J.; Andersen, J.B.

Article / Screening uptake of colonoscopy versus fecal immunochemical testing in first-degree relatives of patients with non-syndromic colorectal cancer: A multicenter, open-label, parallel-group, randomized trial (ParCoFit study)

PLoS Medicine

González-López, N.; Quintero, E.; Gimeno-Garcia, A.Z.; Bujanda, L.; Banales, J.; Cubiella, J.; Salve-Bouzo, M.; Herrero-Rivas, J.M.; Cid-Delgado, E.; Alvarez-Sanchez, V.; Ledo-Rodríguez, A.; de-Castro-Parga, M.L.; Fernández-Poceiro, R.; Sanromán-Álvarez, L.; Santiago-Garcia, J.; Herreros-De-Tejada, A.; Ocaña-Bombardo, T.; Balaguer, F.; Rodríguez-Soler, M.; Jover, R.; Ponce, M.; Alvarez-Urturi, C.; Bessa, X.; Roncales, M.P.; Sopeña, F.; Lanas, A.; Nicolás-Pérez, D.; Adrián-De-Ganzo, Z.; Carrillo-Palau, M.; González-Dávila, E.

Article / Aberrant fucosylation sustains the NOTCH and EGFR/NF-κB pathways and has a prognostic value in human intrahepatic cholangiocarcinoma

Hepatology

Ament, C.E.; Steinmann, S.; Evert, K.; Pes, G.M.; Ribback, S.; Gigante, I.; Pizzuto, E.; Banales, J.M.; Rodrigues, P.M.; Olaizola, P.; Wang, H.; Giannelli, G.; Chen, X.; Evert, M.; Calvisi, D.F.

Article / Identification of taxonomic changes in the fecal bacteriome associated with colorectal polyps and cancer: potential biomarkers for early diagnosis

Frontiers in Microbiology

Grion, B.A.R.; Fonseca, P.L.C.; Kato, R.B.; García, G.J.Y.; Vaz, A.B.M.; Jiménez, B.N.; Dambolenea, A.L.; Garcia-Etxebarria, K.; Brenig, B.; Azevedo, V.; Bujanda, L.; Banales, J.M.; Góes-Neto, A.

Article / Validation and optimization of AFP-based biomarker panels for early HCC detection in Latin America and Europe

Hepatology Communications

Beudeker, B.J.B.; Fu, S.; Balderramo, D.; Mattos, A.Z.; Carrera, E.; Diaz, J.; Prieto, J.; Banales, J.; Vogel, A.; Arrese, M.; Oliveira, J.; Groothuismink, Z.M.A.; Van Oord, G.; Hansen, B.E.; De Man, R.A.; Debes, J.D.; Boonstra, A.

Editorial / PFKFB4 Is a Metabolic Driver of HCC Progression and Chemoresistance Through ROS Mitigation

Cellular and Molecular Gastroenterology and Hepatology

Olaizola, P.; Banales, J.M.

Editorial / Polycystic liver diseases: from molecular basis to development of effective treatments

Revista Espanola de Enfermedades Digestivas

Markaide, E.; Banales, J.M.; Rodrigues, P.M.

Review / Lacking Immunotherapy Biomarkers for Biliary Tract Cancer: A Comprehensive Systematic Literature Review and Meta-Analysis

Cells

Frega, G.; Cossio, F.P.; Banales, J.M.; Cardinale, V.; Macias, R.I.R.; Braconi, C.; Lamarca, A.

Review / Heterogeneity of Cholangiocarcinoma Immune Biology

Cells

Vita, F.; Olaizola, I.; Amato, F.; Rae, C.; Marco, S.; Banales, J.M.; Braconi, C.

Review / Targeting the Heterogeneous Tumour-Associated Macrophages in Hepatocellular Carcinoma

Cancers

Agirre-Lizaso, A.; Huici-Izagirre, M.; Urretabizkaia-Garmendia, J.; Rodrigues, P.M.; Banales, J.M.; Perugorria, M.J.

2022

Article / Detailed stratified GWAS analysis for severe COVID-19 in four European populations

Hum Mol Genet

Degenhardt F, Ellinghaus D, Juzenas S, Lerga-Jaso J, Wendorff M, Maya-Miles D, Uellendahl-Werth F, ElAbd H, Rühlemann MC, Arora J, Özer O, Lenning OB, Myhre R, Vadla MS, Wacker EM, Wienbrandt L, Blandino Ortiz A, de Salazar A, Garrido Chercoles A, Palom A, Ruiz A, Garcia-Fernandez AE, Blanco-Grau A, Mantovani A, Zanella A, Holten AR, Mayer A, Bandera A, Cherubini A, Protti A, Aghemo A, Gerussi A, Ramirez A, Braun A, Nebel A, Barreira A, Lleo A, Teles A, Kildal AB, Biondi A, Caballero-Garralda A, Ganna A, Gori A, Glück A, Lind A, Tanck A, Hinney A, Carreras Nolla A, Fracanzani AL, Peschuck A, Cavallero A, Dyrhol-Riise AM, Ruello A, Julià A, Muscatello A, Pesenti A, Voza A, Rando-Segura A, Solier A, Schmidt A, Cortes B, Mateos B, Nafria-Jimenez B, Schaefer B, Jensen B, Bellinghausen C, Maj C, Ferrando C, de la Horra C, Quereda C, Skurk C, Thibeault C, Scollo C, Herr C, Spinner CD, Gassner C, Lange C, Hu C, Paccapelo C, Lehmann C, Angelini C, Cappadona C, Azuure C; COVICAT study group, Aachen Study (COVAS); Bianco C, Cea C, Sancho C, Hoff DAL, Galimberti D, Prati D, Haschka D, Jiménez D, Pestaña D, Toapanta D, Muñiz-Diaz E, Azzolini E, Sandoval E, Binatti E, Scarpini E, Helbig ET, Casalone E, Urrechaga E, Paraboschi EM, Pontali E, Reverter E, Calderón EJ, Navas E, Solligård E, Contro E, Arana-Arri E, Aziz F, Garcia F, García Sánchez F, Ceriotti F, Martinelli-Boneschi F, Peyvandi F, Kurth F, Blasi F, Malvestiti F, Medrano FJ, Mesonero F, Rodriguez-Frias F, Hanses F, Müller F, Hemmrich-Stanisak G, Bellani G, Grasselli G, Pezzoli G, Costantino G, Albano G, Cardamone G, Bellelli G, Citerio G, Foti G, Lamorte G, Matullo G, Baselli G, Kurihara H, Neb H, My I, Kurth I, Hernández I, Pink I, de Rojas I, Galván-Femenia I, Holter JC, Afset JE, Heyckendorf J, Kässens J, Damås JK, Rybniker J, Altmüller J, Ampuero J, Martín J, Erdmann J, Banales JM, Badia JR, Dopazo J, Schneider J, Bergan J, Barretina J, Walter J, Hernández Quero J, Goikoetxea J, Delgado J, Guerrero JM, Fazaal J, Kr

Article / Detailed stratified GWAS analysis for severe COVID-19 in four European populations

Hum Mol Genet

Degenhardt F, Ellinghaus D, Juzenas S, Lerga-Jaso J, Wendorff M, Maya-Miles D, Uellendahl-Werth F, ElAbd H, Rühlemann MC, Arora J, Özer O, Lenning OB, Myhre R, Vadla MS, Wacker EM, Wienbrandt L, Ortiz AB, Salazar A, Chercoles AG, Palom A, Ruiz A, Garcia-Fernandez AE, Blanco-Grau A, Mantovani A, Zanella A, Holten AR, Mayer A, Bandera A, Cherubini A, Protti A, Aghemo A, Gerussi A, Ramirez A, Braun A, Nebel A, Barreira A, Lleo A, Teles A, Kildal AB, Biondi A, Caballero-Garralda A, Ganna A, Gori A, Glück A, Lind A, Tanck A, Hinney A, Nolla AC, Fracanzani AL, Peschuck A, Cavallero A, Dyrhol-Riise AM, Ruello A, Julià A, Muscatello A, Pesenti A, Voza A, Rando-Segura A, Solier A, Schmidt A, Cortes B, Mateos B, Nafria-Jimenez B, Schaefer B, Jensen B, Bellinghausen C, Maj C, Ferrando C, Horra C, Quereda C, Skurk C, Thibeault C, Scollo C, Herr C, Spinner CD, Gassner C, Lange C, Hu C, Paccapelo C, Lehmann C, Angelini C, Cappadona C, Azuure C; COVICAT study group, Aachen Study (COVAS), Bianco C, Cea C, Sancho C, Hoff DAL, Galimberti D, Prati D, Haschka D, Jiménez D, Pestaña D, Toapanta D, Muñiz-Diaz E, Azzolini E, Sandoval E, Binatti E, Scarpini E, Helbig ET, Casalone E, Urrechaga E, Paraboschi EM, Pontali E, Reverter E, Calderón EJ, Navas E, Solligård E, Contro E, Arana-Arri E, Aziz F, Garcia F, Sánchez FG, Ceriotti F, Martinelli-Boneschi F, Peyvandi F, Kurth F, Blasi F, Malvestiti F, Medrano FJ, Mesonero F, Rodriguez-Frias F, Hanses F, Müller F, Hemmrich-Stanisak G, Bellani G, Grasselli G, Pezzoli G, Costantino G, Albano G, Cardamone G, Bellelli G, Citerio G, Foti G, Lamorte G, Matullo G, Baselli G, Kurihara H, Neb H, My I, Kurth I, Hernández I, Pink I, Rojas I, Galván-Femenia I, Holter JC, Afset JE, Heyckendorf J, Kässens J, Damås JK, Rybniker J, Altmüller J, Ampuero J, Martín J, Erdmann J, Banales JM, Badia JR, Dopazo J, Schneider J, Bergan J, Barretina J, Walter J, Quero JH, Goikoetxea J, Delgado J, Guerrero JM, Fazaal J, Kraft J, Schröder J, Risnes K, Banasik K, Müller KE,

Article / New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming

Journal of Experimental and Clinical Cancer Research

Colyn, L.; Alvarez-Sola, G.; Latasa, M.U.; Uriarte, I.; Herranz, J.M.; Arechederra, M.; Vlachogiannis, G.; Rae, C.; Pineda-Lucena, A.; Casadei-Gardini, A.; Pedica, F.; Aldrighetti, L.; López-López, A.; López-Gonzálvez, A.; Barbas, C.; Ciordia, S.; Van Liempd, S.M.; Falcón-Pérez, J.M.; Urman, J.; Sangro, B.; Vicent, S.; Iraburu, M.J.; Prosper, F.; Nelson, L.J.; Banales, J.M.; Martinez-Chantar, M.L.; Marin, J.J.G.; Braconi, C.; Trautwein, C.; Corrales, F.J.; Cubero, F.J.; Berasain, C.; Fernandez-Barrena, M.G.; Avila, M.A.

Article / Senolytic treatment preserves biliary regenerative capacity lost through cellular senescence during cold storage

Science Translational Medicine

Ferreira-Gonzalez, S.; Man, T.Y.; Esser, H.; Aird, R.; Kilpatrick, A.M.; Rodrigo-Torres, D.; Younger, N.; Campana, L.; Gadd, V.L.; Dwyer, B.; Aleksieva, N.; Boulter, L.; Macmillan, M.T.; Wang, Y.; Mylonas, K.J.; Ferenbach, D.A.; Kendall, T.J.; Lu, W.Y.; Acosta, J.C.; Kurian, D.; O'Neill, S.; Oniscu, G.C.; Banales, J.M.; Krimpenfort, P.J.; Forbes, S.J.

Article / Bcl-xL as prognostic marker and potential therapeutic target in cholangiocarcinoma

Liver International

Hoffmeister-Wittmann, P.; Mock, A.; Nichetti, F.; Korell, F.; Heilig, C.E.; Scherr, A.L.; Günther, M.; Albrecht, T.; Kelmendi, E.; Xu, K.; Nader, L.; Kessler, A.; Schmitt, N.; Fritzsche, S.; Weiler, S.; Sobol, B.; Stenzinger, A.; Boeck, S.; Westphalen, C.B.; Schulze-Osthoff, K.; Trojan, J.; Kindler, T.; Weichert, W.; Spiekermann, K.; Bitzer, M.; Folprecht, G.; Illert, A.L.; Boerries, M.; Klauschen, F.; Ochsenreither, S.; Siveke, J.; Bauer, S.; Glimm, H.; Brors, B.; Hüllein, J.; Hübschmann, D.; Uhrig, S.; Horak, P.; Kreutzfeldt, S.; Banales, J.M.; Springfeld, C.; Jäger, D.; Schirmacher, P.; Roessler, S.; Ormanns, S.; Goeppert, B.; Fröhling, S.; Köhler, B.C.

Article / Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis

Nature Communications

Sáenz de Urturi, D.; Buqué, X.; Porteiro, B.; Folgueira, C.; Mora, A.; Delgado, T.C.; Prieto-Fernández, E.; Olaizola, P.; Gómez-Santos, B.; Apodaka-Biguri, M.; González-Romero, F.; Nieva-Zuluaga, A.; Ruiz de Gauna, M.; Goikoetxea-Usandizaga, N.; García-Rodríguez, J.L.; Gutierrez de Juan, V.; Aurrekoetxea, I.; Montalvo-Romeral, V.; Novoa, E.M.; Martín-Guerrero, I.; Varela-Rey, M.; Bhanot, S.; Lee, R.; Banales, J.M.; Syn, W.K.; Sabio, G.; Martínez-Chantar, M.L.; Nogueiras, R.; Aspichueta, P.

Article / Cholangiocarcinoma progression depends on the uptake and metabolization of extracellular lipids

Hepatology

Ruiz de Gauna, M.; Biancaniello, F.; González-Romero, F.; Rodrigues, P.M.; Lapitz, A.; Gómez-Santos, B.; Olaizola, P.; Di Matteo, S.; Aurrekoetxea, I.; Labiano, I.; Nieva-Zuluaga, A.; Benito-Vicente, A.; Perugorria, M.J.; Apodaka-Biguri, M.; Paiva, N.A.; Sáenz de Urturi, D.; Buqué, X.; Delgado, I.; Martín, C.; Azkargorta, M.; Elortza, F.; Calvisi, D.F.; Andersen, J.B.; Alvaro, D.; Cardinale, V.; Bujanda, L.; Banales, J.; Aspichueta, P.

Article / Metabolic subtypes of patients with NAFLD exhibit distinctive cardiovascular risk profiles

Hepatology

Martínez-Arranz, I.; Bruzzone, C.; Noureddin, M.; Gil-Redondo, R.; Mincholé, I.; Bizkarguenaga, M.; Arretxe, E.; Iruarrizaga-Lejarreta, M.; Fernández-Ramos, D.; Lopitz-Otsoa, F.; Mayo, R.; Embade, N.; Newberry, E.; Mittendorf, B.; Izquierdo-Sánchez, L.; Smid, V.; Arnold, J.; Iruzubieta, P.; Pérez Castaño, Y.; Krawczyk, M.; Marigorta, U.M.; Morrison, M.C.; Kleemann, R.; Martín-Duce, A.; Hayardeny, L.; Vitek, L.; Bruha, R.; Aller de la Fuente, R.; Crespo, J.; Romero-Gomez, M.; Banales, J.M.; Arrese, M.; Cusi, K.; Bugianesi, E.; Klein, S.; Lu, S.C.; Anstee, Q.M.; Millet, O.; Davidson, N.O.; Alonso, C.; Mato, J.M.

Article / Suppression of Hepatic PPARα in Primary Biliary Cholangitis Is Modulated by miR-155

Cells

Adamowicz, M.; Kempinska-Podhorodecka, A.; Abramczyk, J.; Banales, J.M.; Milkiewicz, P.; Milkiewicz, M.

Article / Association between Metabolic Disorders and Cholangiocarcinoma: Impact of a Postulated Risk Factor with Rising Incidence

Cancers

Da Fonseca, L.G.; Hashizume, P.H.; de Oliveira, I.S.; Izquierdo-Sanchez, L.; Saud, L.R.d.C.; Xerfan, M.P.; Alves, V.A.F.; de Mello, E.S.; Herman, P.; Banales, J.M.; Oliveira, C.P.; Carrilho, F.J.

Article / Targeting NAE1-mediated protein hyper-NEDDylation halts cholangiocarcinogenesis and impacts on tumor-stroma crosstalk in experimental models

Journal of Hepatology

Olaizola, P.; Lee-Law, P.Y.; Fernandez-Barrena, M.G.; Alvarez, L.; Cadamuro, M.; Azkargorta, M.; O'Rourke, C.J.; Caballero-Camino, F.J.; Olaizola, I.; Macias, R.I.R.; Marin, J.J.G.; Serrano-Maciá, M.; Martinez-Chantar, M.L.; Avila, M.A.; Aspichueta, P.; Calvisi, D.F.; Evert, M.; Fabris, L.; Castro, R.E.; Elortza, F.; Andersen, J.B.; Bujanda, L.; Rodrigues, P.M.; Perugorria, M.J.; Banales, J.M.

Article / Impact of Positive Lymph Nodes and Resection Margin Status on the Overall Survival of Patients with Resected Perihilar Cholangiocarcinoma: The ENSCCA Registry

Cancers

Nooijen, L.E.; Banales, J.M.; de Boer, M.T.; Braconi, C.; Folseraas, T.; Forner, A.; Holowko, W.; Hoogwater, F.J.H.; Klümpen, H.J.; Koerkamp, B.G.; Lamarca, A.; Casta, A.L.; López-López, F.; Izquierdo-Sánchez, L.; Scheiter, A.; Utpatel, K.; Swijnenburg, R.J.; Kazemier, G.; Erdmann, J.I.

Article / Cholangiocarcinoma landscape in Europe: Diagnostic, prognostic and therapeutic insights from the ENSCCA Registry

Journal of Hepatology

Izquierdo-Sanchez, L.; Lamarca, A.; La Casta, A.; Buettner, S.; Utpatel, K.; Klümpen, H.J.; Adeva, J.; Vogel, A.; Lleo, A.; Fabris, L.; Ponz-Sarvise, M.; Brustia, R.; Cardinale, V.; Braconi, C.; Vidili, G.; Jamieson, N.B.; Macias, R.I.; Jonas, J.P.; Marzioni, M.; Hołówko, W.; Folseraas, T.; Kupčinskas, J.; Sparchez, Z.; Krawczyk, M.; Krupa, Ł.; Scripcariu, V.; Grazi, G.L.; Landa-Magdalena, A.; Ijzermans, J.N.; Evert, K.; Erdmann, J.I.; López-López, F.; Saborowski, A.; Scheiter, A.; Santos-Laso, A.; Carpino, G.; Andersen, J.B.; Marin, J.J.; Alvaro, D.; Bujanda, L.; Forner, A.; Valle, J.W.; Koerkamp, B.G.; Banales, J.M.

Article / Long non-coding RNA ACTA2-AS1 promotes ductular reaction by interacting with the p300/ELK1 complex

Journal of Hepatology

Navarro-Corcuera, A.; Sehrawat, T.S.; Jalan-Sakrikar, N.; Gibbons, H.R.; Pirius, N.E.; Khanal, S.; Hamdan, F.H.; Aseem, S.O.; Cao, S.; Banales, J.M.; Kang, N.; Faubion, W.A.; LaRusso, N.F.; Shah, V.H.; Huebert, R.C.

Article / Setup of multidisciplinary team discussions for patients with cholangiocarcinoma: current practice and recommendations from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)

ESMO Open

Casadio, M.; Cardinale, V.; Klümpen, H.J.; Morement, H.; Lacasta, A.; Koerkamp, B.G.; Banales, J.; Alvaro, D.; Valle, J.W.; Lamarca, A.

Article / TREM-2 plays a protective role in cholestasis by acting as a negative regulator of inflammation

Journal of Hepatology

Labiano, I.; Agirre-Lizaso, A.; Olaizola, P.; Echebarria, A.; Huici-Izagirre, M.; Olaizola, I.; Esparza-Baquer, A.; Sharif, O.; Hijona, E.; Milkiewicz, P.; Milkiewicz, M.; González-Romero, F.; Aspichueta, P.; Monte, M.J.; Marin, J.J.G.; Vucur, M.; Luedde, T.; Marzioni, M.; Mann, D.A.; Bujanda, L.; Rodrigues, P.M.; Banales, J.M.; Perugorria, M.J.

Editorial / PIGR-enriched circulating vesicles contributes to hepatocellular carcinoma aggressiveness

Journal of Hepatology

Zingoni, A.; Banales, J.M.

Editorial / Editorial: bezafibrate in the treatment of patients with primary biliary cholangitis—are we there yet?

Alimentary Pharmacology and Therapeutics

Rodrigues, P.M.; Banales, J.M.

Review / Genetics, pathobiology and therapeutic opportunities of polycystic liver disease

Nature Reviews Gastroenterology and Hepatology

Olaizola, P.; Rodrigues, P.M.; Caballero-Camino, F.J.; Izquierdo-Sanchez, L.; Aspichueta, P.; Bujanda, L.; Larusso, N.F.; Drenth, J.P.H.; Perugorria, M.J.; Banales, J.M.

Review / Clinical relevance of biomarkers in cholangiocarcinoma: critical revision and future directions

Gut

MacIas, R.I.R.; Cardinale, V.; Kendall, T.J.; Avila, M.A.; Guido, M.; Coulouarn, C.; Braconi, C.; Frampton, A.E.; Bridgewater, J.; Overi, D.; Pereira, S.P.; Rengo, M.; Kather, J.N.; Lamarca, A.; Pedica, F.; Forner, A.; Valle, J.W.; Gaudio, E.; Alvaro, D.; Banales, J.M.; Carpino, G.

2021

Article / Risk of gastrointestinal cancer in a symptomatic cohort after a complete colonoscopy: Role of faecal immunochemical test

World J Gastroenterol

Pin-Vieito N, Iglesias MJ, Remedios D, Rodríguez-Alonso L, Rodriguez-Moranta F, Álvarez-Sánchez V, Fernández-Bañares F, Boadas J, Martínez-Bauer E, Campo R, Bujanda L, Ferrandez Á, Piñol V, Rodríguez-Alcalde D, Guardiola J, Cubiella J, On Behalf Of The Colonpredict Study Investigators.

Article / Mapping the human genetic architecture of COVID-19.

Nature

COVID-19 Host Genetics Initiative

Article / Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis

Molecular Metabolism

Serrano-Maciá, M.; Simón, J.; González-Rellan, M.J.; Azkargorta, M.; Goikoetxea-Usandizaga, N.; Lopitz-Otsoa, F.; De Urturi, D.S.; Rodríguez-Agudo, R.; Lachiondo-Ortega, S.; Mercado-Gomez, M.; Gutiérrez de Juan, V.; Bizkarguenaga, M.; Fernández-Ramos, D.; Buque, X.; Baselli, G.A.; Valenti, L.V.C.; Iruzubieta, P.; Crespo, J.; Villa, E.; Banales, J.M.; Avila, M.A.; Marin, J.J.G.; Aspichueta, P.; Sutherland, J.; Barrio, R.; Mayor, U.; Elortza, F.; Xirodimas, D.P.; Nogueiras, R.; Delgado, T.C.; Martínez-Chantar, M.L.

Article / Anti-miR-518d-5p overcomes liver tumor cell death resistance through mitochondrial activity

Cell Death and Disease

Fernández-Tussy, P.; Rodríguez-Agudo, R.; Fernández-Ramos, D.; Barbier-Torres, L.; Zubiete-Franco, I.; Davalillo, S.L.d.; Herraez, E.; Goikoetxea-Usandizaga, N.; Lachiondo-Ortega, S.; Simón, J.; Lopitz-Otsoa, F.; Juan, V.G.d.; McCain, M.V.; Perugorria, M.J.; Mabe, J.; Navasa, N.; Rodrigues, C.M.P.; Fabregat, I.; Boix, L.; Sapena, V.; Anguita, J.; Lu, S.C.; Mato, J.M.; Banales, J.M.; Villa, E.; Reeves, H.L.; Bruix, J.; Reig, M.; Marin, J.J.G.; Delgado, T.C.; Martínez-Chantar, M.L.

Article / p-STAT3 is a PDC-E2 interacting partner in human cholangiocytes and hepatocytes with potential pathobiological implications

Scientific Reports

Kilanczyk, E.; Banales, J.M.; Jurewicz, E.; Milkiewicz, P.; Milkiewicz, M.

Article / Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality

Journal of Clinical Investigation

Nakanishi, T.; Pigazzini, S.; Degenhardt, F.; Cordioli, M.; Butler-Laporte, G.; Maya-Miles, D.; Bujanda, L.; Bouysran, Y.; Niemi, M.E.K.; Palom, A.; Ellinghaus, D.; Khan, A.; Martínez-Bueno, M.; Rolker, S.; Amitrano, S.; Tato, L.R.; Fava, F.; Spinner, C.D.; Prati, D.; Bernardo, D.; Garcia, F.; Darcis, G.; Fernández-Cadenas, I.; Holter, J.C.; Banales, J.M.; Frithiof, R.; Kiryluk, K.; Duga, S.; Asselta, R.; Pereira, A.C.; Romero-Gómez, M.; Nafría-Jiménez, B.; Hov, J.R.; Migeotte, I.; Renieri, A.; Planas, A.M.; Ludwig, K.U.; Buti, M.; Rahmouni, S.; Alarcón-Riquelme, M.E.; Schulte, E.C.; Franke, A.; Karlsen, T.H.; Valenti, L.; Zeberg, H.; Richards, J.B.; Ganna, A.

Article / Zinc Finger E-Box Binding Homeobox 1 Promotes Cholangiocarcinoma Progression Through Tumor Dedifferentiation and Tumor–Stroma Paracrine Signaling

Hepatology

Lobe, C.; Vallette, M.; Arbelaiz, A.; Gonzalez-Sanchez, E.; Izquierdo, L.; Pellat, A.; Guedj, N.; Louis, C.; Paradis, V.; Banales, J.M.; Coulouarn, C.; Housset, C.; Vaquero, J.; Fouassier, L.

Article / Clinical correlates of anti-SARS-CoV-2 antibody profiles in Spanish COVID-19 patients from a high incidence region

Scientific Reports

Markewitz, R.; Torge, A.; Wandinger, K.P.; Pauli, D.; Franke, A.; Bujanda, L.; Marimón, J.M.; Banales, J.M.; Gutierrez-Stampa, M.A.; Nafría, B.; Junker, R.

Article / RIPK3 acts as a lipid metabolism regulator contributing to inflammation and carcinogenesis in non-alcoholic fatty liver disease

Gut

Afonso, M.B.; Rodrigues, P.M.; Mateus-Pinheiro, M.; Simão, A.L.; Gaspar, M.M.; Majdi, A.; Arretxe, E.; Alonso, C.; Santos-Laso, A.; Jimenez-Agüero, R.; Eizaguirre, E.; Bujanda, L.; Pareja, M.J.; Banales, J.M.; Ratziu, V.; Gautheron, J.; Castro, R.E.; Rodrigues, C.M.P.

Article / The altered serum lipidome and its diagnostic potential for Non-Alcoholic Fatty Liver (NAFL)-associated hepatocellular carcinoma: Diagnosis of NAFLD-HCC utilising serum lipidomics

EBioMedicine

Lewinska, M.; Santos-Laso, A.; Arretxe, E.; Alonso, C.; Zhuravleva, E.; Jimenez-Agüero, R.; Eizaguirre, E.; Pareja, M.J.; Romero-Gómez, M.; Jimenez, M.A.; Suppli, M.P.; Knop, F.K.; Oversoe, S.K.; Villadsen, G.E.; Decaens, T.; Carrilho, F.J.; de Oliveira, C.P.; Sangro, B.; Macias, R.I.R.; Banales, J.M.; Andersen, J.B.

Article / Extracellular Signal-Regulated Kinase 5 Regulates the Malignant Phenotype of Cholangiocarcinoma Cells

Hepatology

Gentilini, A.; Lori, G.; Caligiuri, A.; Raggi, C.; Di Maira, G.; Pastore, M.; Piombanti, B.; Lottini, T.; Arcangeli, A.; Madiai, S.; Navari, N.; Banales, J.M.; Di Matteo, S.; Alvaro, D.; Duwe, L.; Andersen, J.B.; Tubita, A.; Tusa, I.; Di Tommaso, L.; Campani, C.; Rovida, E.; Marra, F.

Article / YAP Accelerates Notch-Driven Cholangiocarcinogenesis via mTORC1 in Mice

American Journal of Pathology

Lu, X.; Peng, B.; Chen, G.; Pes, M.G.; Ribback, S.; Ament, C.; Xu, H.; Pal, R.; Rodrigues, P.M.; Banales, J.M.; Evert, M.; Calvisi, D.F.; Chen, X.; Fan, B.; Wang, J.

Article / Analysis of SARS-CoV-2 reverse transcription-quantitative polymerase chain reaction cycle threshold values vis-à-vis anti-SARS-CoV-2 antibodies from a high incidence region

International Journal of Infectious Diseases

Markewitz, R.; Torge, A.; Wandinger, K.P.; Pauli, D.; Dargvainiene, J.; Franke, A.; Bujanda, L.; Marimón, J.M.; Banales, J.M.; Gutierrez-Stampa, M.A.; Nafría, B.; Junker, R.

Article / Inhibition of NAE-dependent protein hyper-NEDDylation in cystic cholangiocytes halts cystogenesis in experimental models of polycystic liver disease

United European Gastroenterology Journal

Lee-Law, P.Y.; Olaizola, P.; Caballero-Camino, F.J.; Izquierdo-Sanchez, L.; Rodrigues, P.M.; Perugorria, M.J.; Azkargorta, M.; Elortza, F.; Martinez-Chantar, M.L.; Aspichueta, P.; Marzioni, M.; Bujanda, L.; Drenth, J.P.H.; Banales, J.M.

Article / Definite and indeterminate nonalcoholic steatohepatitis share similar clinical features and prognosis: A longitudinal study of 1893 biopsy-proven nonalcoholic fatty liver disease subjects

Liver International

Ampuero, J.; Aller, R.; Gallego-Durán, R.; Crespo, J.; Abad, J.; González-Rodríguez, Á.; Gómez-Camarero, J.; Caballería, J.; Lo Iacono, O.; Ibañez, L.; García-Samaniego, J.; Martín-Mateos, R.; Francés, R.; Fernández-Rodríguez, C.; Diago, M.; Soriano, G.; Andrade, R.J.; Latorre, R.; Jorquera, F.; Morillas, R.M.; Escudero, D.; Estévez, P.; Hernández-Guerra, M.; Augustín, S.; Pareja-Megia, M.J.; Banales, J.M.; Aspichueta, P.; Benlloch, S.; Rosales, J.M.; Salmerón, J.; Turnes, J.; Romero-Gómez, M.

Article / Optimizing the use of twitter for research dissemination: The “Three Facts and a Story” randomized-controlled trial

Journal of Hepatology

Tapper, E.B.; Mirabella, R.; Walicki, J.J.; Banales, J.M.

Article / FOSL1 promotes cholangiocarcinoma via transcriptional effectors that could be therapeutically targeted

Journal of Hepatology

Vallejo, A.; Erice, O.; Entrialgo-Cadierno, R.; Feliu, I.; Guruceaga, E.; Perugorria, M.J.; Olaizola, P.; Muggli, A.; Macaya, I.; O'Dell, M.; Ruiz-Fernandez de Cordoba, B.; Ortiz-Espinosa, S.; Hezel, A.F.; Arozarena, I.; Lecanda, F.; Avila, M.A.; Fernandez-Barrena, M.G.; Evert, M.; Ponz-Sarvise, M.; Calvisi, D.F.; Banales, J.M.; Vicent, S.

Article / TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms

Gut

Esparza-Baquer, A.; Labiano, I.; Sharif, O.; Agirre-Lizaso, A.; Oakley, F.; Rodrigues, P.M.; Zhuravleva, E.; O'Rourke, C.J.; Hijona, E.; Jimenez-Agüero, R.; Riaño, I.; Landa, A.; La Casta, A.; Zaki, M.Y.W.; Munoz-Garrido, P.; Azkargorta, M.; Elortza, F.; Vogel, A.; Schabbauer, G.; Aspichueta, P.; Andersen, J.B.; Knapp, S.; Mann, D.A.; Bujanda, L.; Banales, J.M.; Perugorria, M.J.

Article / Adiponectin, Leptin, and IGF-1 Are Useful Diagnostic and Stratification Biomarkers of NAFLD

Frontiers in Medicine

Marques, V.; Afonso, M.B.; Bierig, N.; Duarte-Ramos, F.; Santos-Laso, Á.; Jimenez-Agüero, R.; Eizaguirre, E.; Bujanda, L.; Pareja, M.J.; Luís, R.; Costa, A.; Machado, M.V.; Alonso, C.; Arretxe, E.; Alustiza, J.M.; Krawczyk, M.; Lammert, F.; Tiniakos, D.G.; Flehmig, B.; Cortez-Pinto, H.; Banales, J.M.; Castro, R.E.; Normann, A.; Rodrigues, C.M.P.

Article / E2F1 and E2F2-mediated repression of CPT2 establishes a lipid-rich tumor-promoting environment

Cancer Research

Gonzalez-Romero, F.; Mestre, D.; Aurrekoetxea, I.; O'Rourke, C.J.; Andersen, J.B.; Woodhoo, A.; Tamayo-Caro, M.; Varela-Rey, M.; Palomo-Irigoyen, M.; Gomez-Santos, B.; de Urturi, D.S.; Nuñez-García, M.; García-Rodríguez, J.L.; Fernandez-Ares, L.; Buque, X.; Iglesias-Ara, A.; Bernales, I.; de Juan, V.G.; Delgado, T.C.; Goikoetxea-Usandizaga, N.; Lee, R.; Bhanot, S.; Delgado, I.; Perugorria, M.J.; Errazti, G.; Mosteiro, L.; Gaztambide, S.; de la Piscina, I.M.; Iruzubieta, P.; Crespo, J.; Banales, J.M.; Martínez-Chantar, M.L.; Castaño, L.; Zubiaga, A.M.; Aspichueta, P.

Article / Liver Metastases of Intrahepatic Cholangiocarcinoma: Implications for an Updated Staging System

Hepatology

Lamarca, A.; Santos-Laso, A.; Utpatel, K.; La Casta, A.; Stock, S.; Forner, A.; Adeva, J.; Folseraas, T.; Fabris, L.; Macias, R.I.R.; Krawczyk, M.; Krawczyk, M.; Cardinale, V.; Braconi, C.; Alvaro, D.; Evert, M.; Banales, J.M.; Valle, J.W.

Article / Dual Targeting of G9a and DNA Methyltransferase-1 for the Treatment of Experimental Cholangiocarcinoma

Hepatology

Colyn, L.; Bárcena-Varela, M.; Álvarez-Sola, G.; Latasa, M.U.; Uriarte, I.; Santamaría, E.; Herranz, J.M.; Santos-Laso, A.; Arechederra, M.; Ruiz de Gauna, M.; Aspichueta, P.; Canale, M.; Casadei-Gardini, A.; Francesconi, M.; Carotti, S.; Morini, S.; Nelson, L.J.; Iraburu, M.J.; Chen, C.; Sangro, B.; Marin, J.J.G.; Martinez-Chantar, M.L.; Banales, J.M.; Arnes-Benito, R.; Huch, M.; Patino, J.M.; Dar, A.A.; Nosrati, M.; Oyarzábal, J.; Prósper, F.; Urman, J.; Cubero, F.J.; Trautwein, C.; Berasain, C.; Fernandez-Barrena, M.G.; Avila, M.A.

Article / Epigenomic Evaluation of Cholangiocyte Transforming Growth Factor-β Signaling Identifies a Selective Role for Histone 3 Lysine 9 Acetylation in Biliary Fibrosis

Gastroenterology

Aseem, S.O.; Jalan-Sakrikar, N.; Chi, C.; Navarro-Corcuera, A.; De Assuncao, T.M.; Hamdan, F.H.; Chowdhury, S.; Banales, J.M.; Johnsen, S.A.; Shah, V.H.; Huebert, R.C.

Article / Targeting UBC9-mediated protein hyper-SUMOylation in cystic cholangiocytes halts polycystic liver disease in experimental models

Journal of Hepatology

Lee-Law, P.Y.; Olaizola, P.; Caballero-Camino, F.J.; Izquierdo-Sanchez, L.; Rodrigues, P.M.; Santos-Laso, A.; Azkargorta, M.; Elortza, F.; Martinez-Chantar, M.L.; Perugorria, M.J.; Aspichueta, P.; Marzioni, M.; LaRusso, N.F.; Bujanda, L.; Drenth, J.P.H.; Banales, J.M.

Article / Neutrophils interact with cholangiocytes to cause cholestatic changes in alcoholic hepatitis

Gut

Takeuchi, M.; Vidigal, P.T.; Guerra, M.T.; Hundt, M.A.; Robert, M.E.; Olave-Martinez, M.; Aoki, S.; Khamphaya, T.; Kersten, R.; Kruglov, E.; De La Rosa Rodriguez, R.; Banales, J.M.; Nathanson, M.H.; Weerachayaphorn, J.

Article / rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis

Journal of Hepatology

Teo, K.; Abeysekera, K.W.M.; Adams, L.; Aigner, E.; Anstee, Q.M.; Banales, J.M.; Banerjee, R.; Basu, P.; Berg, T.; Bhatnagar, P.; Buch, S.; Canbay, A.; Caprio, S.; Chatterjee, A.; Ida Chen, Y.D.; Chowdhury, A.; Daly, A.K.; Datz, C.; de Gracia Hahn, D.; DiStefano, J.K.; Dong, J.; Duret, A.; Vreugdenhil, A.; Alisi, A.; Socha, P.; Jańczyk, W.; Baumann, U.; Rajwal, S.; van Mourik, I.; Lacaille, F.; Dabbas, M.; Kelly, D.A.; Nobili, V.; Emdin, C.; Fairey, M.; Gerhard, G.S.; Eiriksdottir, G.; Garcia, M.E.; Gudnason, V.; Harris, T.B.; Kim, L.J.; Launer, L.J.; Nalls, M.A.; Smith, A.V.; Clark, J.M.; Hernaez, R.; Kao, W.H.L.; Mitchell, B.D.; Shuldiner, A.R.; Yerges-Armstrong, L.M.; Borecki, I.B.; Carr, J.J.; Feitosa, M.F.; Wu, J.; Butler, J.L.; Fox, C.S.; Hirschhorn, J.N.; Hoffmann, U.; Hwang, S.J.; Massaro, J.M.; O'Donnell, C.J.; Palmer, C.D.; Sahani, D.V.; Speliotes, E.K.; Guo, X.; Hampe, J.; Hickman, M.; Heintz, L.; Hudert, C.; Hunter, H.; Kelly, M.; Kozlitina, J.; Krawczyk, M.; Lammert, F.; Langenberg, C.; Lavine, J.; Li, L.; Lim, H.K.; Loomba, R.; Luukkonen, P.K.; Melton, P.E.; Mori, T.A.; Palmer, N.D.; Parisinos, C.A.; Pillai, S.G.; Qayyum, F.; Reichert, M.C.; Romeo, S.; Rotter, J.I.; Im, Y.R.; Santoro, N.; Schafmayer, C.; Stender, S.; Stickel, F.; Still, C.D.; Strnad, P.; Taylor, K.D.; Tybjærg-Hansen, A.; Umano, G.R.; Utukuri, M.

Article / Synthetic Conjugates of Ursodeoxycholic Acid Inhibit Cystogenesis in Experimental Models of Polycystic Liver Disease

Hepatology

Caballero-Camino, F.J.; Rivilla, I.; Herraez, E.; Briz, O.; Santos-Laso, A.; Izquierdo-Sanchez, L.; Lee-Law, P.Y.; Rodrigues, P.M.; Munoz-Garrido, P.; Jin, S.; Peixoto, E.; Richard, S.; Gradilone, S.A.; Perugorria, M.J.; Esteller, M.; Bujanda, L.; Marin, J.J.G.; Banales, J.M.; Cossío, F.P.

Editorial / A look back at cholangiocarcinoma in Finland

United European Gastroenterology Journal

Izquierdo-Sanchez, L.; Banales, J.M.; Rodrigues, P.M.

Editorial / Unscrambling a novel pathogenic role for interleukin-20 in acute hepatitis and bacterial infection: A double-edged sword?

Journal of Hepatology

Rodrigues, P.M.; Olaizola, P.; Banales, J.M.

Editorial / Characterizing the Heterogeneity of Liver Cell Populations Under a NASH-Related Hepatotoxicant Using Single-Nuclei RNA Sequencing

Cellular and Molecular Gastroenterology and Hepatology

Rodrigues, P.M.; Banales, J.M.

Letter / Reply to: “We need to talk about #livertwitter”

Journal of Hepatology

Tapper, E.B.; Banales, J.M.

Letter / REPLY:

Hepatology

Letter / REPLY:

Hepatology

Note / Applications of organoids in regenerative medicine: a proof-of-concept for biliary injury

Nature Reviews Gastroenterology and Hepatology

Rodrigues, P.M.; Banales, J.M.

Review / Primary biliary cholangitis: pathogenic mechanisms

Curr Opin Gastroenterol

Prieto J, Banales JM, Medina JF.

Review / Immune Checkpoint Inhibitors: The Emerging Cornerstone in Cholangiocarcinoma Therapy?

Liver Cancer

Gutiérrez-Larrañaga, M.; González-López, E.; Roa-Bautista, A.; Rodrigues, P.M.; Diáz-González, Á.; Banales, J.M.; López-Hoyos, M.; Santos-Laso, A.; Crespo, J.

Review / Next-generation biomarkers for cholangiocarcinoma

Cancers

Rodrigues, P.M.; Vogel, A.; Arrese, M.; Balderramo, D.C.; Valle, J.W.; Banales, J.M.

Review / Primary biliary cholangitis: Pathogenic mechanisms

Current Opinion in Gastroenterology

Prieto, J.; Banales, J.M.; Medina, J.F.

Review / Pathogenesis of Cholangiocarcinoma

Annual Review of Pathology: Mechanisms of Disease

Rodrigues, P.M.; Olaizola, P.; Paiva, N.A.; Olaizola, I.; Agirre-Lizaso, A.; Landa, A.; Bujanda, L.; Perugorria, M.J.; Banales, J.M.

Review / Targeted therapies for extrahepatic cholangiocarcinoma: preclinical and clinical development and prospects for the clinic

Expert Opinion on Investigational Drugs

Cadamuro, M.; Lasagni, A.; Lamarca, A.; Fouassier, L.; Guido, M.; Sarcognato, S.; Gringeri, E.; Cillo, U.; Strazzabosco, M.; Marin, J.J.G.; Banales, J.M.; Fabris, L.

2020

Article / Patients with cholangiocarcinoma present specific RNA profiles in serum and urine extracellular vesicles mirroring the tumor expression: novel liquid biopsy biomarkers for disease diagnosis.

CELLS

Lapitz A, Arbelaiz A, O'Rourke CJ, Lavin JL, Casta A, Ibarra C, Jimeno JP, Santos-Laso A, Izquierdo-Sanchez L, Krawczyk M, Perugorria MJ, Jimenez-Aguero R, Sanchez-Campos A, Riaño I, Gónzalez E, Lammert F, Marzioni M, Macias RIR,......, Banales JM.

Article / Extracellular vesicles in NAFLD/ALD: from pathobiology to therapy.

CELLS

Hernández A, Arab JP, Reyes D, Lapitz A, Moshage H, Bañales JM, Arrese M.

Article / Liver metastases of intrahepatic cholangiocarcinoma: implications for a potential new staging system

Hepatology

Lamarca A, Santos-Laso A, Utpatel K, La Casta A, Stock S, Forner A, Adeva J, Folseraas T, Fabris L, Macias RI, Krawczyk M, Krawczyk M, Cardinale V, Braconi C, Alvaro D, Evert M, Banales JM, Valle JW; European Network for the Study of Cholangiocarcinoma (ENS-CCA).

Article / Epigenomic Evaluation of Cholangiocyte Transforming Growth Factor-β Signaling Identifies a Selective Role for Histone 3 Lysine 9 Acetylation in Biliary Fibrosis

Gastroenterology

Aseem SO, Jalan-Sakrikar N, Chi C, Navarro-Corcuera A, De Assuncao TM, Hamdan FH, Chowdhury S, Banales JM, Johnsen SA, Shah VH, Huebert RC.

Article / TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms

Gut

Esparza-Baquer A, Labiano I, Sharif O, Agirre-Lizaso A, Oakley F, Rodrigues PM, Zhuravleva E, O'Rourke CJ, Hijona E, Jimenez-Agüero R, Riaño I, Landa A, La Casta A, Zaki MYW, Munoz-Garrido P, Azkargorta M, Elortza F, Vogel A, Schabbauer G, Aspichueta P, Andersen JB, Knapp S, Mann DA, Bujanda L, Banales JM, Perugorria MJ.

Article / Genomewide Association Study of Severe Covid-19 with Respiratory Failure

N Engl J Med

Severe Covid-19 GWAS Group, Ellinghaus D, Degenhardt F, Bujanda L, Buti M, Albillos A, Invernizzi P, Fernández J, Prati D, Baselli G, Asselta R, Grimsrud MM, Milani C, Aziz F, Kässens J, May S, Wendorff M, Wienbrandt L, Uellendahl-Werth F, Zheng T, Yi X, de Pablo R, Chercoles AG, Palom A, Garcia-Fernandez AE, Rodriguez-Frias F, Zanella A, Bandera A, Protti A, Aghemo A, Lleo A, Biondi A, Caballero-Garralda A, Gori A, Tanck A, Carreras Nolla A, Latiano A, Fracanzani AL, Peschuck A, Julià A, Pesenti A, Voza A, Jiménez D, Mateos B, Nafria Jimenez B, Quereda C, Paccapelo C, Gassner C, Angelini C, Cea C, Solier A, Pestaña D, Muñiz-Diaz E, Sandoval E, Paraboschi EM, Navas E, García Sánchez F, Ceriotti F, Martinelli-Boneschi F, Peyvandi F, Blasi F, Téllez L, Blanco-Grau A, Hemmrich-Stanisak G, Grasselli G, Costantino G, Cardamone G, Foti G, Aneli S, Kurihara H, ElAbd H, My I, Galván-Femenia I, Martín J, Erdmann J, Ferrusquía-Acosta J, Garcia-Etxebarria K, Izquierdo-Sanchez L, Bettini LR, Sumoy L, Terranova L, Moreira L, Santoro L, Scudeller L, Mesonero F, Roade L, Rühlemann MC, Schaefer M, Carrabba M, Riveiro-Barciela M, Figuera Basso ME, Valsecchi MG, Hernandez-Tejero M, Acosta-Herrera M, D'Angiò M, Baldini M, Cazzaniga M, Schulzky M, Cecconi M, Wittig M, et al.

Article / Genomewide association study of severe Covid-19 with respiratory failure.

N Engl J Med

Ellinghaus D, Degenhardt F, Bujanda L, Buti M, Albillos A, Invernizzi P, Fernández J, Prati D, Baselli G, Asselta R, Grimsrud MM, Milani C, Aziz F, Kässens J, May S, Wendorff M, Wienbrandt L, Uellendahl-Werth F, Zheng T, Yi X, de Pablo R, Chercoles AG, Palom A, Garcia-Fernandez AE, Rodriguez-Frias F, Zanella A, Bandera A, Protti A, Aghemo A, Lleo A, Biondi A, Caballero-Garralda A, Gori A, Tanck A, Carreras Nolla A, Latiano A, Fracanzani AL, Peschuck A, Julià A, Pesenti A, Voza A, Jiménez D, Mateos B, Nafria Jimenez B, Quereda C, Paccapelo C, Gassner C, Angelini C, Cea C, Solier A, Pestaña D, Muñiz-Diaz E, Sandoval E, Paraboschi EM, Navas E, García Sánchez F, Ceriotti F, Martinelli-Boneschi F, Peyvandi F, Blasi F, Téllez L, Blanco-Grau A, Hemmrich-Stanisak G, Grasselli G, Costantino G, Cardamone G, Foti G, Aneli S, Kurihara H, ElAbd H, My I, Galván-Femenia I, Martín J, Erdmann J, Ferrusquía-Acosta J, Garcia-Etxebarria K, Izquierdo-Sanchez L, Bettini LR, Sumoy L, Terranova L, Moreira L, Santoro L, Scudeller L, Mesonero F, Roade L, Rühlemann MC, Schaefer M, Carrabba M, Riveiro-Barciela M, Figuera Basso ME, Valsecchi MG, Hernandez-Tejero M, Acosta-Herrera M, D'Angiò M, Baldini M, Cazzaniga M, Schulzky M, Cecconi M, Wittig M, Ciccarelli M, Rodríguez-Gandía M, Bocciolone M, Miozzo M, Montano N, Braun N, Sacchi N, Martínez N, Özer O, Palmieri O, Faverio P, Preatoni P, Bonfanti P, Omodei P, Tentorio P, Castro P, Rodrigues PM, Blandino Ortiz A, de Cid R, Ferrer R, Gualtierotti R, Nieto R, Goerg S, Badalamenti S, Marsal S, Matullo G, Pelusi S, Juzenas S, Aliberti S, Monzani V, Moreno V, Wesse T, Lenz TL, Pumarola T, Rimoldi V, Bosari S, Albrecht W, Peter W, Romero-Gómez M, D'Amato M, Duga S, Banales JM, Hov JR, Folseraas T, Valenti L, Franke A, Karlsen TH; Severe Covid-19 GWAS Group.

Article / Multi‐omics integration highlights the role of ubiquitination in ccl4‐induced liver fibrosis

International Journal of Molecular Sciences

Mercado‐gómez, M.; Lopitz‐otsoa, F.; Azkargorta, M.; Serrano‐maciá, M.; Lachiondo‐ortega, S.; Goikoetxea‐usandizaga, N.; Rodríguez‐agudo, R.; Fernández‐ramos, D.; Bizkarguenaga, M.; Gutiérrez‐De Juan, V.; Lectez, B.; Aloria, K.; Arizmendi, J.M.; Simon, J.; Alonso, C.; Lozano, J.J.; Avila, M.A.; Banales, J.M.; Marin, J.J.G.; Beraza, N.; Mato, J.M.; Elortza, F.; Barrio, R.; Sutherland, J.D.; Mayor, U.; Martínez‐chantar, M.L.; Delgado, T.C.

Article / Patients with cholangiocarcinoma present specific rna profiles in serum and urine extracellular vesicles mirroring the tumor expression: Novel liquid biopsy biomarkers for disease diagnosis

Cells

Lapitz, A.; Arbelaiz, A.; O’rourke, C.J.; Lavin, J.L.; La Casta, A.; Ibarra, C.; Jimeno, J.P.; Santos-Laso, A.; Izquierdo-Sanchez, L.; Krawczyk, M.; Perugorria, M.J.; Jimenez-Aguero, R.; Sanchez-Campos, A.; Riaño, I.; Gónzalez, E.; Lammert, F.; Marzioni, M.; Macias, R.I.R.; Marin, J.J.G.; Karlsen, T.H.; Bujanda, L.; Falcón-Pérez, J.M.; Andersen, J.B.; Aransay, A.M.; Rodrigues, P.M.; Banales, J.M.

Article / Melatonin protects cholangiocytes from oxidative stress-induced proapoptotic and proinflammatory stimuli via mir-132 and mir-34

International Journal of Molecular Sciences

Ostrycharz, E.; Wasik, U.; Kempinska-Podhorodecka, A.; Banales, J.M.; Milkiewicz, P.; Milkiewicz, M.

Article / Dual pharmacological targeting of hdacs and pde5 inhibits liver disease progression in a mouse model of biliary inflammation and fibrosis

Cancers

Claveria-Cabello, A.; Colyn, L.; Uriarte, I.; Ujue Latasa, M.; Arechederra, M.; Herranz, J.M.; Alvarez, L.; Urman, J.M.; Martinez-Chantar, M.L.; Banales, J.M.; Sangro, B.; Rombouts, K.; Oyarzabal, J.; Marin, J.J.G.; Berasain, C.; Avila, M.A.; Fernandez-Barrena, M.G.

Article / Novel GANAB variants associated with polycystic liver disease

Orphanet Journal of Rare Diseases

van de Laarschot, L.F.M.; te Morsche, R.H.M.; Hoischen, A.; Venselaar, H.; Roelofs, H.M.; Cnossen, W.R.; Banales, J.M.; Roepman, R.; Drenth, J.P.H.

Article / Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors

Nature Communications

Wilson, D.H.; Jarman, E.J.; Mellin, R.P.; Wilson, M.L.; Waddell, S.H.; Tsokkou, P.; Younger, N.T.; Raven, A.; Bhalla, S.R.; Noll, A.T.R.; Olde Damink, S.W.; Schaap, F.G.; Chen, P.; Bates, D.O.; Banales, J.M.; Dean, C.H.; Henderson, D.J.; Sansom, O.J.; Kendall, T.J.; Boulter, L.

Article / S-adenosyl-L-methionine (SAMe) halts the autoimmune response in patients with primary biliary cholangitis (PBC) via antioxidant and S-glutathionylation processes in cholangiocytes

Biochimica et Biophysica Acta - Molecular Basis of Disease

Kilanczyk, E.; Banales, J.M.; Wunsch, E.; Barbier, O.; Avila, M.A.; Mato, J.M.; Milkiewicz, M.; Milkiewicz, P.

Article / MRP3-Mediated Chemoresistance in Cholangiocarcinoma: Target for Chemosensitization Through Restoring SOX17 Expression

Hepatology

Lozano, E.; Asensio, M.; Perez-Silva, L.; Banales, J.M.; Briz, O.; Marin, J.J.G.

Article / Efficacy and safety of the combination of pravastatin and sorafenib for the treatment of advanced hepatocellular carcinoma (Estahep clinical trial)

Cancers

Riaño, I.; Martín, L.; Varela, M.; Serrano, T.; Núñez, O.; Mínguez, B.; Rodrigues, P.M.; Perugorria, M.J.; Banales, J.M.; Arenas, J.I.

Article / Proteostasis disturbances and endoplasmic reticulum stress contribute to polycystic liver disease: New therapeutic targets

Liver International

Santos-Laso, A.; Izquierdo-Sanchez, L.; Rodrigues, P.M.; Huang, B.Q.; Azkargorta, M.; Lapitz, A.; Munoz-Garrido, P.; Arbelaiz, A.; Caballero-Camino, F.J.; Fernández-Barrena, M.G.; Jimenez-Agüero, R.; Argemi, J.; Aragon, T.; Elortza, F.; Marzioni, M.; Drenth, J.P.H.; LaRusso, N.F.; Bujanda, L.; Perugorria, M.J.; Banales, J.M.

Article / Significant fibrosis predicts new-onset diabetes mellitus and arterial hypertension in patients with NASH

Journal of Hepatology

Ampuero, J.; Aller, R.; Gallego-Durán, R.; Crespo, J.; Calleja, J.L.; García-Monzón, C.; Gómez-Camarero, J.; Caballería, J.; Lo Iacono, O.; Ibañez, L.; García-Samaniego, J.; Albillos, A.; Francés, R.; Fernández-Rodríguez, C.; Diago, M.; Soriano, G.; Andrade, R.J.; Latorre, R.; Jorquera, F.; Morillas, R.M.; Escudero, D.; Estévez, P.; Guerra, M.H.; Augustín, S.; Banales, J.M.; Aspichueta, P.; Benlloch, S.; Rosales, J.M.; Salmerón, J.; Turnes, J.; Romero Gómez, M.

Article / Pilot multi-omic analysis of human bile from benign and malignant biliary strictures: A machine-learning approach

Cancers

Urman, J.M.; Herranz, J.M.; Uriarte, I.; Rullán, M.; Oyón, D.; González, B.; Fernandez-Urién, I.; Carrascosa, J.; Bolado, F.; Zabalza, L.; Arechederra, M.; Alvarez-Sola, G.; Colyn, L.; Latasa, M.U.; Puchades-Carrasco, L.; Pineda-Lucena, A.; Iraburu, M.J.; Iruarrizaga-Lejarreta, M.; Alonso, C.; Sangro, B.; Purroy, A.; Gil, I.; Carmona, L.; Cubero, F.J.; Martínez-Chantar, M.L.; Banales, J.M.; Romero, M.R.; Macias, R.I.R.; Monte, M.J.; Marín, J.J.G.; Vila, J.J.; Corrales, F.J.; Berasain, C.; Fernández-Barrena, M.G.; Avila, M.A.

Article / A novel serum metabolomic profile for the differential diagnosis of distal cholangiocarcinoma and pancreatic ductal adenocarcinoma

Cancers

Macias, R.I.R.; Muñoz-Bellvís, L.; Sánchez-Martín, A.; Arretxe, E.; Martínez-Arranz, I.; Lapitz, A.; Gutiérrez, M.L.; La Casta, A.; Alonso, C.; González, L.M.; Avila, M.A.; Martinez-Chantar, M.L.; Castro, R.E.; Bujanda, L.; Banales, J.M.; Marin, J.J.G.

Article / Lignins from agroindustrial by-products as natural ingredients for cosmetics: Chemical structure and in vitro sunscreen and cytotoxic activities

Molecules

Gordobil, O.; Olaizola, P.; Banales, J.M.; Labidi, J.

Article / Type 3 Inositol 1,4,5-Trisphosphate Receptor Is Increased and Enhances Malignant Properties in Cholangiocarcinoma

Hepatology

Ueasilamongkol, P.; Khamphaya, T.; Guerra, M.T.; Rodrigues, M.A.; Gomes, D.A.; Kong, Y.; Wei, W.; Jain, D.; Trampert, D.C.; Ananthanarayanan, M.; Banales, J.M.; Roberts, L.R.; Farshidfar, F.; Nathanson, M.H.; Weerachayaphorn, J.

Article / Development and Validation of Hepamet Fibrosis Scoring System–A Simple, Noninvasive Test to Identify Patients With Nonalcoholic Fatty Liver Disease With Advanced Fibrosis

Clinical Gastroenterology and Hepatology

Ampuero, J.; Pais, R.; Aller, R.; Gallego-Durán, R.; Crespo, J.; García-Monzón, C.; Boursier, J.; Vilar, E.; Petta, S.; Zheng, M.H.; Escudero, D.; Calleja, J.L.; Aspichueta, P.; Diago, M.; Rosales, J.M.; Caballería, J.; Gómez-Camarero, J.; Lo Iacono, O.; Benlloch, S.; Albillos, A.; Turnes, J.; Banales, J.M.; Ratziu, V.; Romero-Gómez, M.; Agustin, S.; Jorquera, F.; Frances, R.; Garcia-Samaniego, J.; Salmeron, J.; Fernandez-Rodriguez, C.; Estevez, P.; Andrade, R.; Soriano, G.; Fernandez-Bermejo, M.; Arias Loste, M.T.; Sigüenza, R.; Giannetti, A.; del Pozo Maroto, E.

Review / Pathogenesis of Cholangiocarcinoma.

Annu Rev Pathol

Rodrigues PM, Olaizola P, Paiva NA, Olaizola I, Agirre-Lizaso A, Landa A, Bujanda L, Perugorria MJ, Banales JM

Review / Current and novel therapeutic opportunities for systemic therapy in biliary cancer

British Journal of Cancer

Marin, J.J.G.; Prete, M.G.; Lamarca, A.; Tavolari, S.; Landa-Magdalena, A.; Brandi, G.; Segatto, O.; Vogel, A.; Macias, R.I.R.; Rodrigues, P.M.; Casta, A.L.; Mertens, J.; Rodrigues, C.M.P.; Fernandez-Barrena, M.G.; Da Silva Ruivo, A.; Marzioni, M.; Mentrasti, G.; Acedo, P.; Munoz-Garrido, P.; Cardinale, V.; Banales, J.M.; Valle, J.W.; Bridgewater, J.; Braconi, C.

Review / Cholangiocarcinoma 2020: the next horizon in mechanisms and management

Nature Reviews Gastroenterology and Hepatology

Banales, J.M.; Marin, J.J.G.; Lamarca, A.; Rodrigues, P.M.; Khan, S.A.; Roberts, L.R.; Cardinale, V.; Carpino, G.; Andersen, J.B.; Braconi, C.; Calvisi, D.F.; Perugorria, M.J.; Fabris, L.; Boulter, L.; Macias, R.I.R.; Gaudio, E.; Alvaro, D.; Gradilone, S.A.; Strazzabosco, M.; Marzioni, M.; Coulouarn, C.; Fouassier, L.; Raggi, C.; Invernizzi, P.; Mertens, J.C.; Moncsek, A.; Rizvi, S.; Heimbach, J.; Koerkamp, B.G.; Bruix, J.; Forner, A.; Bridgewater, J.; Valle, J.W.; Gores, G.J.

Review / Extracellular Vesicles in NAFLD/ALD: From Pathobiology to Therapy

Cells

Hernández, A.; Arab, J.P.; Reyes, D.; Lapitz, A.; Moshage, H.; Bañales, J.M.; Arrese, M.

2019

Chapter / Intrahepatic Cholangiocarcinoma: the emerging entity

Therapy in Liver Diseases

Rodrigues PM, Olaizola P, Paiva NA, Perugorria MJ, Banales JM

Article / Hepatocellular carcinoma, a unique tumor with a lack of biomarkers.

ANNALS OF HEPATOLOGY

Debes JD, Carrera E, Mattos AZ, Prieto JE, Boonstra A; ESCALON investigators.

Article / Hepatobiliary cancers in south America: disparity strikes.

LANCET GASTROENTEROLOGY & HEPATOLOGY

Debes JD, Boonstra A, Balderramo D, Mattos AZ, Arrese M; ESCALON investigators.

Article / Extracellular vesicles in liver diseases: meeting report from the international liver congress 2018.

HEPATOLOGY COMMUNICATIONS

Banales JM, Feldstein AE, Sänger H, Lukacs-Kornek V, Szabo G, Kornek M.

Article / Clinical Characteristics, Associated Malignancies and Management of Primary Sclerosing Cholangitis in Inflammatory Bowel Disease Patients: A Multicentre Retrospective Cohort Study

Journal of Crohn's and Colitis

Guerra, I.; Bujanda, L.; Castro, J.; Merino, O.; Tosca, J.; Camps, B.; Gutiérrez, A.; Gordillo Ábalos, J.; De Castro, L.; Iborra, M.; Carbajo, A.Y.; Taxonera, C.; Rodríguez-Lago, I.; Mesonero, F.; De Francisco, R.; Gómez-Gómez, G.J.; Chaparro, M.; Tardillo, C.A.; Rivero, M.; Algaba, A.; Martín Arranz, E.; Cañete, F.; Vicente, R.; Sicilia, B.; Antolín, B.; Prieto, V.; Márquez, L.; Benítez, J.M.; Camo, P.; Piqueras, M.; Gargallo, C.J.; Hinojosa, E.; Huguet, J.M.; Pérez Calle, J.L.; Van Domselaar, M.; Rodriguez, C.; Calvet, X.; Muñoz-Villafranca, C.; García-Sepulcre, M.F.; Munoz-Garrido, P.; Fernández-Clotet, A.; Gómez Irwin, L.; Hernández, S.; Guardiola, J.; Sempere, L.; González Muñoza, C.; Hernández, V.; Beltrán, B.; Barrio, J.; Alba, C.; Moraleja, I.; López-Sanromán, A.; Riestra, S.; Martínez Montiel, P.; Garre, A.; Arranz, L.; García, M.J.; Martín Arranz, M.D.; Corsino, P.; Arias, L.; Fernández-Salazar, L.; Fernández-Pordomingo, A.; Andreu, M.; Iglesias, E.; Ber, Y.; Mena, R.; Arroyo Villarino, M.T.; Mora, M.; Ruiz, L.; López-Serrano, P.; Blazquez, I.; Villoria, A.; Fernández, M.; Bermejo, F.; Banales, J.M.; Domènech, E.; Gisbert, J.P.

Article / RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury

Cell Death and Differentiation

Krishna-Subramanian, S.; Singer, S.; Armaka, M.; Banales, J.M.; Holzer, K.; Schirmacher, P.; Walczak, H.; Kollias, G.; Pasparakis, M.; Kondylis, V.

Article / Antitumor Activity of a Novel Fibroblast Growth Factor Receptor Inhibitor for Intrahepatic Cholangiocarcinoma

American Journal of Pathology

Raggi, C.; Fiaccadori, K.; Pastore, M.; Correnti, M.; Piombanti, B.; Forti, E.; Navari, N.; Abbadessa, G.; Hall, T.; Destro, A.; Di Tommaso, L.; Roncalli, M.; Meng, F.; Glaser, S.; Rovida, E.; Peraldo-Neia, C.; Olaizola, P.; Banales, J.M.; Gerussi, A.; Elvevi, A.; Droz dit Busset, M.; Bhoori, S.; Mazzaferro, V.; Alpini, G.; Marra, F.; Invernizzi, P.

Article / Causes of hOCT1-Dependent Cholangiocarcinoma Resistance to Sorafenib and Sensitization by Tumor-Selective Gene Therapy

Hepatology

Lozano, E.; Macias, R.I.R.; Monte, M.J.; Asensio, M.; del Carmen, S.; Sanchez-Vicente, L.; Alonso-Peña, M.; Al-Abdulla, R.; Munoz-Garrido, P.; Satriano, L.; O'Rourke, C.J.; Banales, J.M.; Avila, M.A.; Martinez-Chantar, M.L.; Andersen, J.B.; Briz, O.; Marin, J.J.G.

Article / CXCR7 contributes to the aggressive phenotype of cholangiocarcinoma cells

Biochimica et Biophysica Acta - Molecular Basis of Disease

Gentilini, A.; Caligiuri, A.; Raggi, C.; Rombouts, K.; Pinzani, M.; Lori, G.; Correnti, M.; Invernizzi, P.; Rovida, E.; Navari, N.; Di Matteo, S.; Alvaro, D.; Banales, J.M.; Rodrigues, P.; Raschioni, C.; Donadon, M.; Di Tommaso, L.; Marra, F.

Article / Aging-Related Expression of Twinfilin-1 Regulates Cholangiocyte Biological Response to Injury

Hepatology

Maroni, L.; Pinto, C.; Giordano, D.M.; Saccomanno, S.; Banales, J.M.; Spallacci, D.; Albertini, M.C.; Orlando, F.; Provinciali, M.; Milkiewicz, M.; Melum, E.; Labiano, I.; Milkiewicz, P.; Rychlicki, C.; Trozzi, L.; Scarpelli, M.; Benedetti, A.; Svegliati Baroni, G.; Marzioni, M.

Article / Serum Metabolites as Diagnostic Biomarkers for Cholangiocarcinoma, Hepatocellular Carcinoma, and Primary Sclerosing Cholangitis

Hepatology

Banales, J.M.; Iñarrairaegui, M.; Arbelaiz, A.; Milkiewicz, P.; Muntané, J.; Muñoz-Bellvis, L.; La Casta, A.; Gonzalez, L.M.; Arretxe, E.; Alonso, C.; Martínez-Arranz, I.; Lapitz, A.; Santos-Laso, A.; Avila, M.A.; Martínez-Chantar, M.L.; Bujanda, L.; Marin, J.J.G.; Sangro, B.; Macias, R.I.R.

Article / Nuclear Translocation of RELB Is Increased in Diseased Human Liver and Promotes Ductular Reaction and Biliary Fibrosis in Mice

Gastroenterology

Elßner, C.; Goeppert, B.; Longerich, T.; Scherr, A.L.; Stindt, J.; Nanduri, L.K.; Rupp, C.; Kather, J.N.; Schmitt, N.; Kautz, N.; Breuhahn, K.; Ismail, L.; Heide, D.; Hetzer, J.; García-Beccaria, M.; Hövelmeyer, N.; Waisman, A.; Urbanik, T.; Mueller, S.; Gdynia, G.; Banales, J.M.; Roessler, S.; Schirmacher, P.; Jäger, D.; Schölch, S.; Keitel, V.; Heikenwalder, M.; Schulze-Bergkamen, H.; Köhler, B.C.

Article / Severity in polycystic liver disease is associated with aetiology and female gender: Results of the International PLD Registry

Liver International

van Aerts, R.M.M.; Kievit, W.; de Jong, M.E.; Ahn, C.; Bañales, J.M.; Reiterová, J.; Nevens, F.; Drenth, J.P.H.

Article / Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage

Gut

Perugorria, M.J.; Esparza-Baquer, A.; Oakley, F.; Labiano, I.; Korosec, A.; Jais, A.; Mann, J.; Tiniakos, D.; Santos-Laso, A.; Arbelaiz, A.; Gawish, R.; Sampedro, A.; Fontanellas, A.; Hijona, E.; Jimenez-Agüero, R.; Esterbauer, H.; Stoiber, D.; Bujanda, L.; Banales, J.M.; Knapp, S.; Sharif, O.; Mann, D.A.

Article / Extracellular Vesicles in Liver Diseases: Meeting Report from the International Liver Congress 2018

Hepatology Communications

Banales, J.M.; Feldstein, A.E.; Sänger, H.; Lukacs-Kornek, V.; Szabo, G.; Kornek, M.

Article / Adaptive downregulation of Cl - /HCO 3- exchange activity in rat hepatocytes under experimental obstructive cholestasis

PLoS ONE

Miszczuk, G.S.; Banales, J.M.; Zucchetti, A.E.; Pisani, G.B.; Boaglio, A.C.; Saez, E.; Medina, J.F.; Roma, M.G.; Crocenzi, F.A.

Article / Fine-Tuning of Sirtuin 1 Expression Is Essential to Protect the Liver From Cholestatic Liver Disease

Hepatology

Blokker, B.A.; Maijo, M.; Echeandia, M.; Galduroz, M.; Patterson, A.M.; Ten, A.; Philo, M.; Schungel, R.; Gutierrez-de Juan, V.; Halilbasic, E.; Fuchs, C.; Le Gall, G.; Milkiewicz, M.; Milkiewicz, P.; Banales, J.M.; Rushbrook, S.M.; Mato, J.M.; Trauner, M.; Müller, M.; Martínez-Chantar, M.L.; Varela-Rey, M.; Beraza, N.

Article / Effects of Endotoxin on Type 3 Inositol 1,4,5-Trisphosphate Receptor in Human Cholangiocytes

Hepatology

Franca, A.; Carlos Melo Lima Filho, A.; Guerra, M.T.; Weerachayaphorn, J.; Loiola dos Santos, M.; Njei, B.; Robert, M.; Xavier Lima, C.; Vieira Teixeira Vidigal, P.; Banales, J.M.; Ananthanarayanam, M.; Fatima Leite, M.; Nathanson, M.H.

Article / Dual Targeting of Histone Methyltransferase G9a and DNA-Methyltransferase 1 for the Treatment of Experimental Hepatocellular Carcinoma

Hepatology

Bárcena-Varela, M.; Caruso, S.; Llerena, S.; Álvarez-Sola, G.; Uriarte, I.; Latasa, M.U.; Urtasun, R.; Rebouissou, S.; Alvarez, L.; Jimenez, M.; Santamaría, E.; Rodriguez-Ortigosa, C.; Mazza, G.; Rombouts, K.; San José-Eneriz, E.; Rabal, O.; Agirre, X.; Iraburu, M.; Santos-Laso, A.; Banales, J.M.; Zucman-Rossi, J.; Prósper, F.; Oyarzabal, J.; Berasain, C.; Ávila, M.A.; Fernández-Barrena, M.G.

Article / Functional rare variants influence the clinical response to anti-TNF therapy in Crohn’s disease

Therapeutic Advances in Gastroenterology

Chaparro, M.; Aterido, A.; Guerra, I.; Iborra, M.; Cabriada, J.L.; Bujanda, L.; Taxonera, C.; García-Sánchez, V.; Marín-Jiménez, I.; Barreiro-de Acosta, M.; Vera, I.; Martín-Arranz, M.D.; Hernández-Breijo, B.; Mesonero, F.; Sempere, L.; Gomollón, F.; Hinojosa, J.; Bermejo, F.; Beltrán, B.; Rodríguez-Pescador, A.; Banales, J.M.; Olivares, D.; Aguilar-Melero, P.; Menchén, L.; Ferreiro-Iglesias, R.; Blazquez Gómez, I.; Benitez García, B.; Guijarro, L.G.; Marin, A.C.; Bernardo, D.; Marsal, S.; Julia, A.; Gisbert, J.P.

Editorial / Cholangiocyte-to-Hepatocyte Differentiation: A Context-Dependent Process and an Opportunity for Regenerative Medicine

Hepatology

Perugorria, M.J.; Olaizola, P.; Banales, J.M.

Review / Metabolic rearrangements in primary liver cancers: cause and consequences

Nature Reviews Gastroenterology and Hepatology

Satriano, L.; Lewinska, M.; Rodrigues, P.M.; Banales, J.M.; Andersen, J.B.

Review / The challenges of primary biliary cholangitis: What is new and what needs to be done

Journal of Autoimmunity

Terziroli Beretta-Piccoli, B.; Mieli-Vergani, G.; Vergani, D.; Vierling, J.M.; Adams, D.; Alpini, G.; Banales, J.M.; Beuers, U.; Björnsson, E.; Bowlus, C.; Carbone, M.; Chazouillères, O.; Dalekos, G.; De Gottardi, A.; Harada, K.; Hirschfield, G.; Invernizzi, P.; Jones, D.; Krawitt, E.; Lanzavecchia, A.; Lian, Z.X.; Ma, X.; Manns, M.; Mavilio, D.; Quigley, E.M.; Sallusto, F.; Shimoda, S.; Strazzabosco, M.; Swain, M.; Tanaka, A.; Trauner, M.; Tsuneyama, K.; Zigmond, E.; Gershwin, M.E.

Review / Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases

Nature Reviews Gastroenterology and Hepatology

Fabris, L.; Fiorotto, R.; Spirli, C.; Cadamuro, M.; Mariotti, V.; Perugorria, M.J.; Banales, J.M.; Strazzabosco, M.

Review / Diagnostic and prognostic biomarkers in cholangiocarcinoma

Liver International

Macias, R.I.R.; Kornek, M.; Rodrigues, P.M.; Paiva, N.A.; Castro, R.E.; Urban, S.; Pereira, S.P.; Cadamuro, M.; Rupp, C.; Loosen, S.H.; Luedde, T.; Banales, J.M.

Review / Cholangiocyte pathobiology

Nature Reviews Gastroenterology and Hepatology

Banales, J.M.; Huebert, R.C.; Karlsen, T.; Strazzabosco, M.; LaRusso, N.F.; Gores, G.J.

Review / Genetics of polycystic liver diseases

Current Opinion in Gastroenterology

Lee-Law, P.Y.; Van De Laarschot, L.F.M.; Banales, J.M.; Drenth, J.P.H.

Review / Wnt–β-catenin signalling in liver development, health and disease

Nature Reviews Gastroenterology and Hepatology

Perugorria, M.J.; Olaizola, P.; Labiano, I.; Esparza-Baquer, A.; Marzioni, M.; Marin, J.J.G.; Bujanda, L.; Banales, J.M.

2018

Chapter / Fibrocystic Diseases of the Liver

Zakim and Boyer’s hepatology: a textbook of liver disease 7th edition.

Drenth JPH, Banales JM, Devaraj KM, Helmke SM, Everson GT.

Article / Metabolomic-based noninvasive serum test to diagnose nonalcoholic steatohepatitis: results from discovery and validation cohorts.

HEPATOLOGY COMMUNICATIONS

Mayo R, Crespo J, Martínez-Arranz I, Banales JM,......, Caballería J, Romero-Gómez M, Martín-Duce A, Mugüerza Huguet JM, Busteros-Moraza JI, Idowu MO, Castro A, Martínez-Chantar ML, Ortiz P, Bruha R, Lu SC, Bedossa P, Noureddin M, Sanyal AJ, Mato JM.

Article / Factors related to the participation and detection of lesions in colorectal cancer screening programme-based faecal immunochemical test.

Eur J Public Health

Portillo I, Arana-Arri E, Gutiérrez-Ibarluzea I, Bilbao I, Luis Hurtado J, Sarasqueta C, Idigoras I, Bujanda L; EUSKOLON Study Investigators.

Article / MicroRNA-506 promotes primary biliary cholangitis–like features in cholangiocytes and immune activation

Hepatology

Erice, O.; Munoz-Garrido, P.; Vaquero, J.; Perugorria, M.J.; Fernandez-Barrena, M.G.; Saez, E.; Santos-Laso, A.; Arbelaiz, A.; Jimenez-Agüero, R.; Fernandez-Irigoyen, J.; Santamaria, E.; Torrano, V.; Carracedo, A.; Ananthanarayanan, M.; Marzioni, M.; Prieto, J.; Beuers, U.; Oude Elferink, R.P.; LaRusso, N.F.; Bujanda, L.; Marin, J.J.G.; Banales, J.M.

Article / Differential effects of FXR or TGR5 activation in cholangiocarcinoma progression

Biochimica et Biophysica Acta - Molecular Basis of Disease

Erice, O.; Labiano, I.; Arbelaiz, A.; Santos-Laso, A.; Munoz-Garrido, P.; Jimenez-Agüero, R.; Olaizola, P.; Caro-Maldonado, A.; Martín-Martín, N.; Carracedo, A.; Lozano, E.; Marin, J.J.; O'Rourke, C.J.; Andersen, J.B.; Llop, J.; Gómez-Vallejo, V.; Padro, D.; Martin, A.; Marzioni, M.; Adorini, L.; Trauner, M.; Bujanda, L.; Perugorria, M.J.; Banales, J.M.

Article / MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis

Cell Death and Disease

Fernández-Ramos, D.; Fernández-Tussy, P.; Lopitz-Otsoa, F.; Gutiérrez-de-Juan, V.; Navasa, N.; Barbier-Torres, L.; Zubiete-Franco, I.; Simón, J.; Fernández, A.F.; Arbelaiz, A.; Aransay, A.M.; Lavín, J.L.; Beraza, N.; Perugorria, M.J.; Banales, J.M.; Villa, E.; Fraga, M.F.; Anguita, J.; Avila, M.A.; Berasain, C.; Iruzibieta, P.; Crespo, J.; Lu, S.C.; Varela-Rey, M.; Mato, J.M.; Delgado, T.C.; Martínez-Chantar, M.L.

Article / MicroRNA (miR)-433 and miR-22 dysregulations induce histone-deacetylase-6 overexpression and ciliary loss in cholangiocarcinoma

Hepatology

Mansini, A.P.; Lorenzo Pisarello, M.J.; Thelen, K.M.; Cruz-Reyes, M.; Peixoto, E.; Jin, S.; Howard, B.N.; Trussoni, C.E.; Gajdos, G.B.; LaRusso, N.F.; Perugorria, M.J.; Banales, J.M.; Gradilone, S.A.

Article / MiRNA-21 ablation protects against liver injury and necroptosis in cholestasis

Cell Death and Differentiation

Afonso, M.B.; Rodrigues, P.M.; Simão, A.L.; Gaspar, M.M.; Carvalho, T.; Borralho, P.; Bañales, J.M.; Castro, R.E.; Rodrigues, C.M.P.

Article / Metabolomic-based noninvasive serum test to diagnose nonalcoholic steatohepatitis: Results from discovery and validation cohorts

Hepatology Communications

Mayo, R.; Crespo, J.; Martínez-Arranz, I.; Banales, J.M.; Arias, M.; Mincholé, I.; Aller de la Fuente, R.; Jimenez-Agüero, R.; Alonso, C.; de Luis, D.A.; Vitek, L.; Stritesky, J.; Caballería, J.; Romero-Gómez, M.; Martín-Duce, A.; Mugüerza Huguet, J.M.; Busteros-Moraza, J.I.; Idowu, M.O.; Castro, A.; Martínez-Chantar, M.L.; Ortiz, P.; Bruha, R.; Lu, S.C.; Bedossa, P.; Noureddin, M.; Sanyal, A.J.; Mato, J.M.

Editorial / Toward personalized medicine for intrahepatic cholangiocarcinoma: Pharmacogenomic stratification of patients

Hepatology

Olaizola, P.; Perugorria, M.J.; Banales, J.M.

Editorial / Pyroptosis: An inflammatory link between NAFLD and NASH with potential therapeutic implications

Journal of Hepatology

Beier, J.I.; Banales, J.M.

Letter / Reply to: “Diagnostic and prognostic role of circulating microparticles in hepatocellular carcinoma”

Journal of Hepatology

Urban, S.K.; Krawczyk, M.; Willms, A.; Sänger, H.; Lammert, F.; Banales, J.M.; Milkiewicz, P.; Lukacs-Kornek, V.; Kornek, M.

Review / Primary biliary cholangitis: A tale of epigenetically-induced secretory failure?

Journal of Hepatology

Rodrigues, P.M.; Perugorria, M.J.; Santos-Laso, A.; Bujanda, L.; Beuers, U.; Banales, J.M.

Review / Extracellular vesicles in hepatobiliary malignancies

Frontiers in Immunology

Lapitz, A.; Arbelaiz, A.; Olaizola, P.; Aranburu, A.; Bujanda, L.; Perugorria, M.J.; Banales, J.M.

Review / Clinical management of polycystic liver disease

Journal of Hepatology

van Aerts, R.M.M.; van de Laarschot, L.F.M.; Banales, J.M.; Drenth, J.P.H.

Review / The search for novel diagnostic and prognostic biomarkers in cholangiocarcinoma

Biochimica et Biophysica Acta - Molecular Basis of Disease

Macias, R.I.R.; Banales, J.M.; Sangro, B.; Muntané, J.; Avila, M.A.; Lozano, E.; Perugorria, M.J.; Padillo, F.J.; Bujanda, L.; Marin, J.J.G.

Review / MicroRNAs and extracellular vesicles in cholangiopathies

Biochimica et Biophysica Acta - Molecular Basis of Disease

Olaizola, P.; Lee-Law, P.Y.; Arbelaiz, A.; Lapitz, A.; Perugorria, M.J.; Bujanda, L.; Banales, J.M.

2017

Article / Serum extracellular vesicles contain protein biomarkers for primary sclerosing cholangitis and cholangiocarcinoma

Hepatology

Arbelaiz, A.; Azkargorta, M.; Krawczyk, M.; Santos-Laso, A.; Lapitz, A.; Perugorria, M.J.; Erice, O.; Gonzalez, E.; Jimenez-Agüero, R.; Lacasta, A.; Ibarra, C.; Sanchez-Campos, A.; Jimeno, J.P.; Lammert, F.; Milkiewicz, P.; Marzioni, M.; Macias, R.I.R.; Marin, J.J.G.; Patel, T.; Gores, G.J.; Martinez, I.; Elortza, F.; Falcon-Perez, J.M.; Bujanda, L.; Banales, J.M.

Article / SOX17 regulates cholangiocyte differentiation and acts as a tumor suppressor in cholangiocarcinoma

Journal of Hepatology

Merino-Azpitarte, M.; Lozano, E.; Perugorria, M.J.; Esparza-Baquer, A.; Erice, O.; Santos-Laso, Á.; O'Rourke, C.J.; Andersen, J.B.; Jiménez-Agüero, R.; Lacasta, A.; D'Amato, M.; Briz, Ó.; Jalan-Sakrikar, N.; Huebert, R.C.; Thelen, K.M.; Gradilone, S.A.; Aransay, A.M.; Lavín, J.L.; Fernández-Barrena, M.G.; Matheu, A.; Marzioni, M.; Gores, G.J.; Bujanda, L.; Marin, J.J.G.; Banales, J.M.

Article / Cancer-associated circulating large extracellular vesicles in cholangiocarcinoma and hepatocellular carcinoma

Journal of Hepatology

Julich-Haertel, H.; Urban, S.K.; Krawczyk, M.; Willms, A.; Jankowski, K.; Patkowski, W.; Kruk, B.; Krasnodębski, M.; Ligocka, J.; Schwab, R.; Richardsen, I.; Schaaf, S.; Klein, A.; Gehlert, S.; Sänger, H.; Casper, M.; Banales, J.M.; Schuppan, D.; Milkiewicz, P.; Lammert, F.; Krawczyk, M.; Lukacs-Kornek, V.; Kornek, M.

Article / Bile Acids in Polycystic Liver Diseases: Triggers of Disease Progression and Potential Solution for Treatment

Digestive Diseases

Perugorria, M.J.; Labiano, I.; Esparza-Baquer, A.; Marzioni, M.; Marin, J.J.G.; Bujanda, L.; Banales, J.M.

Article / New evidence supporting the biliary bicarbonate umbrella theory

Clinics and Research in Hepatology and Gastroenterology

Fernandez-Barrena, M.G.; Barcena-Varela, M.; Banales, J.M.

Article / Nlrp3 Activation Induces Il-18 Synthesis and Affects the Epithelial Barrier Function in Reactive Cholangiocytes

American Journal of Pathology

Maroni, L.; Agostinelli, L.; Saccomanno, S.; Pinto, C.; Giordano, D.M.; Rychlicki, C.; De Minicis, S.; Trozzi, L.; Banales, J.M.; Melum, E.; Karlsen, T.H.; Benedetti, A.; Baroni, G.S.; Marzioni, M.

Article / Cholangiocarcinoma stem-like subset shapes tumor-initiating niche by educating associated macrophages

Journal of Hepatology

Raggi, C.; Correnti, M.; Sica, A.; Andersen, J.B.; Cardinale, V.; Alvaro, D.; Chiorino, G.; Forti, E.; Glaser, S.; Alpini, G.; Destro, A.; Sozio, F.; Di Tommaso, L.; Roncalli, M.; Banales, J.M.; Coulouarn, C.; Bujanda, L.; Torzilli, G.; Invernizzi, P.

Editorial / O-GlcNAcylation: Undesired tripmate but an opportunity for treatment in NAFLD-HCC

Journal of Hepatology

Santos-Laso, A.; Perugorria, M.J.; Banales, J.M.

Note / Novel lncRNA T-UCR as a potential downstream driver of the Wnt/β-catenin pathway in hepatobiliary carcinogenesis

Gut

Fernández-Barrena, M.G.; Perugorria, M.J.; Banales, J.M.

Review / New advances in the molecular mechanisms driving biliary fibrosis and emerging molecular targets

Current Drug Targets

Santos-Laso, A.; Munoz-Garrido, P.; Felipe-Agirre, M.; Bujanda, L.; Banales, J.M.; Perugorria, M.J.

Review / Molecular mechanisms of cholangiocarcinogenesis: New potential targets for therapy

Current Drug Targets

Erice, O.; Merino-Azpitarte, M.; Arbelaiz, A.; Gutierrez-Larranaga, M.; Jiménez-Agüero, R.; Perugorria, M.J.; Bujanda, L.; Banales, J.M.

Short Survey / Genetics: Novel causative genes for polycystic liver disease

Nature Reviews Gastroenterology and Hepatology

Perugorria, M.J.; Banales, J.M.

2016

Article / PNPLA3 p.I148M variant is associated with greater reduction of liver fat content after bariatric surgery

Surgery for Obesity and Related Diseases

Krawczyk, M.; Jiménez-Agüero, R.; Alustiza, J.M.; Emparanza, J.I.; Perugorria, M.J.; Bujanda, L.; Lammert, F.; Banales, J.M.

Article / Ursodeoxycholic acid in advanced polycystic liver disease: A phase 2 multicenter randomized controlled trial

Journal of Hepatology

D'Agnolo, H.M.A.; Kievit, W.; Takkenberg, R.B.; Riaño, I.; Bujanda, L.; Neijenhuis, M.K.; Brunenberg, E.J.L.; Beuers, U.; Banales, J.M.; Drenth, J.P.H.

Article / Integrative microRNA profiling in alcoholic hepatitis reveals a role for microRNA-182 in liver injury and inflammation

Gut

Blaya, D.; Coll, M.; Rodrigo-Torres, D.; Vila-Casadesús, M.; Altamirano, J.; Llopis, M.; Graupera, I.; Perea, L.; Aguilar-Bravo, B.; Díaz, A.; Banales, J.M.; Clària, J.; Lozano, J.J.; Bataller, R.; Caballería, J.; Ginès, P.; Sancho-Bru, P.

Article / Elevated interleukin-8 in bile of patients with primary sclerosing cholangitis

Liver International

Zweers, S.J.; Shiryaev, A.; Komuta, M.; Vesterhus, M.; Hov, J.R.; Perugorria, M.J.; de Waart, D.R.; Chang, J.C.; Tol, S.; te Velde, A.A.; de Jonge, W.J.; Banales, J.M.; Roskams, T.; Beuers, U.; Karlsen, T.H.; Jansen, P.L.; Schaap, F.G.

Article / Mutations in GANAB, Encoding the Glucosidase IIα Subunit, Cause Autosomal-Dominant Polycystic Kidney and Liver Disease

American Journal of Human Genetics

Porath, B.; Gainullin, V.G.; Cornec-Le Gall, E.; Dillinger, E.K.; Heyer, C.M.; Hopp, K.; Edwards, M.E.; Madsen, C.D.; Mauritz, S.R.; Banks, C.J.; Baheti, S.; Reddy, B.; Herrero, J.I.; Bañales, J.M.; Hogan, M.C.; Tasic, V.; Watnick, T.J.; Chapman, A.B.; Vigneau, C.; Lavainne, F.; Audrézet, M.P.; Ferec, C.; Le Meur, Y.; Torres, V.E.; Harris, P.C.

Article / Mechanisms of resistance to chemotherapy in gastric cancer

Anti-Cancer Agents in Medicinal Chemistry

Marin, J.J.G.; Al-Abdulla, R.; Lozano, E.; Briz, O.; Bujanda, L.; Banales, J.M.; Macias, R.I.R.

Article / Effect of pravastatin on the survival of patients with advanced gastric cancer

Oncotarget

Bujanda, L.; Rodríguez-González, A.; Sarasqueta, C.; Eizaguirre, E.; Hijona, E.; Marín, J.J.G.; Perugorria, M.J.; Banales, J.M.; Cosme, A.

Editorial / More insight into the diversity of cholangiocyte ciliopathies

Journal of Hepatology

Perugorria, M.J.; Bujanda, L.; Banales, J.M.

Review / Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)

Nature Reviews Gastroenterology and Hepatology

Banales, J.M.; Cardinale, V.; Carpino, G.; Marzioni, M.; Andersen, J.B.; Invernizzi, P.; Lind, G.E.; Folseraas, T.; Forbes, S.J.; Fouassier, L.; Geier, A.; Calvisi, D.F.; Mertens, J.C.; Trauner, M.; Benedetti, A.; Maroni, L.; Vaquero, J.; Macias, R.I.R.; Raggi, C.; Perugorria, M.J.; Gaudio, E.; Boberg, K.M.; Marin, J.J.G.; Alvaro, D.

Review / Bile acids in physiology, pathology and pharmacology

Current Drug Metabolism

Marin, J.J.G.; Macias, R.I.R.; Briz, O.; Banales, J.M.; Monte, M.J.

Short Survey / MicroRNAs in cholangiopathies: Potential diagnostic and therapeutic tools

Clinics and Research in Hepatology and Gastroenterology

Esparza-Baquer, A.; Labiano, I.; Bujanda, L.; Perugorria, M.J.; Banales, J.M.

2015

Article / Methods for extracellular vesicles isolation in a hospital setting

Frontiers in Immunology

Sáenz-Cuesta, M.; Arbelaiz, A.; Oregi, A.; Irizar, H.; Osorio-Querejeta, I.; Muñoz-Culla, M.; Banales, J.M.; Falcón-Pérez, J.M.; Olascoaga, J.; Otaegui, D.

Article / Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1

Hepatology

Barbier-Torres, L.; Beraza, N.; Fernández-Tussy, P.; Lopitz-Otsoa, F.; Fernández-Ramos, D.; Zubiete-Franco, I.; Varela-Rey, M.; Delgado, T.C.; Gutiérrez, V.; Anguita, J.; Pares, A.; Banales, J.M.; Villa, E.; Caballería, J.; Alvarez, L.; Lu, S.C.; Mato, J.M.; Martínez-Chantar, M.L.

Article / Enhanced antitumour drug delivery to cholangiocarcinoma through the apical sodium-dependent bile acid transporter (ASBT)

Journal of Controlled Release

Lozano, E.; Monte, M.J.; Briz, O.; Hernández-Hernández, A.; Banales, J.M.; Marin, J.J.G.; Macias, R.I.R.

Article / Ursodeoxycholic acid inhibits hepatic cystogenesis in experimental models of polycystic liver disease

Journal of Hepatology

Munoz-Garrido, P.; Marin, J.J.G.; Perugorria, M.J.; Urribarri, A.D.; Erice, O.; Sáez, E.; Úriz, M.; Sarvide, S.; Portu, A.; Concepcion, A.R.; Romero, M.R.; Monte, M.J.; Santos-Laso, Á.; Hijona, E.; Jimenez-Agüero, R.; Marzioni, M.; Beuers, U.; Masyuk, T.V.; Larusso, N.F.; Prieto, J.; Bujanda, L.; Drenth, J.P.H.; Banales, J.M.

2014

Article / Activation of the developmental pathway neurogenin-3/microRNA-7a regulates cholangiocyte proliferation in response to injury

Hepatology

Marzioni, M.; Agostinelli, L.; Candelaresi, C.; Saccomanno, S.; De Minicis, S.; Maroni, L.; Mingarelli, E.; Rychlicki, C.; Trozzi, L.; Banales, J.M.; Benedetti, A.; Baroni, G.S.

Article / Inhibition of metalloprotease hyperactivity in cystic cholangiocytes halts the development of polycystic liver diseases

Gut

Urribarri, A.D.; Munoz-Garrido, P.; Perugorria, M.J.; Erice, O.; Merino-Azpitarte, M.; Arbelaiz, A.; Lozano, E.; Hijona, E.; Jiménez-Agüero, R.; Fernandez-Barrena, M.G.; Jimeno, J.P.; Marzioni, M.; Marin, J.J.G.; Masyuk, T.V.; LaRusso, N.F.; Prieto, J.; Bujanda, L.; Banales, J.M.

Article / Novel equation to determine the hepatic triglyceride concentration in humans by MRI: Diagnosis and monitoring of NAFLD in obese patients before and after bariatric surgery

BMC Medicine

Jiménez-Agüero, R.; Emparanza, J.I.; Beguiristain, A.; Bujanda, L.; Alustiza, J.M.; García, E.; Hijona, E.; Gallego, L.; Sánchez-González, J.; Perugorria, M.J.; Asensio, J.I.; Larburu, S.; Garmendia, M.; Larzabal, M.; Portillo, M.P.; Aguirre, L.; Banales, J.M.

Article / Polycystic liver in the adult (PLA) in Spain: Analysis of a structured survey analysing the experience and attitude of Spanish gastroenterologists

Revista Espanola de Enfermedades Digestivas

Ampuero, J.; Bañales, J.M.; Soriano, G.; Crespo, J.; Olcoz, J.L.; Diago, M.; Calleja, J.L.; Romero-Gómez, M.

Article / Matrix metalloproteinase-10 expression is induced during hepatic injury and plays a fundamental role in liver tissue repair

Liver International

Garcia-Irigoyen, O.; Carotti, S.; Latasa, M.U.; Uriarte, I.; Fernández-Barrena, M.G.; Elizalde, M.; Urtasun, R.; Vespasiani-Gentilucci, U.; Morini, S.; Banales, J.M.; Parks, W.C.; Rodriguez, J.A.; Orbe, J.; Prieto, J.; Páramo, J.A.; Berasain, C.; Ávila, M.A.

Article / Anion exchanger 2 is critical for CD8+ T cells to maintain pHi homeostasis and modulate immune responses

European Journal of Immunology

Concepcion, A.R.; Salas, J.T.; Sarvide, S.; Sáez, E.; Ferrer, A.; López, M.; Portu, A.; Banales, J.M.; Hervás-Stubbs, S.; Oude Elferink, R.P.J.; Prieto, J.; Medina, J.F.

Article / Cocarcinogenic effects of intrahepatic bile acid accumulation in cholangiocarcinoma development

Molecular Cancer Research

Lozano, E.; Sanchez-Vicente, L.; Monte, M.J.; Herraez, E.; Briz, O.; Banales, J.M.; Marin, J.J.G.; Macias, R.I.R.

Review / MicroRNAs and cholestatic liver diseases

Current Opinion in Gastroenterology

Marin, J.J.G.; Bujanda, L.; Banales, J.M.

2013

Article / Expression of SLC22A1 variants may affect the response of hepatocellular carcinoma and cholangiocarcinoma to sorafenib

Hepatology

Herraez, E.; Lozano, E.; Macias, R.I.R.; Vaquero, J.; Bujanda, L.; Banales, J.M.; Marin, J.J.G.; Briz, O.

Article / Pasireotide is more effective than octreotide in reducing hepatorenal cystogenesis in rodents with polycystic kidney and liver diseases

Hepatology

Masyuk, T.V.; Radtke, B.N.; Stroope, A.J.; Banales, J.M.; Gradilone, S.A.; Huang, B.; Masyuk, A.I.; Hogan, M.C.; Torres, V.E.; Larusso, N.F.

Article / Zolmitriptan: A Novel Portal Hypotensive Agent Which Synergizes with Propranolol in Lowering Portal Pressure

PLoS ONE

Reboredo, M.; Chang, H.C.Y.; Barbero, R.; Rodríguez-Ortigosa, C.M.; Pérez-Vizcaíno, F.; Morán, A.; García, M.; Banales, J.M.; Carreño, N.; Alegre, F.; Herrero, I.; Quiroga, J.; Prieto, J.; Sangro, B.

Letter / Somatic second-hit mutations leads to polycystic liver diseases

World Journal of Gastroenterology

Banales, J.M.; Munoz-Garrido, P.; Bujanda, L.

2012

Article / MicroRNAs in biliary diseases

World Journal of Gastroenterology

Munoz-Garrido, P.; Fernandez-Barrena, M.G.; Hijona, E.; Carracedo, M.; Marín, J.J.G.; Bujanda, L.; Banales, J.M.

2008

Chapter / Ion Transporters and Cholangiocyte Pathophysiology

Pathophysiology of the intrahepatic billiary epithelium (Transworld Research Network)

Banales JM, Prieto J, Medina JF.

2007

Book / Genetics in liver diseases.

Prieto J. and Arroyo V.

Medina JF, Banales JM, Prieto J.

Chapter / Genetic defects of cholangiolar transporters

Genetics in Liver Diseases

Medina JF, Banales JM, Prieto J,

Design, synthesis and validation of new chemotherapeutic agents against cisplatin-resistant cancers: a new therapeutic strategy for cholangiocarcinoma.

University of the Basque Country (UPV/EHU)

Irene Olaizola - Finished

Role of the scavenger receptor MARCO in the progression of chronic liver disease and in the development of liver cancer: new diagnostic, prognostic and therapeutic strategy.

University of the Basque Country (UPV/EHU)

Aloña Agirre - Finished

Role of post-translational modifications on the pathogenesis of polycystic liver diseases (PLDs).

Radboud University (Nijmegen, The Netherlands)

Puy Yuen Lee - Finished

Cholangiocarcinoma landscape in Europe: diagnostic, prognostic and therapeutic insights from the ENSCCA Registry

University of the Basque Country (UPV/EHU)

Laura Izquierdo - Finished

Role of extracellular vesicles in the development and pathogenesis of primary sclerosing cholangitis (PSC): new diagnostic and prognostic strategy.

University of the Basque Country (UPV/EHU)

Ainhoa Lapitz - Finished

Role of the nuclear receptor KLF15 in the etiopathogenesis of cholangiocarcinoma: new diagnostic, prognostic and therapeutic strategy.

University of the Basque Country (UPV/EHU)

Nuno Paiva - Finished

Papel del factor de transcripción KLF5 en la quimioresistencia del colangiocarcinoma.

University of the Basque Country (UPV/EHU)

Ana Landa - Finished

New genetic alterations associated to deafness.

University of the Basque Country (UPV/EHU)

Raquel Muguerza - Finished

Unraveling the role of post-translational modifications on the pathogenesis of cholangiocarcinoma.

University of the Basque Country (UPV/EHU)

Paula Olaizola - Finished

Role of TREM-2 receptor in acute and chronic liver injury.

University of the Basque Country (UPV/EHU)

Ibone Labiano - Finished

Potential therapeutic value of the combination of UDCA and HDCA6 inhibitors for the treatment of polycystic liver diseases (PLDs)

University of the Basque Country (UPV/EHU)

Javier Caballero - Finished

Role of endoplasmic reticulum (ER) stress in the pathogenesis polycystic liver diseases (PLDs): new therapeutic target

University of the Basque Country (UPV/EHU)

Álvaro Santos - Finished

Potential therapeutic value of the combination of pravastatin and sorafenib for the treatment of patients with hepatocellular carcinoma.

University of the Basque Country (UPV/EHU)

Ioana Riaño - Finished

Role of exosomes in the pathophysiology of cholangiocarcinoma

University of the Basque Country (UPV/EHU)

Ander Arbelaiz - Finished

Role of bile acids in the etiopathogenesis of cholangiocarcinoma

University of the Basque Country (UPV/EHU)

Oihane Erice - Finished

Role of SOX17 the etiopathogenesis of cholangiocarcinoma

University of the Basque Country (UPV/EHU)

Maite Merino - Finished

Ursodeoxycholic acid: new approach for the treatment of polycystic liver diseases

University of the Basque Country (UPV/EHU)

Patricia Muñoz Garrido - Finished

Role of cholangiocyte-extracellular matrix interaction in the hepatic cystogenesis of polycystic liver diseases (PCLDs).

University of Navarra

Aura Daniela Urribarri - Finished

Deficiency of Ae2 in mice predisposes to liver injury associated with reduced glutathione, increased apoptosis and development of AMA.

University of Navarra

Alejandro Ferrer - Finished

Mechanisms of regulation of the secretin-stimulated bile flow with bile salts.

University of Navarra

Miriam Úriz - Finished

Role of Ae2 in the pHi regulation of mouse cholangiocytes

University of Navarra

Iker Uriarte Díaz-Varela - Finished

Role of Anion Exchanger 2 (AE2) in Primary Biliary Cirrhosis: Study of Hepatic and Immunologic Alterations in the Ae2a,b-/- Mouse Model

University of Navarra

January T. Salas - Finished

2021

Role of mitochondrial dysfunction and autophagy in the pathogenesis of Primary Biliary Cholangitis (PBC)

Universidad de Navarra

Role of the scavenger receptor MARCO in the immuno-oncology of primary liver tumors: new diagnostic, prognostic and therapeutic strategy

Universitat de Barcelona

2020

Role of SUMOylation in the pathogenesis of cholangiocarcinoma.

University of Navarra

2019

Proteomic characterization of cholangiocarcinoma cell lines: a preliminary investigation into potential prognostic biomarkers.

Sapienza University Rome (Italy)

2017

Role of endothelins in the pathogenesis of polycystic liver diseases.

University of Navarra

Extracellular vesicles in primary sclerosing cholangitis (PSC): source of biomarkers and potential drivers of pathogenesis through the gut liver axis.

University of the Basque Country (UPV/EHU)

2016

Role of TREM-2 in the pathophysiology of biliary cholestasis.

University of Navarra

2015

Role of endoplasmic reticulum stress in the pathogenesis of polycystic liver diseases.

University of Navarra

2012

Role of miR-506 overexpression in human cholangiocytes.

University of Navarra

2011

Study of the vesicular trafficking alterations of the Ae2-deficient mouse cholangiocytes

University of Navarra

2009

Study of the epithelial-mesenchymal transition in cholangiocytes from Ae2a,b-/- mice

University of Navarra

2022

Professor in the 9th Ed. (2021/22) of the Master's Degree in Hepatology at the University of Alcalá and the Autonomous University of Madrid. Lesson "Translational Research in Cholangiocarcinoma"

2021

Professor of the Master in Chemorresistance (Univ. of Salamanca, Salamanca, Spain) since 2015.

Assistant Professor of Sciences (University of Navarra, Spain) 2009-2021. Responsible Professor of the postgraduate Course “Applications of Molecular Biology to Medicine” of the Master since 2012.

Invited talk: "International Cholangiocarcinoma Registry" at Sociedad Ecuatoriana de Gastroenterología (Quito, Ecuador)

Invited talk: "Cholangiocarcinoma: Consensus statement from ENS-CCA" at HBP Surgery Week 2021 (Seoul, Korea)

Invited talk: "Liquid biopsy: next generation biomarkers for liver cancer" at 53rd AISF Virtual Meeting (Roma, Italy)

Invited talk: "Role of protein NEDDylation in the pathogenesis of cholangiocarcinoma: Novel therapeutic opportunities" at Pittsburgh Liver Research Center Virtual Seminar ?(Pittsburgh, USA)

Invited talk: "Natural Course, Management and Outcome of Patients with Cholangiocarcinoma in European Countries: An ENS-CCA Registry Study" at 2021 Cholangiocarcinoma Foundation Annual Conference ?(Salt Lake City, USA)

Invited talk: "Abordaje multidisciplinario del colangiocarcinoma: desde el diagnóstico al tratamiento" at ALEH 2021.

Invited talk: "Investigación Básica: Cáncer Hepático" at The Liver Meeting AEEH 2021.

Invited talk: "Epidemiología. Estado actual del registro del European Network for the Study of Cholangiocarcinoma" at Incye Symposium at the Tratamiento de los Tumores Digestivos (TTD) Meeting

Round table: "From ingredients to delicious dish: How basic science can contribute to clinical trials" at UEG Week - United European Gastroenterology

Round table: "Scientific Associations and Reference Networks: an opportunity for collaboration: European Network for the Study of Cholangiocarcinoma (ENS-CCA)" at EURO-CHOLANGIO-NET COST Action Training school: MULTIDISCIPLINARY MANAGEMENT OF CHOLANGIOCARCINOMA

Invited talk: "The role of protein NEDDylation in the pathogenesis of cholangiocarcinoma: novel therapeutic opportunities" at Fundación Privada Instituto de Investigación Oncológica de Vall d´Hebron (VHIO)

Invited talk: "Primary Liver Cancers – Epidemiology and Global Trends" at Mayo Clinic Hepato-Pancreatico-Biliary Cancer Symposium 2021 (MN, USA)

Round table: "ICD-11 and its role in creating robust data for CCA" at Global Cholangiocarcinoma Alliance

Invited talk: ""Estrategias diagnósticas y pronósticas de última generación para la CEP" at Jornadas de Otoño AEEH: Enfermedades hepáticas colestásicas e inmunomediadas (Malaga, Spain)

Associate Professor of Sciences (University of Navarra, Spain) since 2021. Responsible Professor of the postgraduate Course “Applications of Molecular Biology to Medicine” of the Master since 2012.

2020

Invited to give a talk at the Liver Cancer Summit (Congress organized by EASL) Prague (Czech Republic) 9th/February/2020.

2019

Invited to give a talk at the ESCALON Meeting in the University of Cordoba, Cordoba (Argentina).

Invited to give a talk at the NAFLD summit (Congress organized by EASL) Seville (Spain), 27th/September/2019

Invited to give a talk at the Mayo Clinic (MN, USA), March/2019.

Invited to give a talk on Cholestatic disease at the cholestatic symposium of the 7th Asian Vaccine Conference (ASVAC 2019) Yangon (Myanmar), 14th/September/2019.

Invited to give a talk at AMMF Cholangiocarcinoma Conference 2019, London (United Kingdom), 9th/May/2019.

Invited to give a talk at the Cholangiocarcinoma Foundation Annual Conference, Salt Lake City (Utah, USA), 1st/February/2019.

Invited to give a talk at the Sapanish Association for the Study of the Liver (AEEH) Meeting, San Sebastian (Spain), 5th/October/2019.

Invited to give a talk at the Virginia Commonwealth University (VA, USA).

Invited to give a talk at the University of Minnesota Austin (TX, USA)

Invited to give a NAFLD diagnostic workshop at the University of Seville, Seville (Spain), 2019

2018

Invited Research Seminar, Institute of Biomedicine (IBIS) of Seville (Spain), 22/March/2018.

EASL International Liver Congress (Paris, France), 11-15th/April/2018. Invited to give 2 Lectures.

“Workshop on Cholangiopathies”. Invited to give 2 Lectures at the Antioquia University, Medellin (Colombia), 20th/April/2018.

“Workshop on Biomedical Research”. Invited to give 1 Lecture at the Areandina University, Bogotá (Colombia), 23th/April/2018.

“Workshop on Biomedical Research”. Invited to give 3 Lectures at the University Colegio Mayor Cundinamarca, Bogotá (Colombia), 24-28th/April/2018.

“Workshop on Cancer”, organized by the Spanish Association Against Cancer (AECC), San Sebastian (Spain), 27th/May/2018. Invited lecture on Cholangiocarcinoma.

Invited to give a talk on “non-invasive biomarkers for the early diagnosis of cholangiocarcinoma”, International Primary Sclerosing Cholangitis Study Group Bi-Annual Meeting, Paris (France), 18th/June/2018.

Invited Talk: Non-invasive biomarkers for liver diseases, University of Lisbon (Lisbon, Portugal), 19th/June/2018.

Invited to give 3 Lectures. European Association for the Study of Cholangiocarcinoma (ENS-CCA) Bi-Annual Meeting, Rome (Italy; Sapienza University), 21-23th/June/2018.

Falk Symposium: Invited Talk on Epigenetics and Primary Biliary Cholangitis (PBC). Dublin (Ireland), 7th/July/2018

Ian R. Mackay PBC Symposium: Invited Talk on Epigenetics and Primary Biliary Cholangitis (PBC), Lugano (Switzerland), 25th/September/2018.

Invited Talk on Cholangiocarcinoma, Spanish HCC Congress (organized by the AEEH), Malaga (Spain), 6th/October/2018.

Invited Talk on Extracellular Vesicles and Cholangiopathies (Rising Star 2018 Award), UEG Congress, Vienna (Austria), 22th/October/2018. Also, chair of a workshop on cholestatic liver diseases (23th October)

Invited to give 2 Talks on Cholangiopathies, Basque-Chilean Meeting, Santiago (Chile), 4th/December/2018.

"GI Seminar", Div. of Gastroenterology, Academinc Medical Center (AMC), University of Amsterdam (The Netherlands), 21/December/2018.

2017

Workshop on Cholangiopathies”. Invited to give 4 Lectures at the Antioquia University, Medellin (Colombia), 27-28/February/2017.

“Workshop on Biomediccal Research”. Invited to give 4 Lectures at the Areandina University, Botoga (Colombia), 1-2/March/2017.

Invited to give 4 talks at the “International Liver Congress, European Association for the Study of the Liver (EASL)”, Amsterdam (The Netherlands): 19-23/April/2017

Invited to give the welcome and introductory remarks at the “EASL Monothematic Conference in “Cholangiocytes in Health and Disease: From Basic Science to Novel Trearments” (Oslo, Norway): 9-11th/June/2017

Symposium “MicroRNAs and Liver Diseases”, Amsterdam (The Netherlands): 30/June/2017

Invited to give a Course on “Non-invasive Biomarker for Biliary Disease: United European Gastroenterology (UEG) Course” (Lisbon, Portugal), 24/September/2017.

GI Seminar, University of Lisbon (Lisbon, Portugal): 25/September/2017.

GI Seminar, Mayo Clinic (Rochester, MN, USA): 19/November/2017

Research Seminar, Hormel Institute, University of Minnesota (Ausitin, MN, USA): 18/October/2017.

Invited to give a Research Seminar "My life in Science: LIBRA HORIZON 2020 Project, EU", Biotech Research and Innovation Centre (BRIC), University of Copenhagen (Copenhagen, Denmark): 18/11/2017

Invited Talk: "XXVI International Congress Trends and Perspectives in Hepatology”, University of Padova (Padova, Italy), 30/November/2017

2016

GI Course on NFLD/NASH diseases. OWL Metabolomics. Hotel Melia Recoletos (Valladolid, Spain), 12 February 2016.FLD/NASH diseases. OWL Metabolomics. Hotel Melia Recoletos (Valladolid, Spain).

European Association for the Study of Liver (EASL): "Cholangiocyte Biology Symposium". Invited to give the State of the Art Lecture on "Frontiers in Cholangiocyte Biology: Micro-RNAs and Micro-particles". Barcelona (Spain), 17th of April 2016.

European Association for the Study of Liver (EASL): "Early Morning Workshop". Invited to give the Lecture on "Beyond UDCA in Cholestatic Diseases". Barcelona (Spain), 17th of April 2016.

GI Course on NFLD/NASH diseases. OWL Metabolomics. EASL Meeting (Barcelona, Spain, 14th of April 2016.

Scientific Course, Biotech Research and Innovation Centre, University of Copenhagen (Copenhagen, Denmark): 18/04/2016

European Network for the Study of Cholangiocarcinoma (ENSCCA): Invited to give the State of the Art Lecture on "Biomarkers of CCA in serum and bile: role of extracellular vesicles, miRNAs and beyond". San Sebastian (Spain), 5th of May 2016.

Invited to give a talk at the Course "XXIV International Bile Acid Meeting", Falk Foundation (Düsseldorf, Germany): 18/06/2016

Invited to give a talk at the Course "IV IPSCSG Workshop". Invited to give Lecture about the "European Network for the Study of Cholangiocarcinoma (ENSCCA)". Yale Univ., New Haven (CT, USA), 26th of June 2016.

Invited to give a Courses on "polycystic liver diseases" and "cholangiocarcinoma" at the Master of Hepatology (Univ. Autónoma de Madrid), 10th June 2016

GI Seminar, Virginia Commonwealth University, Richmond (VA, USA), 10th November 2017

GI Seminar, Mayo Clinic (Rochester, MN, USA):17/11/2016

Invited to give a talk at the Congress “4th Basque-Chilenean Congress on Biomedical Research, University of the Basque Country (Leioa, Spain): 1/December/2016

2015

“V Symposium on Research and Innovation”, Center of Research and Development of the University of the Andean Area, Bogota (Colombia), 9th of May 2015. Invited to give the “State of the Art Lecture” about Cancer.

Course, Innovation in Health, “Hospital de Cruces” (Bilbao, Spain), 22th of May 2015.

Research Course, Hormel Institute, University of Minnesota, Austin, MN, USA: 04/06/2015

GI Course, Mayo Clinic (Rochester, MN, USA): 25/06/2015

GI Course, University of Homburg (Homburg, Germany): 05/10/2015

2014

American Association for the Study of Liver Diseases (AASLD): "The Henry M. and Lillian Stratton Basic Research Single Topic Conference". Invited to give the State of the Art Lecture on "microRNAs and Primary Biliary Cirrhosis (PBC)". Miami (FL, USA), 9th of March 2014.

“GI Course”, Division of Hepatology, Newcastle University, Newcastle (United Kingdom): 7th of April 2014.

“IV Symposium on Research and Innovation”, Center of Research and Development of the University of the Andean Area, Bogota (Colombia), 15th of November 2014. Invited to give a “Course” about Biomedicine. (Videoconference)

Course, Center of Molecular Biology Severo Ochoa (CSIC-UAM), Madrid (Spain): 5th of December 2014.

2013

48th Annual Meeting of the European Association for the Study of the Liver (EASL)”, Amsterdam (The Netherlands), 27th of April 2013. Invited to give a course on the Young Investigator Forum.

Invited to give a “Cancer course” organized by the Spanish Association Against Cancer (Asociación Española Contra el Cancer, AECC), San Sebastián (Spain): 12th of October 2013.

Invited to give a "GI course", Division of Gastroenterology, Academinc Medical Center (AMC), University of Amsterdam (The Netherlands), 24th of April 2013.

Invited to give a "GI Course", Division of Gastroenterology and Hepatology, General Hospital of Vienna (Austria), 6th of May 2013.

"GI Course", Division of Gastroenterology, Ancona Hospital (Ancona, Italy), 1st of June 2012.

“Cancer Course” organized by the Spanish Association Against Cancer (Asociación Española Contra el Cancer, AECC), San Sebastián (Spain): 12th of October 2013.

Course at the CICBiogune, Bilbao (Spain): 19th October 2013.

“Cancer Course” organized by the Spanish Association Against Cancer (Asociación Española Contra el Cancer, AECC), Zumarraga (Spain): 16th of October 2013.

2012

Invited to give a "GI Course", Division of Gastroenterology, Ancona Hospital (Italy), 1st of June 2012.

Invited to give a Course at the Model Animal Research Center (MARC), University of Nanjing (Nanjing, China), 12th of June 2012.

III International Symposium of the "Pablo Marmolejo Oliveros” Research Award," Center of Research and Development of the Foundation of the Andean University, Bogota (Colombia), 27th and 28th of September 2012. Invited to give “The State of the Art Lecture” of the Meeting about Biomedicine.

Invited to give a “Cancer course” organized by the Spanish Association Against Cancer (Asociación Española Contra el Cancer, AECC), Zaragoza (Spain: Ibercaja Zentrum): 27th of November of 2012.

Assistant Professor of Sciences (University of Navarra, Spain) since 2009. Responsible Professor of the postgraduate Course “Applications of Molecular Biology to Medicine” of the Master since 2012.

2011

XXXVI Meeting of the Spanish Association for the Study of the Liver (AEEH): Madrid (Spain), 17th of February 2011.

"GI Course", Division of Gastroenterology, "Radboud Medical Hospital" (Nijmegen, The Netherlands): 15th of February 2011.

“4th Dutch Experimental Gastroenterology and Hepatology (DEGH) Meeting” (Veldhoven, The Netherlands): 17th of March 2011. Invited to give “The State of the Art Lecture” of the Meeting.

2010

“GI Unit”, Division of Gastroenterology, Mayo Clinic (Rochester, MN, USA): 12th of May 2010.

“GI Course”, Division of Gastroenterology, Mayo Clinic (Rochester, MN, USA): 24th of May 2010.

“PhD Course of Developmental Biology”, Mayo Clinic (Rochester, MN, USA): 17th of June 2010.

“PhD Course of Developmental Biology”, Mayo Clinic (Rochester, MN, USA): 16th of June 2010.

“GI Course”, Division of Gastroenterology, Mayo Clinic (Rochester, MN, USA): 15th of November 2010.

2009

Assistant Professor of Medicine/Sciences (University of Navarra, Spain).

PhD Course of the “Spanish Research Network of Membrane Transport Proteins (REIT)”. Salamanca (Spain), 8th June 2009.

“GI Course”, Division of Gastroenterology, Mayo Clinic (Rochester, MN, USA): 26th October 2009.

“Schulze Center for Novel Therapeutics”, Mayo Clinic (Rochester, MN, USA): 29th October 2009.

2022

HEAD (Liver Diseases Group: 30 investigators in the Group, Biodonostia Research Institute (Donostia University Hospital) since 2012

AASLD Fellow recognition

Member of the Educational Scientific Committee of the European Association for the Styudy of the Liver (EASL)

2021

Member of the Spanish Research Group in Extracellular Vesicles (GEIVEX), since 2014.

Member of “Asociación Española de Gastroenterología” (AEG), since 2015.

IKERBASQUE Associate Professor (IKERBASQUE Basque Foundation for Science),Basque Government since 2020

CIBERehd Investigator [CIBER of Hepatic and Digestive Diseases (CIBERehd)],Spanish Carlos III Health Institute (ISCIII) since 2006

Assistant Professor Faculty of Medicine,Mayo Clinic, (Minnesota, USA), since 2010

Assistant Professor Faculty of Science, University Area Andina (Bogotá, Colombia), since 2015

Assistant Professor Faculty of Science, University of Navarra (2009). Responsible Professor of a postgraduate Course (3 ECT credits/year), since 2012.

Professor Master in Cellular & Pharmacological Physiology and Pharmacology, University of Salamanca, since 2014.

Member of the American Association for the Study of Liver Diseases (AASLD), since 2010.

Member of the European Association for the Study of the Liver (EASL), since 2009.

Coordinator International Network, European Network for the Study of Cholangiocarcinoma (ENSCCA: www.enscca.org) since 2015

Associate Coordinator Area of Oncology, CIBER of Hepatic and Digestive Diseases (CIBERehd), Spanish Carlos III Health Institute (ISCIII), since 2016

Member of the Advisory Committee, OWL metabolomics (One Way Liver, S.L.), since 2015

Coordinator International Network: Cancer Task Force Group, International Primary Sclerosing Cholangitis Study Group (IPSCSG: www.ipscsg.org), since 2016

Member of the Advisory Committee, EQA Certification I+D+I, Spanish Ministry of Economy and Competitively, since 2015

Member of the Steering Committee, HEPAMET Registry Spanish Association for the Study of the Liver (AEEH), since 2017

Member of the Editorial Board HEPATOLOGY (TOP #1 in Hepatology: 1D, IF: 14.079), Amerian Association for the Study of the Liver (AASLD), since 2017

Member of “Asociación Española para el Estudio del Higado” (AEEH), since 2015.

Member of HEPAmet (Spanish group for the study of liver metabolic diseases), since 2014

Collaborative partner (Member) of the European Reference Network (ERN) on Hepatological Diseases (ERN-Rare Liver Diseases) (EU H2020; https://endo-ern.eu/es/ern/), since 2019

2020

Miguel Servet II Investigator (Biodonostia Research Institute), Spanish Carlos III Health Institute (ISCIII) since 2019

Assistant Professor of Public and Private University Accredited by the ANECA, National Agency for Assessment and Accreditation (ANECA) since 2011

Member of the Steering Committee of the African Hepatooancreaticobiliary Cancer Consortium Meeting (AHPBCC)

2016

HEAD (Liver Diseases Group: 20 investigators in the Group, Biodonostia Research Institute (Donostia University Hospital): July 2012- present

Miguel Servet Investigator, Spanish Carlos III Health Institute (ISCIII): January 2015 - present.

IKERBASQUE Investigator, Basque Foundation for Science, Basque Government: July 2012 - present

CIBERehd Investigator, CIBER of Hepatic and Digestive Diseases (CIBERehd), Spanish Carlos III Health Institute: Nov. 2006 - present.

Assistant Professor, Faculty of Medicine, Mayo Clinic, (Minnesota, USA): Sept. 2010 - present

Assistant Professor, Faculty of Science, University Area Andina (Bogotá, Colombia): Sept. 2015 - present

Assistant Professor, Faculty of Science, University of Navarra: Oct. 2009 - present

Assistant Professor of Public and Private University, Accredited by the ANECA, National Agency for Assessment and Accreditation (ANECA): June 2011 - present

International Coordinator, European Network for the Study of Cholangiocarcinoma (ENSCCA: www.enscca.org): May 2015 - present

Sub-Coordinator, Area of Oncology, CIBER of Hepatic and Digestive Diseases (CIBERehd), Spanish Carlos III Health Institute: January 2016 - present

Member of the Advisory Committee, OWL metabolomics, One Way Liver, S.L.: Oct. 2015 - present

Member of the Advisory Committee, EQA Certification I+D+I, Spanish Ministry of Economy and Competitively: May 2015 - present

Evaluator, “Agencia Nacional de Evaluación y Prospectiva A.N.E.P.”, Spanish Ministry of Economy and Competitively: August 2015 - present

Evaluator, Instituto de Salud Carlos III, Spanish Ministry of Health: September 2015 - present

European Association for the Study of the Liver (EASL), since 2009.

Member, American Association for the Study of Liver Diseases (AASLD), since 2010.

“Asociación Española para el Estudio del Higado” (AEEH), since 2015.

Member, IKERBASQUE (Basque Foundation for Scince): since 2012.

Member, Spanish Research Group in Extracellular Vesicles (GEIVEX), since 2014.

Group Leader, HEPAmet: Spanish group for the study of liver metabolic diseases, since 2015.

“Asociación Española de Gastroenterología” (AEG), since 2015.

2015

Member of the Advisory Committee, Spherium Biomed S.L, Janus Developments & Ferrer Pharma Allianz: June 2014 - June 2015

2012

Chair of the Department of Liver Diseases (Biodonostia Research Institute- Donostia Hospital)

Member of the Advisory Committee of CIBERhed (Area 3) since its creation in 2006 until Feb. 2012

2007

Member, American Society for Cell Biology (ASCB), in 2007.

2023

Full Professor/Catedrático: Department of Biochemistry and Genetics, University of Navarra.

2020

Award IKERBASQUE Research Professor, Basque Foundation for Science: 2020.

Miguel Servet II Award 2020 (the most Senior and Competitive National Program of Research on Biomedicine (ISCIII).

“SER Navarra Prize to the Investigation 2020” (https://cadenaser.com/emisora/2020/01/23/ radio_pamplona/1579797919_477926.html) that distinguish outstanding Senior Scientific Careers in Navarra (Spain).

2018

EASL Young Investigator Award 2018: from the European Association for the Study of the Liver (EASL), which distinguishes outstanding scientists in Hepatology under 40 years old. April 2018 (Paris, France)

UEG Rising Start Award 2018: from the United European Gastroenterology (UEG), which distinguishes outstanding scientists in Gastroenterology under 40 years old. September 2018 (Vienna, Austria)

2015

Miguel Servet Award, Spanish Carlos III Health Institute (2015 – 2020).

2014

Awarded with a travel bursary by the European Association for the Study of the Liver (EASL) to attend the EASL Clinical School of Hepatology Course 22: Cholestatic Liver Disease (Amsterdam, The Netherlands): May 7-9th, 2014

“CIBERehd Award” (Spanish Carlos III Health Institute) for three Registrations the ENSCCA Congress in San Sebastian (May 2016: 750 euros).

2012

AIO Young Investigator Cancer Award: from the Spanish Association Against the Cancer (Asociación Española Contra el Cáncer, AECC): September 13th, 2012. Prize received from the Princess of Spain “Ms. Letizia Ortiz”.

Award from IKERBASQUE, Basque Foundation for Science: June 2012. Prize received from the Lehendakari (Prime Minister) “Iñigo Urkullu”.

2010

“Sheila Sherlock Award” from the European Association for the Study of the Liver (EASL): May 2010.

2006

“Ramón Areces Posdoctoral Award”: October 2006/October 2008

2005

“FPI Award” from the Spanish Ministry of Science and Technology (FP-2001-0090): July 2002/June 2006.

2022

Oral presentation | Cholangiocarcinoma landscape in Europe: diagnostic, prognostic and therapeutic insights from the ENSCCA Registry

Liver Cancer Summit 2022 - Oral presentation

Izquierdo-Sanchez L ;Lamarca A ;La Casta A ;Buettner S ;Utpatel K ;Klümpen HJ ;Adeva J ;Vogel A ;Lleo A ;Fabris L ;Ponz Sarvise M ;Brustia R ;Cardinale V ;Braconi C ;Vidili G ;Jamieson NB ;Macías RIR ;Jonas JP ;Marzioni M ;Hołówko W ;Folseraas T ;Kupčinskas J ;Sparchez Z ;Krawczyk M ;Krupa Ł ;Scripcariu V ;Grazi GL ;Landa Magdalena A ;Ijzermans JNM ;Evert K ;Erdmann JI ;López López F ;Saborowski A ;Scheiter A ;Santos Laso A ;Carpino G ;Andersen JB ;Marín JJG ;Alvaro D ;Bujanda L ;Forner A ;Valle JW ;Koerkamp BG ;Banales JM

Oral presentation | Role of protein NEDDylation in the pathogenesis of cholangiocarcinoma: Novel therapeutic opportunities

Liver Cancer Summit 2022 - Oral presentation

Olaizola P., Lee.-Law P.Y., G. Fernandez-Barrena M., Álvarez L., Cadamuro M., Azkargorta M., O’Rourke C.J., Caballero-Camino F.J., R. Macias R.I., G. Marín J.J., Serrano M., Martínez-Chantar M.L., Avila M.A., Aspichueta P., Calvisi D.F., Fabris L., Elortza F., Andersen J.B., Bujanda L., Rodrigues P.M., Perugorria M.J., Banales J.M.

Oral presentation | Circulating vesicles hold etiology-related protein biomarkers of cholangiocarcinoma risk, early diagnosis and prognosis mirroring tumor cells

Liver Cancer Summit 2022 - Oral presentation

Lapitz A., Azkargorta M., Zhuravleva E., O’Rourke C.J., Arbelaiz A., La Casta A., Vesterhus M., Milkiewicz P., Milkiewicz M., Jiménez-Aguero R., Pastor T., Grimsrud M.M., Riano I., Krawczyk M., Macias R.I.R, Ibarra C., Bustamante J., Elortza F., Falcon-Pérez J.M., Perugorria M.J., Andersen J.B., Bujanda L., Karlsen T.H., Folseraas T., Rodrigues P.M., Banales J.M.

Oral presentation | Cholangiocarcinoma landscape in Europe: diagnostic, prognostic and therapeutic insights from the ENSCCA Registry

CCF Annual Conference - Oral presentation

Oral presentation | Circulating vesicles hold etiology-related protein biomarkers of cholangiocarcinoma risk, early diagnosis and prognosis mirroring tumor cells

CCF Annual Conference - Oral presentation

Oral presentation | Cholangiocarcinoma landscape in Europe: diagnostic, prognostic and therapeutic insights from the ENSCCA Registry

The International Liver Congress EASL - Oral presentation

Oral presentation | Role of protein NEDDylation in the pathogenesis of cholangiocarcinoma: Novel therapeutic opportunities

The International Liver Congress EASL - Oral presentation

Oral presentation | Circulating vesicles hold etiology-related protein biomarkers of cholangiocarcinoma risk, early diagnosis and prognosis mirroring tumor cells

The International Liver Congress EASL - Oral presentation

Oral presentation | Role of protein NEDDylation in the pathogenesis of cholangiocarcinoma: Novel therapeutic opportunities

47º Congreso AEEH - Oral presentation

Poster presentation | Role of protein NEDDylation in the pathogenesis of cholangiocarcinoma: Novel therapeutic opportunities

CCF Annual Conference - Poster presentation

Poster presentation | Circulating vesicles hold etiology-related protein biomarkers of cholangiocarcinoma risk, early diagnosis and prognosis mirroring tumor cells

47º Congreso AEEH - Poster presentation

Poster presentation | Cholangiocarcinoma landscape in Europe: diagnostic, prognostic and therapeutic insights from the ENSCCA Registry

47º Congreso AEEH - Poster presentation

2021

Oral presentation | LAS VESÍCULAS CIRCULANTES CONTIENEN BIOMARCADORES PROTEICOS PARA EL DIAGNÓSTICO Y/O PRONÓSTICO DE LOS COLANGIOCARCINOMAS QUE REFLEJAN LA EXPRESIÓN DE LAS CÉLULAS MALIGNAS EN EL TUMOR

XLIII REUNIÓN VASCO-NAVARRA DE PATOLOGÍA DIGESTIVA - Oral presentation

Oral presentation | COLANGIOCARCINOMA EN EUROPA: CONOCIMIENTOS DIAGNÓSTICOS, PRONÓSTICOS Y TERAPÉUTICOS DEL REGISTRO EURO-CCA

XLIII REUNIÓN VASCO-NAVARRA DE PATOLOGÍA DIGESTIVA - Oral presentation

Izquierdo Sánchez L.1, Lamarca A.2, La Casta A.3, Buettner S.4, Utpatel K.5, Klümpen H.J.6, Adeva J.7, Vogel A.8, Lleo A.9, Fabris L.10, Ponz Sarvise M.11, Brustia R.12, Cardinale V.13, Braconi C.14, Vidili G.15, Jamieson N.B.14, Macías R.I.R.16, Jonas J.P.17, Marzioni M.18, Hołówko W.19, Folseraas T.20, Kupčinskas J.21, Sparchez Z.22, Krawczyk M.23, Krupa Ł.24, Scripcariu V.25, Grazi G.L.26, Landa Magdalena A.3, Ijzermans J.N.M.4, Evert K.5, Erdmann J.I.27, López López F.7, Saborowski A.8, Scheiter A.5, Santos Laso A.3, Carpino G.28, Andersen J.B.29, Marín J.J.G.16, Álvaro D.30, Bujanda L.3, Forner A.31, Valle J.W.32, Koerkamp B.G.4, Banales J.M.3

Oral presentation | PAPEL DE LA NEDDILACIÓN DE PROTEÍNAS EN LA PATOGENIA DEL COLANGIOCARCINOMA: POTENCIAL NUEVA DIANA TERAPÉUTICA

XLIII REUNIÓN VASCO-NAVARRA DE PATOLOGÍA DIGESTIVA - Oral presentation

Poster presentation | Cholangiocarcinoma landscape in Europe: diagnostic, prognostic and therapeutic insights from the ENSCCA Registry

3rd Annual Cholangiocarcinoma Summit - Poster presentation

Poster presentation | Role of protein NEDDylation in the pathogenesis of cholangiocarcinoma: Novel therapeutic opportunities

3rd Annual Cholangiocarcinoma Summit - Poster presentation

Poster presentation | Circulating vesicles hold etiology-related protein biomarkers of cholangiocarcinoma risk, early diagnosis and prognosis mirroring tumor cells

3rd Annual Cholangiocarcinoma Summit - Poster presentation

2020

Oral presentation | Perfiles específicos de RNA en vesículas extracelulares de suero y orina de pacientes con colangiocarcinoma que imitan el tejido tumoral y la expresión celular: nuevo enfoque de biopsia líquida.

23º Reunión Anual de la Asociación Española de Gastroenterología (AEG) - Oral presentation

Lapitz A, Rodrigues PM, Arbelaiz A, Lavin JL, O'Rourke CJ, Krawczyk M, Santos-Laso A, Perugorria MJ, La Casta A, Jiménez-Agüero R, Ibarra C, Sánchez-Campos A, Jimeno JP, Riaño I, Gonzalez E, Erice M, Lammert F, Marzioni M, Macias RIR, Marin JJ, Karlsen TH, Bujanda L, Falcón-Pérez J, Andersen J, Aransay AM, Banales JM.

Oral presentation | TREM2 protects the liver against hepatocellular carcinoma through multifactorial protective mechanisms.

EASL ILC 2020 – Digital International Liver Congress 2020 - Oral presentation

Labiano I, Esparza-Baquer A, Sharif O, Agirre-Lizaso A, Oakley F, Rodrigues PM, Hijona E, Jimenez-Agüero R, Landa A, La Casta A, Zaki MYW, O'Rourke CJ, Munoz-Garrido P, Azkargorta M, Elortza F, Schabbauer G, Andersen JB, Knapp S, Mann DA, Bujanda L, Banales JM, Perugorria MJ.

Oral presentation | The anti-inflammatory receptor TREM2 protects the liver from cholestatic injury.

EASL ILC 2020 – Digital International Liver Congress 2020 - Oral presentation

Labiano I, Esparza-Baquer A, Agirre A, Sharif O, Hijona E, Jiménez-Agüero R, Milkiewicz P, Milkiewicz M, Rodriguez-Romero F, Aspichueta P, Monte MJ, Marin JJG, Vucur M, Luedde T, Marzioni M, Mann DA, Bujanda L, Banales JM, Perugorria MJ.

Oral presentation | TREM2 protects the liver against hepatocellular carcinoma through multifactorial protective mechanisms.

Liver Cancer Summit 2020, EASL - Oral presentation

Poster presentation | Serum and urine extracellular vesicles contain specific RNAs with diagnostic capacity for cholangiocarcinoma, being possibly involved in disease pathogenesis.

EASL ILC 2020 – Digital International Liver Congress 2020 - Poster presentation

Lapitz A, Rodrigues PM, Arbelaiz A, Lavin JL, O'Rourke CJ, Krawczyk M, Santos-Laso A, Perugorria MJ, La Casta A, Jiménez-Agüero R, Ibarra C, Sánchez-Campos A, Jimeno JP, Riaño I, Gonzalez E, Lammert F, Marzioni M, Macias RIR, Marin JJ, Karlsen TH, Bujanda L, Falcón-Pérez J, Andersen J, Aransay AM, Banales JM.

Poster presentation | Novel protein biomarkers in serum extracellular vesicles for the diagnosis of cholangiocarcinoma (CCA) in patients with primary sclerosing cholangitis (PSC).

EASL ILC 2020 – Digital International Liver Congress 2020 - Poster presentation

Lapitz A, Azkargorta M, O'Rourke CJ, Arbelaiz A, La Casta A, Vesterhus M, Milkiewicz P, Jiménez-Agüero R, Riaño I, Landa A, Ibarra C, Bustamante J, Perugorria MJ, Bujanda L, Rodrigues PM, Andersen J, Elortza F, Folseeras T, Karlsen TH, Banales JM.

Poster presentation | Proteostasis improvement in cystic cholangiocytes alleviates endoplasmic reticulum stress and halts polycystic liver disease.

EASL ILC 2020 – Digital International Liver Congress 2020 - Poster presentation

Santos-Laso A, Izquierdo-Sánchez L, Rodrigues PM, Huang BQ, Azkargorta M, Lapitz A, Muñoz-Garrido P, Arbelaiz A, Caballero FJ, Fernández-Barrena MG, Jiménez-Agüero R, Argemí J, Aragón T, Elortza F, Marzioni M, Drenth JP, LaRusso NF, Bujanda L, Perugorria MJ, Banales JM.

Poster presentation | miR-21 is increased in patients with NASH-associated HCC and contributes to hepatocarcinogenesis in mice with NAFLD.

EASL ILC 2020 – Digital International Liver Congress 2020 - Poster presentation

Rodrigues PM, Afonso MB, Simão AL, Islam T, Gaspar MM, O’Rourke CJ, Andersen JB, Santos-Laso A, Jimenez-Agüero R, Eizaguirre E, Bujanda L, Pareja MJ, Prip-Buus C, Banales JM, Rodrigues CMP, Castro RE.

Poster presentation | Hepatic RIP3 signalling differentially modulates lipid metabolism and inflammation/carcinogenesis in non-alcoholic steatohepatitis.

EASL ILC 2020 – Digital International Liver Congress 2020 - Poster presentation

Afonso MB, Simão AL, Rodrigues PM, Mateus-Pinheiro M, Gaspar MM, Majdi A, Ratziu V, Bañales JM, Gautheron J, Castro RE, Rodrigues CMP.

Poster presentation | Deciphering the rewiring of lipid metabolism in cholangiocarcinoma: novel therapeutic opportunities.

Cholangiocarcinoma Foundation Annual Meeting - Poster presentation

Ruiz de Gauna M, Rodrigues PM, Gonzalez-Romero F, Labiano I, Aurrekoetxea I, Biancaniello F, Nieva-Zuluaga A, Lapitz A, Apodaka-Biguri M, Perugorria MJ, Saenz de Urturi D, Gomez-Santos B, Buqué X, Delgado I, Bujanda L, Calvisi DF, Banales JM, Aspichueta P.

Poster presentation | Novel protein biomarkers in serum extracellular vesicles for the diagnosis of cholangiocarcinoma (CCA) in patients with primary sclerosing cholangitis (PSC).

Cholangiocarcinoma Foundation Annual Meeting - Poster presentation

Lapitz A, Azkargorta M, O’Rourke CJ, Arbelaiz A, La Casta A, Vesterhus M, Milkiewicz P, Jimenez-Agüero R, Riaño I, Landa A, Ibarra C, Bustamante J, Perugorria MJ, Bujanda L, Falcon-Perez JM, Rodrigues PM, Andersen JB, Elortza F, Folseraas T, Karlsen TH, Banales JM.

Poster presentation | Obese patients carrying NAFLD-associated genetic variants present specific serum and liver lipidomic profiles: identification of a lipidomic signature in serum to estimate the liver fat content.

XLV Congreso Anual de la Asociación Española para el Estudio del Hígado (AEEH) - Poster presentation

Santos-Laso A*, Velaz A*, Alonso C*, Eizaguirre E, Martínez-Arranz I, Jímenez-Agüero R, Pareja MJ, Izquierdo-Sanchez L, Riaño I, Andersen JB, Arretxe E, Mincholé I, Ortiz P, Perugorria MJ, Landa A, Krawczyk M, Lammert F, Castro RE, Aspichueta P, Romero-Gomez M, Bujanda L, Rodrigues PM$, Banales JM$.

Poster presentation | El receptor anti-inflamatorio TREM2 protege al hígado frente al daño inducido por colestasis.

XLV Congreso Anual de la Asociación Española para el Estudio del Hígado (AEEH) - Poster presentation

Labiano I, Esparza-Baquer A, Agirre-Lizaso A, Oakley F, Rodrigues PM, Sharif O, Hijona E, Jimenez-Agüero R, Milkiewicz P, Milkiewica M, Rodriguez-Romero F, Aspichueta P, Monte MJ, Marin JJG, Vucur M, Luedde T, Marzioni M, Mann DA, Bujanda L, Banales JM, Perugorria MJ.

Poster presentation | Nuevos biomarcadores proteicos en vesículas extracelulares de suero para el diagnóstico del colangiocarcinoma (CCA) en pacientes con colangitis esclerosante primaria (PSC)

XLV Congreso Anual de la Asociación Española para el Estudio del Hígado (AEEH) - Poster presentation

Poster presentation | Hepatic RIP3 signalling differentially modulates lipid metabolism and inflammation/carcinogenesis in non-alcoholic steatohepatitis.

Liver Cancer Summit 2020, EASL - Poster presentation

Afonso MB, Simão AL, Rodrigues PM, Mateus-Pinheiro M, Gaspar MM, Majdi A, Ratziu V, Banales JM, Gautheron J, Castro RE, Rodrigues CMP.

Poster presentation | miR-21 is increased in patients with NASH-associated HCC and contributes to hepatocarcinogenesis in mice with NAFLD

Liver Cancer Summit 2020, EASL - Poster presentation

Poster presentation | miR-34a is activated in NAFLD and NASH-associated HCC, and correlates with key disease hallmarks.

Liver Cancer Summit 2020, EASL - Poster presentation

Simão AL, Rodrigues PM, Afonso MB, O’Rourke CJ, Andersen JB, Santos-Laso A, Jimenez-Agüero R, Eizaguirre E, Bujanda L, Pareja MJ, Macias RIR, Banales JM, Rodrigues CMP, Castro RE.

Poster presentation | Novel protein biomarkers in serum extracellular vesicles for the diagnosis of cholangiocarcinoma (CCA) in patients with primary sclerosing cholangitis (PSC).

Liver Cancer Summit 2020, EASL - Poster presentation

Poster presentation | Serum and urine extracellular vesicles contain specific RNAs with diagnostic capacity for cholangiocarcinoma, being possibly involved in disease pathogenesis

Liver Cancer Summit 2020, EASL - Poster presentation

Lapitz A, Rodrigues PM, Arbelaiz A, Lavin JL, O’Rourke CJ, Krawczyk M, Santos-Laso A, Perugorria MJ, La Casta A, Jimenez-Agüero R, Ibarra C, Sanchez-Campos A, Jimeno JP, Riaño I, Gonzalez E, Lammert F, Marzioni M, Macias RIR, Marin JJG, Karlsen TH, Bujanda L, Falcon-Perez JM, Andersen JB, Aransay AM, Banales JM.

Poster presentation | Nuevos biomarcadores proteicos en vesículas extracelulares de suero para el diagnóstico del colangiocarcinoma (CCA) en pacientes con colangitis esclerosante primaria (PSC)

23º Reunión Anual de la Asociación Española de Gastroenterología (AEG) - Poster presentation

Poster presentation | Serum and urine extracellular vesicles contain specific RNAs with diagnostic capacity for cholangiocarcinoma, being possibly involved in disease pathogenesis

Cholangiocarcinoma Foundation Annual Meeting - Poster presentation

2017

Conference Paper | New Advances in Polycystic Liver Diseases

Seminars in Liver Disease - Conference Paper

Santos-Laso, A.; Izquierdo-Sánchez, L.; Lee-Law, P.Y.; Perugorria, M.J.; Marzioni, M.; Marin, J.J.G.; Bujanda, L.; Banales, J.M.

Oral presentation | Validation to the FIB 4 and NFs indexes to discriminate between hepatic fibrosis in patients with NAFLD in the general clinical practice. Results from the HEPAMET Registry.

Spanish Association for the Study for the Liver (AEEH) - Oral presentation

Gallego-Duran R, Aller R, Pastor-Ramírez H, Banales J, Arias-Loste MT, García-Monzón C, Vilar-Gomez E, Escudero A, Aguilar-Urbano V, Salmerón J, Olcoz JL, Gómez-Camarero J, Calleja JL, Albillos A, Iacono OL, Frances R, Diago M, Fernández-Rodríguez CM, Gar

Oral presentation | Bases genéticas y epigenéticas de la relación entre la pérdida de expresión de OCT1 y la falta de respuesta al tratamiento con sorafenib en carcinoma hepatocelular y colangiocarcinoma

Spanish Association for the Study for the Liver (AEEH) - Oral presentation

Lozano E, Al-Abdulla R, Macias RIR, Perez MJ, Serrano MJ, Monte MJ, Herraez E, Briz O, Banales JM, Bujanda L, Geier A, Marin JJG.

Oral presentation | Extra-intestinal manifestations of inflammatory bowel disease: new concepts on primary sclerosing cholangitis

Spanish Association of Gastroenterology (AEG) - Oral presentation

Karlsen TH (State of the Art Lecture of the Congress; Chair: Banales JM).

Oral presentation | Development of novel epigenetic inhibitors for the treatment of hepatocellular carcinoma.

European Association for the Study of the Liver (EASL) - Oral presentation

Barcena-Varela M, Oyarzabal J, Banales JM, Prieto J, Avarez-Asiain L, Prosper F, Berasain C, Avila MA, Fernandez-Barrena MG.

Oral presentation | European registry data collection on cholangiocarcinoma

European Association for the Study of the Liver (EASL) - Oral presentation

Banales JM

Oral presentation | Early morning workshop on “Extracellular vesicles in liver pathophysiology

European Association for the Study of the Liver (EASL) - Oral presentation

Banales JM

Oral presentation | Oral ePoster season on “Autoimmune and cholestatic liver disease (experimental)”.

European Association for the Study of the Liver (EASL) - Oral presentation

Banales JM

Oral presentation | New initiatives from the European Network for the Study of Cholangiocarcinoma (ENSCCA): International Primary Sclerosing Cholangitis Study Group (IPSCSG) workshop.

European Association for the Study of the Liver (EASL) - Oral presentation

Banales JM

Oral presentation | Best posters summary on “Basic and Translational Science”.

European Association for the Study of the Liver (EASL) - Oral presentation

Banales JM

Oral presentation | The role of ageing in the pathophysiology of the biliary epithelium: identification of a molecular profile

European Association for the Study of the Liver (EASL) Monothematic Congress “Cholangiocyte in health and disease: from basic science to novel treatments” - Oral presentation

Maroni L, Pinto C, Giordano DM, Saccomanno S, Rychlicki C, Trozzi L, Albertini MC, Orlando F, Melum E, Banales J, Benedetti A, Svegliati-Baroni G, Marzioni M.

Oral presentation | Young investigators- selected abstracts (5 oral communications)

European Association for the Study of the Liver (EASL) Monothematic Congress “Cholangiocyte in health and disease: from basic science to novel treatments” - Oral presentation

Banales JM and Oude Elferink R (Chairs).

Oral presentation | Non coding-RNAs and extracellular vesicles.

European Association for the Study of the Liver (EASL) Monothematic Congress “Cholangiocyte in health and disease: from basic science to novel treatments” - Oral presentation

Banales JM.

Oral presentation | Welcome and introductory remarks of the “Cholangiocyte in health and disease: from basic science to novel treatments”: EASL Monothematic Congress

European Association for the Study of the Liver (EASL) Monothematic Congress “Cholangiocyte in health and disease: from basic science to novel treatments” - Oral presentation

Banales JM, Jansen P, LaRusso NF, Marzioni M.

Poster presentation | Advanced fibrosis is independently associated with impaired kidney function in biopsy-proven NAFLD. Results from the HEPAMET Registry.

Spanish Association for the Study for the Liver (AEEH) - Poster presentation

Vilar-Gomez E, Gallego-Duran R, Aller R, Pastor-Ramírez H, Banales J, Arias-Loste MT, García-Monzón C, García-Torres ML, Aguilar-Urbano V, Salmerón J, Olcoz-Goñi JL, Gómez-Camarero J, Calleja JL, Abad J, Albillos A, Iacono OL, Frances R, Diago M, Fernánde

Poster presentation | Diagnóstico y monitorización de hígado graso mediante métodos no invasivos: correlación entre una nueva huella lipidómica en suero y la cantidad de grasa hepática medida por resonancia magnética y por métodos bioquímicos

Spanish Association for the Study for the Liver (AEEH) - Poster presentation

Jimenez-Agüero R, Arretxe E, Martinez-Arranz I, Bujanda L, Arribas J, Lanza B, Pareja-Megia MJ, Romero-Gomez M, Alonso C, Perugorria MJ, Eizaguirre E, Krawczyk M, Lammert F, Castro A, Banales JM.

Poster presentation | El receptor anti-inflamarotio TREM-2 protege frente al desarrollo de carcinoma hepatocelular

Spanish Association for the Study for the Liver (AEEH) - Poster presentation

Esparza-Baquer A, Labiano I, Erice O, Lapitz A, Olaizola P, Lee-Law P, Jimenez-Agüero R, Knapp S, Oakley F, Mann DA, Shariff O, Bujanda L, Banales JM, Perugorria MJ.

Poster presentation | A pragmatic algorithm to rule out non-alcoholic steatohepatitis in patients at risk of non-alcohotic fatty liver disease in spite of a normal ultrasound.

European Association for the Study of the Liver (EASL) - Poster presentation

Ampuero J, Aller R, Gallego-Duran R, Banales J, Loste MTA, Teresa M, García-Monzón C, Vilar-Gomez E, Escudero A, Gómez-Camarero J, Ramirez HP, Caballeria J, Aguilar-Urbano V, Salmerón J, Calleja JL, Goñi JLO, Albillos A, Diago M, Iacono OL, Frances R, Fer

Poster presentation | Metabolic and biochemical phenotype can distinguish different patterns of histological severity in biosy-proven NAFLD.

European Association for the Study of the Liver (EASL) - Poster presentation

Gomez EV, Aller R, Gallego-Duran R, Banales J, Loste MTA, García-Monzón C, Ramirez HP, Garcia-Torres ML, Gómez-Camarero J, Caballeria J, Aguilar-Urbano V, Salmerón J, Calleja JL, Abad J, Olcoz-Goñi JL, Albillos A, Diago M, Iacono OL, Frances R, Fernández-

Poster presentation | Genetic and epigenetic bases of the relationship between reduced OCT1 expression and poor response to sorafenib in hepatocellular carcinoma and cholangiocarcinoma

European Association for the Study of the Liver (EASL) - Poster presentation

Al-dulla R, Lozano E, Matias RI, O´Rourke CJ, Perez MJ, Serrano MJ, Romero MR, Monte MJ, Herraez H, Briz O, Banales JM, Bujanda L, Geier A, Andersen JB, Marin JJ.

Poster presentation | El receptor anti-inflamarotio TREM-2 protege frente al desarrollo de carcinoma hepatocelular

European Association for the Study of the Liver (EASL) - Poster presentation

Esparza-Baquer A, Labiano I, Erice O, Lapitz A, Olaizola P, Lee-Law P, Jimenez-Agüero R, Knapp S, Oakley F, Mann DA, Shariff O, Bujanda L, Banales JM, Perugorria MJ.

Poster presentation | Hepatoprotective effect of S-Adenosyl L-Methionine (SAMe) in oxidative stress: in vitro study on hepatocytes and cholangiocytes

European Association for the Study of the Liver (EASL) Monothematic Congress “Cholangiocyte in health and disease: from basic science to novel treatments” - Poster presentation

Kilanczyk E, Milkiewicz P, Banales JM, Milkiewicz M

Poster presentation | The anti-inflammatory receptor TREM-2 protects the liver from cholestatic injury in mice

European Association for the Study of the Liver (EASL) Monothematic Congress “Cholangiocyte in health and disease: from basic science to novel treatments” - Poster presentation

Esparza-Baquer A, Labiano I, Santos-Laso A, Erice O, Arbelaiz A, Sharif O, Hijona E, Jiménez-Agüero R, Marzioni M, Mann DA, Bujanda L, Banales JM, Perugorria MJ

Poster presentation | MiRNA-506 promotes primary biliary cholangitis (PBC)- like features in cholangiocytes and immune activation

European Association for the Study of the Liver (EASL) Monothematic Congress “Cholangiocyte in health and disease: from basic science to novel treatments” - Poster presentation

Erice O, Munoz-Garrido P, Vaquero J, Perugorria MJ, Fernandez-Barrena MG, Saez E, Santos-Laso A, Arbelaiz A, Jimenez-Agüero R, Fernandez-Irigoyen J, Santamaria E, Torrano V, Carracedo A, Ananthanarayanan M, Marzioni M, Prieto J, Beuers U, Oude-Elferink R,

Poster presentation | SOX17 selectively sensitizes cholangiocarcinoma cells to anticancer drugs by interfering with promoter activation of the export pumps ABCC3 and ABCG2

European Association for the Study of the Liver (EASL) Monothematic Congress “Cholangiocyte in health and disease: from basic science to novel treatments” - Poster presentation

Lozano E, Briz O, Asensio M, Perez-Silva L, Monte MJ, Perez MJ, Herraez E, Romero MR, Serrano MA, Macias RIR, Bujanda L, Banales JM, Marin JJG.

Poster presentation | microRNA-21 is overexpressed in primary biliary cholangitis and contributes to liver injury and necroptosis in cholestatic bile duct-ligated mice

European Association for the Study of the Liver (EASL) Monothematic Congress “Cholangiocyte in health and disease: from basic science to novel treatments” - Poster presentation

Afonso MB, Rodrigues PM, Simão AL, Gaspar MM, Bañales JM, Castro RE, Rodrigues CMP.

Poster presentation | Circulating cancer-associated large extracellular vesicles in cholangiocarcinoma

European Association for the Study of the Liver (EASL) Monothematic Congress “Cholangiocyte in health and disease: from basic science to novel treatments” - Poster presentation

Urban SK, Julich-Haertel H, Krawczyk M, Willms A, Jankowski K, Patkowski W, Schwab R, Richardsen I, Schaaf S, Gehlert S, Banales JM, Milkiewicz P, Lammert F, Krawczyk M, Lukacs-Kornek V, Kornek M.

Poster presentation | MiRNA-506 promotes primary biliary cholangitis-like features in cholangiocytes and immune activation

United Euroepan Gastroenterology (UEG) - Poster presentation

Erice O, Munoz-Garrido P, Vaquero J, Perugorria M.J, Fernandez-Barrena M.G, Saez E, Santos-Laso A, Arbelaiz A, Jimenez-Agüero R, Fernandez-Irigoyen J, Santamaria E, Torrano V, Carracedo A, Ananthanarayanan M, Marzioni M, Prieto J, Beuers U, Elferink R.O,

2016

Invited talk | Frontiers in Cholangiocyte Biology: Micro-RNAs and Micro-particles.

European Association for the Study of the Liver (EASL) - Invited talk

Banales JM.

Invited talk | Beyond UDCA in Cholestatic Diseases

European Association for the Study of the Liver (EASL) - Invited talk

Banales JM and Beuers U.

Invited talk | Biomarkers of CCA in serum and bile: role of extracellular vesicles, miRNAs and beyond

European Network of the Study of Cholangiocarcinoma (ENSCCA) - Invited talk

Banales JM

Oral presentation | Validation of Non-invasive Methods for the Determination of Advance Fibrosis in Patients with NAFLD in Spain

51th Meeting of the Spanish Association for the Study of the Liver (AEEH) - Oral presentation

Gallego R, Aller R, Pastor H, Garcia-Monzon C, Bañales J, Arias MT, Vilar E, Aguilar V, Garcia M, Calleja JL, Olcoz JL, Salmeron J, Prieto M, Garcia-Samaniego J, Diago M, Ampuero J, Fernandez M, Gomez J, Andrade R, Estevez P, Fernandez C, Grande L, Moreno

Oral presentation | Multicenter Study about the Prevalence and Associated Factors of Fatigue in Patients with Inflammatory Bowel Disease.

Meeting of the Spanish Association of Gastroenterology (AEG) - Oral presentation

Chaparro M, Molina B, Merino O, Nuevo-Siguairo OK, Dueñas-Sadornil C, Garcia-Albert AM, Hervias D, Calvet X, Bujanda L, Rodriguez GE, Montoro MA, Castro-Laria L, Lopez-Diaz J, Van Domselaar M, Huguet JM, Ramirez de la Piscina P, Barrio J, Algaba A, Avila

Oral presentation | Multicenter Study about the Prevalence and Associated Factors of Fatigue in Patients with Inflammatory Bowel Disease.

Meeting of the Spanish Association of Gastroenterology (AEG) - Oral presentation

Chavarria-Herbozo CM, Casanova MJ, Barreiro-de Acosta M, Chaparro M, Ezquiaga E, Bujanda L, Rivero M, Argüelles-Arias F, Martin-Arranz MD, Martinez-Montiel P, Valss M, Ferreiro R, Llao J, Moraleja I, Casellas-Jorda J, Antolin-Melero B, Cortes X, Plaza R,

Oral presentation | TREM-2 Protects the Liver from Immune-mediated Hepatocellular Damage.

European Association for the Study of the Liver (EASL) - Oral presentation

Perugorria MJ, Sharif O, Oakley F, Esparza-Baquer A, Korosec A, Mann J, Labiano I, Tiniakos D, Gawish R, Jimenez-Agüero R, Bujanda L, Banales JM, Knapp S, Mann DA.

Oral presentation | Biomarkers of CCA in serum and bile: role of extracellular vesicles, miRNAs and beyond.

European Network of the Study of Cholangiocarcinoma (ENSCCA) - Oral presentation

Banales JM.

Oral presentation | Metabolomics in a liquid biopsy provides a noninvasive comprehensive NAFLD-diagnostic tool

American Association for the Study of Liver Diseases (AASLD) - Oral presentation

Alonso C, Puri P, Martinez-Arranz I, Banales JM, Idowu MO, Castro A, Collaborative Group NASH metabolomics, Noureddin M, Bedossa P, Mato JM, Sanyal AJ.

Poster presentation | Overexpression of MiRNA-506 in Human Cholangiocytes Causes Primary Biliary Cholangitis (PBC)-like Features Including Mitochondrial Dysfunction and Increased Sensitivity to Apoptosis.

51th Meeting of the Spanish Association for the Study of the Liver (AEEH) - Poster presentation

Erice O, Munoz-Garrido P, Vaquero J, Peruogorria MJ, Fernandez-Barrena MG, Sáez E, Arbelaiz A, Santos-Laso A, Jiménez-Agüero R, Fernandez-Irigoyen J, Santamaria E, Torrano V, Carracedo A, Marzioni M, Prieto J, Beuers U, Elferink RO, LaRusso NF, Bujanda L,

Poster presentation | TREM-2 Protects the Liver from Immune-mediated Hepatocellular Damage.

51th Meeting of the Spanish Association for the Study of the Liver (AEEH) - Poster presentation

Perugorria MJ, Sharif O, Oakley F, Esparza-Baquer A, Korosec A, Mann J, Labiano I, Tiniakos D, Gawish R, Jimenez-Agüero R, Bujanda L, Banales JM, Knapp S, Mann DA.

Meeting of the Spanish Association of Gastroenterology (AEG) - Poster presentation

Poster presentation | Correlation of the Serum Levels of Anti-TNF and the Short Term Response in Patients with Crohn Disease (CD): Results from the Predicrohn Study.

Meeting of the Spanish Association of Gastroenterology (AEG) - Poster presentation

Chaparro M, Guerra I, Iborra M, Cabriada JL, Bujanda L, Taxonera C, Garcia-Sanchez C, Martin-Jimenez I, Barreiro-de Acosta M, Vera I, Martin-Arranz MD, Hernandez-Breijo B, Mesonero F, Sempere L, Gomollon F, Hinojosa J, Algaba A, Beltran B, Rodriguez-Pesca

Poster presentation | Ursodeoxycholic Acid in Advance Polycystic Liver Disease: a Multicenter Randomized Controlled Phase II Trial (CURSOR)

European Association for the Study of the Liver (EASL) - Poster presentation

D´Agnolo HMA, Kievit W, Takkenberg B, Riaño I, Bujanda L, Neijenhuis MK, Brunenberg EJL, Beuers U, Banales JM, Drenth JPH.

European Association for the Study of the Liver (EASL) - Poster presentation

Poster presentation | The Common Prosteatotic PNPLA3 (Adiponutrin) P.I148M Variant Might Protect Against Gallstone Disease.

European Association for the Study of the Liver (EASL) - Poster presentation

Krawczyk M, Jimenez-Agüero R, Perugorria MJ, Gallego L, Bujanda L, Lammert F, Banales JM.

Poster presentation | Advanced fibrosis is independently associated with impaired kidney function in biopsy-proven NAFLD. Results of a multicenter cross-sectional study.

American Association for the Study of Liver Diseases (AASLD) - Poster presentation

Vilar-Gomez E, Aller R, Gallego-Duran R, Pastor-Ramírez H, Banales J, Arias-Loste MT, García-Monzón C, García-Torres ML, Aguilar-Urbano V, Salmerón J, Olcoz-Goñi JL, Gómez-Camarero J, Calleja JL, Abad J, Albillos A, Iacono OL, Frances R, Diago M, Fernánde

2015

Poster presentation | PNPLA3 variant p.I148M improves response to bariatric surgery in obese patients with fatty liver disease.

European Association for the Study of the Liver (EASL): EASL Monothematic Conference on “Microbiota, Metabolism and NAFLD”. - Poster presentation

Marcin Krawczyk, Raúl Jiménez-Agüero, José M. Aluztiza, José I. Emparanza, Luis Bujanda, Frank Lammert, Jesus M. Banales.

Poster presentation | Microbiotal Product Activation on NLRP3 Induces IL-18 Synthesis and Impairs the Epithelial Barrier Function in Reactive Cholangiocytes.

European Association for the Study of the Liver (EASL) - Poster presentation

Marzioni M, Agostinelli L, Maroni L, Saccomanno S, Mingarello E, Rychlicki C, De Minicis S, Banales JM, Benedetti A, Svegliati-Baroni G.

Poster presentation | Mir-506 Is Upregulated by Pro-inflammatory Cytokines in Human Cholangiocytes and Inhibits Cell Proliferation and Adhesion.

European Association for the Study of the Liver (EASL) - Poster presentation

Erice O, Munoz-Garrido P, Vaquero J, Perugorria MJ, Fernandez-Barrena M, Saez E, Merino M, Arbelaiz A, Santos-Laso A, Jimenez-Agüero R, Marzioni M, LaRusso NF, Marin JJG, Bujanda L, and Banales JM.

Poster presentation | Targeting of MiR-518 Reduces Chemorresistance in Hepatocellular Carcinoma Cell Lines.

European Association for the Study of the Liver (EASL) - Poster presentation

Fernandez-Ramos D, Fernandez-Tussy P, Perugorria MJ, Banales JM, Briz O, Herraez E, Marin JJG, Mato JJ, Martinez-Chantar ML.

Poster presentation | Efficacy of Ursodeoxycholic Acid as a Volume Reducing Treatment for Symptomatic Polycystic Liver Disease: an International, Multicenter, Randomized Controlled Trial.

European Association for the Study of the Liver (EASL) - Poster presentation

D´Agnolo HD, Gevers TJ, Riaño I, Bujanda L, Takkenberg B, Beuers U, Banales JM and Drenth JP.

Poster presentation | PNPLA3 Variant P.I.148M Improves Response to Bariatric Surgery in Obese Patients with Fatty Liver Disease.

: European Association for the Study of the Liver (EASL) - Poster presentation

Krawczyk M, Jimenez-Agüero R, Alustiza JM, Emparanza JI, Lammert F, Banales JM.

Poster presentation | Identification of the Apical Sodium Bile Salt Transporter (ASBT) as a Novel Molecular Target to Enhance the Sensitivity of Cholangiocarcinoma to Chemotherapy.

European Association for the Study of the Liver (EASL) - Poster presentation

Lozano E, Macias RI, Monte MJ, Briz O, Jimenez F, Jimenez S, Cataño B, Al-Abdulla R, Al-Aqil F, Hernandez A, Banales JM, Serrano MA and Marin JJ.

2014

Invited talk | MicroRNAs in Primary Biliary Cirrhosis

American Association for the Study of Liver Diseases (AASLD). The Henry M. and Lillian Stratton Basic Research Single Topic Conference “Non-coding RNAs in Liver Function and Dysfunction” - Invited talk

Banales JM..

Oral presentation | Role of SLC22A1 gene mutations encoding the OCT1 human organic cation transporter in the lack of response of liver cancer to sorafenib.

XXXVI Meeting of the Spanish Society of Biochemistry and Molecular Biology - Oral presentation

Lozano E, Herráez E, Macías RIR, Vaquero J, Bujanda L, Bañales JM, Marín JJG, Briz O.

Poster presentation | Magnetic Resonance Imaging Allows Quantitation of Hepatic Triclyceride Concentration in Humans.

European Association for the Study of the Liver (EASL) - Poster presentation

Jiménez-Agüero R, Emparanza JI, Beguiristain A, Bujanda L, Alustiza JM, García E, Hijona E, Gallego L, Sánchez J, Perugorria M, Asensio J, Larburu S, Garmendia M, Larzabal M, Portillo M, Aguirre L, Banales J.

Poster presentation | microRNA-506 (miR-506) downregulates type 3 Inositol trisphosphate receptor (InsP3R3) in cholangiocytes

Ananthanarayanan M., Banales JM, Spirli C, Guerra M, Tafur D, Munoz-Garrido P, Saez E. and Nathanson M

Poster presentation | Human cholangiocarcinoma cells secrete extracellular microvesicles: potential pathological and diagnostic role

GEIVEX - Poster presentation

Arbelaiz A, Santos-Laso A, Palomo L, Falcón-Pérez JM, Perugorria MJ, Jiménez-Agüero R, Bujanda L, Banales JM.

2013

Invited talk | Dame Sheila Sherlock Award: Young Investigator Perspectives

European Association for the Study of the Liver (EASL) - Invited talk

Banales JM.

Oral presentation | Role of SLC22A1 gene mutations encoding the OCT1 human organic cation transporter in the lack of response of liver cancer to sorafenib.

XXXVI Meeting of the Spanish Society of Biochemistry and Molecular Biology - Oral presentation

Lozano E, Herráez E, Macías RIR, Vaquero J, Bujanda L, Bañales JM, Marín JJG, Briz O.

Poster presentation | MicroRNA506 (mIR506) downregulates Inositol trisphosphate receptor, Type 3 (ITPR3) expression in cholangiocytes.

American Association for the Study of Liver Diseases (AASLD) - Poster presentation

Ananthanarayanan M, Weerachayaphorn J, Tafur D, Banales JM, Nathanson MH.

Poster presentation | The Magnitude of the Response of Hepatocellular Carcinoma and Cholangiocarcinoma to Sorafenib Is Affected by the Expression of Inactivating Variants in the SLC22A1 Gene.

European Association for the Study of the Liver (EASL) - Poster presentation

Herráez E, Briz O, Lozano E, Macias R.I.R, Robledo V.S, Hernandez-Iglesias J, González-Hernandez A, Bujanda L, Banales JM, Marin J.J.G.

Poster presentation | MicroRNA506 (mIR506) downregulates Inositol trisphosphate receptor, Type 3 (ITPR3) expression in cholangiocytes

American Association for the Study of Liver Diseases (AASLD) - Poster presentation

Ananthanarayanan M, Weerachayaphorn J, Tafur D, Banales JM, Nathanson MH

Poster presentation | Magnetic Resonance Imaging Allows Quantitation of Hepatic Triclyceride Concentration in Humans.

XXXVI Meeting of the Basque-Navarre Society of Digestive Pathology - Poster presentation

2012

Oral presentation | Upregulation of mir-506 Leads to Decreased AE2 Expression in Biliary Epithelium of Patients with Primary Biliary Cirrhosis

European Association for the Study of the Liver (EASL) - Oral presentation

Banales JM, Sáez E, Úriz M, Splinter P, Tietz PS, Prieto J, Medina JF, LaRusso NF.

Poster presentation | Ae2-Deficiency in Mice Predisposes to Liver Injury Associated with Reduced Glutathione, Increased Apoptosis and Development of AMA.

European Association for the Study of the Liver (EASL) - Poster presentation

Ferrer A, Sarvide S, Portu A, Uriarte I, Oude Elferink RPJ, Prieto P, Medina JF and Banales JM.

Poster presentation | Polycystic Human Cholangiocytes Show Increased Matriz-Metalloprotease Activity Stimulated by Interleukin-6, Interleukin-8 and Estrogens.

European Association for the Study of the Liver (EASL) - Poster presentation

Urribarri AD, Sarvide S, Sáez E, Portu A, Jimeno JP, Masyuk TV, Prieto J, LaRusso NF and Banales JM.

Poster presentation | Ae2a,b Deficiency May Lead to Vesicular Trafficking Alterations in Mouse Cholangiocytes.

European Association for the Study of the Liver (EASL) - Poster presentation

Sánchez de Viteri M, Sáez E, Salas JT, Oude Elferink RPJ, Prieto J, Medina JF, and Banales JM.

Poster presentation | High Affinity Adenosine Receptors Modulate CNT3 Activity on Biliary Epithelia.

European Association for the Study of the Liver (EASL) - Poster presentation

Godoy V, Banales JM, Medina JF, Pastor-Anglada M.

Poster presentation | Obstructive Cholestasis Leads to Downregulated Cl-/HCO3- Exchange Activity in Rat Hepatocytes.

European Association for the Study of the Liver (EASL) - Poster presentation

Crocenzi FA. Banales JM, Zucchetti AE, Boaglio AC, Sáez E, Roma MG, Medina JF.

Poster presentation | Polycystic Human Cholangiocytes Show Increased Matriz-Metalloprotease Activity Stimulated by Interleukin-6, Interleukin-8 and Estrogens.

Spanish Association for the Study of the Liver (“Asociación Española de Estudios del Hígado, AEEH) - Poster presentation

Urribarri AD, Sarvide S, Sáez E, Portu A, Jimeno JP, Masyuk TV, Prieto J, LaRusso NF and Banales JM.

2011

Invited talk | Role of Primary Cilium in Cholangiocytes and Involvement in Polycystic Liver Disease.

4th Dutch Experimental Gastroenterology and Hepatology (DEGH) Meeting - Invited talk

Banales JM

Invited talk | Presentation of the Best Posters Presented at the Meeting.

Congress of the Spanish Association for the Study of the Liver (AEEH). - Invited talk

Banales JM

Oral presentation | Oral methylthioadenosine administration attenuates fibrosis and chronic liver disease progression in mdr2-/- mice.

Congress of the Spanish Association for the Study of the Liver (AEEH). - Oral presentation

Latasa MU, Gil-Puig C, Fernández-Barrena MG, Rodríguez-Ortigosa CM, Banales JM, Urtasun R, Goñi S, Méndez M, Arcelus S, Juanarena N, Recio JA, Lotersztajn S, Prieto J, Berasain C, Corrales FJ, Lecanda J, Avila MA.

Poster presentation | Hemodynamic effects of zolmitriptan, an agonist of the serotonin receptors 5HT1B/D, alone and in combination with propranolol in rats with portal hypertension.

Congress of the Spanish Association for the Study of the Liver (AEEH). - Poster presentation

Reboredo M, Chang H, Barbero R, Rodríguez C, Banales J, Herrero I, Quiroga J, Sangro B, Prieto J.

2010

Oral presentation | Effect of Pravastatin in In Vitro and In Vivo Models of Hepatocellular Carcinoma.

Basque-Navarra Meeting of Digestive Pathology - Oral presentation

Hijona E, Banales JM, Medina JF, Hijona L, Arenas J, Cosme A, Aldazabal P, Rodríguez A, Rojas NG, Jiménez R, Bujanda L.

Poster presentation | S-nitrosoglutathione (GSNO) is a Key Contributor to the Hypercholeretic Effect of Ursodeoxycholic Acid (UDCA).

European Association for the Study of the Liver (EASL) - Poster presentation

Rodríguez-Ortigosa CM, Banales JM, Olivas I, Uriarte I, Corrales FJ, Medina JF, Prieto J.

Poster presentation | Bicarbonate Secretion of Mouse Cholangiocytes Involves Na+-HCO3? Cotransport in Addition to Na+-independent Cl?/HCO3? Exchange

European Association for the Study of the Liver (EASL) - Poster presentation

Uriarte I, Banales JM, Sáez E, Arenas F, Oude Elferink RP, Prieto J, Medina JF.

2009

Poster presentation | Hedgehog signaling is abnormal in Polycystic Liver Disease.

American Association for the Study of Liver Diseases (AASLD) - Poster presentation

Masyuk AI, Gradilone SA, Banales JM, Ward CJ, Huang BQ, Masyuk TV and LaRusso NF.

Poster presentation | The cAMP Effectors, EPAC and PKA, are Involved in the Benign Hyperproliferation of Cholangiocytes in an Animal Model of ARPKD.

Sociedad Española de Patología Digestiva (SEPD) - Poster presentation

Banales JM, Masyuk TV, Gradilone SA, Masyuk AI, Medina JF, LaRusso NF

Poster presentation | Ae2a,b-deficient mice develop antimitochondrial antibodies and other features resembling primary biliary cirrhosis.

European Association for the Study of the Liver (EASL) - Poster presentation

Salas JT, Banales JM, Sarvide S, Recalde S, Ferrer A, Uriarte I, Oude Elferink RP, Prieto J, Medina JF.

Poster presentation | The cAMP Effectors, EPAC and PKA, are Involved in the Benign Hyperproliferation of Cholangiocytes in an Animal Model of ARPKD.

European Association for the Study of the Liver (EASL) - Poster presentation

Banales JM, Masyuk TV, Gradilone SA, Masyuk AI, Medina JF, LaRusso NF

2008

Oral presentation | TRPV4 is a Potent Target to Reduce the Hyperproliferative Phenotype of Cholangiocytes in Polycystic Liver Disease.

American Association for the Study of Liver Diseases (AASLD) - Oral presentation

Gradilone SA, Banales JM, Masyuk TV, Masyuk AI, LaRusso NF.

Oral presentation | Biliary Exosomes interact with Cholangiocytes Cilia and Influence Intracellular Signaling and Cholangiocyte Proliferation: a Novel Paracrine Regulatory Pathway in Bile Ducts.

American Association for the Study of Liver Diseases (AASLD) - Oral presentation

Masyuk AI, Ward CJ, Gradilone SA, Huang BQ, Banales JM, Masyuk TV, LaRusso NF

Poster presentation | miR-15a Modulates Cdc25A Protein Expression, Cholangiocyte Proliferation and Centrosome Function: Implications for Hepatic Cystogenesis.

American Society for Cell Biology - Poster presentation

Masyuk T, Lee P, Splinter P, Banales JM, Masyuk A, Stroope A, LaRusso NF.

Poster presentation | Biliary Exosomes Interact with Cholangiocyte Primary Cilia Influencing Intracellular Signaling and Cell Proliferation.

American Society for Cell Biology - Poster presentation

Masyuk A, Ward C, Gradilone S, Huang B, Banales JM, Masyuk T, LaRusso NF.

Poster presentation | The cAMP Effectors, EPAC and PKA, are Involved in the Benign Hyperproliferation of Cholangiocytes in an Animal Model of ARPKD.

American Association for the Study of Liver Diseases (AASLD) - Poster presentation

Banales JM, Masyuk TV, Gradilone SA, Masyuk AI, Medina JF, LaRusso NF

Poster presentation | Vitamin K3 Inhibits Hepatic Cystogenesis in Vitro and in Vivo: a New Therapeutic Approach for Treatment of Polycystic Liver Diseases.

American Association for the Study of Liver Diseases (AASLD) - Poster presentation

Masyuk TV, Banales JM, Gradilone SA, Stroope AJ, Radtke BN, Masyuk AI, Ritman EL, LaRusso NF.

Poster presentation | P2Y12 and the Components of the AKAP-Signaling Complex Are Localized to Cholangiocyte Cilia Providing Chemosensory Functions of These Organelles.

Digestive Disease Week and the Annual Meeting of the AGA Institute - Poster presentation

Masyuk AI, Banales JM, Gradilone SA, Masyuk TV, Huang BQ, Stroope AJ, LaRusso NF.

2007

Oral presentation | Cholangiocyte Cilia Express the Osmosensory Protein TRPV4 and Detect Changes in Luminal Tonicity that Induce Ductal Bicarbonate Secretion.

American Association for the Study of Liver Diseases (AASLD) - Oral presentation

Gradilone SA, Masyuk AI, Splinter PL, Huang BQ, Tietz PS, Banales JM, Masyuk TV and LaRusso NF.

Poster presentation | Cholangiocyte Primary Cilia Express the Elements of the cAMP Signalling Cascade Necessary for Ciliary Sensory Functions.

American Society for Cell Biology - Poster presentation

Masyuk AI, Banales JM, Gradilone SA, Masyuk TV, Huang BQ, Stroope AJ, LaRusso NF.

Poster presentation | Abnormalities in Expression and Topographic Localization of Solute and Water Transporters in Cholangiocytes of the PCK Rat, an Animal Model of Autosomal Recessive Polycystic Kidney Disease (ARPKD), Are Associated with Hepatic Cystogenesis.

American Society for Cell Biology - Poster presentation

Banales JM, Masyuk TV, Tietz PS, Lee S, Huang BQ, Stroope AJ, Gradilone SA, Masyuk AI, Medina JF and LaRusso NF.

Poster presentation | cAMP-downstream Effectors, EPAC and PKA, Are Involved in Hyper-proliferation of Cholangiocytes in the PCK Rat, an Animal Model of Autosomal Recessive Polycystic Kidney Disease.

American Society for Cell Biology - Poster presentation

Banales JM, Masyuk TV, Gradilone SA, Masyuk AI, Medina JF and LaRusso NF.

Poster presentation | Expression of Solute and Water Transporters in ARPKD: Implications for Hepatic Cystogenesis.

American Association for the Study of Liver Diseases (AASLD) - Poster presentation

Banales JM, Tietz PS, Lee S, Huang BQ, Masyuk TV, Stroope AJ, Gradilone SA, Masyuk AI, Medina JF and LaRusso NF.

Poster presentation | Cholangiocyte Primary Cilia Function as Chemosensory Organelles.

American Society of Nephrology Renal Week - Poster presentation

Masyuk AI, Gradilone SA, Banales JM, Lee S, Masyuk TV, Huang BQ, Harris P and LaRusso NF.

Poster presentation | Expression of Solute and Water Transporters in ARPKD: Implications for Hepatic Cystogenesis.

International Conference of Aquaporin. - Poster presentation

Banales JM, Tietz PS, Lee S, Huang BQ, Masyuk TV, Stroope AJ, Masyuk AI, Medina JF, LaRusso NF.